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UniProtKB - Q6PDM1 (MSL1_MOUSE)

Entry version 119 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Male-specific lethal 1 homolog

Gene

Msl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:24913909). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:21217699). Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys-16' (H4K16ac) (PubMed:24913909).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3214847, HATs acetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Male-specific lethal 1 homolog
Short name:
MSL-1
Alternative name(s):
Hampin
Male-specific lethal 1-like 1
Short name:
MSL1-like 1
Male-specific lethal-1 homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Msl1
Synonyms:Msl1l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921276, Msl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi498E → R: Abolishes interaction with KAT8. 1 Publication1
Mutagenesisi505F → R: Abolishes interaction with KAT8. 1 Publication1
Mutagenesisi509H → R: Abolishes interaction with KAT8. 1 Publication1
Mutagenesisi556F → E: Strongly reduces interaction with MSL3; when associated with E-576 and E-589 or E-577 and E-589. 1
Mutagenesisi576A → E: No effect on interaction with MSL3. Reduces interaction; when associated with E-589. Strongly reduces interaction with MSL3; when associated with E-556 and E-589. 1 Publication1
Mutagenesisi577F → E: No effect on interaction with MSL3. Reduces interaction; when associated with E-589. Strongly reduces interaction with MSL3; when associated with E-556 and E-589. 1 Publication1
Mutagenesisi589F → E: Strongly reduces interaction with MSL3; when associated with E-556 and E-576 or E-556 and E-577. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492371 – 616Male-specific lethal 1 homologAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei207PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei355N6-acetyllysineBy similarity1
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki380Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei395PhosphoserineBy similarity1
Modified residuei398PhosphothreonineBy similarity1
Modified residuei444PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated with SUMO1.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6PDM1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PDM1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PDM1

PeptideAtlas

More...PeptideAtlasi		Q6PDM1

PRoteomics IDEntifications database

More...PRIDEi		Q6PDM1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PDM1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PDM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 and isoform 5 are testis-specific (PubMed:16119455). Isoform 1 and isoform 4 are ubiquitously expressed (PubMed:16119455). Isoform 2 is expressed at low levels in the testis and brain (PubMed:16119455).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000052915, Expressed in cochlea and 306 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6PDM1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PDM1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (By similarity). Directly interacts with MSL2 via its coiled coil domain (By similarity). Directly interacts with NUPR1 (By similarity).

Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity (By similarity).

Forms a MSL heterotetrameric core with MSL2 (By similarity).

Interacts with KAT8 and MSL3; both interactions are direct (PubMed:21217699, PubMed:17335777). Isoform 1 and isoform 3 interact with TTC4 (PubMed:17335777).

Isoform 1 interacts with ECM2 and PIHD1 (PubMed:17335777).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		216434, 5 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-859, MSL histone acetyltransferase complex

Protein interaction database and analysis system

More...IntActi		Q6PDM1, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000042792

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6PDM1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1616
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PDM1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q6PDM1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 239Interaction with MSL2By similarityAdd BLAST15
Regioni500 – 520Interaction with KAT81 PublicationAdd BLAST21
Regioni552 – 593Interaction with MSL3 MRG domainAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili215 – 284By similarityAdd BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi319 – 348Nuclear localization signal1 PublicationAdd BLAST30
Motifi507 – 521Bipartite nuclear localization signal1 PublicationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 187Pro-richAdd BLAST133
Compositional biasi210 – 216Poly-Gly7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil is formed by helices from two subunits in the MSL1 homodimer.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the msl-1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQ0S, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018292

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030878_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PDM1

KEGG Orthology (KO)

More...KOi		K13163

Identification of Orthologs from Complete Genome Data

More...OMAi		GPSGHPK

Database of Orthologous Groups

More...OrthoDBi		560559at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6PDM1

TreeFam database of animal gene trees

More...TreeFami		TF330735

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026711, Msl-1
IPR031840, MSL1_dimer
IPR029332, PEHE_dom

