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Entry version 122 (10 Apr 2019)
Sequence version 2 (10 May 2005)
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Protein

Zinc finger CCHC domain-containing protein 12

Gene

ZCCHC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri345 – 362CCHC-typeAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 12
Alternative name(s):
Smad-interacting zinc finger protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZCCHC12
Synonyms:SIZN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174460.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27273 ZCCHC12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300701 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PEW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
170261

Open Targets

More...
OpenTargetsi
ENSG00000174460

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885304

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZCCHC12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85718626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509711 – 402Zinc finger CCHC domain-containing protein 12Add BLAST402

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PEW1

PeptideAtlas

More...
PeptideAtlasi
Q6PEW1

PRoteomics IDEntifications database

More...
PRIDEi
Q6PEW1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67083

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PEW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PEW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174460 Expressed in 117 organ(s), highest expression level in left uterine tube

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PEW1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031016
HPA034940

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127997, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PEW1, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308921

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6PEW1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PEW1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZCCHC12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 362CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J95G Eukaryota
ENOG4111945 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230940

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG073535

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PEW1

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFQGSPP

Database of Orthologous Groups

More...
OrthoDBi
697027at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PEW1

TreeFam database of animal gene trees

More...
TreeFami
TF335054

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026523 PNMA
IPR036875 Znf_CCHC_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23095 PTHR23095, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14893 PNMA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756 SSF57756, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PEW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASIIARVGN SRRLNAPLPP WAHSMLRSLG RSLGPIMASM ADRNMKLFSG
60 70 80 90 100
RVVPAQGEET FENWLTQVNG VLPDWNMSEE EKLKRLMKTL RGPAREVMRV
110 120 130 140 150
LQATNPNLSV ADFLRAMKLV FGESESSVTA HGKFFNTLQA QGEKASLYVI
160 170 180 190 200
RLEVQLQNAI QAGIIAEKDA NRTRLQQLLL GGELSRDLRL RLKDFLRMYA
210 220 230 240 250
NEQERLPNFL ELIRMVREEE DWDDAFIKRK RPKRSESMVE RAVSPVAFQG
260 270 280 290 300
SPPIVIGSAD CNVIEIDDTL DDSDEDVILV ESQDPPLPSW GAPPLRDRAR
310 320 330 340 350
PQDEVLVIDS PHNSRAQFPS TSGGSGYKNN GPGEMRRARK RKHTIRCSYC
360 370 380 390 400
GEEGHSKETC DNESDKAQVF ENLIITLQEL THTEMERSRV APGEYNDFSE

PL
Length:402
Mass (Da):45,369
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD748B77689E38518
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0459087R → C. Corresponds to variant dbSNP:rs35356061Ensembl.1
Natural variantiVAR_045909179L → I1 PublicationCorresponds to variant dbSNP:rs17854957Ensembl.1
Natural variantiVAR_045910214R → G1 PublicationCorresponds to variant dbSNP:rs17853670Ensembl.1
Natural variantiVAR_075208241R → T1 PublicationCorresponds to variant dbSNP:rs140976011Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122676 mRNA Translation: BAG53660.1
CH471161 Genomic DNA Translation: EAW89892.1
BC031241 mRNA Translation: AAH31241.1
BC036572 mRNA Translation: AAH36572.1
BC057841 mRNA Translation: AAH57841.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14574.1

NCBI Reference Sequences

More...
RefSeqi
NP_001299820.1, NM_001312891.1
NP_776159.1, NM_173798.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.21417

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310164; ENSP00000308921; ENSG00000174460

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:170261

UCSC genome browser

More...
UCSCi
uc004equ.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122676 mRNA Translation: BAG53660.1
CH471161 Genomic DNA Translation: EAW89892.1
BC031241 mRNA Translation: AAH31241.1
BC036572 mRNA Translation: AAH36572.1
BC057841 mRNA Translation: AAH57841.1
CCDSiCCDS14574.1
RefSeqiNP_001299820.1, NM_001312891.1
NP_776159.1, NM_173798.3
UniGeneiHs.21417

3D structure databases

ProteinModelPortaliQ6PEW1
SMRiQ6PEW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127997, 13 interactors
IntActiQ6PEW1, 24 interactors
STRINGi9606.ENSP00000308921

PTM databases

iPTMnetiQ6PEW1
PhosphoSitePlusiQ6PEW1

Polymorphism and mutation databases

BioMutaiZCCHC12
DMDMi85718626

Proteomic databases

PaxDbiQ6PEW1
PeptideAtlasiQ6PEW1
PRIDEiQ6PEW1
ProteomicsDBi67083

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
170261
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310164; ENSP00000308921; ENSG00000174460
GeneIDi170261
KEGGihsa:170261
UCSCiuc004equ.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170261
DisGeNETi170261
EuPathDBiHostDB:ENSG00000174460.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZCCHC12
HGNCiHGNC:27273 ZCCHC12
HPAiHPA031016
HPA034940
MIMi300701 gene
neXtProtiNX_Q6PEW1
OpenTargetsiENSG00000174460
PharmGKBiPA134885304

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J95G Eukaryota
ENOG4111945 LUCA
GeneTreeiENSGT00950000182785
HOGENOMiHOG000230940
HOVERGENiHBG073535
InParanoidiQ6PEW1
OMAiAFQGSPP
OrthoDBi697027at2759
PhylomeDBiQ6PEW1
TreeFamiTF335054

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
170261

Protein Ontology

More...
PROi
PR:Q6PEW1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174460 Expressed in 117 organ(s), highest expression level in left uterine tube
GenevisibleiQ6PEW1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR036875 Znf_CCHC_sf
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCH12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PEW1
Secondary accession number(s): B3KV48, Q6PID5, Q8N1C1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 10, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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