UniProtKB - Q6PFS5 (ERD23_DANRE)
Protein
ER lumen protein-retaining receptor 3
Gene
kdelr3
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 193 | Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity | 1 |
GO - Molecular functioni
- ER retention sequence binding Source: GO_Central
- KDEL sequence binding Source: UniProtKB
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- protein retention in ER lumen Source: GO_Central
- protein transport Source: UniProtKB-KW
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-DRE-6807878, COPI-mediated anterograde transport R-DRE-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: ER lumen protein-retaining receptor 3Alternative name(s): KDEL endoplasmic reticulum protein retention receptor 3 Short name: KDEL receptor 3 |
Gene namesi | Name:kdelr3 ORF Names:zgc:64171 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-1387, kdelr3 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- COPI-coated vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB
Golgi apparatus
- cis-Golgi network Source: GO_Central
- Golgi membrane Source: UniProtKB
Other locations
- COPI-coated vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4 | LumenalCurated | 4 | |
Transmembranei | 5 – 24 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 25 – 32 | CytoplasmicCurated | 8 | |
Transmembranei | 33 – 52 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 53 – 58 | LumenalCurated | 6 | |
Transmembranei | 59 – 79 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 80 – 92 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 93 – 110 | HelicalBy similarityAdd BLAST | 18 | |
Topological domaini | 111 – 116 | LumenalCurated | 6 | |
Transmembranei | 117 – 135 | HelicalBy similarityAdd BLAST | 19 | |
Topological domaini | 136 – 149 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 150 – 168 | HelicalBy similarityAdd BLAST | 19 | |
Topological domaini | 169 – 178 | LumenalCurated | 10 | |
Transmembranei | 179 – 199 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 200 – 215 | CytoplasmicCuratedAdd BLAST | 16 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252352 | 1 – 215 | ER lumen protein-retaining receptor 3Add BLAST | 215 |
Proteomic databases
PaxDbi | Q6PFS5 |
Interactioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 5 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 1 | |
Sitei | 54 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 1 | |
Sitei | 117 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 1 |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000059955 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 47 – 48 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 2 | |
Regioni | 159 – 169 | Interaction with the K-D-E-L motif on target proteinsBy similarityAdd BLAST | 11 | |
Regioni | 204 – 208 | Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity | 5 |
Domaini
Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).By similarity
Sequence similaritiesi
Belongs to the ERD2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3106, Eukaryota |
InParanoidi | Q6PFS5 |
OrthoDBi | 1186269at2759 |
PhylomeDBi | Q6PFS5 |
Family and domain databases
InterProi | View protein in InterPro IPR000133, ER_ret_rcpt |
PANTHERi | PTHR10585, PTHR10585, 1 hit |
Pfami | View protein in Pfam PF00810, ER_lumen_recept, 1 hit |
PRINTSi | PR00660, ERLUMENR |
PROSITEi | View protein in PROSITE PS00951, ER_LUMEN_RECEPTOR_1, 1 hit PS00952, ER_LUMEN_RECEPTOR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6PFS5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIFRLSGDV CHLIAIIILF LKIWRSKSCA GISGKSQVLF ALVFTTRYLD
60 70 80 90 100
LFTSYISAYN TVMKVVYLLL AYSTVGLIFF RFRNSYDSES DSFRVEFLLV
110 120 130 140 150
PVAGLSFLEN YAFTPLEILW TFSIYLESVA ILPQLFMITK TGEAESITAH
160 170 180 190 200
YLLFLGLYRA LYLANWLWRF HTEGFYDQIA VVSGVVQTIF YCDFFYLYFT
210
RVLRGSGKMS LPMPV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1QNR6 | F1QNR6_DANRE | ER lumen protein-retaining receptor | kdelr3 | 215 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC057436 mRNA Translation: AAH57436.1 |
RefSeqi | NP_956934.1, NM_200640.1 |
Genome annotation databases
GeneIDi | 393613 |
KEGGi | dre:393613 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC057436 mRNA Translation: AAH57436.1 |
RefSeqi | NP_956934.1, NM_200640.1 |
3D structure databases
SMRi | Q6PFS5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000059955 |
Proteomic databases
PaxDbi | Q6PFS5 |
Genome annotation databases
GeneIDi | 393613 |
KEGGi | dre:393613 |
Organism-specific databases
CTDi | 11015 |
ZFINi | ZDB-GENE-040426-1387, kdelr3 |
Phylogenomic databases
eggNOGi | KOG3106, Eukaryota |
InParanoidi | Q6PFS5 |
OrthoDBi | 1186269at2759 |
PhylomeDBi | Q6PFS5 |
Enzyme and pathway databases
Reactomei | R-DRE-6807878, COPI-mediated anterograde transport R-DRE-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
PROi | PR:Q6PFS5 |
Family and domain databases
InterProi | View protein in InterPro IPR000133, ER_ret_rcpt |
PANTHERi | PTHR10585, PTHR10585, 1 hit |
Pfami | View protein in Pfam PF00810, ER_lumen_recept, 1 hit |
PRINTSi | PR00660, ERLUMENR |
PROSITEi | View protein in PROSITE PS00951, ER_LUMEN_RECEPTOR_1, 1 hit PS00952, ER_LUMEN_RECEPTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERD23_DANRE | |
Accessioni | Q6PFS5Primary (citable) accession number: Q6PFS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families