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Protein

Platelet-derived growth factor receptor-like protein

Gene

Pdgfrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor receptor-like protein
Short name:
PDGFR-like protein
Gene namesi
Name:Pdgfrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916047 Pdgfrl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000023309222 – 375Platelet-derived growth factor receptor-like proteinAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi96 ↔ 143PROSITE-ProRule annotation
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi293 ↔ 357PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6PE55
PRIDEiQ6PE55

PTM databases

iPTMnetiQ6PE55
PhosphoSitePlusiQ6PE55

Expressioni

Gene expression databases

CleanExiMM_PDGFRL

Interactioni

Subunit structurei

Forms a complex composed of PDGFRL, TNK2 and GRB2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034004

Structurei

3D structure databases

ProteinModelPortaliQ6PE55
SMRiQ6PE55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 159Ig-like C2-type 1Add BLAST113
Domaini272 – 375Ig-like C2-type 2Add BLAST104

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
HOGENOMiHOG000012984
HOVERGENiHBG053893
InParanoidiQ6PE55
PhylomeDBiQ6PE55

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6PE55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFWLLLGLL LLHEALEDVA GQHSPKNKRP KEQGENRIKP TNKKAKPKIP
60 70 80 90 100
KVKDRDSTDS TAKSQSIMMQ AMGNGRFQRP AATVSLLAGQ TLELRCKGSK
110 120 130 140 150
VEWSYPAYLD TFKDSRLTVK QSERYGQLTL VNSTAADTGE FSCWEQLCNG
160 170 180 190 200
YICRRDEAKT GSTYIFFTEK GELFVPSPSY FDVVYLNPDR QAVVPCRVTA
210 220 230 240 250
PSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSDH QGVVYCKAEA
260 270 280 290 300
GGKSQISVKY QLLYVEVPSG PPSTTILASS NKVRGGDDIS VLCTVLGEPD
310 320 330 340 350
VEVEFRWLFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VIIVEDFETI
360 370
DAGYYICTAQ NLRGQTTVAT TVEFS
Length:375
Mass (Da):41,928
Last modified:July 5, 2004 - v1
Checksum:iD87133C6BF9F7326
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0C9A0A0R4J0C9_MOUSE
Platelet-derived growth factor rece...
Pdgfrl
375Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → G in BAB23210 (PubMed:16141072).Curated1
Sequence conflicti20A → G in BAE21269 (PubMed:16141072).Curated1
Sequence conflicti327I → V in BAB23210 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004179 mRNA Translation: BAB23210.1
AK132625 mRNA Translation: BAE21269.1
BC058275 mRNA Translation: AAH58275.1
CCDSiCCDS22259.1
RefSeqiNP_081116.3, NM_026840.3
UniGeneiMm.284246

Genome annotation databases

GeneIDi68797
KEGGimmu:68797
UCSCiuc009lni.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004179 mRNA Translation: BAB23210.1
AK132625 mRNA Translation: BAE21269.1
BC058275 mRNA Translation: AAH58275.1
CCDSiCCDS22259.1
RefSeqiNP_081116.3, NM_026840.3
UniGeneiMm.284246

3D structure databases

ProteinModelPortaliQ6PE55
SMRiQ6PE55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034004

PTM databases

iPTMnetiQ6PE55
PhosphoSitePlusiQ6PE55

Proteomic databases

PaxDbiQ6PE55
PRIDEiQ6PE55

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi68797
KEGGimmu:68797
UCSCiuc009lni.2 mouse

Organism-specific databases

CTDi5157
MGIiMGI:1916047 Pdgfrl

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
HOGENOMiHOG000012984
HOVERGENiHBG053893
InParanoidiQ6PE55
PhylomeDBiQ6PE55

Miscellaneous databases

PROiPR:Q6PE55
SOURCEiSearch...

Gene expression databases

CleanExiMM_PDGFRL

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGFRL_MOUSE
AccessioniPrimary (citable) accession number: Q6PE55
Secondary accession number(s): Q3V182, Q9D0Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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