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Protein

Transmembrane protein 47

Gene

tmem47

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates cell junction organization in epithelial cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 47
Alternative name(s):
Transmembrane 4 superfamily member 10
Gene namesi
Name:tmem47
Synonyms:tm4sf10
ORF Names:zgc:63990
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-040426-2644 tmem47

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725711 – 181Transmembrane protein 47Add BLAST181

Proteomic databases

PaxDbiQ6PFT6
PRIDEiQ6PFT6

Expressioni

Gene expression databases

BgeeiENSDARG00000057322 Expressed in 26 organ(s), highest expression level in embryo
ExpressionAtlasiQ6PFT6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104833

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM47 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000124678
HOVERGENiHBG080233
InParanoidiQ6PFT6
OMAiWTRDIGY
OrthoDBiEOG091G0S9P
PhylomeDBiQ6PFT6
TreeFamiTF312855

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR14399 PTHR14399, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PFT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSVSGAEE VRVSALTPLK LVGLVCVFLA LCLDVGAVLS PAWVTADDQY
60 70 80 90 100
HLSLWKSCSK PAASATWRCN STLGTDWQIA TLALLLGGAF LILLSFLVAL
110 120 130 140 150
VSVCIRSRRR FYRPVAIMLF AAVVLQACCL VLYPIKFIET ISLRIYHEFN
160 170 180
WGYGLAWGAT IFSFGGAILY CLNPKNYEDY Y
Length:181
Mass (Da):19,947
Last modified:July 5, 2004 - v1
Checksum:i1DA80DCE9524B753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057424 mRNA Translation: AAH57424.1
RefSeqiNP_999928.1, NM_214763.2
UniGeneiDr.77778

Genome annotation databases

EnsembliENSDART00000123917; ENSDARP00000104833; ENSDARG00000057322
GeneIDi406640
KEGGidre:406640

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057424 mRNA Translation: AAH57424.1
RefSeqiNP_999928.1, NM_214763.2
UniGeneiDr.77778

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104833

Proteomic databases

PaxDbiQ6PFT6
PRIDEiQ6PFT6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000123917; ENSDARP00000104833; ENSDARG00000057322
GeneIDi406640
KEGGidre:406640

Organism-specific databases

CTDi83604
ZFINiZDB-GENE-040426-2644 tmem47

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000124678
HOVERGENiHBG080233
InParanoidiQ6PFT6
OMAiWTRDIGY
OrthoDBiEOG091G0S9P
PhylomeDBiQ6PFT6
TreeFamiTF312855

Miscellaneous databases

PROiPR:Q6PFT6

Gene expression databases

BgeeiENSDARG00000057322 Expressed in 26 organ(s), highest expression level in embryo
ExpressionAtlasiQ6PFT6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR14399 PTHR14399, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM47_DANRE
AccessioniPrimary (citable) accession number: Q6PFT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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