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Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Gene

PPIP5K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.3 Publications

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

Kineticsi

The catalytic efficiency is 80 folds higher for 5-PP-InsP5 (InsP7) compared to InsP6.
  1. KM=0.12 µM for InsP63 Publications
  2. KM=0.10 µM for InsP73 Publications
  1. Vmax=0.03 nmol/min/mg enzyme with InsP6 as substrate3 Publications
  2. Vmax=0.13 nmol/min/mg enzyme with InsP7 as substrate3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei145ATPBy similarity1
Binding sitei198ATPBy similarity1
Binding sitei205ATPBy similarity1
Binding sitei224ATPBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei273SubstrateBy similarity1
Binding sitei275ATPBy similarity1
Binding sitei320ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi248 – 251ATPBy similarity4
Nucleotide bindingi257 – 259ATPBy similarity3
Nucleotide bindingi332 – 334ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS09822-MONOMER
BRENDAi2.7.4.24 2681
ReactomeiR-HSA-1855167 Synthesis of pyrophosphates in the cytosol
SABIO-RKiQ6PFW1

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC:2.7.4.21, EC:2.7.4.24)
Alternative name(s):
Diphosphoinositol pentakisphosphate kinase 1
Histidine acid phosphatase domain-containing protein 2A
IP6 kinase
Inositol pyrophosphate synthase 1
InsP6 and PP-IP5 kinase 1
VIP1 homolog
Short name:
hsVIP1
Gene namesi
Name:PPIP5K1
Synonyms:HISPPD2A, IP6K, IPS1, KIAA0377, VIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000168781.21
HGNCiHGNC:29023 PPIP5K1
MIMi610979 gene
neXtProtiNX_Q6PFW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi399R → A: Decreases 8-fold the affinity for PtdIns(3,4,5)P3. 1 Publication1
Mutagenesisi417R → A: Decreases 16-fold the affinity for PtdIns(3,4,5)P3. 1 Publication1

Organism-specific databases

DisGeNETi9677
OpenTargetsiENSG00000168781
PharmGKBiPA165479401

Chemistry databases

ChEMBLiCHEMBL5046

Polymorphism and mutation databases

BioMutaiPPIP5K1
DMDMi74758334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156881 – 1433Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1Add BLAST1433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei944PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PFW1
MaxQBiQ6PFW1
PaxDbiQ6PFW1
PeptideAtlasiQ6PFW1
PRIDEiQ6PFW1
ProteomicsDBi67105
67106 [Q6PFW1-2]
67107 [Q6PFW1-3]
67108 [Q6PFW1-4]
67109 [Q6PFW1-5]
67110 [Q6PFW1-6]
67111 [Q6PFW1-7]

PTM databases

iPTMnetiQ6PFW1
PhosphoSitePlusiQ6PFW1

Expressioni

Tissue specificityi

Widely expressed, with a higher expression in skeletal muscle, heart and brain.1 Publication

Gene expression databases

BgeeiENSG00000168781 Expressed in 213 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ6PFW1 baseline and differential
GenevisibleiQ6PFW1 HS

Organism-specific databases

HPAiHPA039380

Interactioni

Protein-protein interaction databases

BioGridi115031, 11 interactors
STRINGi9606.ENSP00000380129

Structurei

3D structure databases

ProteinModelPortaliQ6PFW1
SMRiQ6PFW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 65Substrate bindingBy similarity2
Regioni224 – 225Substrate bindingBy similarity2
Regioni337 – 340Substrate bindingBy similarity4
Regioni382 – 453Polyphosphoinositide-binding domain1 PublicationAdd BLAST72

Domaini

The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1057 Eukaryota
ENOG410XNSN LUCA
GeneTreeiENSGT00390000009048
HOVERGENiHBG108657
InParanoidiQ6PFW1
KOiK13024
OMAiMHSNQAS
OrthoDBiEOG091G00ZU
PhylomeDBiQ6PFW1
TreeFamiTF313594

