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Entry version 130 (13 Feb 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Histone-lysine N-methyltransferase 2D

Gene

Kmt2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (By similarity).By similarity

Caution

Human protein KMT2B/MLL4 was first named MLL2 (see AC Q9UMN6). Thus, also mouse Mll4 is often referred to as Mll2 and vice versa in the literature.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei5502S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5528ZincBy similarity1
Metal bindingi5576ZincBy similarity1
Metal bindingi5578ZincBy similarity1
Metal bindingi5583ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri104 – 149C2HC pre-PHD-type 1; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri170 – 218PHD-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri226 – 276PHD-type 2; degeneratePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri229 – 274RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Zinc fingeri270 – 323PHD-type 3PROSITE-ProRule annotationAdd BLAST54
Zinc fingeri276 – 321RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1071 – 1124PHD-type 4PROSITE-ProRule annotationAdd BLAST54
Zinc fingeri1121 – 1171PHD-type 5PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1198 – 1253PHD-type 6PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri1201 – 1251RING-type 3; atypicalPROSITE-ProRule annotationAdd BLAST51
Zinc fingeri4829 – 4874RING-type 4; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri5080 – 5120C2HC pre-PHD-type 2PROSITE-ProRule annotationAdd BLAST41
Zinc fingeri5141 – 5188PHD-type 7PROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase 2D (EC:2.1.1.43)
Short name:
Lysine N-methyltransferase 2D
Alternative name(s):
ALL1-related protein
Myeloid/lymphoid or mixed-lineage leukemia protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kmt2d
Synonyms:Mll2, Mll4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2682319 Kmt2d

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004019381 – 5588Histone-lysine N-methyltransferase 2DAdd BLAST5588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei727PhosphoserineCombined sources1
Modified residuei1107PhosphoserineBy similarity1
Modified residuei1205PhosphoserineBy similarity1
Modified residuei1223PhosphothreonineCombined sources1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1562PhosphoserineBy similarity1
Modified residuei1627PhosphoserineCombined sources1
Modified residuei1791PhosphoserineBy similarity1
Modified residuei1822PhosphothreonineCombined sources1
Modified residuei2196PhosphoserineBy similarity1
Modified residuei2197PhosphothreonineBy similarity1
Modified residuei2203N6-acetyllysineBy similarity1
Modified residuei2217PhosphoserineBy similarity1
Modified residuei2231PhosphoserineBy similarity1
Modified residuei2266PhosphoserineCombined sources1
Modified residuei2268PhosphoserineBy similarity1
Modified residuei2299PhosphoserineCombined sources1
Modified residuei2492Asymmetric dimethylarginineCombined sources1
Modified residuei2597PhosphoserineCombined sources1
Modified residuei2829Asymmetric dimethylarginineCombined sources1
Modified residuei3071N6-acetyllysineCombined sources1
Modified residuei3122PhosphoserineBy similarity1
Modified residuei3193PhosphoserineBy similarity1
Modified residuei3430N6-acetyllysineBy similarity1
Modified residuei3725Asymmetric dimethylarginineCombined sources1
Modified residuei4255Asymmetric dimethylarginineCombined sources1
Modified residuei4272PhosphoserineBy similarity1
Modified residuei4410PhosphoserineCombined sources1
Modified residuei4516N6-acetyllysineBy similarity1
Modified residuei4789PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki4807Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei4827N6-acetyllysineBy similarity1
Cross-linki4931Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PDK2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PDK2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PDK2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PDK2

PeptideAtlas

More...
PeptideAtlasi
Q6PDK2

PRoteomics IDEntifications database

More...
PRIDEi
Q6PDK2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PDK2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PDK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048154 Expressed in 242 organ(s), highest expression level in mesenteric lymph node

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6PDK2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PDK2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESR1; interaction is direct (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6PDK2, 3 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000135941

