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UniProtKB - Q6PDH0 (PHLB1_MOUSE)

Entry version 122 (10 Feb 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Pleckstrin homology-like domain family B member 1

Gene

Phldb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology-like domain family B member 1
Alternative name(s):
Protein LL5-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Phldb1
Synonyms:Kiaa0638, Ll5a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2143230, Phldb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538921 – 1371Pleckstrin homology-like domain family B member 1Add BLAST1371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphoserineCombined sources1
Modified residuei131Asymmetric dimethylarginineCombined sources1
Modified residuei192PhosphoserineBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei223PhosphoserineCombined sources1
Modified residuei325PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei382PhosphoserineCombined sources1
Modified residuei405PhosphoserineBy similarity1
Modified residuei431PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1
Modified residuei463PhosphoserineBy similarity1
Modified residuei472PhosphoserineCombined sources1
Modified residuei491PhosphoserineBy similarity1
Modified residuei503PhosphoserineCombined sources1
Modified residuei514Omega-N-methylarginineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei524PhosphothreonineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei541PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1
Modified residuei565PhosphoserineBy similarity1
Modified residuei580PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei683PhosphoserineBy similarity1
Modified residuei976PhosphoserineBy similarity1
Modified residuei1022PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6PDH0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6PDH0

PeptideAtlas

More...PeptideAtlasi		Q6PDH0

PRoteomics IDEntifications database

More...PRIDEi		Q6PDH0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6PDH0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6PDH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000048537, Expressed in ear vesicle and 301 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6PDH0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6PDH0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		221937, 4 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000034611

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6PDH0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PDH0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 125FHAAdd BLAST62
Domaini1261 – 1364PHPROSITE-ProRule annotationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili688 – 798Sequence analysisAdd BLAST111
Coiled coili1150 – 1216Sequence analysisAdd BLAST67

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain mediates the binding to phosphoinositides.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPZY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155231

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6PDH0

Database of Orthologous Groups

More...OrthoDBi		70229at2759

TreeFam database of animal gene trees

More...TreeFami		TF329165

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit
cd14673, PH_PHLDB1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000253, FHA_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037810, PHLDB1/2/3_PH
IPR008984, SMAD_FHA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PDH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPLNRSQLG PGCKTQAVVQ KGPLDLIETG QGLKVQTDKP HLVSLGSGRL 
        60         70         80         90        100
STAITLLPLE EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG 
       110        120        130        140        150
NACTIDGLPV RQPTRLTQGC MLCLGQSTFL RFNHPAEAKW MKSMIPAGVR 
       160        170        180        190        200
APGPTYNPGS AESESLVNGN HTAQPATRAP SACASHSSLV SSIEKDLQEI 
       210        220        230        240        250
MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG AMSVGSSYEN 
       260        270        280        290        300
TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ 
       310        320        330        340        350
SRPSGSRSSD SPRLGRKGGH ERPPSPGLRG LLTDSPAATV LAEARRTTES 
       360        370        380        390        400
PRLGGQLPVV AISLSEYPSS GARSQPASIP GSPKFQSPVP APRNKIGTLQ 
       410        420        430        440        450
DRPPSPFREP PGTERVLTSS PSRQLVGRTF SDGLAATRTL QPPESPRLGR 
       460        470        480        490        500
RGLDSMRELP PLSPSLSRRA LSPLPARTAP DPKLSREVAE SPRPRRWAAH 
       510        520        530        540        550
GTSPEDFSLT LGARGRRTRS PSPTLGESLA PRKGSFSGRL SPAYSLGSLT 
       560        570        580        590        600
GASPRQSPRA QRKLSSGDLR VPIPRERKNS ITEISDNEDE LLEYHRRQRQ 
       610        620        630        640        650
ERLREQEMER LERQRLETIL NLCAEYSRAD GGPETGELPS IGEATAALAL 
       660        670        680        690        700
AGRRPSRGLA GAIVVSGRCG EESGGASQRL WESMERSDEE NLKEECSSTE 
       710        720        730        740        750
STQQEHEDAP GAKHQGEVLA VEEERAQVLG RVEQLKIRVK ELEQQLQEAA 
       760        770        780        790        800
REAEMERALL QGEREAERAS LQKEQRAVDQ LQEKLVALET GIQKDRDKEA 
       810        820        830        840        850
DALETETKLF EDLEFQQLER ESRVEEEREL AGQGLLRSKA ELLRSVSKRK 
       860        870        880        890        900
ERLAVLDSQA GQIRAQAVQE SERLAREKNA ALQLLQKEKE KLNVLERRYH 
       910        920        930        940        950
SLTGGRPFPK TTSTLKEMEK LLLPAVDLEQ WYQELMSGLG TGLAAASPRS 
       960        970        980        990       1000
SPPPLPAKAS RQLQVYRSKM DSDAASPLPR TRSGPLPSSS GSSSSSSQLS 
      1010       1020       1030       1040       1050
VATLGRSPSP KSALLAQNGT SSLPRNLAAT LQDIETKRQL ALQQKGHQVI 
      1060       1070       1080       1090       1100
EEQRRRLAEL KQKAAAEAQC QWDALHGAGP FSAGPSGFPA LMHHSILHHL 
      1110       1120       1130       1140       1150
PAGRERGEEG EHAYDTLSLE SSDSMETSIS TGGNSACSPD NMSSASGLDM 
      1160       1170       1180       1190       1200
GKIEEMEKML KEAHAEKSRL MESREREMEL RRQALEEERR RREQVERRLQ 
      1210       1220       1230       1240       1250
SESARRQQLV EKEVKLREKQ FSQARPLTRY LPNRKEDFDL KTHIESSGHG 
      1260       1270       1280       1290       1300
VDTCLHVVLS SKVCRGYLIK MGGKIKSWKK RWFVFDRLKR TLSYYVDKHE 
      1310       1320       1330       1340       1350
TKLKGVIYFQ AIEEVYYDHL RSAAKSPNPA LTFCVKTHDR LYYMVAPSAE 
      1360       1370 
AMRIWMDVIV TGAEGYTQFM N
Length:1,371
Mass (Da):150,070
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0E5204FF8C3C8C5
GO
Isoform 2 (identifier: Q6PDH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     917-917: E → EYVTLEQLRVVWGTPPMPPSPSPGLPSWASASQDLAPITCLPPMLPSSFASITRSSK
     1174-1174: R → RVRLTGARRQQV
     1325-1325: K → KKRFFHFTMVTE

