UniProtKB - Q6PDJ6 (FBX42_MOUSE)
Protein
F-box only protein 42
Gene
Fbxo42
Organism
Mus musculus (Mouse)
Status
Functioni
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity).By similarity
Keywordsi
Biological process | Ubl conjugation pathway |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 42 |
Gene namesi | Name:Fbxo42 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924992, Fbxo42 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119943 | 1 – 717 | F-box only protein 42Add BLAST | 717 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 365 | PhosphoserineCombined sources | 1 | |
Modified residuei | 373 | PhosphoserineCombined sources | 1 | |
Modified residuei | 378 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 552 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6PDJ6 |
MaxQBi | Q6PDJ6 |
PaxDbi | Q6PDJ6 |
PRIDEi | Q6PDJ6 |
PTM databases
iPTMneti | Q6PDJ6 |
PhosphoSitePlusi | Q6PDJ6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028920, Expressed in secondary oocyte and 272 other tissues |
Genevisiblei | Q6PDJ6, MM |
Interactioni
Subunit structurei
Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42.
Interacts (via the kelch domain) with p53/TP53; interaction is direct (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030757 |
Miscellaneous databases
RNActi | Q6PDJ6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 93 | F-boxPROSITE-ProRule annotationAdd BLAST | 50 | |
Repeati | 132 – 184 | Kelch 1Add BLAST | 53 | |
Repeati | 186 – 242 | Kelch 2Add BLAST | 57 | |
Repeati | 244 – 293 | Kelch 3Add BLAST | 50 | |
Repeati | 295 – 342 | Kelch 4Add BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 508 – 513 | Poly-Ser | 6 |
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | KOG0379, Eukaryota |
GeneTreei | ENSGT00440000039706 |
HOGENOMi | CLU_023579_0_0_1 |
InParanoidi | Q6PDJ6 |
OMAi | QMSSDVW |
OrthoDBi | 838833at2759 |
PhylomeDBi | Q6PDJ6 |
TreeFami | TF324505 |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR015915, Kelch-typ_b-propeller IPR011498, Kelch_2 |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF07646, Kelch_2, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PDJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSSDSEDD SVMAVDQEET ALEGTMEQDE DPHPVLEVEE TRHNRSMSEL
60 70 80 90 100
PEEVLEYILS FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG
110 120 130 140 150
NIQWESRTYP YPGTPITQRF SHSACYYDAN QSMYVFGGCT QSSCNAAFND
160 170 180 190 200
LWRLDLNSKE WIRPLASGSY PSPKAGATLV VYKDLLVLFG GWTRPSPYPL
210 220 230 240 250
HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI GDKMIVFGGS
260 270 280 290 300
LGSRQMSNEV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDTTLLILG
310 320 330 340 350
GCGGPNALFK DAWLLHMHPG PWAWQPLKVE NEDHGAPELW CHPACRVGQC
360 370 380 390 400
VVVFSQAPSG RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE
410 420 430 440 450
APCVNGRWGT LRPRAQRQTP SGSREGSLSP ARGDGSPILN GGNLSPGTVA
460 470 480 490 500
VGGASLDSPV QVVSPSTPSA SDGYDLKVGL SLAPRRGSLP DQKDLRLSSI
510 520 530 540 550
DLNWDLKSAS SSSHVDSIDN RTVAGSVRHP PEQTNGVHTP PHVASALAGA
560 570 580 590 600
VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPSSPGS QSLSSGETVP
610 620 630 640 650
NSRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD
660 670 680 690 700
IKDTKEKGRV KWKVFTSSSV VGPPETSLHT VVQGRGELIV FGGLMDKKQN
710
VKYYPKTNAL YFVRAKR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | S → Y in BAC26160 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 518 | I → T in AAH03960 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 602 | S → P in AAH03960 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028867 mRNA Translation: BAC26160.1 AL607087 Genomic DNA No translation available. BC003960 mRNA Translation: AAH03960.1 BC058667 mRNA Translation: AAH58667.1 |
CCDSi | CCDS18866.1 |
RefSeqi | NP_766106.2, NM_172518.3 |
Genome annotation databases
Ensembli | ENSMUST00000030757; ENSMUSP00000030757; ENSMUSG00000028920 |
GeneIDi | 213499 |
KEGGi | mmu:213499 |
UCSCi | uc008vnz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028867 mRNA Translation: BAC26160.1 AL607087 Genomic DNA No translation available. BC003960 mRNA Translation: AAH03960.1 BC058667 mRNA Translation: AAH58667.1 |
CCDSi | CCDS18866.1 |
RefSeqi | NP_766106.2, NM_172518.3 |
3D structure databases
SMRi | Q6PDJ6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030757 |
PTM databases
iPTMneti | Q6PDJ6 |
PhosphoSitePlusi | Q6PDJ6 |
Proteomic databases
EPDi | Q6PDJ6 |
MaxQBi | Q6PDJ6 |
PaxDbi | Q6PDJ6 |
PRIDEi | Q6PDJ6 |
Protocols and materials databases
Antibodypediai | 14535, 312 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000030757; ENSMUSP00000030757; ENSMUSG00000028920 |
GeneIDi | 213499 |
KEGGi | mmu:213499 |
UCSCi | uc008vnz.2, mouse |
Organism-specific databases
CTDi | 54455 |
MGIi | MGI:1924992, Fbxo42 |
Phylogenomic databases
eggNOGi | KOG0379, Eukaryota |
GeneTreei | ENSGT00440000039706 |
HOGENOMi | CLU_023579_0_0_1 |
InParanoidi | Q6PDJ6 |
OMAi | QMSSDVW |
OrthoDBi | 838833at2759 |
PhylomeDBi | Q6PDJ6 |
TreeFami | TF324505 |
Miscellaneous databases
BioGRID-ORCSi | 213499, 6 hits in 18 CRISPR screens |
ChiTaRSi | Fbxo42, mouse |
PROi | PR:Q6PDJ6 |
RNActi | Q6PDJ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028920, Expressed in secondary oocyte and 272 other tissues |
Genevisiblei | Q6PDJ6, MM |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR015915, Kelch-typ_b-propeller IPR011498, Kelch_2 |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF07646, Kelch_2, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX42_MOUSE | |
Accessioni | Q6PDJ6Primary (citable) accession number: Q6PDJ6 Secondary accession number(s): A2A824, Q8CE76, Q99KY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot