UniProtKB - Q6PER3 (MARE3_MOUSE)

BLAST

>sp|Q6PER3|MARE3_MOUSE Microtubule-associated protein RP/EB family member 3 OS=Mus musculus OX=10090 GN=Mapre3 PE=1 SV=1
MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRK
VKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYD
GKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAP
PCILRKNPPSARNGGHEADAQILELNQQLLDLKLTVDGLEKERDFYFSKLRDIELICQEH
ESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY

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History
Entry version 130 (12 Sep 2018)
Sequence version 1 (05 Jul 2004)
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Protein

Microtubule-associated protein RP/EB family member 3

Gene

Mapre3

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (By similarity). May play a role in cell migration (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI
microtubule binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17310996
protein C-terminus binding Source: MGI
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
positive regulation of cyclin-dependent protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17310996
positive regulation of microtubule plus-end binding
Source: MGI
Inferred from genetic interactionⁱ
- 16148041
positive regulation of protein kinase activity Source: MGI
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17310996

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis

Biological process

Cell cycle, Cell division, Mitosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Microtubule-associated protein RP/EB family member 3 Alternative name(s): EB1 protein family member 3 Short name: EBF3 End-binding protein 3 Short name: EB3 RP3
Gene namesⁱ	Name:Mapre3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2140967 Mapre3

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213429	1 – 281	Microtubule-associated protein RP/EB family member 3Add BLAST		281

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	162	PhosphoserineCombined sources		1
Modified residueⁱ	176	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6PER3
PaxDbⁱ	Q6PER3
PRIDEⁱ	Q6PER3

PTM databases

iPTMnetⁱ	Q6PER3
PhosphoSitePlusⁱ	Q6PER3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029166 Expressed in 214 organ(s), highest expression level in brain
ExpressionAtlasⁱ	Q6PER3 baseline and differential
Genevisibleⁱ	Q6PER3 MM

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Heterodimer with MAPRE1 (By similarity). Interacts with DCTN1 and SRCIN1 (By similarity). Binds to the C-terminal domain of APC (By similarity). Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with CLIP1 (By similarity). Interacts with SLAIN2 (By similarity). Interacts with SLAIN1 (PubMed:21646404). Interacts with APC2 (PubMed:17310996). Interacts with AKAP9 (By similarity). Interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

identical protein binding Source: MGI
microtubule binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17310996
protein C-terminus binding Source: MGI
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	221519, 2 interactors
IntActⁱ	Q6PER3, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q6PER3
STRINGⁱ	10090.ENSMUSP00000031058

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PER3
SMRⁱ	Q6PER3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 116	Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST		103
Domainⁱ	194 – 264	EB1 C-terminalPROSITE-ProRule annotationAdd BLAST		71

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	217 – 281	DCTN1-bindingBy similarityAdd BLAST		65
Regionⁱ	217 – 260	APC-bindingBy similarityAdd BLAST		44

Domainⁱ

Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.By similarity

Sequence similaritiesⁱ

Belongs to the MAPRE family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3000 Eukaryota COG5217 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00490000043329
HOGENOMⁱ	HOG000198048
HOVERGENⁱ	HBG052410
InParanoidⁱ	Q6PER3
KEGG Orthology (KO) More...KOⁱ	K10436
OMAⁱ	DSLHLTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FT4
PhylomeDBⁱ	Q6PER3
TreeFamⁱ	TF313620

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR036872 CH_dom_sf IPR004953 EB1_C IPR036133 EB1_C_sf IPR027738 EB3 IPR027328 MAPRE
PANTHERⁱ	PTHR10623 PTHR10623, 1 hit PTHR10623:SF10 PTHR10623:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00307 CH, 1 hit PF03271 EB1, 1 hit
SUPFAMⁱ	SSF140612 SSF140612, 1 hit SSF47576 SSF47576, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit PS51230 EB1_C, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.ⁱShow all

Q6PER3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVNVYSTSV TSENLSRHDM LAWVNDSLHL NYTKIEQLCS GAAYCQFMDM 
        60         70         80         90        100
LFPGCVHLRK VKFQAKLEHE YIHNFKVLQA AFKKMGVDKI IPVEKLVKGK 
       110        120        130        140        150
FQDNFEFIQW FKKFFDANYD GKDYNPLLAR QGQDVAPPPN PGDQIFNKSK 
       160        170        180        190        200
KLIGTAVPQR TSPTGPKNMQ TSGRLSNVAP PCILRKNPPS ARNGGHEADA 
       210        220        230        240        250
QILELNQQLL DLKLTVDGLE KERDFYFSKL RDIELICQEH ESENSPVISG 
       260        270        280 
IIGILYATEE GFAPPEDDEI EEHQQEDQDE Y