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6PDK2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6PDK2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati442 – 44615
Repeati460 – 46425
Repeati469 – 47345
Repeati477 – 48155
Repeati520 – 52475
Repeati529 – 53385
Repeati538 – 54295
Repeati547 – 551105
Repeati574 – 578115
Repeati583 – 587125
Repeati592 – 596135
Repeati610 – 614145
Repeati637 – 641155
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5226 – 5286FYR N-terminalPROSITE-ProRule annotationAdd BLAST61
Domaini5287 – 5372FYR C-terminalPROSITE-ProRule annotationAdd BLAST86
Domaini5448 – 5564SETPROSITE-ProRule annotationAdd BLAST117
Domaini5572 – 5588Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni439 – 64215 X 5 AA repeats of S/P-P-P-E/P-E/AAdd BLAST204
Regioni5525 – 5526S-adenosyl-L-methionine bindingBy similarity2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2627 – 2665Sequence analysisAdd BLAST39
Coiled coili2768 – 2813Sequence analysisAdd BLAST46
Coiled coili3559 – 3613Sequence analysisAdd BLAST55
Coiled coili3712 – 3747Sequence analysisAdd BLAST36
Coiled coili3854 – 3883Sequence analysisAdd BLAST30
Coiled coili3912 – 4052Sequence analysisAdd BLAST141

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2644 – 2648LXXLL motif 15
Motifi3030 – 3034LXXLL motif 25
Motifi4279 – 4293LXXLL motif 3Add BLAST15
Motifi4310 – 4314LXXLL motif 45
Motifi4514 – 4518LXXLL motif 55
Motifi5041 – 5045LXXLL motif 65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1307 – 1311Poly-Glu5
Compositional biasi2064 – 2583Pro-richAdd BLAST520
Compositional biasi2610 – 2613Poly-Ser4
Compositional biasi2769 – 2812Gln-richAdd BLAST44
Compositional biasi2813 – 2819Poly-Ala7
Compositional biasi3255 – 4332Gln-richAdd BLAST1078
Compositional biasi4841 – 4844Poly-Ala4
Compositional biasi4960 – 5028Pro-richAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

LXXLL motifs 5 and 6 are essential for the association with ESR1 nuclear receptor.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri104 – 149C2HC pre-PHD-type 1; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri170 – 218PHD-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri226 – 276PHD-type 2; degeneratePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri229 – 274RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Zinc fingeri270 – 323PHD-type 3PROSITE-ProRule annotationAdd BLAST54
Zinc fingeri276 – 321RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1071 – 1124PHD-type 4PROSITE-ProRule annotationAdd BLAST54
Zinc fingeri1121 – 1171PHD-type 5PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1198 – 1253PHD-type 6PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri1201 – 1251RING-type 3; atypicalPROSITE-ProRule annotationAdd BLAST51
Zinc fingeri4829 – 4874RING-type 4; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri5080 – 5120C2HC pre-PHD-type 2PROSITE-ProRule annotationAdd BLAST41
Zinc fingeri5141 – 5188PHD-type 7PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4443 Eukaryota
COG2940 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156707