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam
PANTHERiPTHR12750 PTHR12750, 1 hit
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PFW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSLTASEGE STTAHFFLGA GDEGLGTRGI GMRPEESDSE LLEDEEDEVP
60 70 80 90 100
PEPQIIVGIC AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE
110 120 130 140 150
NWPSCHCLIS FHSKGFPLDK AVAYSKLRNP FLINDLAMQY YIQDRREVYR
160 170 180 190 200
ILQEEGIDLP RYAVLNRDPA RPEECNLIEG EDQVEVNGAV FPKPFVEKPV
210 220 230 240 250
SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR KTGSYIYEEF
260 270 280 290 300
MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE IRYPVMLTAM
310 320 330 340 350
EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA
360 370 380 390 400
KILGNTIMRE LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH
410 420 430 440 450
GDRTPKQKMK MEVKHPRFFA LFEKHGGYKT GKLKLKRPEQ LQEVLDITRL
460 470 480 490 500
LLAELEKEPG GEIEEKTGKL EQLKSVLEMY GHFSGINRKV QLTYYPHGVK
510 520 530 540 550
ASNEGQDPQR ETLAPSLLLV LKWGGELTPA GRVQAEELGR AFRCMYPGGQ
560 570 580 590 600
GDYAGFPGCG LLRLHSTFRH DLKIYASDEG RVQMTAAAFA KGLLALEGEL
610 620 630 640 650
TPILVQMVKS ANMNGLLDSD GDSLSSCQHR VKARLHHILQ QDAPFGPEDY
660 670 680 690 700
DQLAPTRSTS LLNSMTIIQN PVKVCDQVFA LIENLTHQIR ERMQDPRSVD
710 720 730 740 750
LQLYHSETLE LMLQRWSKLE RDFRQKSGRY DISKIPDIYD CVKYDVQHNG
760 770 780 790 800
SLGLQGTAEL LRLSKALADV VIPQEYGISR EEKLEIAVGF CLPLLRKILL
810 820 830 840 850
DLQRTHEDES VNKLHPLCYL RYSRGVLSPG RHVRTRLYFT SESHVHSLLS
860 870 880 890 900
VFRYGGLLDE TQDAQWQRAL DYLSAISELN YMTQIVIMLY EDNTQDPLSE
910 920 930 940 950
ERFHVELHFS PGVKGVEEEG SAPAGCGFRP ASSENEEMKT NQGSMENLCP
960 970 980 990 1000
GKASDEPDRA LQTSPQPPEG PGLPRRSPLI RNRKAGSMEV LSETSSSRPG
1010 1020 1030 1040 1050
GYRLFSSSRP PTEMKQSGLG SQCTGLFSTT VLGGSSSAPN LQDYARSHGK
1060 1070 1080 1090 1100
KLPPASLKHR DELLFVPAVK RFSVSFAKHP TNGFEGCSMV PTIYPLETLH
1110 1120 1130 1140 1150
NALSLRQVSE FLSRVCQRHT DAQAQASAAL FDSMHSSQAS DNPFSPPRTL
1160 1170 1180 1190 1200
HSPPLQLQQR SEKPPWYSSG PSSTVSSAGP SSPTTVDGNS QFGFSDQPSL
1210 1220 1230 1240 1250
NSHVAEEHQG LGLLQETPGS GAQELSIEGE QELFEPNQSP QVPPMETSQP
1260 1270 1280 1290 1300
YEEVSQPCQE VPDISQPCQD ISEALSQPCQ KVPDISQQCQ ENHDNGNHTC
1310 1320 1330 1340 1350
QEVPHISQPC QKSSQLCQKV SEEVCQLCLE NSEEVSQPCQ GVSVEVGKLV
1360 1370 1380 1390 1400
HKFHVGVGSL VQETLVEVGS PAEEIPEEVI QPYQEFSVEV GRLAQETSAI
1410 1420 1430
NLLSQGIPEI DKPSQEFPEE IDLQAQEVPE EIN
Length:1,433
Mass (Da):159,521
Last modified:July 5, 2004 - v1
Checksum:iBA0DEFB2A71B1467
GO
Isoform 2 (identifier: Q6PFW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1082-1082: N → NG

Show »
Length:1,430
Mass (Da):159,042
Checksum:i11E6EC888FB5703C
GO
Isoform 3 (identifier: Q6PFW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1062-1082: Missing.

Show »
Length:1,408
Mass (Da):156,616
Checksum:iE88E96597599F5BA
GO
Isoform 4 (identifier: Q6PFW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     653-653: Missing.
     818-821: Missing.
     1062-1082: Missing.

Show »
Length:1,407
Mass (Da):156,502
Checksum:i1DC5FCBF5A726F14
GO
Isoform 5 (identifier: Q6PFW1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-821: Missing.
     865-957: Missing.
     1107-1240: Missing.

Show »
Length:1,194
Mass (Da):133,447
Checksum:iF29D866BFAD98841
GO
Isoform 6 (identifier: Q6PFW1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-1433: Missing.

