UniProtKB - Q6PDM1 (MSL1_MOUSE)
Male-specific lethal 1 homolog
Msl1
Functioni
GO - Molecular functioni
- chromatin binding Source: GO_Central
GO - Biological processi
- histone H4-K16 acetylation Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator |
Enzyme and pathway databases
Reactomei | R-MMU-3214847, HATs acetylate histones |
Names & Taxonomyi
Protein namesi | Recommended name: Male-specific lethal 1 homologShort name: MSL-1 Alternative name(s): Hampin Male-specific lethal 1-like 1 Short name: MSL1-like 1 Male-specific lethal-1 homolog 1 |
Gene namesi | Name:Msl1 Synonyms:Msl1l1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921276, Msl1 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- Nucleus 1 Publication
- Nucleus speckle 1 Publication
Nucleus
- Nucleus 2 Publications
- Nucleus speckle 1 Publication
Nucleus
- Nucleus 1 Publication
- nucleoplasm 1 Publication
Nucleus
- nucleoplasm 1 Publication
Nucleus
- nucleoplasm 1 Publication
Nucleus
- MSL complex Source: UniProtKB
- nuclear speck Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 498 | E → R: Abolishes interaction with KAT8. 1 Publication | 1 | |
Mutagenesisi | 505 | F → R: Abolishes interaction with KAT8. 1 Publication | 1 | |
Mutagenesisi | 509 | H → R: Abolishes interaction with KAT8. 1 Publication | 1 | |
Mutagenesisi | 556 | F → E: Strongly reduces interaction with MSL3; when associated with E-576 and E-589 or E-577 and E-589. | 1 | |
Mutagenesisi | 576 | A → E: No effect on interaction with MSL3. Reduces interaction; when associated with E-589. Strongly reduces interaction with MSL3; when associated with E-556 and E-589. 1 Publication | 1 | |
Mutagenesisi | 577 | F → E: No effect on interaction with MSL3. Reduces interaction; when associated with E-589. Strongly reduces interaction with MSL3; when associated with E-556 and E-589. 1 Publication | 1 | |
Mutagenesisi | 589 | F → E: Strongly reduces interaction with MSL3; when associated with E-556 and E-576 or E-556 and E-577. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349237 | 1 – 616 | Male-specific lethal 1 homologAdd BLAST | 616 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | PhosphoserineBy similarity | 1 | |
Modified residuei | 127 | PhosphoserineBy similarity | 1 | |
Modified residuei | 207 | PhosphoserineCombined sources | 1 | |
Cross-linki | 303 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 355 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 367 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 380 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 395 | PhosphoserineBy similarity | 1 | |
Modified residuei | 398 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 444 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6PDM1 |
jPOSTi | Q6PDM1 |
PaxDbi | Q6PDM1 |
PeptideAtlasi | Q6PDM1 |
PRIDEi | Q6PDM1 |
PTM databases
iPTMneti | Q6PDM1 |
PhosphoSitePlusi | Q6PDM1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000052915, Expressed in cochlea and 306 other tissues |
ExpressionAtlasi | Q6PDM1, baseline and differential |
Genevisiblei | Q6PDM1, MM |
Interactioni
Subunit structurei
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (By similarity). Directly interacts with MSL2 via its coiled coil domain (By similarity). Directly interacts with NUPR1 (By similarity).
Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity (By similarity).
Forms a MSL heterotetrameric core with MSL2 (By similarity).
Interacts with KAT8 and MSL3; both interactions are direct (PubMed:21217699, PubMed:17335777). Isoform 1 and isoform 3 interact with TTC4 (PubMed:17335777).