Length:281

Mass (Da):31,966

Last modified:July 5, 2004 - v1

Checksum:ⁱ6713427C480838DC

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	D3Z6G3	D3Z6G3_MOUSE		Microtubule-associated protein RP/E... Microtubule-associated protein RP/EB family member 3	Mapre3	266	Annotation score:
	A0A0J9YVB9	A0A0J9YVB9_MOUSE		Microtubule-associated protein RP/E... Microtubule-associated protein RP/EB family member 3	Mapre3	140	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC057918 mRNA Translation: AAH57918.1 U51204 mRNA Translation: AAA96321.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19163.1
NCBI Reference Sequences More...RefSeqⁱ	NP_579928.1, NM_133350.2 XP_006503686.1, XM_006503623.3
UniGeneⁱ	Mm.332295 Mm.471154

Genome annotation databases

Ensemblⁱ	ENSMUST00000031058; ENSMUSP00000031058; ENSMUSG00000029166
GeneIDⁱ	100732
KEGGⁱ	mmu:100732
UCSC genome browser More...UCSCⁱ	uc008wvz.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6PER3	Microtubule-associated protein RP/EB family member 3		RAT		281	UniRef100_Q6PER3
Microtubule-associated protein RP/EB family member 3		CRIGR		281
Microtubule-associated protein		MOUSE		281
UPI000A315621		MUSCR		287

Protein	Similar proteins		Species	Score	Length	Source
Q6PER3	Microtubule-associated protein RP/EB family member 3	)	HUMAN		281	UniRef90_Q9UPY8
Microtubule-associated protein RP/EB family member 3		RAT		281
MAPRE3 isoform 1		PANTR		281
Microtubule-associated protein RP/EB family member 3		MACMU		281
Microtubule associated protein RP/EB family member 3		MACNE		281
+66

Protein	Similar proteins		Species	Score	Length	Source
Q6PER3	Microtubule-associated protein RP/EB family member 3	)	HUMAN		281	UniRef50_Q9UPY8
Microtubule-associated protein RP/EB family member 3		RAT		281
Microtubule-associated protein RP/EB family member 2		XENLA		327
MAPRE3 isoform 1		PANTR		281
Microtubule-associated protein RP/EB family member 3		MACMU		281
+273

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC057918 mRNA Translation: AAH57918.1 U51204 mRNA Translation: AAA96321.1
CCDSⁱ	CCDS19163.1
RefSeqⁱ	NP_579928.1, NM_133350.2 XP_006503686.1, XM_006503623.3
UniGeneⁱ	Mm.332295 Mm.471154

3D structure databases

ProteinModelPortalⁱ	Q6PER3
SMRⁱ	Q6PER3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	221519, 2 interactors
IntActⁱ	Q6PER3, 2 interactors
MINTⁱ	Q6PER3
STRINGⁱ	10090.ENSMUSP00000031058

PTM databases

iPTMnetⁱ	Q6PER3
PhosphoSitePlusⁱ	Q6PER3

Proteomic databases

MaxQBⁱ	Q6PER3
PaxDbⁱ	Q6PER3
PRIDEⁱ	Q6PER3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031058; ENSMUSP00000031058; ENSMUSG00000029166
GeneIDⁱ	100732
KEGGⁱ	mmu:100732
UCSCⁱ	uc008wvz.1 mouse

Organism-specific databases

CTDⁱ	22924
MGIⁱ	MGI:2140967 Mapre3

Phylogenomic databases

eggNOGⁱ	KOG3000 Eukaryota COG5217 LUCA
GeneTreeⁱ	ENSGT00490000043329
HOGENOMⁱ	HOG000198048
HOVERGENⁱ	HBG052410
InParanoidⁱ	Q6PER3
KOⁱ	K10436
OMAⁱ	DSLHLTY
OrthoDBⁱ	EOG091G0FT4
PhylomeDBⁱ	Q6PER3
TreeFamⁱ	TF313620

Miscellaneous databases

ChiTaRSⁱ	Mapre3 mouse
Protein Ontology More...PROⁱ	PR:Q6PER3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029166 Expressed in 214 organ(s), highest expression level in brain
ExpressionAtlasⁱ	Q6PER3 baseline and differential
Genevisibleⁱ	Q6PER3 MM

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR036872 CH_dom_sf IPR004953 EB1_C IPR036133 EB1_C_sf IPR027738 EB3 IPR027328 MAPRE
PANTHERⁱ	PTHR10623 PTHR10623, 1 hit PTHR10623:SF10 PTHR10623:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF00307 CH, 1 hit PF03271 EB1, 1 hit
SUPFAMⁱ	SSF140612 SSF140612, 1 hit SSF47576 SSF47576, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit PS51230 EB1_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MARE3_MOUSE
Accessionⁱ	Q6PER3Primary (citable) accession number: Q6PER3 Secondary accession number(s): Q61167
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6PER3 (MARE3_MOUSE)

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Microtubule-associated protein RP/EB family member 3

Mapre3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