Skp1

Functionⁱ

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2.By similarity

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processⁱ

protein ubiquitination Source: UniProtKB-UniPathway
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-RNO-1169091 Activation of NF-kappaB in B cells R-RNO-1170546 Prolactin receptor signaling R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1 R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21 R-RNO-195253 Degradation of beta-catenin by the destruction complex R-RNO-202424 Downstream TCR signaling R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition R-RNO-2871837 FCERI mediated NF-kB activation R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-RNO-5607764 CLEC7A (Dectin-1) signaling R-RNO-5610780 Degradation of GLI1 by the proteasome R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome R-RNO-5676590 NIK-->noncanonical NF-kB signaling R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation R-RNO-68949 Orc1 removal from chromatin R-RNO-69231 Cyclin D associated events in G1 R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-RNO-8939902 Regulation of RUNX2 expression and activity R-RNO-8951664 Neddylation R-RNO-9020702 Interleukin-1 signaling R-RNO-917937 Iron uptake and transport R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayⁱ	UPA00143

Reactomeⁱ

R-RNO-1169091 Activation of NF-kappaB in B cells
R-RNO-1170546 Prolactin receptor signaling
R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-202424 Downstream TCR signaling
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5676590 NIK-->noncanonical NF-kB signaling
R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-RNO-68949 Orc1 removal from chromatin
R-RNO-69231 Cyclin D associated events in G1
R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939902 Regulation of RUNX2 expression and activity
R-RNO-8951664 Neddylation
R-RNO-9020702 Interleukin-1 signaling
R-RNO-917937 Iron uptake and transport
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathwayⁱ

UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: S-phase kinase-associated protein 1 Alternative name(s): Cyclin-A/CDK2-associated protein p19 S-phase kinase-associated protein 1A p19A p19skp1
Gene namesⁱ	Name:Skp1 Synonyms:Skp1a
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1359648 Skp1

RGDⁱ

1359648 Skp1

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000187253	1 – 163	S-phase kinase-associated protein 1Add BLAST		163

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	131	PhosphothreonineCombined sources		1
Cross-linkⁱ	142	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q6PEC4
PRIDEⁱ	Q6PEC4

PTM databases

iPTMnetⁱ	Q6PEC4
PhosphoSitePlusⁱ	Q6PEC4
SwissPalmⁱ	Q6PEC4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000005828 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	Q6PEC4 baseline and differential
Genevisibleⁱ	Q6PEC4 RN

Interactionⁱ

Subunit structureⁱ

Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CEP68. Interacts with NOTCH2 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Ccna2	G3V802	2	EBI-919194,EBI-15694230
Ccne1	P39949	2	EBI-919194,EBI-847441
Cdc6	D3ZRK7	2	EBI-919194,EBI-15694427

Protein-protein interaction databases

BioGridⁱ	252084, 2 interactors
Database of interacting proteins More...DIPⁱ	DIP-29863N
IntActⁱ	Q6PEC4, 7 interactors
STRINGⁱ	10116.ENSRNOP00000007676

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PEC4
SMRⁱ	Q6PEC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	104 – 163	Interaction with the F-box domain of F-box proteinsBy similarityAdd BLAST		60

Sequence similaritiesⁱ

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1724 Eukaryota COG5201 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012652
HOGENOMⁱ	HOG000172184
HOVERGENⁱ	HBG057008
InParanoidⁱ	Q6PEC4
KEGG Orthology (KO) More...KOⁱ	K03094
PhylomeDBⁱ	Q6PEC4
TreeFamⁱ	TF354233

Family and domain databases

InterProⁱ	View protein in InterPro IPR016897 SKP1 IPR001232 SKP1-like IPR036296 SKP1-like_dim_sf IPR011333 SKP1/BTB/POZ_sf IPR016072 Skp1_comp_dimer IPR016073 Skp1_comp_POZ
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01466 Skp1, 1 hit PF03931 Skp1_POZ, 1 hit
PIRSFⁱ	PIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTⁱ	View protein in SMART SM00512 Skp1, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF81382 SSF81382, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q6PEC4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPTIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV 
        60         70         80         90        100
NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL 
       110        120        130        140        150
FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE 
       160 
AQVRKENQWC EEK

Length:163

Mass (Da):18,672

Last modified:January 23, 2007 - v3

Checksum:ⁱAE184C00BE6556DB

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2K4X8	A0A0G2K4X8_RAT		S-phase kinase-associated protein 1 S-phase kinase-associated protein 1	Skp1	165	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC058152 mRNA Translation: AAH58152.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001007609.1, NM_001007608.2
UniGeneⁱ	Rn.3477

Genome annotation databases

Ensemblⁱ	ENSRNOT00000007676; ENSRNOP00000007676; ENSRNOG00000005828
GeneIDⁱ	287280
KEGGⁱ	rno:287280
UCSC genome browser More...UCSCⁱ	RGD:1359648 rat

