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Entry version 52 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Major vault protein

Gene

mvp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major vault protein
Short name:
MVP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mvp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5880964 mvp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002474911 – 849Major vault proteinAdd BLAST849

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6PF69

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6PF69, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 55MVP 1Add BLAST54
Repeati56 – 110MVP 2Add BLAST55
Repeati111 – 162MVP 3Add BLAST52
Repeati163 – 215MVP 4Add BLAST53
Repeati216 – 270MVP 5Add BLAST55
Repeati271 – 321MVP 6Add BLAST51
Repeati322 – 378MVP 7Add BLAST57
Repeati379 – 454MVP 8Add BLAST76
Repeati455 – 517MVP 9Add BLAST63

Keywords - Domaini

Repeat

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K17266

Database of Orthologous Groups

More...
OrthoDBi
256008at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08825 MVP_shoulder, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.550, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039059 MVP
IPR041139 MVP_rep_dom
IPR043023 MVP_rep_sf
IPR021870 MVP_shoulder
IPR041134 Vault_2
IPR040989 Vault_3
IPR041136 Vault_4
IPR002499 Vault_N

The PANTHER Classification System

More...
PANTHERi
PTHR14165 PTHR14165, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PF17794 Vault_2, 2 hits
PF17795 Vault_3, 1 hit
PF17796 Vault_4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51224 MVP, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PF69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEESIIRIP PYCYIHVLDQ NSNISRVETG PKTYIRQDNE RVLHHPQRMV
60 70 80 90 100
MVPPRHYCVI QNPVQRDSEE KVLFDDVGQA KLSHGDKEIR LTQDPFPLYP
110 120 130 140 150
GEELQLGITP LTVVLANTAL HLKALLDLED ESGKYVAGDE WLFEGPGTYI
160 170 180 190 200
PRKEVEVVQT IQATVIRHNQ AIRLRARKEC KDREEQDRVT GEEWLVKKVG
210 220 230 240 250
AYLPGVFEEV VDIVDAFVLT DKRALHIRAT KTFRGDKGNL RRTGEEWLVT
260 270 280 290 300
MEDTEAYIPN VYEEVVGVVD ITTLNSRQYC VILDPVGEDG KPQLGQKRVV
310 320 330 340 350
KGEKSFFLQP GESLEYGIQD VYILSEEEGL VLRALQVLED KDEEGTEVER
360 370 380 390 400
KPGDRWMIRG PIEYAPPVEV EVVVRREAIP LDENEGIYVR DIKTGKVRAV
410 420 430 440 450
VGQSYMLTQD EELWEKELPA NVETLLASGK DPLADRSERQ GQAQEVQPRD
460 470 480 490 500
KTRAVTYRVP HNAAVQVYDY REKKSRVVFG PELVVLGPDE QFTVLSLSGS
510 520 530 540 550
TPKRANVIKA ICLLLGPDFC TDIINIETAD HARLQIKLSY NWHFDIKDRK
560 570 580 590 600
DPAEASKLFT VPDFVGDACK AIASRIRGAV ASVQFDDFHK NSNRIICSAV
610 620 630 640 650
FGFDEAMKIR NSFRFPQNNL IITSVDIQTV EPVDQRTRDA LQKSVQLAIE
660 670 680 690 700
ITTNSQEATA RHEAERLEQE AKGRLERQRI TDQAEAEKAR KELLELEALS
710 720 730 740 750
TIVESTGAAK AEAESKAEAA RIEGEGAVLQ AKLRAEALAI ETDAELQRLR
760 770 780 790 800
QARSEELRYL QDKNKLEVQK TQELAEIEIK KFREMVESIG SGTLRDIALA
810 820 830 840
GPELQVKMLR GLGIQSTLIT DGSTPINLFS TAHGLLGLTS KPAQEKESD
Length:849
Mass (Da):95,670
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF48B187D7471CBB8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC057708 mRNA Translation: AAH57708.1

NCBI Reference Sequences

More...
RefSeqi
NP_001079939.1, NM_001086470.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
379630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:379630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057708 mRNA Translation: AAH57708.1
RefSeqiNP_001079939.1, NM_001086470.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6PF69, 1 interactor

Proteomic databases

PRIDEiQ6PF69

Genome annotation databases

GeneIDi379630
KEGGixla:379630

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
379630
XenbaseiXB-GENE-5880964 mvp

Phylogenomic databases

KOiK17266
OrthoDBi256008at2759

Family and domain databases

CDDicd08825 MVP_shoulder, 1 hit
Gene3Di2.30.30.550, 4 hits
InterProiView protein in InterPro
IPR039059 MVP
IPR041139 MVP_rep_dom
IPR043023 MVP_rep_sf
IPR021870 MVP_shoulder
IPR041134 Vault_2
IPR040989 Vault_3
IPR041136 Vault_4
IPR002499 Vault_N
PANTHERiPTHR14165 PTHR14165, 1 hit
PfamiView protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PF17794 Vault_2, 2 hits
PF17795 Vault_3, 1 hit
PF17796 Vault_4, 1 hit
PROSITEiView protein in PROSITE
PS51224 MVP, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMVP_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PF69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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