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Entry version 141 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Gene

PPIP5K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The catalytic efficiency is 80 folds higher for 5-PP-InsP5 (InsP7) compared to InsP6.
  1. KM=0.12 µM for InsP63 Publications
  2. KM=0.10 µM for InsP73 Publications
  1. Vmax=0.03 nmol/min/mg enzyme with InsP6 as substrate3 Publications
  2. Vmax=0.13 nmol/min/mg enzyme with InsP7 as substrate3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei145ATPBy similarity1
Binding sitei198ATPBy similarity1
Binding sitei205ATPBy similarity1
Binding sitei224ATPBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei273SubstrateBy similarity1
Binding sitei275ATPBy similarity1
Binding sitei320ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi248 – 251ATPBy similarity4
Nucleotide bindingi257 – 259ATPBy similarity3
Nucleotide bindingi332 – 334ATPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS09822-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.4.24 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q6PFW1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC:2.7.4.21, EC:2.7.4.24)
Alternative name(s):
Diphosphoinositol pentakisphosphate kinase 1
Histidine acid phosphatase domain-containing protein 2A
IP6 kinase
Inositol pyrophosphate synthase 1
InsP6 and PP-IP5 kinase 1
VIP1 homolog
Short name:
hsVIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPIP5K1
Synonyms:HISPPD2A, IP6K, IPS1, KIAA0377, VIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168781.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29023 PPIP5K1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610979 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PFW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi399R → A: Decreases 8-fold the affinity for PtdIns(3,4,5)P3. 1 Publication1
Mutagenesisi417R → A: Decreases 16-fold the affinity for PtdIns(3,4,5)P3. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9677

Open Targets

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OpenTargetsi
ENSG00000168781

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165479401

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PFW1 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5046

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PPIP5K1

Domain mapping of disease mutations (DMDM)

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DMDMi
74758334

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003156881 – 1433Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1Add BLAST1433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei944PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6PFW1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PFW1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6PFW1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PFW1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PFW1

PeptideAtlas

More...
PeptideAtlasi
Q6PFW1

PRoteomics IDEntifications database

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PRIDEi
Q6PFW1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67105 [Q6PFW1-1]
67106 [Q6PFW1-2]
67107 [Q6PFW1-3]
67108 [Q6PFW1-4]
67109 [Q6PFW1-5]
67110 [Q6PFW1-6]
67111 [Q6PFW1-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PFW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PFW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with a higher expression in skeletal muscle, heart and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168781 Expressed in 213 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6PFW1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6PFW1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039380

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115031, 11 interactors

Protein interaction database and analysis system

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IntActi
Q6PFW1, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000400887

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PFW1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6PFW1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 65Substrate bindingBy similarity2
Regioni224 – 225Substrate bindingBy similarity2
Regioni337 – 340Substrate bindingBy similarity4
Regioni382 – 453Polyphosphoinositide-binding domain1 PublicationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1057 Eukaryota
ENOG410XNSN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009048

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PFW1

KEGG Orthology (KO)

More...
KOi
K13024

Identification of Orthologs from Complete Genome Data

More...
OMAi
YPIEALM

Database of Orthologous Groups

More...
OrthoDBi
93740at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PFW1

TreeFam database of animal gene trees

More...
TreeFami
TF313594

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07061 HP_HAP_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam
IPR040557 VIP1_N