Isoform 1 interacts with ECM2 and PIHD1 (PubMed:17335777).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 216434, 5 interactors |
ComplexPortali | CPX-859, MSL histone acetyltransferase complex |
IntActi | Q6PDM1, 3 interactors |
STRINGi | 10090.ENSMUSP00000042792 |
Miscellaneous databases
RNActi | Q6PDM1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6PDM1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6PDM1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 225 – 239 | Interaction with MSL2By similarityAdd BLAST | 15 | |
Regioni | 500 – 520 | Interaction with KAT81 PublicationAdd BLAST | 21 | |
Regioni | 552 – 593 | Interaction with MSL3 MRG domainAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 215 – 284 | By similarityAdd BLAST | 70 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 319 – 348 | Nuclear localization signal1 PublicationAdd BLAST | 30 | |
Motifi | 507 – 521 | Bipartite nuclear localization signal1 PublicationAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 187 | Pro-richAdd BLAST | 133 | |
Compositional biasi | 210 – 216 | Poly-Gly | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQ0S, Eukaryota |
GeneTreei | ENSGT00390000018292 |
HOGENOMi | CLU_030878_1_0_1 |
InParanoidi | Q6PDM1 |
OMAi | GPSGHPK |
OrthoDBi | 560559at2759 |
PhylomeDBi | Q6PDM1 |
TreeFami | TF330735 |
Family and domain databases
InterProi | View protein in InterPro IPR026711, Msl-1 IPR031840, MSL1_dimer IPR029332, PEHE_dom |
PANTHERi | PTHR21656, PTHR21656, 1 hit |
Pfami | View protein in Pfam PF16801, MSL1_dimer, 1 hit PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDESGA AEAHFLPRHR
60 70 80 90 100
KLKEPGPPLA SSQGGSPSPS PAGCGGGKGR GLLLPAGAAP GQQEESWGGS
110 120 130 140 150
VPLPCPPPAT KQAGIGGEPV AAGAGCSPRP KYQAVLPIQT GSIVVAAAKE
160 170 180 190 200
PTPWAGDKGG AAPPAATASD PAGPPPLPLP GPPPLAPTAT AGTLAASEGR
210 220 230 240 250
WKSIRKSPLG GGGGSGASSQ AACLKQILLL QLDLIEQQQQ QLQAKEKEIE
260 270 280 290 300
ELKSERDTLL ARIERMERRM QLVKRDNEKE RHKLLQGYEP EEREEAELSE
310 320 330 340 350
KIKLERQPEL CETSQALPSK PFSCGRSGKG HKRKTPFGNT ERKTPVKKLA
360 370 380 390 400
PEFSKVKTKT PKHSPIKEEP CGSISETVCK RELRSQETPE KPRSSVDTPP
410 420 430 440 450
RLSTPQKGPS THPKEKAFSS EMEDLPYLST TEMYLCRWHQ PPPSPLPLRE
460 470 480 490 500
SSPKKEETVA RCLMPSSVAG ETSVLAVPSW RDHSVEPLRD PNPSDILENL
510 520 530 540 550
DDSVFSKRHA KLELDEKRRK RWDIQRIREQ RILQRLQLRM YKKKGIQESE
560 570 580 590 600
PEVTSFFPEP DDVESLLITP FLPVVAFGRP LPKLAPQNFE LPWLDERSRC
610
RLEIQKKHTP HRTCRK
The sequence of this isoform differs from the canonical sequence as follows:
1-230: Missing.
231-258: QLDLIEQQQQQLQAKEKEIEELKSERDT → MLRVFARHGQEALIPSLAAQTTTTNRNK
461-463: RCL → SKA
464-616: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF7CR37 | F7CR37_MOUSE | Male-specific lethal 1 homolog | Msl1 | 147 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 344 | T → N in BAB29369 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 388 – 389 | TP → PQ in BAB29868 (PubMed:16141072).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035238 | 1 – 265 | Missing in isoform 6. 1 PublicationAdd BLAST | 265 | |
Alternative sequenceiVSP_035239 | 1 – 230 | Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 230 | |
Alternative sequenceiVSP_035240 | 231 – 258 | QLDLI…SERDT → MLRVFARHGQEALIPSLAAQ TTTTNRNK in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_035241 | 461 – 477 | RCLMP…SVLAV → I in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_035242 | 461 – 463 | RCL → SKA in isoform 4, isoform 5 and isoform 6. 3 Publications | 3 | |
Alternative sequenceiVSP_035243 | 464 – 616 | Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST | 153 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ387855 mRNA Translation: ABD46887.1 AK014463 mRNA Translation: BAB29369.1 AK015496 mRNA Translation: BAB29868.1 AK161412 mRNA Translation: BAE36380.1 AK053719 mRNA Translation: BAC35489.1 Frameshift. AL590963 Genomic DNA No translation available. BC043039 mRNA Translation: AAH43039.1 BC055715 mRNA Translation: AAH55715.1 BC058629 mRNA Translation: AAH58629.1 |
