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Protein

Transmembrane protein 88

Gene

TMEM88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.1 Publication

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
  • protein localization to plasma membrane Source: ParkinsonsUK-UCL
  • protein stabilization Source: ParkinsonsUK-UCL
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 88
Gene namesi
Name:TMEM88
Synonyms:TMEM88A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167874.6
HGNCiHGNC:32371 TMEM88
MIMi617813 gene
neXtProtiNX_Q6PEY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi92162
OpenTargetsiENSG00000167874
PharmGKBiPA142670741

Polymorphism and mutation databases

BioMutaiTMEM88
DMDMi74758328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517071 – 159Transmembrane protein 88Add BLAST159

Proteomic databases

PaxDbiQ6PEY1
PeptideAtlasiQ6PEY1
PRIDEiQ6PEY1
ProteomicsDBi67088

PTM databases

PhosphoSitePlusiQ6PEY1

Expressioni

Gene expression databases

BgeeiENSG00000167874 Expressed in 93 organ(s), highest expression level in apex of heart
CleanExiHS_TMEM88
ExpressionAtlasiQ6PEY1 baseline and differential
GenevisibleiQ6PEY1 HS

Organism-specific databases

HPAiHPA052991

Interactioni

Subunit structurei

Interacts (via C-terminus) with DVL1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6PEY1, 8 interactors
STRINGi9606.ENSP00000301599

Structurei

3D structure databases

ProteinModelPortaliQ6PEY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM88 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZIZ Eukaryota
ENOG41121G3 LUCA
GeneTreeiENSGT00510000047877
HOGENOMiHOG000118356
InParanoidiQ6PEY1
OMAiIFGFLCH
OrthoDBiEOG091G11O8
PhylomeDBiQ6PEY1
TreeFamiTF332743

Family and domain databases

InterProiView protein in InterPro
IPR033355 TMEM88
IPR033354 TMEM88A
PANTHERiPTHR28628 PTHR28628, 1 hit
PTHR28628:SF3 PTHR28628:SF3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6PEY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADVPGAQRA VPGDGPEPRD PLDCWACAVL VTAQNLLVAA FNLLLLVLVL
60 70 80 90 100
GTILLPAVTM LGFGFLCHSQ FLRSQAPPCT AHLRDPGFTA LLVTGFLLLV
110 120 130 140 150
PLLVLALASY RRLCLRLRLA DCLVPYSRAL YRRRRAPQPR QIRASPGSQA

VPTSGKVWV
Length:159
Mass (Da):17,251
Last modified:July 5, 2004 - v1
Checksum:iB77503ABB3D4295B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2J3I3L2J3_HUMAN
Transmembrane protein 88
TMEM88
126Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02770244L → F. Corresponds to variant dbSNP:rs2270518Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057812 mRNA Translation: AAH57812.1
CCDSiCCDS11121.1
RefSeqiNP_981956.1, NM_203411.1
UniGeneiHs.389669

Genome annotation databases

EnsembliENST00000301599; ENSP00000301599; ENSG00000167874
GeneIDi92162
KEGGihsa:92162
UCSCiuc002giy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057812 mRNA Translation: AAH57812.1
CCDSiCCDS11121.1
RefSeqiNP_981956.1, NM_203411.1
UniGeneiHs.389669

3D structure databases

ProteinModelPortaliQ6PEY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PEY1, 8 interactors
STRINGi9606.ENSP00000301599

PTM databases

PhosphoSitePlusiQ6PEY1

Polymorphism and mutation databases

BioMutaiTMEM88
DMDMi74758328

Proteomic databases

PaxDbiQ6PEY1
PeptideAtlasiQ6PEY1
PRIDEiQ6PEY1
ProteomicsDBi67088

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301599; ENSP00000301599; ENSG00000167874
GeneIDi92162
KEGGihsa:92162
UCSCiuc002giy.4 human

Organism-specific databases

CTDi92162
DisGeNETi92162
EuPathDBiHostDB:ENSG00000167874.6
GeneCardsiTMEM88
HGNCiHGNC:32371 TMEM88
HPAiHPA052991
MIMi617813 gene
neXtProtiNX_Q6PEY1
OpenTargetsiENSG00000167874
PharmGKBiPA142670741
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZIZ Eukaryota
ENOG41121G3 LUCA
GeneTreeiENSGT00510000047877
HOGENOMiHOG000118356
InParanoidiQ6PEY1
OMAiIFGFLCH
OrthoDBiEOG091G11O8
PhylomeDBiQ6PEY1
TreeFamiTF332743

Miscellaneous databases

GenomeRNAii92162
PROiPR:Q6PEY1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167874 Expressed in 93 organ(s), highest expression level in apex of heart
CleanExiHS_TMEM88
ExpressionAtlasiQ6PEY1 baseline and differential
GenevisibleiQ6PEY1 HS

Family and domain databases

InterProiView protein in InterPro
IPR033355 TMEM88
IPR033354 TMEM88A
PANTHERiPTHR28628 PTHR28628, 1 hit
PTHR28628:SF3 PTHR28628:SF3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM88_HUMAN
AccessioniPrimary (citable) accession number: Q6PEY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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