The PANTHER Classification System

More...
PANTHERi
PTHR12750 PTHR12750, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00328 His_Phos_2, 1 hit
PF18086 PPIP5K2_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53254 SSF53254, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PFW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSLTASEGE STTAHFFLGA GDEGLGTRGI GMRPEESDSE LLEDEEDEVP
60 70 80 90 100
PEPQIIVGIC AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE
110 120 130 140 150
NWPSCHCLIS FHSKGFPLDK AVAYSKLRNP FLINDLAMQY YIQDRREVYR
160 170 180 190 200
ILQEEGIDLP RYAVLNRDPA RPEECNLIEG EDQVEVNGAV FPKPFVEKPV
210 220 230 240 250
SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR KTGSYIYEEF
260 270 280 290 300
MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE IRYPVMLTAM
310 320 330 340 350
EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA
360 370 380 390 400
KILGNTIMRE LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH
410 420 430 440 450
GDRTPKQKMK MEVKHPRFFA LFEKHGGYKT GKLKLKRPEQ LQEVLDITRL
460 470 480 490 500
LLAELEKEPG GEIEEKTGKL EQLKSVLEMY GHFSGINRKV QLTYYPHGVK
510 520 530 540 550
ASNEGQDPQR ETLAPSLLLV LKWGGELTPA GRVQAEELGR AFRCMYPGGQ
560 570 580 590 600
GDYAGFPGCG LLRLHSTFRH DLKIYASDEG RVQMTAAAFA KGLLALEGEL
610 620 630 640 650
TPILVQMVKS ANMNGLLDSD GDSLSSCQHR VKARLHHILQ QDAPFGPEDY
660 670 680 690 700
DQLAPTRSTS LLNSMTIIQN PVKVCDQVFA LIENLTHQIR ERMQDPRSVD
710 720 730 740 750
LQLYHSETLE LMLQRWSKLE RDFRQKSGRY DISKIPDIYD CVKYDVQHNG
760 770 780 790 800
SLGLQGTAEL LRLSKALADV VIPQEYGISR EEKLEIAVGF CLPLLRKILL
810 820 830 840 850
DLQRTHEDES VNKLHPLCYL RYSRGVLSPG RHVRTRLYFT SESHVHSLLS
860 870 880 890 900
VFRYGGLLDE TQDAQWQRAL DYLSAISELN YMTQIVIMLY EDNTQDPLSE
910 920 930 940 950
ERFHVELHFS PGVKGVEEEG SAPAGCGFRP ASSENEEMKT NQGSMENLCP
960 970 980 990 1000
GKASDEPDRA LQTSPQPPEG PGLPRRSPLI RNRKAGSMEV LSETSSSRPG
1010 1020 1030 1040 1050
GYRLFSSSRP PTEMKQSGLG SQCTGLFSTT VLGGSSSAPN LQDYARSHGK
1060 1070 1080 1090 1100
KLPPASLKHR DELLFVPAVK RFSVSFAKHP TNGFEGCSMV PTIYPLETLH
1110 1120 1130 1140 1150
NALSLRQVSE FLSRVCQRHT DAQAQASAAL FDSMHSSQAS DNPFSPPRTL
1160 1170 1180 1190 1200
HSPPLQLQQR SEKPPWYSSG PSSTVSSAGP SSPTTVDGNS QFGFSDQPSL
1210 1220 1230 1240 1250
NSHVAEEHQG LGLLQETPGS GAQELSIEGE QELFEPNQSP QVPPMETSQP
1260 1270 1280 1290 1300
YEEVSQPCQE VPDISQPCQD ISEALSQPCQ KVPDISQQCQ ENHDNGNHTC
1310 1320 1330 1340 1350
QEVPHISQPC QKSSQLCQKV SEEVCQLCLE NSEEVSQPCQ GVSVEVGKLV
1360 1370 1380 1390 1400
HKFHVGVGSL VQETLVEVGS PAEEIPEEVI QPYQEFSVEV GRLAQETSAI
1410 1420 1430
NLLSQGIPEI DKPSQEFPEE IDLQAQEVPE EIN
Length:1,433
Mass (Da):159,521
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA0DEFB2A71B1467
GO
Isoform 2 (identifier: Q6PFW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1082-1082: N → NG

Show »
Length:1,430
Mass (Da):159,042
Checksum:i11E6EC888FB5703C
GO
Isoform 3 (identifier: Q6PFW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1062-1082: Missing.

Show »
Length:1,408
Mass (Da):156,616
Checksum:iE88E96597599F5BA
GO
Isoform 4 (identifier: Q6PFW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     653-653: Missing.
     818-821: Missing.
     1062-1082: Missing.

Show »
Length:1,407
Mass (Da):156,502
Checksum:i1DC5FCBF5A726F14
GO
Isoform 5 (identifier: Q6PFW1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-821: Missing.
     865-957: Missing.
     1107-1240: Missing.

Show »
Length:1,194
Mass (Da):133,447
Checksum:iF29D866BFAD98841
GO
Isoform 6 (identifier: Q6PFW1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-1433: Missing.