The PANTHER Classification System

More...PANTHERi		PTHR21656, PTHR21656, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16801, MSL1_dimer, 1 hit
PF15275, PEHE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01300, PEHE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PDM1-1) [UniParc]FASTAAdd to basket
Also known as: Hampin A1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDESGA AEAHFLPRHR 
        60         70         80         90        100
KLKEPGPPLA SSQGGSPSPS PAGCGGGKGR GLLLPAGAAP GQQEESWGGS 
       110        120        130        140        150
VPLPCPPPAT KQAGIGGEPV AAGAGCSPRP KYQAVLPIQT GSIVVAAAKE 
       160        170        180        190        200
PTPWAGDKGG AAPPAATASD PAGPPPLPLP GPPPLAPTAT AGTLAASEGR 
       210        220        230        240        250
WKSIRKSPLG GGGGSGASSQ AACLKQILLL QLDLIEQQQQ QLQAKEKEIE 
       260        270        280        290        300
ELKSERDTLL ARIERMERRM QLVKRDNEKE RHKLLQGYEP EEREEAELSE 
       310        320        330        340        350
KIKLERQPEL CETSQALPSK PFSCGRSGKG HKRKTPFGNT ERKTPVKKLA 
       360        370        380        390        400
PEFSKVKTKT PKHSPIKEEP CGSISETVCK RELRSQETPE KPRSSVDTPP 
       410        420        430        440        450
RLSTPQKGPS THPKEKAFSS EMEDLPYLST TEMYLCRWHQ PPPSPLPLRE 
       460        470        480        490        500
SSPKKEETVA RCLMPSSVAG ETSVLAVPSW RDHSVEPLRD PNPSDILENL 
       510        520        530        540        550
DDSVFSKRHA KLELDEKRRK RWDIQRIREQ RILQRLQLRM YKKKGIQESE 
       560        570        580        590        600
PEVTSFFPEP DDVESLLITP FLPVVAFGRP LPKLAPQNFE LPWLDERSRC 
       610 
RLEIQKKHTP HRTCRK
Length:616
Mass (Da):67,320
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2679AF230DBC0A7D
GO
Isoform 2 (identifier: Q6PDM1-2) [UniParc]FASTAAdd to basket
Also known as: Hampin B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     461-477: RCLMPSSVAGETSVLAV → I

Show »
Length:600
Mass (Da):65,731
Checksum:i57FF48BFFC755A86
GO
Isoform 3 (identifier: Q6PDM1-3) [UniParc]FASTAAdd to basket
Also known as: Hampin C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-230: Missing.
     231-258: QLDLIEQQQQQLQAKEKEIEELKSERDT → MLRVFARHGQEALIPSLAAQTTTTNRNK
     461-477: RCLMPSSVAGETSVLAV → I

Show »
Length:370
Mass (Da):43,157
Checksum:i33AEF4186B4F06CC
GO
Isoform 4 (identifier: Q6PDM1-4) [UniParc]FASTAAdd to basket
Also known as: Hampin D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     461-463: RCL → SKA
     464-616: Missing.

Show »
Length:463
Mass (Da):49,207
Checksum:iC52E141065B00CF2
GO
Isoform 5 (identifier: Q6PDM1-5) [UniParc]FASTAAdd to basket
Also known as: Hampin E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-230: Missing.
     231-258: QLDLIEQQQQQLQAKEKEIEELKSERDT → MLRVFARHGQEALIPSLAAQTTTTNRNK
     461-463: RCL → SKA
     464-616: Missing.

Show »
Length:233
Mass (Da):26,633
Checksum:iC22A56BF0EEA593A
GO
Isoform 6 (identifier: Q6PDM1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.
     461-463: RCL → SKA
     464-616: Missing.

Show »
Length:198
Mass (Da):22,674
Checksum:iC9154B063512747B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CR37F7CR37_MOUSE
Male-specific lethal 1 homolog
Msl1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC35489 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti344T → N in BAB29369 (PubMed:16141072).Curated1
Sequence conflicti388 – 389TP → PQ in BAB29868 (PubMed:16141072).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0352381 – 265Missing in isoform 6. 1 PublicationAdd BLAST265
Alternative sequenceiVSP_0352391 – 230Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST230
Alternative sequenceiVSP_035240231 – 258QLDLI…SERDT → MLRVFARHGQEALIPSLAAQ TTTTNRNK in isoform 3 and isoform 5. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_035241461 – 477RCLMP…SVLAV → I in isoform 2 and isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_035242461 – 463RCL → SKA in isoform 4, isoform 5 and isoform 6. 3 Publications3
Alternative sequenceiVSP_035243464 – 616Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ387855 mRNA Translation: ABD46887.1
AK014463 mRNA Translation: BAB29369.1
AK015496 mRNA Translation: BAB29868.1
AK161412 mRNA Translation: BAE36380.1
AK053719 mRNA Translation: BAC35489.1 Frameshift.
AL590963 Genomic DNA No translation available.
BC043039 mRNA Translation: AAH43039.1
BC055715 mRNA Translation: AAH55715.1
BC058629 mRNA Translation: AAH58629.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS25364.1 [Q6PDM1-1]
CCDS88248.1 [Q6PDM1-2]
CCDS88249.1 [Q6PDM1-4]
CCDS88250.1 [Q6PDM1-3]