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168503

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6PDK2

Identification of Orthologs from Complete Genome Data

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OMAi
HLRIPPQ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6PDK2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.30.10, 1 hit
3.30.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR037890 KMT2D
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR22884:SF380 PTHR22884:SF380, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 3 hits
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00398 HMG, 1 hit
SM00249 PHD, 7 hits
SM00508 PostSET, 1 hit
SM00184 RING, 6 hits
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit
SSF57903 SSF57903, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 2 hits
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 5 hits
PS50016 ZF_PHD_2, 4 hits
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6PDK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSQKPPAED KDSDPAADGL AAPEKPGATE PDLPILCIGE VSVPGSGGSR
60 70 80 90 100
PQKPPHDCSR GPARRCALCN CGEPGLHGQR ELQRFELPSD WPGFPVVPSG
110 120 130 140 150
GNSGPCEAVL PKEDASQIGF PEGLTPAHLG EPGGHCWAHH WCAAWSAGVW
160 170 180 190 200
GQEGPELCGV DKAIFSGISQ RCSHCARFGA SVPCRSPGCS RLYHFPCATA
210 220 230 240 250
SGSFLSMKTL QLLCPEHSDG AAHLEEARCA VCEGPGQLCD LLFCTSCGHH
260 270 280 290 300
YHGACLDTAL TARKRASWQC PECKVCQSCR KPGNDSKMLV CETCDKGYHT
310 320 330 340 350
FCLKPPMEDL PAHSWKCKTC RLCRACGAGS AELNPNSEWF ENYSLCHRCH
360 370 380 390 400
KAQGSQPVTS VAEQHPAVCS RLSPPEPGEI PIDAPDALYV ACQGQPKGGH
410 420 430 440 450
VTSMQPKELA PLQCEAKPLG RAGTQLEAQL EAPLHEEMPL LPPPEESPLS
460 470 480 490 500
PPPEESPTSP PPEASRLSPP TEESPLSPPP ESSPFSPLEG CPPSPALDTP
510 520 530 540 550
LSPPPEASPL SPPFEESPLS PPPEELPSSP PPEASRLSPP PEESPMSPPP
560 570 580 590 600
EESPMSPPPE ASRLFPPFEE SPLSPPPEDS PLSPPPEASR LSPPPEDSPM
610 620 630 640 650
SPPPEDSPMS PPPEVSRFLP LPVLSHLSPL PEVSRLSPPP EESPLSPPPE
660 670 680 690 700
DSPASPPPEA SRLSPPPEDS PASPPPEASR LSRPREDSPA SPPPEDSLVS
710 720 730 740 750
LPMEESPLSP LPEELRLCPQ PEEPYLSPQP EEPRLCPQPE ELPLSPQSEE
760 770 780 790 800
PCLSPVLVEP GPSSQPEEPH LSPVPQEPHL SPQPEEPHLS PQPQQLHLSP
810 820 830 840 850
HSEEPCLSPM PEEPCLSPQP EELNGPPQPA EPPEEPSQSS APKELSLFSP
860 870 880 890 900
SGEPPLPPML GEPALSEPGE PPLSPLPEEL PLSLSGEPVL SPQLMPPDPL
910 920 930 940 950
PPPLSPIIPA AAPPALSPLG ELEYPFGAKG DSDPESPLAA PILETPISPP
960 970 980 990 1000
PEANCTDPEP VPPMILPPSP GSPLGPASPI LMERLPPPCS PLLPHSLPPP
1010 1020 1030 1040 1050
TPPPSHCSPP ALPLSVPSPL SPVQKAVDVS DEAELHEMET DKGPEPECPA
1060 1070 1080 1090 1100
LEPRATSPLP SPLGDLSCPA PSPAPALDDF SGLGEDTAPL DGTGQMSGSL