Note: No experimental confirmation available.
Show »
Length:817
Mass (Da):92,061
Checksum:i4DBCE9B366905530
GO
Isoform 7 (identifier: Q6PFW1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1020-1082: Missing.
     1167-1167: Y → LETRFCHVGQAGLELLTSSDLPASASQSAGITGVSHRTQPD

Note: No experimental confirmation available.
Show »
Length:1,406
Mass (Da):156,320
Checksum:i77C01F2E2AC7446D
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WPL9B7WPL9_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
1,429Annotation score:
F8W9A8F8W9A8_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
1,409Annotation score:
A0A2R8YGT1A0A2R8YGT1_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
499Annotation score:
H7C398H7C398_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
259Annotation score:
C9JZX6C9JZX6_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
133Annotation score:
H7C436H7C436_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
118Annotation score:
H0Y3Y5H0Y3Y5_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
196Annotation score:
C9J490C9J490_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
71Annotation score:
C9J5E6C9J5E6_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
114Annotation score:

Sequence cautioni

The sequence BAA20831 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44D → G in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti304V → M in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti374E → V in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti423E → Q in AAP30843 (PubMed:12825070).Curated1
Sequence conflicti423E → Q in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti423E → Q in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti473L → P in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti483F → S in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti483F → S in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti490V → E in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti548G → V in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti738I → L in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti738I → L in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti788V → A in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti788V → A in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti936E → G in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti985A → V in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti985A → V in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1020G → A in AAP30843 (PubMed:12825070).Curated1
Sequence conflicti1041L → P in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1041L → P in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1066V → L in AAP30842 (PubMed:12825070).Curated1
Sequence conflicti1126A → T in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1134M → V in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1198P → R in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1293H → M in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1293H → M in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1294D → T in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1294D → T in AAN40768 (PubMed:12825070).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030615653Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_030616810 – 821Missing in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030617818 – 1433Missing in isoform 6. 1 PublicationAdd BLAST616
Alternative sequenceiVSP_030618818 – 821Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 3 Publications4
Alternative sequenceiVSP_030619865 – 957Missing in isoform 5. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0306201020 – 1082Missing in isoform 7. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_0306211062 – 1082Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0306221082N → NG in isoform 2. 1 Publication1
Alternative sequenceiVSP_0306231107 – 1240Missing in isoform 5. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_0306241167Y → LETRFCHVGQAGLELLTSSD LPASASQSAGITGVSHRTQP D in isoform 7. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502586 mRNA Translation: AAP30842.1
AF502587 mRNA Translation: AAP30843.1
AF502588 mRNA Translation: AAP30844.1
AF502589 mRNA Translation: AAP30845.1
AF543190 mRNA Translation: AAN40768.1
AB002375 mRNA Translation: BAA20831.2 Different initiation.
BX538022 mRNA Translation: CAD97968.1
BX647814 mRNA Translation: CAI46011.1
BC050263 mRNA Translation: AAH50263.1
BC057395 mRNA Translation: AAH57395.1
CCDSiCCDS32215.1 [Q6PFW1-3]
CCDS45252.1 [Q6PFW1-1]
CCDS53937.1 [Q6PFW1-7]
RefSeqiNP_001124330.1, NM_001130858.2 [Q6PFW1-1]
NP_001124331.1, NM_001130859.2 [Q6PFW1-3]
NP_001177143.1, NM_001190214.1 [Q6PFW1-7]
NP_055474.3, NM_014659.5 [Q6PFW1-3]
XP_005254861.1, XM_005254804.1 [Q6PFW1-3]
XP_016878237.1, XM_017022748.1 [Q6PFW1-3]
XP_016878238.1, XM_017022749.1
XP_016878239.1, XM_017022750.1
XP_016878240.1, XM_017022751.1
XP_016878248.1, XM_017022759.1 [Q6PFW1-6]
UniGeneiHs.156814
Hs.679105
Hs.679911