NCBI Reference Sequences

More...RefSeqi		NP_082998.2, NM_028722.2 [Q6PDM1-1]
XP_006534414.1, XM_006534351.2
XP_011247586.1, XM_011249284.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000037915; ENSMUSP00000042792; ENSMUSG00000052915 [Q6PDM1-1]
ENSMUST00000037930; ENSMUSP00000043328; ENSMUSG00000052915 [Q6PDM1-3]
ENSMUST00000107485; ENSMUSP00000103109; ENSMUSG00000052915 [Q6PDM1-4]
ENSMUST00000107487; ENSMUSP00000103111; ENSMUSG00000052915 [Q6PDM1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		74026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:74026

UCSC genome browser

More...UCSCi		uc007lhi.2, mouse [Q6PDM1-4]
uc007lhj.2, mouse [Q6PDM1-1]
uc007lhk.2, mouse [Q6PDM1-2]
uc007lhm.1, mouse [Q6PDM1-5]
uc007lhn.2, mouse [Q6PDM1-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ387855 mRNA Translation: ABD46887.1
AK014463 mRNA Translation: BAB29369.1
AK015496 mRNA Translation: BAB29868.1
AK161412 mRNA Translation: BAE36380.1
AK053719 mRNA Translation: BAC35489.1 Frameshift.
AL590963 Genomic DNA No translation available.
BC043039 mRNA Translation: AAH43039.1
BC055715 mRNA Translation: AAH55715.1
BC058629 mRNA Translation: AAH58629.1
CCDSiCCDS25364.1 [Q6PDM1-1]
CCDS88248.1 [Q6PDM1-2]
CCDS88249.1 [Q6PDM1-4]
CCDS88250.1 [Q6PDM1-3]
RefSeqiNP_082998.2, NM_028722.2 [Q6PDM1-1]
XP_006534414.1, XM_006534351.2
XP_011247586.1, XM_011249284.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y0MX-ray2.70B470-540[»]
2Y0NX-ray3.00E/F/G/H545-597[»]
SMRiQ6PDM1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi216434, 5 interactors
ComplexPortaliCPX-859, MSL histone acetyltransferase complex
IntActiQ6PDM1, 3 interactors
STRINGi10090.ENSMUSP00000042792

PTM databases

iPTMnetiQ6PDM1
PhosphoSitePlusiQ6PDM1

Proteomic databases

EPDiQ6PDM1
jPOSTiQ6PDM1
PaxDbiQ6PDM1
PeptideAtlasiQ6PDM1
PRIDEiQ6PDM1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7890, 87 antibodies

Genome annotation databases

EnsembliENSMUST00000037915; ENSMUSP00000042792; ENSMUSG00000052915 [Q6PDM1-1]
ENSMUST00000037930; ENSMUSP00000043328; ENSMUSG00000052915 [Q6PDM1-3]
ENSMUST00000107485; ENSMUSP00000103109; ENSMUSG00000052915 [Q6PDM1-4]
ENSMUST00000107487; ENSMUSP00000103111; ENSMUSG00000052915 [Q6PDM1-2]
GeneIDi74026
KEGGimmu:74026
UCSCiuc007lhi.2, mouse [Q6PDM1-4]
uc007lhj.2, mouse [Q6PDM1-1]
uc007lhk.2, mouse [Q6PDM1-2]
uc007lhm.1, mouse [Q6PDM1-5]
uc007lhn.2, mouse [Q6PDM1-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		339287
MGIiMGI:1921276, Msl1

Phylogenomic databases

eggNOGiENOG502QQ0S, Eukaryota
GeneTreeiENSGT00390000018292
HOGENOMiCLU_030878_1_0_1
InParanoidiQ6PDM1
KOiK13163
OMAiGPSGHPK
OrthoDBi560559at2759
PhylomeDBiQ6PDM1
TreeFamiTF330735

Enzyme and pathway databases

ReactomeiR-MMU-3214847, HATs acetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		74026, 7 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Msl1, mouse
EvolutionaryTraceiQ6PDM1

Protein Ontology

More...PROi		PR:Q6PDM1
RNActiQ6PDM1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000052915, Expressed in cochlea and 306 other tissues
ExpressionAtlasiQ6PDM1, baseline and differential
GenevisibleiQ6PDM1, MM

Family and domain databases

InterProiView protein in InterPro
IPR026711, Msl-1
IPR031840, MSL1_dimer
IPR029332, PEHE_dom
PANTHERiPTHR21656, PTHR21656, 1 hit
PfamiView protein in Pfam
PF16801, MSL1_dimer, 1 hit
PF15275, PEHE, 1 hit
SMARTiView protein in SMART
SM01300, PEHE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSL1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PDM1
Secondary accession number(s): A3KFP2
, A3KFP4, Q27QB3, Q3TTE5, Q80XS0, Q8BPN3, Q9CXF9, Q9D5C9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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