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Entry version 120 (26 Feb 2020)
Sequence version 2 (18 May 2010)
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Protein

MORN repeat-containing protein 3

Gene

MORN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MORN repeat-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MORN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29807 MORN3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PF18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000139714

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485546

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PF18 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MORN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296438295

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002474591 – 240MORN repeat-containing protein 3Add BLAST240

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PF18

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PF18

PeptideAtlas

More...
PeptideAtlasi
Q6PF18

PRoteomics IDEntifications database

More...
PRIDEi
Q6PF18

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67103 [Q6PF18-1]
67104 [Q6PF18-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PF18

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PF18

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139714 Expressed in testis and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PF18 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PF18 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038709
HPA038710

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
129545, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PF18, 67 interactors

Molecular INTeraction database

More...
MINTi
Q6PF18

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347486

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PF18 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PF18

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 60MORN 1Add BLAST23
Repeati62 – 84MORN 2Add BLAST23
Repeati91 – 113MORN 3Add BLAST23
Repeati114 – 136MORN 4Add BLAST23
Repeati137 – 159MORN 5Add BLAST23
Repeati160 – 182MORN 6Add BLAST23
Repeati184 – 205MORN 7Add BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0231 Eukaryota
COG4642 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159285

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032017_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PF18

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPHGEGM

Database of Orthologous Groups

More...
OrthoDBi
1309439at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PF18

TreeFam database of animal gene trees

More...
TreeFami
TF323893

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003409 MORN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02493 MORN, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00698 MORN, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6PF18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVSKCPKKS ESLWKGWDRK AQRNGLRSQV YAVNGDYYVG EWKDNVKHGK
60 70 80 90 100
GTQVWKKKGA IYEGDWKFGK RDGYGTLSLP DQQTGKCRRV YSGWWKGDKK
110 120 130 140 150
SGYGIQFFGP KEYYEGDWCG SQRSGWGRMY YSNGDIYEGQ WENDKPNGEG
160 170 180 190 200
MLRLKNGNRY EGCWERGMKN GAGRFFHLDH GQLFEGFWVD NMAKCGTMID
210 220 230 240
FGRDEAPEPT QFPIPEVKIL DPDGVLAEAL AMFRKTEEGD
Length:240
Mass (Da):27,585
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B87C00C47203D55
GO
Isoform 2 (identifier: Q6PF18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-160: KNGNRY → SQNPRP
     161-240: Missing.

Show »
Length:160
Mass (Da):18,546
Checksum:iC756381DBD39E318
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43K → E in AAH57760 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019996155 – 160KNGNRY → SQNPRP in isoform 2. 1 Publication6
Alternative sequenceiVSP_019997161 – 240Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY177732 mRNA Translation: AAO18675.1
AC084018 Genomic DNA No translation available.
AC140062 Genomic DNA No translation available.
BC057760 mRNA Translation: AAH57760.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31917.1 [Q6PF18-1]

NCBI Reference Sequences

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RefSeqi
NP_776254.3, NM_173855.4 [Q6PF18-1]
XP_005253926.1, XM_005253869.4
XP_011536515.1, XM_011538213.2 [Q6PF18-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355329; ENSP00000347486; ENSG00000139714 [Q6PF18-1]
ENST00000392462; ENSP00000376255; ENSG00000139714 [Q6PF18-2]
ENST00000542364; ENSP00000445643; ENSG00000139714 [Q6PF18-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
283385

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:283385

UCSC genome browser

More...
UCSCi
uc001uax.4 human [Q6PF18-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177732 mRNA Translation: AAO18675.1
AC084018 Genomic DNA No translation available.
AC140062 Genomic DNA No translation available.
BC057760 mRNA Translation: AAH57760.1
CCDSiCCDS31917.1 [Q6PF18-1]
RefSeqiNP_776254.3, NM_173855.4 [Q6PF18-1]
XP_005253926.1, XM_005253869.4
XP_011536515.1, XM_011538213.2 [Q6PF18-1]

3D structure databases

SMRiQ6PF18
ModBaseiSearch...

Protein-protein interaction databases

BioGridi129545, 18 interactors
IntActiQ6PF18, 67 interactors
MINTiQ6PF18
STRINGi9606.ENSP00000347486

PTM databases

iPTMnetiQ6PF18
PhosphoSitePlusiQ6PF18

Polymorphism and mutation databases

BioMutaiMORN3
DMDMi296438295

Proteomic databases

MassIVEiQ6PF18
PaxDbiQ6PF18
PeptideAtlasiQ6PF18
PRIDEiQ6PF18
ProteomicsDBi67103 [Q6PF18-1]
67104 [Q6PF18-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
283385

Genome annotation databases

EnsembliENST00000355329; ENSP00000347486; ENSG00000139714 [Q6PF18-1]
ENST00000392462; ENSP00000376255; ENSG00000139714 [Q6PF18-2]
ENST00000542364; ENSP00000445643; ENSG00000139714 [Q6PF18-2]
GeneIDi283385
KEGGihsa:283385
UCSCiuc001uax.4 human [Q6PF18-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283385

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MORN3
HGNCiHGNC:29807 MORN3
HPAiHPA038709
HPA038710
neXtProtiNX_Q6PF18
OpenTargetsiENSG00000139714
PharmGKBiPA143485546

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00940000159285
HOGENOMiCLU_032017_3_0_1
InParanoidiQ6PF18
OMAiKPHGEGM
OrthoDBi1309439at2759
PhylomeDBiQ6PF18
TreeFamiTF323893

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MORN3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
283385
PharosiQ6PF18 Tdark

Protein Ontology

More...
PROi
PR:Q6PF18
RNActiQ6PF18 protein

Gene expression databases

BgeeiENSG00000139714 Expressed in testis and 110 other tissues
ExpressionAtlasiQ6PF18 baseline and differential
GenevisibleiQ6PF18 HS

Family and domain databases

InterProiView protein in InterPro
IPR003409 MORN
PfamiView protein in Pfam
PF02493 MORN, 5 hits
SMARTiView protein in SMART
SM00698 MORN, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMORN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PF18
Secondary accession number(s): Q86YQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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