1110 1120 1130 1140 1150
AGELKGSPVL LDPEELTPVT PMEVYGPECK QAGQGSPCEE QEEPGAPMAP
1160 1170 1180 1190 1200
MPPTLIKSDI VNEISNLSQG DASASFPGSE PLLGSPDPEG GGSLSMELGV
1210 1220 1230 1240 1250
STDVSPARDE GSLRLCTDSL PETDDSLLCD TGTATSGGKA EGDKGRRRSS
1260 1270 1280 1290 1300
PARSRIKQGR SSSFPGRRRP RGGAAHGGRG RGRARLKSTT SSVETLVADI
1310 1320 1330 1340 1350
DSSPSKEEEE EDDDTMQNTV VLFSNTDKFV LMQDMCVVCG SFGRGAEGHL
1360 1370 1380 1390 1400
LACSQCSQCY HPYCVNSKIT KVMLLKGWRC VECIVCEVCG QASDPSRLLL
1410 1420 1430 1440 1450
CDDCDISYHT YCLDPPLLTV PKGGWKCKWC VSCMQCGAAS PGFHCEWQNS
1460 1470 1480 1490 1500
YTHCGPCASL VTCPVCHAPY VEEDLLIQCR HCERWMHAGC ESLFTEDEVE
1510 1520 1530 1540 1550
QAADEGFDCV SCQPYVVKPV VPVAPPELVP VKVKEPEPQF FRFEGVWLTE
1560 1570 1580 1590 1600
TGMAVLRNLT MSPLHKRRQR RGRLGLPGEA GLEGSEPSDA LGPDDKKDGD
1610 1620 1630 1640 1650
LDTDDLLKGE GGVEQMECEI KLEGPASPDV ELGKEETEES KKRKRKPYRP
1660 1670 1680 1690 1700
GIGGFMVRQR KSHTRVKRGP AAQAEVLSGD GQPDEVMPAD LPAEGSVEQS
1710 1720 1730 1740 1750
LAEGDEKKKQ QRRARKKSKL EDMFPAYLQA AFFGKDLLDL SRKALFAVGV
1760 1770 1780 1790 1800
GRPGFGLGAS KPRADGGSDR KELMTAMHKG DDGPDVADEE SHGPEGTADL
1810 1820 1830 1840 1850
PGLEDGGVKA SPVPSDPEKP GTPGEGVLSS DLDRIPTEEL PKMESKDLQQ
1860 1870 1880 1890 1900
LFKDVLGSER EQHLGCGTPG LEGGRTSLQR PFLQGGLALG SLPSSSPMDS
1910 1920 1930 1940 1950
YPGLCQSPFL DSRERGGFFS PEPGEPDSPW TGSGGTTPST PTTPTTEGEG
1960 1970 1980 1990 2000
DGLSYNQRSL QRWEKDEELG QLSTISPVLY ANINFPNLKQ DYPDWSSRCK
2010 2020 2030 2040 2050
QIMKLWRKVP AADKAPYLQK AKDNRAAHRI SKVQKQAESQ ISKQAKMGDI
2060 2070 2080 2090 2100
ARKTDRPALH LRIPSQPGAL GSPPPAAAPT IFLGSPTTPA GLSTSADGFL
2110 2120 2130 2140 2150
KPPAGTVPGP DSPGELFLKL PPQVPAQVPS QDPFGLAPAY APEPRFSAAP
2160 2170 2180 2190 2200
PTYPPYPSPT GAPAQPPMLG TTTRPGTGQP GEFHTTPPGT PRHQPSTPDP
2210 2220 2230 2240 2250
FLKPRCPSLD NLAVPESPGV AGGKASEPLL SPPPFGESRK SLEVKKEELG
2260 2270 2280 2290 2300
ASSPGYGPPN LGCVDSPSAG PHLGGLELKA PDVFKAPLTP RASQVEPQSP
2310 2320 2330 2340 2350
GLGLRAQEPP PAQALAPSPP SHPDVFRSGP YPDPYAQPPL TPRPQPPPPE
2360 2370 2380 2390 2400
SCCAPPPRSL PSDPFSRVPA SPQSQSSSQS PLTPRPLSAE AFCPSPVTPR
2410 2420 2430 2440 2450
FQSPDPYSRP PSRPQSRDPF APLHKPPRPQ PPEVAFKAGP LAHTPLGAGG
2460 2470 2480 2490 2500
FPAALPSGPA GELHAKVPSG QPTNFARSPG TGTFVGTPSP MRFTFPQGVG
2510 2520 2530 2540 2550
EPSLKPPVPQ PGLPSPHGIN SHFGPGPTLG KPQSTNYAVA TGNFHPSGSP
2560 2570 2580 2590 2600
LGPNSGPTGE GYGLSPLRPA SVLPPPAPDG SLPYLTHGAS QRVGITSPVE
2610 2620 2630 2640 2650
KREDPGATMS SSSLATPELS SAQDAGISSL SQTELEKQRQ RQRLRELLIR
2660 2670 2680 2690 2700
QQIQRNTLRQ EKETAAAAAG AVGPPGNWGA EPSSPAFEQL SRGQTPFTGS
2710 2720 2730 2740 2750
QDRSSIVGLP ASKLGGPTLG PGAFSSDDRL ARPLPPATPS SMDMNSRQLV
2760 2770 2780 2790 2800
