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Protein

VWFA and cache domain-containing protein 1

Gene

Cachd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May regulate voltage-dependent calcium channels.By similarity

GO - Molecular functioni

  • voltage-gated calcium channel activity Source: GO_Central

Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
VWFA and cache domain-containing protein 1
Short name:
Cache domain-containing protein 1
Gene namesi
Name:Cachd1
Synonyms:Kiaa1573, Vwcd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2444177 Cachd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 1109ExtracellularSequence analysisAdd BLAST1060
Transmembranei1110 – 1130HelicalSequence analysisAdd BLAST21
Topological domaini1131 – 1288CytoplasmicSequence analysisAdd BLAST158

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 49Sequence analysisAdd BLAST49
ChainiPRO_000030466250 – 1288VWFA and cache domain-containing protein 1Add BLAST1239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PDJ1
PeptideAtlasiQ6PDJ1
PRIDEiQ6PDJ1

PTM databases

iPTMnetiQ6PDJ1
PhosphoSitePlusiQ6PDJ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000028532 Expressed in 286 organ(s), highest expression level in choroid plexus epithelium
CleanExiMM_CACHD1
ExpressionAtlasiQ6PDJ1 baseline and differential
GenevisibleiQ6PDJ1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030257

Structurei

3D structure databases

ProteinModelPortaliQ6PDJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 457VWFAPROSITE-ProRule annotationAdd BLAST216
Domaini467 – 546Cache 1Add BLAST80
Domaini786 – 867Cache 2Add BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi957 – 996Cys-richAdd BLAST40
Compositional biasi1257 – 1274His-richAdd BLAST18

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2353 Eukaryota
ENOG410XPDX LUCA
GeneTreeiENSGT00530000062904
HOGENOMiHOG000111294
HOVERGENiHBG059120
InParanoidiQ6PDJ1
OrthoDBiEOG091G013E
PhylomeDBiQ6PDJ1
TreeFamiTF315824

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029151 Sensor-like_sf
IPR013608 VWA_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00092 VWA, 1 hit
PF08399 VWA_N, 1 hit
SUPFAMiSSF103190 SSF103190, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PDJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAREPEEEET VRPAAVVRRC PRCPGWPGAP RPPLWLLCLV ACWILGAVAD
60 70 80 90 100
ADFSILDEAQ VLASQMRRLA AEELGVVTMQ RIFNSLVYTE KISNGESEVQ
110 120 130 140 150
QLAKKIREKF NRYLDVVNRN KQVVEASYTA HLTSPLTAIQ DCCTIPPSMM
160 170 180 190 200
EFDGNFNTNV SRTVSCDRLS TTVNSRAFNP GRDLNSVLAD NLKSNPGIKW
210 220 230 240 250
QYFSSEEGIF TVFPAHKFRC KGSYEHRSRP IYVSTVRPQS KHIVVILDHG
260 270 280 290 300
ASVTDTQLQI AKDAAQVILS AIDEHDKISV LTVADAVRTC SLDQCYKTYL
310 320 330 340 350
SPATSETKRK MSTFVSSVKP SDSPTQHAVG FHRAFQLIRS TSNSTRFQAN
360 370 380 390 400
TDMVIIYLSA GITSKDSSEE DKKATLRVIN EENGFLNNSV MILTYALMND
410 420 430 440 450
GVTGLKELAF LRDLAEQNSG KYGIPDRTAL PVIKGSMMVL NQLSNLETTV
460 470 480 490 500
GRFYTNLPNR MIDEAVFSLP FSDEMGDGLI MTVSKPCYFG NLLLGIVGVD
510 520 530 540 550
VNLAYILEDV TYYQDSLASY TFLIDDKGYT LMHPSLTRPY LLSEPPLHTD
560 570 580 590 600
IIHYENIPKF ELVRQNILSL PLGSQIITVP VNSSLSWHIN KLRETGKEAY
610 620 630 640 650
NVSYAWKMVQ DTSFILCIVV IQPEIPVKQL KNLNTVPSSK LLYHRLDLLG
660 670 680 690 700
QPSACLHFKQ LATLESPTVM LSAGSFSSPY EHLSQPETKR MVEHYTAYLS
710 720 730 740 750
DNTRLIANPG LKFSVRNEVM ATSHVTDEWM TQMEMSSLNT YIVRRYIATP
760 770 780 790 800
NGVLRIYPGS LMDKAFDPTR RQWYLHAVAN PGLISLTGPY LDVGGAGYVV
810 820 830 840 850
TISHTIHSSS TQLSSGHTVA VMGIDFTLRY FYKVLMDLLP VCNQDGGNKI
860 870 880 890 900
RCFIMEDRGY LVAHPTLVDP KGHAPLEQQH ITHKEPLVAN DILNHPNFVK
910 920 930 940 950
KNLCNSFSDR TVQRSYKFNT SLVGDLTNLV HGSHCSKYRL TRIPGTNAFV
960 970 980 990 1000
GIVNETCDSL AFCACSMVDR LCLNCHRMEQ NECECPCECP LEVNECTGNL
1010 1020 1030 1040 1050
TNAENRNPSC EVHQEPVTYT AIDPGLQDAL QQCVNSRCNQ RMESGDCFGV
1060 1070 1080 1090 1100
LDCEWCVVDS DGKTHLDKSY CAPQKECFGG IVGAKSPYVD DMGAIGDEVI
1110 1120 1130 1140 1150
TLNMIKSAPV GPVAGGIMGC IMVLVLAVYA YRHQIHRRSH QHMSPLAAQE
1160 1170 1180 1190 1200
MSVRMSNLEN DRDERDDDSH EDRGIISNTR FIAAVMERHV HSPERRRRYW
1210 1220 1230 1240 1250
GRSGTESDHG YSTMSPQEDS ENPPCNNDPL SAGVDVGNHD DDLDLDTPPQ
1260 1270 1280
TAALLSHKFH HYRPHHPTLH HSHHLQAAVT VHTVDAEC
Length:1,288
Mass (Da):143,812
Last modified:July 5, 2004 - v1
Checksum:iCF4ABE98727BABF5
GO
Isoform 2 (identifier: Q6PDJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-828: Missing.

Note: No experimental confirmation available.
Show »
Length:1,282
Mass (Da):143,166
Checksum:iF31FDC1445747565
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YK18Z4YK18_MOUSE
VWFA and cache domain-containing pr...
Cachd1
1,210Annotation score:

Sequence cautioni

The sequence CAM20140 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM22543 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028073823 – 828Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670223, AL627083 Genomic DNA Translation: CAM20139.1
AL670223, AL627083 Genomic DNA Translation: CAM20140.1 Sequence problems.
AL627083, AL670223 Genomic DNA Translation: CAM22542.1
AL627083, AL670223 Genomic DNA Translation: CAM22543.1 Sequence problems.
BC058676 mRNA Translation: AAH58676.1
BC057356 mRNA Translation: AAH57356.1
BC080313 mRNA Translation: AAH80313.1
AK080923 mRNA Translation: BAC38080.1
AK129397 Transcribed RNA Translation: BAC98207.1
CCDSiCCDS18391.1 [Q6PDJ1-1]
RefSeqiNP_932154.1, NM_198037.1 [Q6PDJ1-1]
UniGeneiMm.151962

Genome annotation databases

EnsembliENSMUST00000030257; ENSMUSP00000030257; ENSMUSG00000028532 [Q6PDJ1-1]
GeneIDi320508
KEGGimmu:320508
UCSCiuc008tvg.1 mouse [Q6PDJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670223, AL627083 Genomic DNA Translation: CAM20139.1
AL670223, AL627083 Genomic DNA Translation: CAM20140.1 Sequence problems.
AL627083, AL670223 Genomic DNA Translation: CAM22542.1
AL627083, AL670223 Genomic DNA Translation: CAM22543.1 Sequence problems.
BC058676 mRNA Translation: AAH58676.1
BC057356 mRNA Translation: AAH57356.1
BC080313 mRNA Translation: AAH80313.1
AK080923 mRNA Translation: BAC38080.1
AK129397 Transcribed RNA Translation: BAC98207.1
CCDSiCCDS18391.1 [Q6PDJ1-1]
RefSeqiNP_932154.1, NM_198037.1 [Q6PDJ1-1]
UniGeneiMm.151962

3D structure databases

ProteinModelPortaliQ6PDJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030257

PTM databases

iPTMnetiQ6PDJ1
PhosphoSitePlusiQ6PDJ1

Proteomic databases

PaxDbiQ6PDJ1
PeptideAtlasiQ6PDJ1
PRIDEiQ6PDJ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030257; ENSMUSP00000030257; ENSMUSG00000028532 [Q6PDJ1-1]
GeneIDi320508
KEGGimmu:320508
UCSCiuc008tvg.1 mouse [Q6PDJ1-1]

Organism-specific databases

CTDi57685
MGIiMGI:2444177 Cachd1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2353 Eukaryota
ENOG410XPDX LUCA
GeneTreeiENSGT00530000062904
HOGENOMiHOG000111294
HOVERGENiHBG059120
InParanoidiQ6PDJ1
OrthoDBiEOG091G013E
PhylomeDBiQ6PDJ1
TreeFamiTF315824

Miscellaneous databases

PROiPR:Q6PDJ1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028532 Expressed in 286 organ(s), highest expression level in choroid plexus epithelium
CleanExiMM_CACHD1
ExpressionAtlasiQ6PDJ1 baseline and differential
GenevisibleiQ6PDJ1 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029151 Sensor-like_sf
IPR013608 VWA_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00092 VWA, 1 hit
PF08399 VWA_N, 1 hit
SUPFAMiSSF103190 SSF103190, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAHD1_MOUSE
AccessioniPrimary (citable) accession number: Q6PDJ1
Secondary accession number(s): A2A8W3
, Q6PFZ0, Q6ZPM4, Q8BNP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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