CCDSi | CCDS25364.1 [Q6PDM1-1] CCDS88248.1 [Q6PDM1-2] CCDS88249.1 [Q6PDM1-4] CCDS88250.1 [Q6PDM1-3] |
RefSeqi | NP_082998.2, NM_028722.2 [Q6PDM1-1] XP_006534414.1, XM_006534351.2 XP_011247586.1, XM_011249284.2 |
Genome annotation databases
Ensembli | ENSMUST00000037915; ENSMUSP00000042792; ENSMUSG00000052915 [Q6PDM1-1] ENSMUST00000037930; ENSMUSP00000043328; ENSMUSG00000052915 [Q6PDM1-3] ENSMUST00000107485; ENSMUSP00000103109; ENSMUSG00000052915 [Q6PDM1-4] ENSMUST00000107487; ENSMUSP00000103111; ENSMUSG00000052915 [Q6PDM1-2] |
GeneIDi | 74026 |
KEGGi | mmu:74026 |
UCSCi | uc007lhi.2, mouse [Q6PDM1-4] uc007lhj.2, mouse [Q6PDM1-1] uc007lhk.2, mouse [Q6PDM1-2] uc007lhm.1, mouse [Q6PDM1-5] uc007lhn.2, mouse [Q6PDM1-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ387855 mRNA Translation: ABD46887.1 AK014463 mRNA Translation: BAB29369.1 AK015496 mRNA Translation: BAB29868.1 AK161412 mRNA Translation: BAE36380.1 AK053719 mRNA Translation: BAC35489.1 Frameshift. AL590963 Genomic DNA No translation available. BC043039 mRNA Translation: AAH43039.1 BC055715 mRNA Translation: AAH55715.1 BC058629 mRNA Translation: AAH58629.1 |
CCDSi | CCDS25364.1 [Q6PDM1-1] CCDS88248.1 [Q6PDM1-2] CCDS88249.1 [Q6PDM1-4] CCDS88250.1 [Q6PDM1-3] |
RefSeqi | NP_082998.2, NM_028722.2 [Q6PDM1-1] XP_006534414.1, XM_006534351.2 XP_011247586.1, XM_011249284.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Y0M | X-ray | 2.70 | B | 470-540 | [»] | |
2Y0N | X-ray | 3.00 | E/F/G/H | 545-597 | [»] | |
SMRi | Q6PDM1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 216434, 5 interactors |
ComplexPortali | CPX-859, MSL histone acetyltransferase complex |
IntActi | Q6PDM1, 3 interactors |
STRINGi | 10090.ENSMUSP00000042792 |
PTM databases
iPTMneti | Q6PDM1 |
PhosphoSitePlusi | Q6PDM1 |
Proteomic databases
EPDi | Q6PDM1 |
jPOSTi | Q6PDM1 |
PaxDbi | Q6PDM1 |
PeptideAtlasi | Q6PDM1 |
PRIDEi | Q6PDM1 |
Protocols and materials databases
Antibodypediai | 7890, 87 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000037915; ENSMUSP00000042792; ENSMUSG00000052915 [Q6PDM1-1] ENSMUST00000037930; ENSMUSP00000043328; ENSMUSG00000052915 [Q6PDM1-3] ENSMUST00000107485; ENSMUSP00000103109; ENSMUSG00000052915 [Q6PDM1-4] ENSMUST00000107487; ENSMUSP00000103111; ENSMUSG00000052915 [Q6PDM1-2] |
GeneIDi | 74026 |
KEGGi | mmu:74026 |
UCSCi | uc007lhi.2, mouse [Q6PDM1-4] uc007lhj.2, mouse [Q6PDM1-1] uc007lhk.2, mouse [Q6PDM1-2] uc007lhm.1, mouse [Q6PDM1-5] uc007lhn.2, mouse [Q6PDM1-3] |
Organism-specific databases
CTDi | 339287 |
MGIi | MGI:1921276, Msl1 |
Phylogenomic databases
eggNOGi | ENOG502QQ0S, Eukaryota |
GeneTreei | ENSGT00390000018292 |
HOGENOMi | CLU_030878_1_0_1 |
InParanoidi | Q6PDM1 |
OMAi | GPSGHPK |
OrthoDBi | 560559at2759 |
PhylomeDBi | Q6PDM1 |
TreeFami | TF330735 |
Enzyme and pathway databases
Reactomei | R-MMU-3214847, HATs acetylate histones |
Miscellaneous databases
BioGRID-ORCSi | 74026, 7 hits in 17 CRISPR screens |
ChiTaRSi | Msl1, mouse |
EvolutionaryTracei | Q6PDM1 |
PROi | PR:Q6PDM1 |
RNActi | Q6PDM1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052915, Expressed in cochlea and 306 other tissues |
ExpressionAtlasi | Q6PDM1, baseline and differential |
Genevisiblei | Q6PDM1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR026711, Msl-1 IPR031840, MSL1_dimer IPR029332, PEHE_dom |
PANTHERi | PTHR21656, PTHR21656, 1 hit |
Pfami | View protein in Pfam PF16801, MSL1_dimer, 1 hit PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSL1_MOUSE | |
Accessioni | Q6PDM1Primary (citable) accession number: Q6PDM1 Secondary accession number(s): A3KFP2 Q9D5C9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families