Olig3

Functionⁱ

May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.1 Publication

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro
transcription corepressor activity
Source: MGI
Inferred from direct assayⁱ
- 15769945

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 15769945
regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 15769945
spinal cord motor neuron cell fate specification
Source: MGI
Inferred from mutant phenotypeⁱ
- 15769945
spinal cord motor neuron differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15769945
spinal cord motor neuron migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 15769945
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oligodendrocyte transcription factor 3 Short name: Oligo3 Alternative name(s): Class B basic helix-loop-helix protein 7 Short name: bHLHb7 Oligodendrocyte-specific bHLH transcription factor 3
Gene namesⁱ	Name:Olig3 Synonyms:Bhlhb7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:2149955 Olig3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127418	1 – 273	Oligodendrocyte transcription factor 3Add BLAST		273

Proteomic databases

PaxDbⁱ	Q6PFG8
PRIDEⁱ	Q6PFG8

PTM databases

PhosphoSitePlusⁱ	Q6PFG8

PhosphoSitePlusⁱ

Q6PFG8

Expressionⁱ

Tissue specificityⁱ

Weakly expressed, mainly in non-neural tissues.1 Publication

Developmental stageⁱ

Restricted to the CNS. At 9.25 and 10.5 dpc, specifically expressed in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc, expressed continuously from the upper rhombic lip to the tail. From 10.5 to 12.5 dpc, located in the most dorsal aspect of the spinal cord, excluding the roof plate, mainly in proliferating progenitor cells; quickly down-regulated in postmitotic neurons. At 11.5 dpc, 3 ventral expression clusters, corresponding to p3, p2 and p0 domains, transiently appear on the lateral margin of the subventricular zone, in addition to dorsal expression. At 14.5 dpc, weakly expressed in cells scattered in the mantle zone. Expression declines after 15.5 dpc. In the 11.5 dpc forebrain, expressed in the ventricular zone of the dorsal thalamus. In the 11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and lower rhombic lip, in the cerebellar neuroepithelium.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000045591 Expressed in 44 organ(s), highest expression level in head
CleanExⁱ	MM_OLIG3
Genevisibleⁱ	Q6PFG8 MM

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PFG8
SMRⁱ	Q6PFG8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	84 – 138	bHLHPROSITE-ProRule annotationAdd BLAST		55

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	69 – 90	Sequence analysisAdd BLAST		22

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	25 – 33	Poly-His		9
Compositional biasⁱ	248 – 251	Poly-Pro		4

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063239
HOGENOMⁱ	HOG000015765
HOVERGENⁱ	HBG053370
InParanoidⁱ	Q6PFG8
KEGG Orthology (KO) More...KOⁱ	K09085
OMAⁱ	VQKMPGE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	Q6PFG8
TreeFamⁱ	TF322733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032659 Olig3
PANTHERⁱ	PTHR19290:SF96 PTHR19290:SF96, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6PFG8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHHQESRLNS VSSTQGDMVQ 
        60         70         80         90        100
KMPGESLSRA GAKAAGESSK YKIKKQLSEQ DLQQLRLKIN GRERKRMHDL 
       110        120        130        140        150
NLAMDGLREV MPYAHGPSVR KLSKIATLLL ARNYILMLTS SLEEMKRLVG 
       160        170        180        190        200
EIYGGHHSAF HCGTVGHSAG HPAHAANAVH PVHPILGGAL SSGNASSPLS 
       210        220        230        240        250
ATSLPTIGTI RPPHSLLKAP STPPALQLGS GFQHWAGLPC PCTICQMPPP 
       260        270 
PHLSALSTAN MARLSAESKD LLK

Length:273

Mass (Da):29,507

Last modified:July 5, 2004 - v1

Checksum:ⁱ5795CF3FC23121DD

GO

Sequence cautionⁱ

The sequence BAB18908 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB038698 mRNA Translation: BAB18908.1 Different initiation. BC057564 mRNA Translation: AAH57564.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35855.1
NCBI Reference Sequences More...RefSeqⁱ	NP_443734.2, NM_053008.3
UniGeneⁱ	Mm.156946

Genome annotation databases

Ensemblⁱ	ENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591
GeneIDⁱ	94222
KEGGⁱ	mmu:94222
UCSC genome browser More...UCSCⁱ	uc007ene.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6PFG8	Oligodendrocyte transcription factor 3		HUMAN		272	UniRef90_Q6PFG8
oligodendrocyte transcription factor 3		TARSY		313
Uncharacterized protein		RHIBE		274
Oligodendrocyte transcription factor 3		RAT		273
Uncharacterized protein		MYOLU		273
+91

Protein	Similar proteins		Species	Score	Length	Source
Q6PFG8	Oligodendrocyte transcription factor 3		HUMAN		272	UniRef50_Q6PFG8
Oligodendrocyte transcription factor 2		CHICK		298
oligodendrocyte transcription factor 3		TARSY		313
Uncharacterized protein		RHIBE		274
oligodendrocyte transcription factor 3		DIPOR		273
+132

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB038698 mRNA Translation: BAB18908.1 Different initiation. BC057564 mRNA Translation: AAH57564.1
CCDSⁱ	CCDS35855.1
RefSeqⁱ	NP_443734.2, NM_053008.3
UniGeneⁱ	Mm.156946

3D structure databases

ProteinModelPortalⁱ	Q6PFG8
SMRⁱ	Q6PFG8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

PhosphoSitePlusⁱ	Q6PFG8

PhosphoSitePlusⁱ

Q6PFG8

Proteomic databases

PaxDbⁱ	Q6PFG8
PRIDEⁱ	Q6PFG8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591
GeneIDⁱ	94222
KEGGⁱ	mmu:94222
UCSCⁱ	uc007ene.1 mouse

Organism-specific databases

CTDⁱ	167826
MGIⁱ	MGI:2149955 Olig3

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
GeneTreeⁱ	ENSGT00530000063239
HOGENOMⁱ	HOG000015765
HOVERGENⁱ	HBG053370
InParanoidⁱ	Q6PFG8
KOⁱ	K09085
OMAⁱ	VQKMPGE
OrthoDBⁱ	EOG091G129L
PhylomeDBⁱ	Q6PFG8
TreeFamⁱ	TF322733

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6PFG8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000045591 Expressed in 44 organ(s), highest expression level in head
CleanExⁱ	MM_OLIG3
Genevisibleⁱ	Q6PFG8 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032659 Olig3
PANTHERⁱ	PTHR19290:SF96 PTHR19290:SF96, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OLIG3_MOUSE
Accessionⁱ	Q6PFG8Primary (citable) accession number: Q6PFG8 Secondary accession number(s): Q9EQW5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6PFG8 (OLIG3_MOUSE)

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Oligodendrocyte transcription factor 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