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Protein

WAS/WASL-interacting protein family member 2

Gene

Wipf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
WAS/WASL-interacting protein family member 2
Alternative name(s):
WASP-interacting protein-related protein
WIP-related protein
Gene namesi
Name:Wipf2
Synonyms:Wire
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1924462 Wipf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659761 – 440WAS/WASL-interacting protein family member 2Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ6PEV3
PaxDbiQ6PEV3
PeptideAtlasiQ6PEV3
PRIDEiQ6PEV3

PTM databases

iPTMnetiQ6PEV3
PhosphoSitePlusiQ6PEV3

Expressioni

Gene expression databases

BgeeiENSMUSG00000038013 Expressed in 230 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_WIPF2
ExpressionAtlasiQ6PEV3 baseline and differential
GenevisibleiQ6PEV3 MM

Interactioni

Subunit structurei

Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046991

Structurei

3D structure databases

ProteinModelPortaliQ6PEV3
SMRiQ6PEV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 53WH2PROSITE-ProRule annotationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 52Binds actinSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 17Poly-ProAdd BLAST16
Compositional biasi177 – 182Poly-Pro6
Compositional biasi250 – 254Poly-Pro5
Compositional biasi296 – 299Poly-Pro4
Compositional biasi311 – 314Poly-Pro4
Compositional biasi325 – 330Poly-Pro6
Compositional biasi340 – 345Poly-Pro6
Compositional biasi359 – 363Poly-Pro5
Compositional biasi370 – 377Poly-Pro8

Sequence similaritiesi

Belongs to the verprolin family.Curated

Phylogenomic databases

eggNOGiKOG4462 Eukaryota
ENOG4111FVT LUCA
GeneTreeiENSGT00910000144192
HOGENOMiHOG000231914
HOVERGENiHBG060210
InParanoidiQ6PEV3
KOiK19475
OMAiPMHSSKA
OrthoDBiEOG091G16MU
PhylomeDBiQ6PEV3
TreeFamiTF332135

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
IPR028294 WIPF2
PANTHERiPTHR23202:SF3 PTHR23202:SF3, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6PEV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIPPPPPPP PGPPPPPTFN QANTEQPKLS RDEQRNRGAL LQDICKGTKL
60 70 80 90 100
KKVTNVNDRS APVIEKPRGS SGGYGPGAAA LQPKGGLFQG GVPKLRPVGA
110 120 130 140 150
KDASEAPAGK PALQVPSSRA AAPRPPGSAA SGRPHDDTDS NRASLPELPR
160 170 180 190 200
MQRPSLPDLS RPNTASGTGM KHSSSAPPPP PPGRRANAPP TPLPLHSNKA
210 220 230 240 250
QAYNREKPLP PTPGQRLHPG REGHPAPPPV KPPPSPVNIR TGPSGQSLAP
260 270 280 290 300
PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT
310 320 330 340 350
SATPSLLSNR PPPPAREPPS RGAAPPPPPP MIRNGARDAP PPPPPYRMHG
360 370 380 390 400
SEPPSRGKPP PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY
410 420 430 440
SFHPVEDFPA PEEYKHLQRV YPSKTNRAAR GAPPLPPILR
Length:440
Mass (Da):46,297
Last modified:July 5, 2004 - v1
Checksum:i8DBE6864CABD52B4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0K7D3Z0K7_MOUSE
WAS/WASL-interacting protein family...
Wipf2
183Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057854 mRNA Translation: AAH57854.1
CCDSiCCDS25366.1
RefSeqiNP_922922.1, NM_197940.2
XP_006534119.1, XM_006534056.3
XP_006534120.1, XM_006534057.3
XP_006534121.1, XM_006534058.2
XP_006534122.1, XM_006534059.3
UniGeneiMm.28661
Mm.473466

Genome annotation databases

EnsembliENSMUST00000037480; ENSMUSP00000046991; ENSMUSG00000038013
GeneIDi68524
KEGGimmu:68524
UCSCiuc007lht.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057854 mRNA Translation: AAH57854.1
CCDSiCCDS25366.1
RefSeqiNP_922922.1, NM_197940.2
XP_006534119.1, XM_006534056.3
XP_006534120.1, XM_006534057.3
XP_006534121.1, XM_006534058.2
XP_006534122.1, XM_006534059.3
UniGeneiMm.28661
Mm.473466

3D structure databases

ProteinModelPortaliQ6PEV3
SMRiQ6PEV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046991

PTM databases

iPTMnetiQ6PEV3
PhosphoSitePlusiQ6PEV3

Proteomic databases

MaxQBiQ6PEV3
PaxDbiQ6PEV3
PeptideAtlasiQ6PEV3
PRIDEiQ6PEV3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037480; ENSMUSP00000046991; ENSMUSG00000038013
GeneIDi68524
KEGGimmu:68524
UCSCiuc007lht.2 mouse

Organism-specific databases

CTDi147179
MGIiMGI:1924462 Wipf2

Phylogenomic databases

eggNOGiKOG4462 Eukaryota
ENOG4111FVT LUCA
GeneTreeiENSGT00910000144192
HOGENOMiHOG000231914
HOVERGENiHBG060210
InParanoidiQ6PEV3
KOiK19475
OMAiPMHSSKA
OrthoDBiEOG091G16MU
PhylomeDBiQ6PEV3
TreeFamiTF332135

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

PROiPR:Q6PEV3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038013 Expressed in 230 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_WIPF2
ExpressionAtlasiQ6PEV3 baseline and differential
GenevisibleiQ6PEV3 MM

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
IPR028294 WIPF2
PANTHERiPTHR23202:SF3 PTHR23202:SF3, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWIPF2_MOUSE
AccessioniPrimary (citable) accession number: Q6PEV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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