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Protein

Transformer-2 protein homolog alpha

Gene

Tra2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • RNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Transformer-2 protein homolog alpha
Short name:
TRA-2 alpha
Short name:
TRA2-alpha
Alternative name(s):
Transformer-2 protein homolog A
Gene namesi
Name:Tra2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1933972 Tra2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000819822 – 281Transformer-2 protein homolog alphaAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei24PhosphothreonineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei82PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei86PhosphothreonineBy similarity1
Modified residuei94PhosphoserineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei200PhosphothreonineBy similarity1
Modified residuei202PhosphothreonineBy similarity1
Modified residuei233Omega-N-methylarginineCombined sources1
Modified residuei237PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PFR5
MaxQBiQ6PFR5
PaxDbiQ6PFR5
PeptideAtlasiQ6PFR5
PRIDEiQ6PFR5

PTM databases

iPTMnetiQ6PFR5
PhosphoSitePlusiQ6PFR5

Expressioni

Gene expression databases

CleanExiMM_TRA2A

Interactioni

Subunit structurei

Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6PFR5, 5 interactors
MINTiQ6PFR5
STRINGi10090.ENSMUSP00000031841

Structurei

3D structure databases

ProteinModelPortaliQ6PFR5
SMRiQ6PFR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 195RRMPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 223LinkerAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 110Arg/Ser-rich (RS1 domain)Add BLAST81
Compositional biasi224 – 281Arg/Ser-rich (RS2 domain)Add BLAST58

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGiENOG410IQWZ Eukaryota
ENOG4111HSX LUCA
HOGENOMiHOG000276232
HOVERGENiHBG102125
InParanoidiQ6PFR5
PhylomeDBiQ6PFR5

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6PFR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDVEENNFE GRESRSQSKS PTGTPARVKS ESRSGSRSPS RVSKHSESHS
60 70 80 90 100
RSRSKSRSRS RRHSHRRYTR SRSHSHRRRS RSRSYTPEYR RRRSRSHSPM
110 120 130 140 150
SNRRRHTGSR ANPDPNTCLG VFGLSLYTTE RDLREVFSRY GPLSGVNVVY
160 170 180 190 200
DQRTGRSRGF AFVYFERIDD SKEAMERANG MELDGRRIRV DYSITKRAHT
210 220 230 240 250
PTPGIYMGRP THSGGGGGGG GGGGGGGGGG GGRRRDSYYD RGYDRGYDRY
260 270 280
EDYDYRRRSP SPYYSRYRSR SRSRSYSPRR Y
Length:281
Mass (Da):32,316
Last modified:July 5, 2004 - v1
Checksum:i8074C89D4494D7F0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QP00E9QP00_MOUSE
Transformer-2 protein homolog alpha
Tra2a
282Annotation score:
A0A0N4SVC2A0A0N4SVC2_MOUSE
Transformer-2 protein homolog alpha
Tra2a
280Annotation score:
A0A0N4SV13A0A0N4SV13_MOUSE
Transformer-2 protein homolog alpha
Tra2a
59Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057448 mRNA Translation: AAH57448.1
UniGeneiMm.196598

Genome annotation databases

UCSCiuc009bwm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057448 mRNA Translation: AAH57448.1
UniGeneiMm.196598

3D structure databases

ProteinModelPortaliQ6PFR5
SMRiQ6PFR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PFR5, 5 interactors
MINTiQ6PFR5
STRINGi10090.ENSMUSP00000031841

PTM databases

iPTMnetiQ6PFR5
PhosphoSitePlusiQ6PFR5

Proteomic databases

EPDiQ6PFR5
MaxQBiQ6PFR5
PaxDbiQ6PFR5
PeptideAtlasiQ6PFR5
PRIDEiQ6PFR5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009bwm.1 mouse

Organism-specific databases

MGIiMGI:1933972 Tra2a

Phylogenomic databases

eggNOGiENOG410IQWZ Eukaryota
ENOG4111HSX LUCA
HOGENOMiHOG000276232
HOVERGENiHBG102125
InParanoidiQ6PFR5
PhylomeDBiQ6PFR5

Miscellaneous databases

ChiTaRSiTra2a mouse
PROiPR:Q6PFR5
SOURCEiSearch...

Gene expression databases

CleanExiMM_TRA2A

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRA2A_MOUSE
AccessioniPrimary (citable) accession number: Q6PFR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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