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Protein

Inactive serine protease 54

Gene

PRSS54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Although related to peptidase S1 family, lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 83, 129 and 221 and is therefore predicted to have lost protease activity.Curated

GO - Molecular functioni

Keywordsi

Molecular functionSerine protease homolog

Protein family/group databases

MEROPSiS01.992

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease 54
Alternative name(s):
Cancer/testis antigen 67
Short name:
CT67
Plasma kallikrein-like protein 4
Gene namesi
Name:PRSS54
Synonyms:KLKBL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103023.11
HGNCiHGNC:26336 PRSS54
neXtProtiNX_Q6PEW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi221191
OpenTargetsiENSG00000103023
PharmGKBiPA165450675

Polymorphism and mutation databases

BioMutaiPRSS54
DMDMi148876818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000028880131 – 395Inactive serine protease 54Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 227PROSITE-ProRule annotation
Disulfide bondi195 ↔ 205PROSITE-ProRule annotation
Disulfide bondi217 ↔ 248PROSITE-ProRule annotation
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6PEW0
PeptideAtlasiQ6PEW0
PRIDEiQ6PEW0
ProteomicsDBi67082

Expressioni

Gene expression databases

BgeeiENSG00000103023
ExpressionAtlasiQ6PEW0 baseline and differential
GenevisibleiQ6PEW0 HS

Organism-specific databases

HPAiHPA041549

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000219301

Structurei

3D structure databases

ProteinModelPortaliQ6PEW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 269Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00770000120569
HOGENOMiHOG000285942
HOVERGENiHBG106642
InParanoidiQ6PEW0
OMAiGWNPTSA
OrthoDBiEOG091G0EH9
PhylomeDBiQ6PEW0
TreeFamiTF338267

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PEW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSAAGLSGD GKMRGVLLVL LGLLYSSTSC GVQKASVFYG PDPKEGLVSS
60 70 80 90 100
MEFPWVVSLQ DSQYTHLAFG CILSEFWVLS IASAIQNRKD IVVIVGISNM
110 120 130 140 150
DPSKIAHTEY PVNTIIIHED FDNNSMSNNI ALLKTDTAMH FGNLVQSICF
160 170 180 190 200
LGRMLHTPPV LQNCWVSGWN PTSATGNHMT MSVLRKIFVK DLDMCPLYKL
210 220 230 240 250
QKTECGSHTK EETKTACLGD PGSPMMCQLQ QFDLWVLRGV LNFGGETCPG
260 270 280 290 300
LFLYTKVEDY SKWITSKAER AGPPLSSLHH WEKLISFSHH GPNATMTQKT
310 320 330 340 350
YSDSELGHVG SYLQGQRRTI THSRLGNSSR DSLDVREKDV KESGRSPEAS
360 370 380 390
VQPLYYDYYG GEVGEGRIFA GQNRLYQPEE IILVSFVLVF FCSSI
Length:395
Mass (Da):43,832
Last modified:May 29, 2007 - v3
Checksum:i5414B2DB041066EF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032497182S → G1 PublicationCorresponds to variant dbSNP:rs3815803Ensembl.1
Natural variantiVAR_032498240V → I1 PublicationCorresponds to variant dbSNP:rs1052276Ensembl.1
Natural variantiVAR_032499295T → A1 PublicationCorresponds to variant dbSNP:rs2241414Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058068 mRNA Translation: BAB71649.1
BC057843 mRNA Translation: AAH57843.2
AL137484 mRNA Translation: CAB70765.1
CCDSiCCDS32463.1
PIRiT46470
RefSeqiNP_001073961.1, NM_001080492.1
NP_001292102.1, NM_001305173.1
UniGeneiHs.411239

Genome annotation databases

EnsembliENST00000219301; ENSP00000219301; ENSG00000103023
ENST00000567164; ENSP00000455024; ENSG00000103023
GeneIDi221191
KEGGihsa:221191
UCSCiuc002enf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRS54_HUMAN
AccessioniPrimary (citable) accession number: Q6PEW0
Secondary accession number(s): Q96LN9, Q9NT77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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