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Protein

Coiled-coil domain-containing protein 85B

Gene

Ccdc85b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (PubMed:15644333, PubMed:22666460).2 Publications

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processDifferentiation, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85B
Alternative name(s):
Hepatitis delta antigen-interacting protein A homolog
Short name:
Delta-interacting protein A homolog
Gene namesi
Name:Ccdc85b
Synonyms:Dipa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147607 Ccdc85b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799091 – 202Coiled-coil domain-containing protein 85BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6PDY0
PaxDbiQ6PDY0
PRIDEiQ6PDY0

PTM databases

PhosphoSitePlusiQ6PDY0

Expressioni

Tissue specificityi

Expressed in white and brown adipose tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000095098 Expressed in 225 organ(s), highest expression level in brain
CleanExiMM_CCDC85B
GenevisibleiQ6PDY0 MM

Interactioni

Subunit structurei

Interacts with MCRS1 (By similarity). Interacts with TCF7L2; competes with CTNNB1 (By similarity). Interacts with CEBPB (PubMed:15644333). May interact with CEBPD (PubMed:15644333). Interacts with ANKRD26 (By similarity). Interacts with EURL (PubMed:27404227).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137537

Structurei

3D structure databases

SMRiQ6PDY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 82Sequence analysisAdd BLAST39
Coiled coili118 – 141Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3819 Eukaryota
ENOG410YXPD LUCA
GeneTreeiENSGT00390000003531
HOVERGENiHBG107255
InParanoidiQ6PDY0
KOiK16758
OMAiGHHAAKV
OrthoDBiEOG091G0MA4
PhylomeDBiQ6PDY0
TreeFamiTF320243

Family and domain databases

InterProiView protein in InterPro
IPR019359 CCDC85
PANTHERiPTHR13546 PTHR13546, 1 hit
PfamiView protein in Pfam
PF10226 CCDC85, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PDY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN
60 70 80 90 100
RQLQGHLGEI RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL
110 120 130 140 150
FGTQASRAVR EDLGGCWQKL AELEGRQEEL LRENLALKEL CLALGEEWGP
160 170 180 190 200
RGGPGGAVGS GAGPTPELAL PPCGPRDLGD GSSSTGSVGS PDQLPLACSP

DD
Length:202
Mass (Da):22,133
Last modified:July 5, 2004 - v1
Checksum:iDD49A77706FDE2C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058411 mRNA Translation: AAH58411.1
CCDSiCCDS50357.1
RefSeqiNP_941018.1, NM_198616.4
UniGeneiMm.329657
Mm.486877

Genome annotation databases

EnsembliENSMUST00000179549; ENSMUSP00000137537; ENSMUSG00000095098
GeneIDi240514
KEGGimmu:240514
UCSCiuc012bgx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058411 mRNA Translation: AAH58411.1
CCDSiCCDS50357.1
RefSeqiNP_941018.1, NM_198616.4
UniGeneiMm.329657
Mm.486877

3D structure databases

SMRiQ6PDY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137537

PTM databases

PhosphoSitePlusiQ6PDY0

Proteomic databases

MaxQBiQ6PDY0
PaxDbiQ6PDY0
PRIDEiQ6PDY0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000179549; ENSMUSP00000137537; ENSMUSG00000095098
GeneIDi240514
KEGGimmu:240514
UCSCiuc012bgx.2 mouse

Organism-specific databases

CTDi11007
MGIiMGI:2147607 Ccdc85b

Phylogenomic databases

eggNOGiKOG3819 Eukaryota
ENOG410YXPD LUCA
GeneTreeiENSGT00390000003531
HOVERGENiHBG107255
InParanoidiQ6PDY0
KOiK16758
OMAiGHHAAKV
OrthoDBiEOG091G0MA4
PhylomeDBiQ6PDY0
TreeFamiTF320243

Miscellaneous databases

ChiTaRSiCcdc85b mouse
PROiPR:Q6PDY0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000095098 Expressed in 225 organ(s), highest expression level in brain
CleanExiMM_CCDC85B
GenevisibleiQ6PDY0 MM

Family and domain databases

InterProiView protein in InterPro
IPR019359 CCDC85
PANTHERiPTHR13546 PTHR13546, 1 hit
PfamiView protein in Pfam
PF10226 CCDC85, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC85B_MOUSE
AccessioniPrimary (citable) accession number: Q6PDY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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