C-C motif chemokine

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CCR1 chemokine receptor binding Source: Ensembl
• CCR4 chemokine receptor binding Source: InterPro
• CCR5 chemokine receptor binding Source: Ensembl
• chemoattractant activity Source: Ensembl
• chemokine activity Source: Ensembl
• chemokine receptor antagonist activity Source: Ensembl
• phosphatidylinositol phospholipase C activity Source: Ensembl
• phospholipase activator activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• protein kinase activity Source: Ensembl
• protein self-association Source: Ensembl
• receptor signaling protein tyrosine kinase activator activity Source: Ensembl

GO - Biological processⁱ

• activation of phospholipase D activity Source: Ensembl
• calcium ion transport Source: Ensembl
• cell-cell signaling Source: Ensembl
• cellular calcium ion homeostasis Source: Ensembl
• cellular response to fibroblast growth factor stimulus Source: Ensembl
• cellular response to interferon-gamma Source: Ensembl
• cellular response to interleukin-1 Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• cellular response to tumor necrosis factor Source: Ensembl
• chemokine-mediated signaling pathway Source: Ensembl
• eosinophil chemotaxis Source: Ensembl
• exocytosis Source: Ensembl
• G protein-coupled receptor signaling pathway Source: Ensembl
• inflammatory response Source: Ensembl
• leukocyte cell-cell adhesion Source: Ensembl
• lipopolysaccharide-mediated signaling pathway Source: Ensembl
• MAPK cascade Source: Ensembl
• negative regulation by host of viral transcription Source: Ensembl
• negative regulation of G protein-coupled receptor signaling pathway Source: Ensembl
• negative regulation of macrophage apoptotic process Source: Ensembl
• negative regulation of T cell apoptotic process Source: Ensembl
• negative regulation of viral genome replication Source: Ensembl
• neutrophil activation Source: Ensembl
• positive regulation of calcium ion transport Source: Ensembl
• positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
• positive regulation of cellular biosynthetic process Source: Ensembl
• positive regulation of epithelial cell proliferation Source: Ensembl
• positive regulation of homotypic cell-cell adhesion Source: Ensembl
• positive regulation of macrophage chemotaxis Source: Ensembl
• positive regulation of monocyte chemotaxis Source: Ensembl
• positive regulation of natural killer cell chemotaxis Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of smooth muscle cell migration Source: Ensembl
• positive regulation of smooth muscle cell proliferation Source: Ensembl
• positive regulation of T cell apoptotic process Source: Ensembl
• positive regulation of T cell chemotaxis Source: Ensembl
• positive regulation of T cell proliferation Source: Ensembl
• positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
• protein kinase B signaling Source: Ensembl
• regulation of insulin secretion Source: Ensembl
• regulation of neuron death Source: Ensembl
• response to toxic substance Source: Ensembl
• response to virus Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• CCR1 chemokine receptor binding Source: Ensembl
• CCR4 chemokine receptor binding Source: InterPro
• CCR5 chemokine receptor binding Source: Ensembl
• chemoattractant activity Source: Ensembl
• chemokine activity Source: Ensembl
• chemokine receptor antagonist activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• protein self-association Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKISTAASLT VILVAAALCT PAPASPYGSD TTPCCFAYLS LALPRAHVKE 
        60         70         80         90 
YFYTSSKCSN LAVVFVTRRN RQVCANPEKK WVQEYINYLE MS         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