We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q6PEX3 (KR261_HUMAN)
Protein
Keratin-associated protein 26-1
Gene
KRTAP26-1
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Enzyme and pathway databases
PathwayCommonsi | Q6PEX3 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q6PEX3 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 26-1 |
Gene namesi | Name:KRTAP26-1 Synonyms:KAP26.1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33760, KRTAP26-1 |
neXtProti | NX_Q6PEX3 |
VEuPathDBi | HostDB:ENSG00000197683 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
PharmGKBi | PA162393763 |
Miscellaneous databases
Pharosi | Q6PEX3, Tdark |
Genetic variation databases
BioMutai | KRTAP26-1 |
DMDMi | 74737618 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223916 | 1 – 210 | Keratin-associated protein 26-1Add BLAST | 210 |
Proteomic databases
MassIVEi | Q6PEX3 |
PaxDbi | Q6PEX3 |
PeptideAtlasi | Q6PEX3 |
PRIDEi | Q6PEX3 |
ProteomicsDBi | 67085 |
Expressioni
Tissue specificityi
Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla).1 Publication
Gene expression databases
Bgeei | ENSG00000197683, Expressed in placenta and 14 other tissues |
Organism-specific databases
HPAi | ENSG00000197683, Tissue enriched (skin) |
Interactioni
Subunit structurei
Interacts with hair keratins.
Binary interactionsi
Q6PEX3
Protein-protein interaction databases
BioGRIDi | 132867, 93 interactors |
IntActi | Q6PEX3, 90 interactors |
MINTi | Q6PEX3 |
STRINGi | 9606.ENSP00000353742 |
Miscellaneous databases
RNActi | Q6PEX3, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q6PEX3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PMG family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502SVJ1, Eukaryota |
GeneTreei | ENSGT00730000111511 |
HOGENOMi | CLU_1312603_0_0_1 |
InParanoidi | Q6PEX3 |
OMAi | CLAYRPQ |
OrthoDBi | 1411177at2759 |
PhylomeDBi | Q6PEX3 |
TreeFami | TF337331 |
Family and domain databases
InterProi | View protein in InterPro IPR007951, KRTAP_PMG |
PANTHERi | PTHR19051, PTHR19051, 1 hit |
Pfami | View protein in Pfam PF05287, PMG, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PEX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSCPNYCSGN SNSGSLRTSR HIPLTSIDLC PTSVSCGDVL YLPTSSQDHT
60 70 80 90 100
WVTDNCQETC GEPTSCQPVH CETGNLETSC GSSTAYYVPR PCQGSSFLPA
110 120 130 140 150
SFFSSSCLPV SCRPQRYVSS GCRPLRPLLN SYQPIGDCVP NAYRPQFCLS
160 170 180 190 200
KSCQPQNLLT SGCQPSSCLA YRPQSLHVVS SSLRPLGPLF SGCQPLTHVF
210
STCRPSCSGL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053477 | 26 | S → Y. Corresponds to variant dbSNP:rs3804007Ensembl. | 1 | |
Natural variantiVAR_053478 | 188 | P → T. Corresponds to variant dbSNP:rs12483584Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096936 mRNA Translation: BAE46351.1 AM941740 mRNA Translation: CAQ03502.1 BC057825 mRNA Translation: AAH57825.1 |
CCDSi | CCDS13588.1 |
RefSeqi | NP_981950.1, NM_203405.1 |
Genome annotation databases
Ensembli | ENST00000360542.5; ENSP00000353742.3; ENSG00000197683.5 |
GeneIDi | 388818 |
KEGGi | hsa:388818 |
MANE-Selecti | ENST00000360542.5; ENSP00000353742.3; NM_203405.2; NP_981950.1 |
UCSCi | uc002ynw.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096936 mRNA Translation: BAE46351.1 AM941740 mRNA Translation: CAQ03502.1 BC057825 mRNA Translation: AAH57825.1 |
CCDSi | CCDS13588.1 |
RefSeqi | NP_981950.1, NM_203405.1 |
3D structure databases
AlphaFoldDBi | Q6PEX3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132867, 93 interactors |
IntActi | Q6PEX3, 90 interactors |
MINTi | Q6PEX3 |
STRINGi | 9606.ENSP00000353742 |
Genetic variation databases
BioMutai | KRTAP26-1 |
DMDMi | 74737618 |
Proteomic databases
MassIVEi | Q6PEX3 |
PaxDbi | Q6PEX3 |
PeptideAtlasi | Q6PEX3 |
PRIDEi | Q6PEX3 |
ProteomicsDBi | 67085 |
Protocols and materials databases
Antibodypediai | 76496, 33 antibodies from 9 providers |
DNASUi | 388818 |
Genome annotation databases
Ensembli | ENST00000360542.5; ENSP00000353742.3; ENSG00000197683.5 |
GeneIDi | 388818 |
KEGGi | hsa:388818 |
MANE-Selecti | ENST00000360542.5; ENSP00000353742.3; NM_203405.2; NP_981950.1 |
UCSCi | uc002ynw.5, human |
Organism-specific databases
CTDi | 388818 |
GeneCardsi | KRTAP26-1 |
HGNCi | HGNC:33760, KRTAP26-1 |
HPAi | ENSG00000197683, Tissue enriched (skin) |
neXtProti | NX_Q6PEX3 |
PharmGKBi | PA162393763 |
VEuPathDBi | HostDB:ENSG00000197683 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SVJ1, Eukaryota |
GeneTreei | ENSGT00730000111511 |
HOGENOMi | CLU_1312603_0_0_1 |
InParanoidi | Q6PEX3 |
OMAi | CLAYRPQ |
OrthoDBi | 1411177at2759 |
PhylomeDBi | Q6PEX3 |
TreeFami | TF337331 |
Enzyme and pathway databases
PathwayCommonsi | Q6PEX3 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | Q6PEX3 |
Miscellaneous databases
BioGRID-ORCSi | 388818, 10 hits in 1060 CRISPR screens |
GenomeRNAii | 388818 |
Pharosi | Q6PEX3, Tdark |
PROi | PR:Q6PEX3 |
RNActi | Q6PEX3, protein |
Gene expression databases
Bgeei | ENSG00000197683, Expressed in placenta and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR007951, KRTAP_PMG |
PANTHERi | PTHR19051, PTHR19051, 1 hit |
Pfami | View protein in Pfam PF05287, PMG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KR261_HUMAN | |
Accessioni | Q6PEX3Primary (citable) accession number: Q6PEX3 Secondary accession number(s): B0RZD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families