Show »
Length:1,449
Mass (Da):158,694
Checksum:i60C2084D57B499AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0X5D3Z0X5_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
1,449Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PWB1E9PWB1_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
1,324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PWW4E9PWW4_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
684Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z4N0D3Z4N0_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
1,382Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q340E9Q340_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RUK9F6RUK9_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
1,131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RYD0F6RYD0_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
832Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q307E9Q307_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
641Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7AWU3F7AWU3_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B296F7B296_MOUSE
Pleckstrin homology-like domain fam...
Phldb1
309Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti402R → H in BAC65618 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016741917E → EYVTLEQLRVVWGTPPMPPS PSPGLPSWASASQDLAPITC LPPMLPSSFASITRSSK in isoform 2. 1 Publication1
Alternative sequenceiVSP_0167421174R → RVRLTGARRQQV in isoform 2. 1 Publication1
Alternative sequenceiVSP_0167431325K → KKRFFHFTMVTE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC058712 mRNA Translation: AAH58712.1
AK122336 mRNA Translation: BAC65618.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23118.1 [Q6PDH0-1]

NCBI Reference Sequences

More...RefSeqi		NP_705765.3, NM_153537.4 [Q6PDH0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000034611; ENSMUSP00000034611; ENSMUSG00000048537 [Q6PDH0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102693

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:102693

UCSC genome browser

More...UCSCi		uc009peh.2, mouse [Q6PDH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058712 mRNA Translation: AAH58712.1
AK122336 mRNA Translation: BAC65618.1
CCDSiCCDS23118.1 [Q6PDH0-1]
RefSeqiNP_705765.3, NM_153537.4 [Q6PDH0-1]

3D structure databases

SMRiQ6PDH0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi221937, 4 interactors
STRINGi10090.ENSMUSP00000034611

PTM databases

iPTMnetiQ6PDH0
PhosphoSitePlusiQ6PDH0

Proteomic databases

jPOSTiQ6PDH0
PaxDbiQ6PDH0
PeptideAtlasiQ6PDH0
PRIDEiQ6PDH0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45815, 67 antibodies

Genome annotation databases

EnsembliENSMUST00000034611; ENSMUSP00000034611; ENSMUSG00000048537 [Q6PDH0-1]
GeneIDi102693
KEGGimmu:102693
UCSCiuc009peh.2, mouse [Q6PDH0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23187
MGIiMGI:2143230, Phldb1

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502QPZY, Eukaryota
GeneTreeiENSGT00940000155231
InParanoidiQ6PDH0
OrthoDBi70229at2759
TreeFamiTF329165

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		102693, 4 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Phldb1, mouse

Protein Ontology

More...PROi		PR:Q6PDH0
RNActiQ6PDH0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000048537, Expressed in ear vesicle and 301 other tissues
ExpressionAtlasiQ6PDH0, baseline and differential
GenevisibleiQ6PDH0, MM

Family and domain databases

CDDicd00060, FHA, 1 hit
cd14673, PH_PHLDB1_2, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000253, FHA_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037810, PHLDB1/2/3_PH
IPR008984, SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHLB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PDH0
Secondary accession number(s): Q80TV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: February 10, 2021
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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