Show »
Length:817
Mass (Da):92,061
Checksum:i4DBCE9B366905530
GO
Isoform 7 (identifier: Q6PFW1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1020-1082: Missing.
     1167-1167: Y → LETRFCHVGQAGLELLTSSDLPASASQSAGITGVSHRTQPD

Show »
Length:1,406
Mass (Da):156,320
Checksum:i77C01F2E2AC7446D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WPL9B7WPL9_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
1,429Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9A8F8W9A8_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
1,409Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGT1A0A2R8YGT1_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
499Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C398H7C398_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3Y5H0Y3Y5_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZX6C9JZX6_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J490C9J490_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5E6C9J5E6_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C436H7C436_HUMAN
Inositol hexakisphosphate and dipho...
PPIP5K1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20831 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44D → G in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti304V → M in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti374E → V in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti423E → Q in AAP30843 (PubMed:12825070).Curated1
Sequence conflicti423E → Q in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti423E → Q in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti473L → P in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti483F → S in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti483F → S in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti490V → E in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti548G → V in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti738I → L in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti738I → L in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti788V → A in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti788V → A in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti936E → G in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti985A → V in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti985A → V in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1020G → A in AAP30843 (PubMed:12825070).Curated1
Sequence conflicti1041L → P in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1041L → P in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1066V → L in AAP30842 (PubMed:12825070).Curated1
Sequence conflicti1126A → T in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1134M → V in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1198P → R in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1293H → M in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1293H → M in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1294D → T in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1294D → T in AAN40768 (PubMed:12825070).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030615653Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_030616810 – 821Missing in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030617818 – 1433Missing in isoform 6. 1 PublicationAdd BLAST616
Alternative sequenceiVSP_030618818 – 821Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 3 Publications4
Alternative sequenceiVSP_030619865 – 957Missing in isoform 5. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0306201020 – 1082Missing in isoform 7. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_0306211062 – 1082Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0306221082N → NG in isoform 2. 1 Publication1
Alternative sequenceiVSP_0306231107 – 1240Missing in isoform 5. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_0306241167Y → LETRFCHVGQAGLELLTSSD LPASASQSAGITGVSHRTQP D in isoform 7. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF502586 mRNA Translation: AAP30842.1
AF502587 mRNA Translation: AAP30843.1
AF502588 mRNA Translation: AAP30844.1
AF502589 mRNA Translation: AAP30845.1
AF543190 mRNA Translation: AAN40768.1
AB002375 mRNA Translation: BAA20831.2 Different initiation.
BX538022 mRNA Translation: CAD97968.1
BX647814 mRNA Translation: CAI46011.1
BC050263 mRNA Translation: AAH50263.1
BC057395 mRNA Translation: AAH57395.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32215.1 [Q6PFW1-3]
CCDS45252.1 [Q6PFW1-1]
CCDS53937.1 [Q6PFW1-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001124330.1, NM_001130858.2 [Q6PFW1-1]
NP_001124331.1, NM_001130859.2 [Q6PFW1-3]
NP_001177143.1, NM_001190214.1 [Q6PFW1-7]
NP_055474.3, NM_014659.5 [Q6PFW1-3]
XP_005254861.1, XM_005254804.1 [Q6PFW1-3]
XP_016878237.1, XM_017022748.1 [Q6PFW1-3]
XP_016878238.1, XM_017022749.1
XP_016878239.1, XM_017022750.1
XP_016878240.1, XM_017022751.1
XP_016878248.1, XM_017022759.1 [Q6PFW1-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334933; ENSP00000334779; ENSG00000168781 [Q6PFW1-3]
ENST00000348806; ENSP00000308773; ENSG00000168781 [Q6PFW1-7]
ENST00000360135; ENSP00000353253; ENSG00000168781 [Q6PFW1-7]
ENST00000360301; ENSP00000353446; ENSG00000168781 [Q6PFW1-3]
ENST00000396923; ENSP00000380129; ENSG00000168781 [Q6PFW1-1]
ENST00000420765; ENSP00000400887; ENSG00000168781 [Q6PFW1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9677