GGSQAFYQRT PYPGSLPLQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQLWQ
2810 2820 2830 2840 2850
QQQQQQQQQQ QQAAAAAAAT SMRLAMSARF PSTPGPELGR QALGSPLAGI
2860 2870 2880 2890 2900
PTRLPGPAEP VPGPAGPAQF IELRHNVQKG LGPGVSPFPG QGPPQRPRFY
2910 2920 2930 2940 2950
PVSEELHRLA PEGLRGLAVP GLPSQKPSAL PAPELNNSLH QTPHAKGPAL
2960 2970 2980 2990 3000
ASGLELVSRP PSNTELSRPP LALEAGKLPC EDPELDDDFD AHKALEDDEE
3010 3020 3030 3040 3050
LAHLGLGVDV AKGDDELGTL ENLETNDPHL DDLLNGDEFD LLAYTDPELD
3060 3070 3080 3090 3100
TGDKKDIFNE HLRLVESANE KAEREALLRG VEPVSLGPEE RPPPAPDNSE
3110 3120 3130 3140 3150
PRLTSVLPEV KPKVEEGGRH PSPCQFTINT PKVEPAPPAT SLSLGLKPGQ
3160 3170 3180 3190 3200
TVMGTRDTRG GVGTGSFPSS GHTAEKGPFG ATGGTPAHLL NPSSLSGPAA
3210 3220 3230 3240 3250
SSLLEKFELE SGALTLPSGH AAAGDELDKM ESSLVASELP LLIEDLLEHE
3260 3270 3280 3290 3300
KKELQKKQQL SAQTVLPAQQ QQQQQQQQQQ QQQQHTLLPT PGPAQALPLP
3310 3320 3330 3340 3350
HEPGPPQQLA LGIGSTRQPG LGQSMVPIQP PAHALQQRLA PSVAMVSNQG
3360 3370 3380 3390 3400
HMLSGQQAGQ TGLVPQQSSQ PVLAQKPMSA MPASMCMKPQ QLAMQQQQLA
3410 3420 3430 3440 3450
NSFFPDTDLD KFAAEDIIDP IAKAKMVALK GIKKVMAQGS IGVAPGMNRQ
3460 3470 3480 3490 3500
QVSLLAQRLS GGSGSDLQNH VAPGSGQERN AGDPAQPRPN PPTFAQGVIN
3510 3520 3530 3540 3550
EADQRQYEEW LFHTQQLLQM QLKVLEEQIG VHRKSRKALC AKQRTAKKAG
3560 3570 3580 3590 3600
REFPEADAEK LKLVTEQQSK IQKQLDQVRK QQKEHTNLMA EYRNKQQQQQ
3610 3620 3630 3640 3650
QQQQQQQQQQ HSAVLAVSPS QNPRVLTKLP GQLLPAHGLQ PPQAPPGGQA
3660 3670 3680 3690 3700
GGLRLPPGGM VLPGQSGGPF LNTTLAQQQQ QQHSGVAGSL TGPPGSFFPG
3710 3720 3730 3740 3750
NLALRSLGPD SRLLQERQLQ LQQQRMQLAQ KLQQQQQQQQ QQQQQQHLLG
3760 3770 3780 3790 3800
QVAIQQQQGP GVQNQALGPK PQGLLPPSNH QGLLVQQLSP QQSQGSQGLL
3810 3820 3830 3840 3850
GPAQVTVLQQ QQQQQQHSGA LGPQGPHRQV LMTQSRVLSS PQLAQQGHSL
3860 3870 3880 3890 3900
MGHRLLTAQQ QQQQQQQQQQ QQQQQQQQQQ QQQGSMTGLS QLQQGMMSHG
3910 3920 3930 3940 3950
GQPKMSAQAL GSLQQQQQQL QQQQMLQQQQ LQQQQQQLQQ QQQQQQLQQQ
3960 3970 3980 3990 4000
QQQQLQLQQQ QQQQQQHLQH QQQQQQQLQQ QQQLQQQQQQ QLHLQQQLHQ
4010 4020 4030 4040 4050
QQQLQLQQQQ MGLLNQNRTL LSPQQQQQQQ QQQQQQQQQQ QQQQQQQQQV
4060 4070 4080 4090 4100
TLGPGLPVKP LQHFSSSGAL GPTLLLTGKE QNNAETALPS EVTEGPSTHQ
4110 4120 4130 4140 4150
GGPPAVGTAP EPMSVEPGEV KPSISGDSQL LLVQSQAQSQ ATSVQLQPPL
4160 4170 4180 4190 4200
RLPGQPQPQV NLLHTAGGGS HGQQLGSGSS SESPAVPHLL AQPSVSLGEQ
4210 4220 4230 4240 4250
PGPMAQNLLG SQQPLGLDRP IQNNTGSQPP KSGPAPQSGQ GPPGAGVMPT
4260 4270 4280 4290 4300
VGQLRAQLQG VLAKNPQLRH LSPQQQQQLQ ALLMQRQLQQ SQAVRQTPPF
4310 4320 4330 4340 4350
QEPGTQPSPL QGLLGCQPQP GGFSVSQTGP LQELGAGSRP QGPPRLPVPQ
4360 4370 4380 4390 4400
GALSTGPVLG PAHPTPPPSS PQEPKRPSQL PSPSAQLTPT HPGTPKPQGP
4410 4420 4430 4440 4450
ALELPPGRVS PAAAQLADTF FGKGLGPWDP SDNLTEAQKP EQSSLVPGHL
