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Entry version 126 (16 Oct 2019)
Sequence version 3 (03 Sep 2014)
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Protein

Kelch-like protein 35

Gene

KLHL35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch-like protein 35
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHL35
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26597 KLHL35

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PF15

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
283212

Open Targets

More...
OpenTargetsi
ENSG00000149243

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393595

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PF15

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLHL35

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205831238

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003444661 – 583Kelch-like protein 35Add BLAST583

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PF15

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PF15

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PF15

PeptideAtlas

More...
PeptideAtlasi
Q6PF15

PRoteomics IDEntifications database

More...
PRIDEi
Q6PF15

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
26436
67101 [Q6PF15-1]
67102 [Q6PF15-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PF15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PF15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149243 Expressed in 118 organ(s), highest expression level in frontal pole

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PF15 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PF15 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039232
HPA039864

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129497, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PF15, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000438526

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PF15

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 119BTBPROSITE-ProRule annotationAdd BLAST79
Domaini146 – 248BACKAdd BLAST103
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati301 – 350Kelch 1Add BLAST50
Repeati352 – 394Kelch 2Add BLAST43
Repeati395 – 441Kelch 3Add BLAST47
Repeati443 – 489Kelch 4Add BLAST47
Repeati490 – 531Kelch 5Add BLAST42
Repeati533 – 579Kelch 6Add BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 220Ala-richAdd BLAST164

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4441 Eukaryota
ENOG410XNX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161093

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230817

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PF15

KEGG Orthology (KO)

More...
KOi
K10461

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESEPGCE

Database of Orthologous Groups

More...
OrthoDBi
602930at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PF15

TreeFam database of animal gene trees

More...
TreeFami
TF351654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030601 KLHL35
IPR011333 SKP1/BTB/POZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24412:SF187 PTHR24412:SF187, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PF15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQGHAPEES EPGCEAPCAG PCHAQRVLQA LNAYRRSGTL TDVVLRAGGR
60 70 80 90 100
DFPCHRAALS AGSAYFRSLF AAGRPERGPA VVPVVPVAPE APGTSPAGAA
110 120 130 140 150
AALAVVLDYV YGAGVRLRAE DEAAAVLALA ERLGVAGLRE ACVRFLEGRL
160 170 180 190 200
RAANSLALRR VAAAFSLAPL AERCGRVLRQ AFAEVARHAD FLELAPDEVV
210 220 230 240 250
ALLADPALGV AREEAVFEAA MRWVRHDAPA RRGQLRRLLE HVRLPLLAPA
260 270 280 290 300
YFLEKVEADE LLQACGECRP LLLEARACFI LGREAGALRT RPRRFMDLAE
310 320 330 340 350
VIVVIGGCDR KGLLKLPFAD AYHPESQRWT PLPSLPGYTR SEFAACALRN
360 370 380 390 400
DVYVSGGHIN SHDVWMFSSH LHTWIKVASL HKGRWRHKMA VVQGQLFAVG
410 420 430 440 450
GFDGLRRLHS VERYDPFSNT WAAAAPLPEA VSSAAVASCA GKLFVIGGAR
460 470 480 490 500
QGGVNTDKVQ CFDPKEDRWS LRSPAPFSQR CLEAVSLEDT IYVMGGLMSK
510 520 530 540 550
IFTYDPGTDV WGEAAVLPSP VESCGVTVCD GKVHILGGRD DRGESTDKVF
560 570 580
TFDPSSGQVE VQPSLQRCTS SHGCVTIIQS LGR
Length:583
Mass (Da):62,892
Last modified:September 3, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05BA7D11DF77FD30
GO
Isoform 2 (identifier: Q6PF15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-293: R → RRHWAYPHA
     396-419: LFAVGGFDGLRRLHSVERYDPFSN → VGTSCSGCPGTQGTDLWMCWREVL
     420-583: Missing.

Show »
Length:427
Mass (Da):46,467
Checksum:iB546A2EE68943F03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFW7A0A0C4DFW7_HUMAN
Kelch-like protein 35
KLHL35
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH42952 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH57763 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI32709 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI32711 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC03585 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW74965 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW74966 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034783293R → RRHWAYPHA in isoform 2. 1 Publication1
Alternative sequenceiVSP_034784396 – 419LFAVG…DPFSN → VGTSCSGCPGTQGTDLWMCW REVL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_034785420 – 583Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP000744 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74965.1 Sequence problems.
CH471076 Genomic DNA Translation: EAW74966.1 Sequence problems.
BC042952 mRNA Translation: AAH42952.3 Different initiation.
BC057763 mRNA Translation: AAH57763.1 Different initiation.
BC132708 mRNA Translation: AAI32709.1 Different initiation.
BC132710 mRNA Translation: AAI32711.1 Different initiation.
AK091109 mRNA Translation: BAC03585.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44685.2 [Q6PF15-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001034637.2, NM_001039548.2 [Q6PF15-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000539798; ENSP00000438526; ENSG00000149243 [Q6PF15-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
283212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:283212

UCSC genome browser

More...
UCSCi
uc001owm.3 human [Q6PF15-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000744 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74965.1 Sequence problems.
CH471076 Genomic DNA Translation: EAW74966.1 Sequence problems.
BC042952 mRNA Translation: AAH42952.3 Different initiation.
BC057763 mRNA Translation: AAH57763.1 Different initiation.
BC132708 mRNA Translation: AAI32709.1 Different initiation.
BC132710 mRNA Translation: AAI32711.1 Different initiation.
AK091109 mRNA Translation: BAC03585.1 Different initiation.
CCDSiCCDS44685.2 [Q6PF15-1]
RefSeqiNP_001034637.2, NM_001039548.2 [Q6PF15-1]

3D structure databases

SMRiQ6PF15
ModBaseiSearch...

Protein-protein interaction databases

BioGridi129497, 4 interactors
IntActiQ6PF15, 8 interactors
STRINGi9606.ENSP00000438526

PTM databases

iPTMnetiQ6PF15
PhosphoSitePlusiQ6PF15

Polymorphism and mutation databases

BioMutaiKLHL35
DMDMi205831238

Proteomic databases

MassIVEiQ6PF15
MaxQBiQ6PF15
PaxDbiQ6PF15
PeptideAtlasiQ6PF15
PRIDEiQ6PF15
ProteomicsDBi26436
67101 [Q6PF15-1]
67102 [Q6PF15-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
283212

Genome annotation databases

EnsembliENST00000539798; ENSP00000438526; ENSG00000149243 [Q6PF15-1]
GeneIDi283212
KEGGihsa:283212
UCSCiuc001owm.3 human [Q6PF15-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283212
DisGeNETi283212

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KLHL35
HGNCiHGNC:26597 KLHL35
HPAiHPA039232
HPA039864
neXtProtiNX_Q6PF15
OpenTargetsiENSG00000149243
PharmGKBiPA162393595

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00940000161093
HOGENOMiHOG000230817
InParanoidiQ6PF15
KOiK10461
OMAiESEPGCE
OrthoDBi602930at2759
PhylomeDBiQ6PF15
TreeFamiTF351654

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
283212
PharosiQ6PF15

Protein Ontology

More...
PROi
PR:Q6PF15

Gene expression databases

BgeeiENSG00000149243 Expressed in 118 organ(s), highest expression level in frontal pole
ExpressionAtlasiQ6PF15 baseline and differential
GenevisibleiQ6PF15 HS

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030601 KLHL35
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF187 PTHR24412:SF187, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLH35_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PF15
Secondary accession number(s): A2RU06
, F5H412, Q86XM7, Q8NBB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: September 3, 2014
Last modified: October 16, 2019
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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