Genome annotation databases

EnsembliENST00000334933; ENSP00000334779; ENSG00000168781 [Q6PFW1-3]
ENST00000348806; ENSP00000308773; ENSG00000168781 [Q6PFW1-7]
ENST00000360135; ENSP00000353253; ENSG00000168781 [Q6PFW1-7]
ENST00000360301; ENSP00000353446; ENSG00000168781 [Q6PFW1-3]
ENST00000396923; ENSP00000380129; ENSG00000168781 [Q6PFW1-1]
ENST00000420765; ENSP00000400887; ENSG00000168781 [Q6PFW1-1]
GeneIDi9677
KEGGihsa:9677
UCSCiuc001zrw.3 human [Q6PFW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502586 mRNA Translation: AAP30842.1
AF502587 mRNA Translation: AAP30843.1
AF502588 mRNA Translation: AAP30844.1
AF502589 mRNA Translation: AAP30845.1
AF543190 mRNA Translation: AAN40768.1
AB002375 mRNA Translation: BAA20831.2 Different initiation.
BX538022 mRNA Translation: CAD97968.1
BX647814 mRNA Translation: CAI46011.1
BC050263 mRNA Translation: AAH50263.1
BC057395 mRNA Translation: AAH57395.1
CCDSiCCDS32215.1 [Q6PFW1-3]
CCDS45252.1 [Q6PFW1-1]
CCDS53937.1 [Q6PFW1-7]
RefSeqiNP_001124330.1, NM_001130858.2 [Q6PFW1-1]
NP_001124331.1, NM_001130859.2 [Q6PFW1-3]
NP_001177143.1, NM_001190214.1 [Q6PFW1-7]
NP_055474.3, NM_014659.5 [Q6PFW1-3]
XP_005254861.1, XM_005254804.1 [Q6PFW1-3]
XP_016878237.1, XM_017022748.1 [Q6PFW1-3]
XP_016878238.1, XM_017022749.1
XP_016878239.1, XM_017022750.1
XP_016878240.1, XM_017022751.1
XP_016878248.1, XM_017022759.1 [Q6PFW1-6]
UniGeneiHs.156814
Hs.679105
Hs.679911

3D structure databases

ProteinModelPortaliQ6PFW1
SMRiQ6PFW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115031, 11 interactors
STRINGi9606.ENSP00000380129

Chemistry databases

ChEMBLiCHEMBL5046

PTM databases

iPTMnetiQ6PFW1
PhosphoSitePlusiQ6PFW1

Polymorphism and mutation databases

BioMutaiPPIP5K1
DMDMi74758334

Proteomic databases

EPDiQ6PFW1
MaxQBiQ6PFW1
PaxDbiQ6PFW1
PeptideAtlasiQ6PFW1
PRIDEiQ6PFW1
ProteomicsDBi67105
67106 [Q6PFW1-2]
67107 [Q6PFW1-3]
67108 [Q6PFW1-4]
67109 [Q6PFW1-5]
67110 [Q6PFW1-6]
67111 [Q6PFW1-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334933; ENSP00000334779; ENSG00000168781 [Q6PFW1-3]
ENST00000348806; ENSP00000308773; ENSG00000168781 [Q6PFW1-7]
ENST00000360135; ENSP00000353253; ENSG00000168781 [Q6PFW1-7]
ENST00000360301; ENSP00000353446; ENSG00000168781 [Q6PFW1-3]
ENST00000396923; ENSP00000380129; ENSG00000168781 [Q6PFW1-1]
ENST00000420765; ENSP00000400887; ENSG00000168781 [Q6PFW1-1]
GeneIDi9677
KEGGihsa:9677
UCSCiuc001zrw.3 human [Q6PFW1-1]

Organism-specific databases

CTDi9677
DisGeNETi9677
EuPathDBiHostDB:ENSG00000168781.21
GeneCardsiPPIP5K1
H-InvDBiHIX0012186
HGNCiHGNC:29023 PPIP5K1
HPAiHPA039380
MIMi610979 gene
neXtProtiNX_Q6PFW1
OpenTargetsiENSG00000168781
PharmGKBiPA165479401
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1057 Eukaryota
ENOG410XNSN LUCA
GeneTreeiENSGT00390000009048
HOVERGENiHBG108657
InParanoidiQ6PFW1
KOiK13024
OMAiMHSNQAS
OrthoDBiEOG091G00ZU
PhylomeDBiQ6PFW1
TreeFamiTF313594

Enzyme and pathway databases

BioCyciMetaCyc:HS09822-MONOMER
BRENDAi2.7.4.24 2681
ReactomeiR-HSA-1855167 Synthesis of pyrophosphates in the cytosol
SABIO-RKiQ6PFW1

Miscellaneous databases

ChiTaRSiPPIP5K1 human
GenomeRNAii9677
PROiPR:Q6PFW1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168781 Expressed in 213 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ6PFW1 baseline and differential
GenevisibleiQ6PFW1 HS

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam
PANTHERiPTHR12750 PTHR12750, 1 hit
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVIP1_HUMAN
AccessioniPrimary (citable) accession number: Q6PFW1
Secondary accession number(s): O15082
, Q5HYF8, Q7Z3A7, Q86TE7, Q86UV3, Q86UV4, Q86XW8, Q8IZN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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