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9677

UCSC genome browser

More...
UCSCi
uc001zrw.3 human [Q6PFW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502586 mRNA Translation: AAP30842.1
AF502587 mRNA Translation: AAP30843.1
AF502588 mRNA Translation: AAP30844.1
AF502589 mRNA Translation: AAP30845.1
AF543190 mRNA Translation: AAN40768.1
AB002375 mRNA Translation: BAA20831.2 Different initiation.
BX538022 mRNA Translation: CAD97968.1
BX647814 mRNA Translation: CAI46011.1
BC050263 mRNA Translation: AAH50263.1
BC057395 mRNA Translation: AAH57395.1
CCDSiCCDS32215.1 [Q6PFW1-3]
CCDS45252.1 [Q6PFW1-1]
CCDS53937.1 [Q6PFW1-7]
RefSeqiNP_001124330.1, NM_001130858.2 [Q6PFW1-1]
NP_001124331.1, NM_001130859.2 [Q6PFW1-3]
NP_001177143.1, NM_001190214.1 [Q6PFW1-7]
NP_055474.3, NM_014659.5 [Q6PFW1-3]
XP_005254861.1, XM_005254804.1 [Q6PFW1-3]
XP_016878237.1, XM_017022748.1 [Q6PFW1-3]
XP_016878238.1, XM_017022749.1
XP_016878239.1, XM_017022750.1
XP_016878240.1, XM_017022751.1
XP_016878248.1, XM_017022759.1 [Q6PFW1-6]

3D structure databases

SMRiQ6PFW1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115031, 11 interactors
IntActiQ6PFW1, 1 interactor
STRINGi9606.ENSP00000400887

Chemistry databases

ChEMBLiCHEMBL5046

PTM databases

iPTMnetiQ6PFW1
PhosphoSitePlusiQ6PFW1

Polymorphism and mutation databases

BioMutaiPPIP5K1
DMDMi74758334

Proteomic databases

EPDiQ6PFW1
jPOSTiQ6PFW1
MassIVEiQ6PFW1
MaxQBiQ6PFW1
PaxDbiQ6PFW1
PeptideAtlasiQ6PFW1
PRIDEiQ6PFW1
ProteomicsDBi67105 [Q6PFW1-1]
67106 [Q6PFW1-2]
67107 [Q6PFW1-3]
67108 [Q6PFW1-4]
67109 [Q6PFW1-5]
67110 [Q6PFW1-6]
67111 [Q6PFW1-7]

Genome annotation databases

EnsembliENST00000334933; ENSP00000334779; ENSG00000168781 [Q6PFW1-3]
ENST00000348806; ENSP00000308773; ENSG00000168781 [Q6PFW1-7]
ENST00000360135; ENSP00000353253; ENSG00000168781 [Q6PFW1-7]
ENST00000360301; ENSP00000353446; ENSG00000168781 [Q6PFW1-3]
ENST00000396923; ENSP00000380129; ENSG00000168781 [Q6PFW1-1]
ENST00000420765; ENSP00000400887; ENSG00000168781 [Q6PFW1-1]
GeneIDi9677
KEGGihsa:9677
UCSCiuc001zrw.3 human [Q6PFW1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9677
DisGeNETi9677
EuPathDBiHostDB:ENSG00000168781.21

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPIP5K1
HGNCiHGNC:29023 PPIP5K1
HPAiHPA039380
MIMi610979 gene
neXtProtiNX_Q6PFW1
OpenTargetsiENSG00000168781
PharmGKBiPA165479401

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1057 Eukaryota
ENOG410XNSN LUCA
GeneTreeiENSGT00390000009048
InParanoidiQ6PFW1
KOiK13024
OMAiYPIEALM
OrthoDBi93740at2759
PhylomeDBiQ6PFW1
TreeFamiTF313594

Enzyme and pathway databases

BioCyciMetaCyc:HS09822-MONOMER
BRENDAi2.7.4.24 2681
ReactomeiR-HSA-1855167 Synthesis of pyrophosphates in the cytosol
SABIO-RKiQ6PFW1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPIP5K1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9677
PharosiQ6PFW1 Tbio

Protein Ontology

More...
PROi
PR:Q6PFW1
RNActiQ6PFW1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168781 Expressed in 213 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ6PFW1 baseline and differential
GenevisibleiQ6PFW1 HS

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR037446 His_Pase_VIP1
IPR029033 His_PPase_superfam
IPR040557 VIP1_N
PANTHERiPTHR12750 PTHR12750, 1 hit
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
PF18086 PPIP5K2_N, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PFW1
Secondary accession number(s): O15082
, Q5HYF8, Q7Z3A7, Q86TE7, Q86UV3, Q86UV4, Q86XW8, Q8IZN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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