Protein	Similar proteins		Species	Score	Length	Source
Q6PEC4	S-phase kinase-associated protein 1		MOUSE		163	UniRef100_Q9WTX5
S-phase kinase-associated protein 1		FUNHE		208
S-phase kinase-associated protein 1		NOTFU		163
S-phase kinase-associated protein 1		SALSA		163
S-phase kinase-associated protein 1		Nothobranchius korthausae		163
+17

Protein	Similar proteins		Species	Score	Length	Source
Q6PEC4	S-phase kinase-associated protein 1		MOUSE		163	UniRef90_Q9WTX5
S-phase kinase-associated protein 1		FUNHE		208
S-phase kinase-associated protein 1		NOTFU		163
S-phase kinase-associated protein 1		SALSA		163
S-phase kinase-associated protein 1		Nothobranchius korthausae		163
+34

Protein	Similar proteins		Species	Score	Length	Source
Q6PEC4	S-phase kinase-associated protein 1		MOUSE		163	UniRef50_Q9WTX5
S-phase kinase-associated protein 1		FUNHE		208
S-phase kinase-associated protein 1		NOTFU		163
S-phase kinase-associated protein 1		SALSA		163
S-phase kinase-associated protein 1		Nothobranchius korthausae		163
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC058152 mRNA Translation: AAH58152.1
RefSeqⁱ	NP_001007609.1, NM_001007608.2
UniGeneⁱ	Rn.3477

3D structure databases

ProteinModelPortalⁱ	Q6PEC4
SMRⁱ	Q6PEC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	252084, 2 interactors
DIPⁱ	DIP-29863N
IntActⁱ	Q6PEC4, 7 interactors
STRINGⁱ	10116.ENSRNOP00000007676

PTM databases

iPTMnetⁱ	Q6PEC4
PhosphoSitePlusⁱ	Q6PEC4
SwissPalmⁱ	Q6PEC4

Proteomic databases

PaxDbⁱ	Q6PEC4
PRIDEⁱ	Q6PEC4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000007676; ENSRNOP00000007676; ENSRNOG00000005828
GeneIDⁱ	287280
KEGGⁱ	rno:287280
UCSCⁱ	RGD:1359648 rat

Organism-specific databases

CTDⁱ	6500
RGDⁱ	1359648 Skp1

Phylogenomic databases

eggNOGⁱ	KOG1724 Eukaryota COG5201 LUCA
GeneTreeⁱ	ENSGT00390000012652
HOGENOMⁱ	HOG000172184
HOVERGENⁱ	HBG057008
InParanoidⁱ	Q6PEC4
KOⁱ	K03094
PhylomeDBⁱ	Q6PEC4
TreeFamⁱ	TF354233

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-RNO-1169091 Activation of NF-kappaB in B cells R-RNO-1170546 Prolactin receptor signaling R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1 R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21 R-RNO-195253 Degradation of beta-catenin by the destruction complex R-RNO-202424 Downstream TCR signaling R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition R-RNO-2871837 FCERI mediated NF-kB activation R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-RNO-5607764 CLEC7A (Dectin-1) signaling R-RNO-5610780 Degradation of GLI1 by the proteasome R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome R-RNO-5676590 NIK-->noncanonical NF-kB signaling R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation R-RNO-68949 Orc1 removal from chromatin R-RNO-69231 Cyclin D associated events in G1 R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-RNO-8939902 Regulation of RUNX2 expression and activity R-RNO-8951664 Neddylation R-RNO-9020702 Interleukin-1 signaling R-RNO-917937 Iron uptake and transport R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathwayⁱ

UPA00143

Reactomeⁱ

R-RNO-1169091 Activation of NF-kappaB in B cells
R-RNO-1170546 Prolactin receptor signaling
R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-202424 Downstream TCR signaling
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5676590 NIK-->noncanonical NF-kB signaling
R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-RNO-68949 Orc1 removal from chromatin
R-RNO-69231 Cyclin D associated events in G1
R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939902 Regulation of RUNX2 expression and activity
R-RNO-8951664 Neddylation
R-RNO-9020702 Interleukin-1 signaling
R-RNO-917937 Iron uptake and transport
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6PEC4

PROⁱ

PR:Q6PEC4

Gene expression databases

Bgeeⁱ	ENSRNOG00000005828 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	Q6PEC4 baseline and differential
Genevisibleⁱ	Q6PEC4 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR016897 SKP1 IPR001232 SKP1-like IPR036296 SKP1-like_dim_sf IPR011333 SKP1/BTB/POZ_sf IPR016072 Skp1_comp_dimer IPR016073 Skp1_comp_POZ
Pfamⁱ	View protein in Pfam PF01466 Skp1, 1 hit PF03931 Skp1_POZ, 1 hit
PIRSFⁱ	PIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTⁱ	View protein in SMART SM00512 Skp1, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF81382 SSF81382, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SKP1_RAT
Accessionⁱ	Q6PEC4Primary (citable) accession number: Q6PEC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Proteomes

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Supporting data

UniProtKB - Q6PEC4 (SKP1_RAT)

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S-phase kinase-associated protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