4460 4470 4480 4490 4500
DQVNGQVVHE PSQLSIKQEP REEPCALGAQ TVKREANGEP AGAPGTSNHL
4510 4520 4530 4540 4550
LLAGSRSEAG HLLLQKLLRA KNVQLGAGRG PEGLRAEING HIDSKLSGLE
4560 4570 4580 4590 4600
QKLQGTSSNK EDAATRKPLP AKPKRVQKTS DRLPSSRKKL RKEDGVRANE
4610 4620 4630 4640 4650
ALLKQLKQEL SQLPLTEPTI TANFSLFAPF GSGCLVSGQS QLRGAFGSGA
4660 4670 4680 4690 4700
LHTGPDYYSQ LLTKNNLSNP PTPPSSLPPT PPPSVQQKMV NGVTPSDELG
4710 4720 4730 4740 4750
ERPKDTASAQ DSEGALRDAA EVKSLDLLAA LPTPPHNQTE DVRMESDEDS
4760 4770 4780 4790 4800
DSPDSIVPAS SPESILGEEA PRFPQLGSGR WEQDNRALSP VIPIIPRTGI
4810 4820 4830 4840 4850
PVFPDTKPYG VLDLEVPGKL PATAWEKGKG SEVSVMLTVS AAAAKNLNGV
4860 4870 4880 4890 4900
MVAVAELLSM KIPNSYEVLF PDGPARAGLE PKKGEAEGPG GKEKGLSGKG
4910 4920 4930 4940 4950
PDTGPDWLKQ FDAVLPGYTL KSQLDILSLL KQESPAPEPS IQHSYTYNVS
4960 4970 4980 4990 5000
NLDVRQLSAP PPEEPSPPPS PLAPSPASPP AEPMVELQAE RPAEPPIPSP
5010 5020 5030 5040 5050
LPLASSPESA RPKPRARPPE ESEDSRPPRL KKWKGVRWKR LRLLLTIQKG
5060 5070 5080 5090 5100
SGHQEDEREV AEFMEQFGTA LRPSKVPRDN RRCCFCHEEG DGATDGPARL
5110 5120 5130 5140 5150
LNLDLDLWVH LNCALWSTEV YETQGGALMN VEVALHRGLL TKCSLCQRTG
5160 5170 5180 5190 5200
ATSSCNRMRC PNVYHFACAI RAKCMFFKDK TMLCPVHKIK GPCEQELSSF
5210 5220 5230 5240 5250
AVFRRVYIER DEVKQIASII QRGERLHMFR VGGLVFHAIG QLLPHQMADF
5260 5270 5280 5290 5300
HSATALYPVG YEATRIYWSL RTNNRRCCYR CSISENNGRP EFVIKVIEQG
5310 5320 5330 5340 5350
LEDLVFTDAS PQAVWNRIIE PVAAMRKEAD MLRLFPEYLK GEELFGLTVH
5360 5370 5380 5390 5400
AVLRIAESLP GVESCQNYLF RYGRHPLMEL PLMINPTGCA RSEPKILTHY
5410 5420 5430 5440 5450
KRPHTLNSTS MSKAYQSTFT GETNTPYSKQ FVHSKSSQYR RLRTEWKNNV
5460 5470 5480 5490 5500
YLARSRIQGL GLYAAKDLEK HTMVIEYIGT IIRNEVANRR EKIYEEQNRG
5510 5520 5530 5540 5550
IYMFRINNEH VIDATLTGGP ARYINHSCAP NCVAEVVTFD KEDKIIIISS
5560 5570 5580
RRIPKGEELT YDYQFDFEDD QHKIPCHCGA WNCRKWMN
Length:5,588
Mass (Da):600,245
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37A0E5D319A5F1A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQ73A0A0A0MQ73_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2d
5,588Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YY77A0A0A6YY77_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2d
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GX77V9GX77_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2d
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VHD4A0A2R8VHD4_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2d
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC161165 Genomic DNA No translation available.
BC058659 mRNA Translation: AAH58659.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49725.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.264889

