Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q6PFT4 (Q6PFT4_DANRE)

Entry version 133 (19 Jan 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Zgc:64042

Gene

myo1eb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi110 – 117ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:64042Imported
Submitted name:
Zgc:64042 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myo1ebImported
ORF Names:zgc:64042Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-040426-1347, myo1eb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 690Myosin motorInterPro annotationAdd BLAST674
Domaini728 – 920TH1InterPro annotationAdd BLAST193
Domaini1039 – 1096SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni567 – 589Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni917 – 1042DisorderedSequence analysisAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi935 – 950Polar residuesSequence analysisAdd BLAST16
Compositional biasi968 – 998Polar residuesSequence analysisAdd BLAST31
Compositional biasi1011 – 1025Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		FSSWNKG

Database of Orthologous Groups

More...OrthoDBi		122881at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd01378, MYSc_Myo1, 1 hit
cd11827, SH3_MyoIe_If_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035507, Ie/If_SH3
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR027417, P-loop_NTPase
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193, MYOSINHEAVY
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00242, MYSc, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS50002, SH3, 1 hit
PS51757, TH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PFT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSKEKYHWQ TQNVKVSGVD DMVLLSKITE DAITDNLKKR YMDDYIFTYI 
        60         70         80         90        100
GPVLISVNPF KQLPYFTDRE IELYQGAAQY ENPPHIYALA DNMYRNMMID 
       110        120        130        140        150
SENQCVIISG ESGAGKTVAA KYIMSYISKV SGGGPKVQHV KDIILQSNPL 
       160        170        180        190        200
LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG EPDGGKISNF LLEKSRVVSQ 
       210        220        230        240        250
NNGERNFHIY YQLLKGATKE QRENLGVTTP DYYFYLNQSD TYTVEDVNDK 
       260        270        280        290        300
KEFEDTMNAM SVVGLSMDAQ DSVLQIVAGI LHLGNIAFRE EGNYAVVESE 
       310        320        330        340        350
DFLAFPSYLL GINQDGLKSK LTSRIMDSKW GGKTETISVT LNTEQASFTR 
       360        370        380        390        400
DALSKALYSR LFDYLVDAIN KAMQKDREEL NIGVLDIYGF EIFQKNGFEQ 
       410        420        430        440        450
FCINFVNEKL QQIFIELTLK AEQEEYVQEG ISWTPIEYFN NKVVCDLIES 
       460        470        480        490        500
KLNPPGIMSI LDDVCATMHA KGEGADQTLL QKLQSQIGTH EHFNSWNKGF 
       510        520        530        540        550
VVHHYAGKVS YDVSGFCERN RDVLFSDIIE LMQSSEFAFI KGLFPENIEA 
       560        570        580        590        600
EKRGRPTTAG SKIKKQANTL VQTLMKCTPH YIRCIKPNET KKSRDWEESR 
       610        620        630        640        650
VKHQVEYLGL RENIRVRRAG YAFRRIFKKF LHRYAILTRE TWPQWRGDEK 
       660        670        680        690        700
QGVLHLLKSV NMDSDQYQLG KTKIFIKAPE SLFLLEEMRE RKYNGYARVI 
       710        720        730        740        750
QQAWRKHIAV RKYVRMREEA SDLLLNKKER RKNSLNRNFV GDYIGTDNHP 
       760        770        780        790        800
EIRQFVGRRE RIDFADVVVK YDRRFKSVKR DLILTPKFLY LIGREKVKQG 
       810        820        830        840        850
PEKGQIREVL KRKIEVEKIQ SVSLSTLQDD IFILHEDQYD SVLQSVFKTE 
       860        870        880        890        900
FLSLLYKRFE EKTKKKLPLK FNNLLEFKVK KGGWGPFASA GSRQIQFQMG 
       910        920        930        940        950
QGDDAVLKPS SKILTVSIGS GLPKNTRPTR RDNRKSSFMG NQNRSAGQYS 
       960        970        980        990       1000
REAPKSAGRG RGQPAVRHSL LRQQSTMDQP TLPRLQGSVR SQRESQVYTD 
      1010       1020       1030       1040       1050
MGFMKVPDQG VAGMHRRRSK EYKPLPGSGR PKPSPKPVPR TPRCKALYAY 
      1060       1070       1080       1090 
DAQDTDELSF QPDDIIEILS EDPSGWWQGR LRGKEGMFPG NYVEKI
Length:1,096
Mass (Da):125,945
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i340703DAC04B7905
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC057426 mRNA Translation: AAH57426.1
BC164037 mRNA Translation: AAI64037.1

NCBI Reference Sequences

More...RefSeqi		NP_956930.1, NM_200636.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		393609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:393609

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057426 mRNA Translation: AAH57426.1
BC164037 mRNA Translation: AAI64037.1
RefSeqiNP_956930.1, NM_200636.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi393609
KEGGidre:393609

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		393609
ZFINiZDB-GENE-040426-1347, myo1eb

Phylogenomic databases

OMAiFSSWNKG
OrthoDBi122881at2759

Family and domain databases

CDDicd01378, MYSc_Myo1, 1 hit
cd11827, SH3_MyoIe_If_like, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035507, Ie/If_SH3
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR027417, P-loop_NTPase
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00242, MYSc, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS50002, SH3, 1 hit
PS51757, TH1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6PFT4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PFT4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 19, 2022
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again