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Protein

Cytoplasmic dynein 1 light intermediate chain 2

Gene

Dync1li2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi61 – 68ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • dynein heavy chain binding Source: GO_Central
  • microtubule motor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 2
Alternative name(s):
Dynein light intermediate chain 2, cytosolic
Gene namesi
Name:Dync1li2
Synonyms:Dncli2, Dnclic2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:107738 Dync1li2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146721 – 492Cytoplasmic dynein 1 light intermediate chain 2Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1
Modified residuei383PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei397Omega-N-methylarginineCombined sources1
Modified residuei441PhosphothreonineBy similarity1
Modified residuei443PhosphoserineBy similarity1
Modified residuei446PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ6PDL0
MaxQBiQ6PDL0
PaxDbiQ6PDL0
PeptideAtlasiQ6PDL0
PRIDEiQ6PDL0

PTM databases

iPTMnetiQ6PDL0
PhosphoSitePlusiQ6PDL0

Expressioni

Gene expression databases

BgeeiENSMUSG00000035770 Expressed in 244 organ(s), highest expression level in cerebellum
CleanExiMM_DYNC1LI2
ExpressionAtlasiQ6PDL0 baseline and differential
GenevisibleiQ6PDL0 MM

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231551, 2 interactors
STRINGi10090.ENSMUSP00000045480

Structurei

3D structure databases

ProteinModelPortaliQ6PDL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905 Eukaryota
ENOG410XQS4 LUCA
GeneTreeiENSGT00390000008295
HOGENOMiHOG000236263
HOVERGENiHBG005546
InParanoidiQ6PDL0
KOiK10416
OrthoDBiEOG091G0B3J
TreeFamiTF352602

Family and domain databases

InterProiView protein in InterPro
IPR008467 Dynein1_light_intermed_chain
IPR022780 Dynein_light_int_chain
IPR027417 P-loop_NTPase
PANTHERiPTHR12688 PTHR12688, 1 hit
PfamiView protein in Pfam
PF05783 DLIC, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6PDL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK
60 70 80 90 100
LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD
110 120 130 140 150
HTRCNVWILD GDLYHKGLLK FAVSAESLRE TLVIFVADMS RPWTIMESLQ
160 170 180 190 200
KWASVLREHI DKMKIPPEEM RDLERKFMKE FQDYIEPEEG CQGSPQRRGP
210 220 230 240 250
LTSGSDEDSV ALPLGDNVLT HNLGIPVLVV CTKCDAMSVL EKEHDYRDEH
260 270 280 290 300
LDFIQAHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTIPA
310 320 330 340 350
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH
360 370 380 390 400
DKELAAEDEQ VFLMKQQSLL AKQPATPTRT SESPARGPSG SPRTQGRGGP
410 420 430 440 450
ASVPSASPGT SVKKPDPNIK NNAASEGVLA SFFNSLLSKK TGSPGSPSAG
460 470 480 490
GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD SMVTNSSTEN EA
Length:492
Mass (Da):54,218
Last modified:July 27, 2011 - v2
Checksum:i6418DF74FFD7175E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RM94A0A1D5RM94_MOUSE
Cytoplasmic dynein 1 light intermed...
Dync1li2
470Annotation score:
A0A1D5RLH6A0A1D5RLH6_MOUSE
Cytoplasmic dynein 1 light intermed...
Dync1li2
53Annotation score:
A0A1D5RMC1A0A1D5RMC1_MOUSE
Cytoplasmic dynein 1 light intermed...
Dync1li2
406Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353E → K in AAH58645 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140743 mRNA Translation: BAE24463.1
AK147899 mRNA Translation: BAE28215.1
AK152157 mRNA Translation: BAE30992.1
AK161434 mRNA Translation: BAE36394.1
BC058645 mRNA Translation: AAH58645.1
CCDSiCCDS22579.1
RefSeqiNP_001013398.2, NM_001013380.2
UniGeneiMm.289583

Genome annotation databases

EnsembliENSMUST00000041769; ENSMUSP00000045480; ENSMUSG00000035770
GeneIDi234663
KEGGimmu:234663
UCSCiuc009nao.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140743 mRNA Translation: BAE24463.1
AK147899 mRNA Translation: BAE28215.1
AK152157 mRNA Translation: BAE30992.1
AK161434 mRNA Translation: BAE36394.1
BC058645 mRNA Translation: AAH58645.1
CCDSiCCDS22579.1
RefSeqiNP_001013398.2, NM_001013380.2
UniGeneiMm.289583

3D structure databases

ProteinModelPortaliQ6PDL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231551, 2 interactors
STRINGi10090.ENSMUSP00000045480

PTM databases

iPTMnetiQ6PDL0
PhosphoSitePlusiQ6PDL0

Proteomic databases

EPDiQ6PDL0
MaxQBiQ6PDL0
PaxDbiQ6PDL0
PeptideAtlasiQ6PDL0
PRIDEiQ6PDL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041769; ENSMUSP00000045480; ENSMUSG00000035770
GeneIDi234663
KEGGimmu:234663
UCSCiuc009nao.2 mouse

Organism-specific databases

CTDi1783
MGIiMGI:107738 Dync1li2

Phylogenomic databases

eggNOGiKOG3905 Eukaryota
ENOG410XQS4 LUCA
GeneTreeiENSGT00390000008295
HOGENOMiHOG000236263
HOVERGENiHBG005546
InParanoidiQ6PDL0
KOiK10416
OrthoDBiEOG091G0B3J
TreeFamiTF352602

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiDync1li2 mouse
PROiPR:Q6PDL0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035770 Expressed in 244 organ(s), highest expression level in cerebellum
CleanExiMM_DYNC1LI2
ExpressionAtlasiQ6PDL0 baseline and differential
GenevisibleiQ6PDL0 MM

Family and domain databases

InterProiView protein in InterPro
IPR008467 Dynein1_light_intermed_chain
IPR022780 Dynein_light_int_chain
IPR027417 P-loop_NTPase
PANTHERiPTHR12688 PTHR12688, 1 hit
PfamiView protein in Pfam
PF05783 DLIC, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDC1L2_MOUSE
AccessioniPrimary (citable) accession number: Q6PDL0
Secondary accession number(s): Q3UGJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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