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000178486; ENSMUSP00000135941; ENSMUSG00000048154

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161165 Genomic DNA No translation available.
BC058659 mRNA Translation: AAH58659.1
CCDSiCCDS49725.2
UniGeneiMm.264889

3D structure databases

ProteinModelPortaliQ6PDK2
SMRiQ6PDK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PDK2, 3 interactors
STRINGi10090.ENSMUSP00000135941

PTM databases

iPTMnetiQ6PDK2
PhosphoSitePlusiQ6PDK2

Proteomic databases

EPDiQ6PDK2
jPOSTiQ6PDK2
MaxQBiQ6PDK2
PaxDbiQ6PDK2
PeptideAtlasiQ6PDK2
PRIDEiQ6PDK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000178486; ENSMUSP00000135941; ENSMUSG00000048154

Organism-specific databases

MGIiMGI:2682319 Kmt2d

Phylogenomic databases

eggNOGiKOG4443 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000156707
HOGENOMiHOG000168503
InParanoidiQ6PDK2
OMAiHLRIPPQ
PhylomeDBiQ6PDK2

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Kmt2d mouse

Protein Ontology

More...
PROi
PR:Q6PDK2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048154 Expressed in 242 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ6PDK2 baseline and differential
GenevisibleiQ6PDK2 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
3.30.40.10, 6 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR037890 KMT2D
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR22884:SF380 PTHR22884:SF380, 2 hits
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 3 hits
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00398 HMG, 1 hit
SM00249 PHD, 7 hits
SM00508 PostSET, 1 hit
SM00184 RING, 6 hits
SM00317 SET, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
SSF57903 SSF57903, 5 hits
PROSITEiView protein in PROSITE
PS51805 EPHD, 2 hits
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 5 hits
PS50016 ZF_PHD_2, 4 hits
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKMT2D_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PDK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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