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UniProtKB - Q6PFG8 (OLIG3_MOUSE)
Protein
Oligodendrocyte transcription factor 3
Gene
Olig3
Organism
Mus musculus (Mouse)
Status
Functioni
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
1 PublicationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: MGI
- neuron differentiation Source: GO_Central
- regulation of gene expression Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- spinal cord motor neuron cell fate specification Source: MGI
- spinal cord motor neuron differentiation Source: MGI
- spinal cord motor neuron migration Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Oligodendrocyte transcription factor 3Short name: Oligo3 Alternative name(s): Class B basic helix-loop-helix protein 7 Short name: bHLHb7 Oligodendrocyte-specific bHLH transcription factor 3 |
Gene namesi | Name:Olig3 Synonyms:Bhlhb7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2149955, Olig3 |
VEuPathDBi | HostDB:ENSMUSG00000045591 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation2 Publications
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127418 | 1 – 273 | Oligodendrocyte transcription factor 3Add BLAST | 273 |
Proteomic databases
PaxDbi | Q6PFG8 |
PRIDEi | Q6PFG8 |
ProteomicsDBi | 289986 |
PTM databases
PhosphoSitePlusi | Q6PFG8 |
Expressioni
Tissue specificityi
Weakly expressed, mainly in non-neural tissues.1 Publication
Developmental stagei
Restricted to the CNS. At 9.25 and 10.5 dpc, specifically expressed in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc, expressed continuously from the upper rhombic lip to the tail. From 10.5 to 12.5 dpc, located in the most dorsal aspect of the spinal cord, excluding the roof plate, mainly in proliferating progenitor cells; quickly down-regulated in postmitotic neurons. At 11.5 dpc, 3 ventral expression clusters, corresponding to p3, p2 and p0 domains, transiently appear on the lateral margin of the subventricular zone, in addition to dorsal expression. At 14.5 dpc, weakly expressed in cells scattered in the mantle zone. Expression declines after 15.5 dpc. In the 11.5 dpc forebrain, expressed in the ventricular zone of the dorsal thalamus. In the 11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and lower rhombic lip, in the cerebellar neuroepithelium.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000045591, Expressed in head and 68 other tissues |
Genevisiblei | Q6PFG8, MM |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057106 |
Miscellaneous databases
RNActi | Q6PFG8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 84 – 138 | bHLHPROSITE-ProRule annotationAdd BLAST | 55 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | DisorderedSequence analysisAdd BLAST | 72 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 69 – 90 | Sequence analysisAdd BLAST | 22 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000160850 |
HOGENOMi | CLU_065376_1_0_1 |
InParanoidi | Q6PFG8 |
OMAi | PHALMKG |
OrthoDBi | 1290623at2759 |
PhylomeDBi | Q6PFG8 |
TreeFami | TF322733 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032659, Olig3 |
PANTHERi | PTHR19290:SF96, PTHR19290:SF96, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PFG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHHQESRLNS VSSTQGDMVQ
60 70 80 90 100
KMPGESLSRA GAKAAGESSK YKIKKQLSEQ DLQQLRLKIN GRERKRMHDL
110 120 130 140 150
NLAMDGLREV MPYAHGPSVR KLSKIATLLL ARNYILMLTS SLEEMKRLVG
160 170 180 190 200
EIYGGHHSAF HCGTVGHSAG HPAHAANAVH PVHPILGGAL SSGNASSPLS
210 220 230 240 250
ATSLPTIGTI RPPHSLLKAP STPPALQLGS GFQHWAGLPC PCTICQMPPP
260 270
PHLSALSTAN MARLSAESKD LLK
Sequence cautioni
The sequence BAB18908 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB038698 mRNA Translation: BAB18908.1 Different initiation. BC057564 mRNA Translation: AAH57564.1 |
CCDSi | CCDS35855.1 |
RefSeqi | NP_443734.2, NM_053008.3 |
Genome annotation databases
Ensembli | ENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591 |
GeneIDi | 94222 |
KEGGi | mmu:94222 |
UCSCi | uc007ene.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB038698 mRNA Translation: BAB18908.1 Different initiation. BC057564 mRNA Translation: AAH57564.1 |
CCDSi | CCDS35855.1 |
RefSeqi | NP_443734.2, NM_053008.3 |
3D structure databases
AlphaFoldDBi | Q6PFG8 |
SMRi | Q6PFG8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057106 |
PTM databases
PhosphoSitePlusi | Q6PFG8 |
Proteomic databases
PaxDbi | Q6PFG8 |
PRIDEi | Q6PFG8 |
ProteomicsDBi | 289986 |
Protocols and materials databases
Antibodypediai | 19782, 195 antibodies from 29 providers |
DNASUi | 94222 |
Genome annotation databases
Ensembli | ENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591 |
GeneIDi | 94222 |
KEGGi | mmu:94222 |
UCSCi | uc007ene.1, mouse |
Organism-specific databases
CTDi | 167826 |
MGIi | MGI:2149955, Olig3 |
VEuPathDBi | HostDB:ENSMUSG00000045591 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000160850 |
HOGENOMi | CLU_065376_1_0_1 |
InParanoidi | Q6PFG8 |
OMAi | PHALMKG |
OrthoDBi | 1290623at2759 |
PhylomeDBi | Q6PFG8 |
TreeFami | TF322733 |
Miscellaneous databases
BioGRID-ORCSi | 94222, 2 hits in 72 CRISPR screens |
PROi | PR:Q6PFG8 |
RNActi | Q6PFG8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045591, Expressed in head and 68 other tissues |
Genevisiblei | Q6PFG8, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032659, Olig3 |
PANTHERi | PTHR19290:SF96, PTHR19290:SF96, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OLIG3_MOUSE | |
Accessioni | Q6PFG8Primary (citable) accession number: Q6PFG8 Secondary accession number(s): Q9EQW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot