UniProtKB - Q6PEW1 (ZCH12_HUMAN)
Protein
Zinc finger CCHC domain-containing protein 12
Gene
ZCCHC12
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 345 – 362 | CCHC-typeAdd BLAST | 18 |
GO - Molecular functioni
- nuclear receptor transcription coactivator activity Source: GO_Central
- nucleic acid binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6PEW1 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger CCHC domain-containing protein 12Alternative name(s): Smad-interacting zinc finger protein 1 |
Gene namesi | Name:ZCCHC12 Synonyms:SIZN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000174460.3 |
HGNCi | HGNC:27273, ZCCHC12 |
MIMi | 300701, gene |
neXtProti | NX_Q6PEW1 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 170261 |
OpenTargetsi | ENSG00000174460 |
PharmGKBi | PA134885304 |
Miscellaneous databases
Pharosi | Q6PEW1, Tbio |
Polymorphism and mutation databases
BioMutai | ZCCHC12 |
DMDMi | 85718626 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150971 | 1 – 402 | Zinc finger CCHC domain-containing protein 12Add BLAST | 402 |
Proteomic databases
MassIVEi | Q6PEW1 |
PaxDbi | Q6PEW1 |
PeptideAtlasi | Q6PEW1 |
PRIDEi | Q6PEW1 |
ProteomicsDBi | 67083 |
PTM databases
iPTMneti | Q6PEW1 |
PhosphoSitePlusi | Q6PEW1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174460, Expressed in left uterine tube and 135 other tissues |
Genevisiblei | Q6PEW1, HS |
Organism-specific databases
HPAi | ENSG00000174460, Group enriched (brain, endometrium, fallopian tube, smooth muscle) |
Interactioni
Subunit structurei
Interacts with SMAD1 and CREB-binding protein (CBP).
Forms a protein-DNA complex through its association with SMAD1 (By similarity).
By similarityBinary interactionsi
Hide detailsQ6PEW1
Protein-protein interaction databases
BioGRIDi | 127997, 30 interactors |
IntActi | Q6PEW1, 25 interactors |
STRINGi | 9606.ENSP00000308921 |
Miscellaneous databases
RNActi | Q6PEW1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ZCCHC12 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 345 – 362 | CCHC-typeAdd BLAST | 18 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502RU0T, Eukaryota |
GeneTreei | ENSGT01000000214513 |
HOGENOMi | CLU_686127_0_0_1 |
InParanoidi | Q6PEW1 |
OMAi | RKHTIRC |
OrthoDBi | 697027at2759 |
PhylomeDBi | Q6PEW1 |
TreeFami | TF335054 |
Family and domain databases
InterProi | View protein in InterPro IPR026523, PNMA IPR036875, Znf_CCHC_sf |
PANTHERi | PTHR23095, PTHR23095, 1 hit |
Pfami | View protein in Pfam PF14893, PNMA, 1 hit |
SUPFAMi | SSF57756, SSF57756, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PEW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASIIARVGN SRRLNAPLPP WAHSMLRSLG RSLGPIMASM ADRNMKLFSG
60 70 80 90 100
RVVPAQGEET FENWLTQVNG VLPDWNMSEE EKLKRLMKTL RGPAREVMRV
110 120 130 140 150
LQATNPNLSV ADFLRAMKLV FGESESSVTA HGKFFNTLQA QGEKASLYVI
160 170 180 190 200
RLEVQLQNAI QAGIIAEKDA NRTRLQQLLL GGELSRDLRL RLKDFLRMYA
210 220 230 240 250
NEQERLPNFL ELIRMVREEE DWDDAFIKRK RPKRSESMVE RAVSPVAFQG
260 270 280 290 300
SPPIVIGSAD CNVIEIDDTL DDSDEDVILV ESQDPPLPSW GAPPLRDRAR
310 320 330 340 350
PQDEVLVIDS PHNSRAQFPS TSGGSGYKNN GPGEMRRARK RKHTIRCSYC
360 370 380 390 400
GEEGHSKETC DNESDKAQVF ENLIITLQEL THTEMERSRV APGEYNDFSE
PL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045908 | 7 | R → C. Corresponds to variant dbSNP:rs35356061EnsemblClinVar. | 1 | |
Natural variantiVAR_045909 | 179 | L → I1 PublicationCorresponds to variant dbSNP:rs17854957Ensembl. | 1 | |
Natural variantiVAR_045910 | 214 | R → G1 PublicationCorresponds to variant dbSNP:rs17853670Ensembl. | 1 | |
Natural variantiVAR_075208 | 241 | R → T1 PublicationCorresponds to variant dbSNP:rs140976011Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122676 mRNA Translation: BAG53660.1 CH471161 Genomic DNA Translation: EAW89892.1 BC031241 mRNA Translation: AAH31241.1 BC036572 mRNA Translation: AAH36572.1 BC057841 mRNA Translation: AAH57841.1 |
CCDSi | CCDS14574.1 |
RefSeqi | NP_001299820.1, NM_001312891.1 NP_776159.1, NM_173798.3 |
Genome annotation databases
Ensembli | ENST00000310164; ENSP00000308921; ENSG00000174460 |
GeneIDi | 170261 |
KEGGi | hsa:170261 |
UCSCi | uc004equ.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122676 mRNA Translation: BAG53660.1 CH471161 Genomic DNA Translation: EAW89892.1 BC031241 mRNA Translation: AAH31241.1 BC036572 mRNA Translation: AAH36572.1 BC057841 mRNA Translation: AAH57841.1 |
CCDSi | CCDS14574.1 |
RefSeqi | NP_001299820.1, NM_001312891.1 NP_776159.1, NM_173798.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127997, 30 interactors |
IntActi | Q6PEW1, 25 interactors |
STRINGi | 9606.ENSP00000308921 |
PTM databases
iPTMneti | Q6PEW1 |
PhosphoSitePlusi | Q6PEW1 |
Polymorphism and mutation databases
BioMutai | ZCCHC12 |
DMDMi | 85718626 |
Proteomic databases
MassIVEi | Q6PEW1 |
PaxDbi | Q6PEW1 |
PeptideAtlasi | Q6PEW1 |
PRIDEi | Q6PEW1 |
ProteomicsDBi | 67083 |
Protocols and materials databases
Antibodypediai | 29736, 106 antibodies |
DNASUi | 170261 |
Genome annotation databases
Ensembli | ENST00000310164; ENSP00000308921; ENSG00000174460 |
GeneIDi | 170261 |
KEGGi | hsa:170261 |
UCSCi | uc004equ.4, human |
Organism-specific databases
CTDi | 170261 |
DisGeNETi | 170261 |
EuPathDBi | HostDB:ENSG00000174460.3 |
GeneCardsi | ZCCHC12 |
HGNCi | HGNC:27273, ZCCHC12 |
HPAi | ENSG00000174460, Group enriched (brain, endometrium, fallopian tube, smooth muscle) |
MIMi | 300701, gene |
neXtProti | NX_Q6PEW1 |
OpenTargetsi | ENSG00000174460 |
PharmGKBi | PA134885304 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU0T, Eukaryota |
GeneTreei | ENSGT01000000214513 |
HOGENOMi | CLU_686127_0_0_1 |
InParanoidi | Q6PEW1 |
OMAi | RKHTIRC |
OrthoDBi | 697027at2759 |
PhylomeDBi | Q6PEW1 |
TreeFami | TF335054 |
Enzyme and pathway databases
PathwayCommonsi | Q6PEW1 |
Miscellaneous databases
BioGRID-ORCSi | 170261, 3 hits in 470 CRISPR screens |
GenomeRNAii | 170261 |
Pharosi | Q6PEW1, Tbio |
PROi | PR:Q6PEW1 |
RNActi | Q6PEW1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174460, Expressed in left uterine tube and 135 other tissues |
Genevisiblei | Q6PEW1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026523, PNMA IPR036875, Znf_CCHC_sf |
PANTHERi | PTHR23095, PTHR23095, 1 hit |
Pfami | View protein in Pfam PF14893, PNMA, 1 hit |
SUPFAMi | SSF57756, SSF57756, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZCH12_HUMAN | |
Accessioni | Q6PEW1Primary (citable) accession number: Q6PEW1 Secondary accession number(s): B3KV48, Q6PID5, Q8N1C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations