UniProtKB - Q6PDH0 (PHLB1_MOUSE)
Protein
Pleckstrin homology-like domain family B member 1
Gene
Phldb1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
Names & Taxonomyi
Protein namesi | Recommended name: Pleckstrin homology-like domain family B member 1Alternative name(s): Protein LL5-alpha |
Gene namesi | Name:Phldb1 Synonyms:Kiaa0638, Ll5a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2143230, Phldb1 |
Subcellular locationi
Other locations
- basal cortex Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053892 | 1 – 1371 | Pleckstrin homology-like domain family B member 1Add BLAST | 1371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | PhosphoserineCombined sources | 1 | |
Modified residuei | 131 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 192 | PhosphoserineBy similarity | 1 | |
Modified residuei | 220 | PhosphoserineBy similarity | 1 | |
Modified residuei | 223 | PhosphoserineCombined sources | 1 | |
Modified residuei | 325 | PhosphoserineBy similarity | 1 | |
Modified residuei | 335 | PhosphoserineBy similarity | 1 | |
Modified residuei | 382 | PhosphoserineCombined sources | 1 | |
Modified residuei | 405 | PhosphoserineBy similarity | 1 | |
Modified residuei | 431 | PhosphoserineBy similarity | 1 | |
Modified residuei | 445 | PhosphoserineBy similarity | 1 | |
Modified residuei | 463 | PhosphoserineBy similarity | 1 | |
Modified residuei | 472 | PhosphoserineCombined sources | 1 | |
Modified residuei | 491 | PhosphoserineBy similarity | 1 | |
Modified residuei | 503 | PhosphoserineCombined sources | 1 | |
Modified residuei | 514 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 520 | PhosphoserineCombined sources | 1 | |
Modified residuei | 522 | PhosphoserineCombined sources | 1 | |
Modified residuei | 524 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 535 | PhosphoserineCombined sources | 1 | |
Modified residuei | 541 | PhosphoserineCombined sources | 1 | |
Modified residuei | 553 | PhosphoserineCombined sources | 1 | |
Modified residuei | 557 | PhosphoserineCombined sources | 1 | |
Modified residuei | 565 | PhosphoserineBy similarity | 1 | |
Modified residuei | 580 | PhosphoserineCombined sources | 1 | |
Modified residuei | 585 | PhosphoserineCombined sources | 1 | |
Modified residuei | 683 | PhosphoserineBy similarity | 1 | |
Modified residuei | 976 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1022 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | Q6PDH0 |
PaxDbi | Q6PDH0 |
PeptideAtlasi | Q6PDH0 |
PRIDEi | Q6PDH0 |
PTM databases
iPTMneti | Q6PDH0 |
PhosphoSitePlusi | Q6PDH0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048537, Expressed in ear vesicle and 301 other tissues |
ExpressionAtlasi | Q6PDH0, baseline and differential |
Genevisiblei | Q6PDH0, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 221937, 4 interactors |
STRINGi | 10090.ENSMUSP00000034611 |
Miscellaneous databases
RNActi | Q6PDH0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 125 | FHAAdd BLAST | 62 | |
Domaini | 1261 – 1364 | PHPROSITE-ProRule annotationAdd BLAST | 104 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 688 – 798 | Sequence analysisAdd BLAST | 111 | |
Coiled coili | 1150 – 1216 | Sequence analysisAdd BLAST | 67 |
Domaini
The PH domain mediates the binding to phosphoinositides.By similarity
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QPZY, Eukaryota |
GeneTreei | ENSGT00940000155231 |
InParanoidi | Q6PDH0 |
OrthoDBi | 70229at2759 |
TreeFami | TF329165 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd14673, PH_PHLDB1_2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037810, PHLDB1/2/3_PH IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6PDH0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPLNRSQLG PGCKTQAVVQ KGPLDLIETG QGLKVQTDKP HLVSLGSGRL
60 70 80 90 100
STAITLLPLE EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG
110 120 130 140 150
NACTIDGLPV RQPTRLTQGC MLCLGQSTFL RFNHPAEAKW MKSMIPAGVR
160 170 180 190 200
APGPTYNPGS AESESLVNGN HTAQPATRAP SACASHSSLV SSIEKDLQEI
210 220 230 240 250
MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG AMSVGSSYEN
260 270 280 290 300
TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ
310 320 330 340 350
SRPSGSRSSD SPRLGRKGGH ERPPSPGLRG LLTDSPAATV LAEARRTTES
360 370 380 390 400
PRLGGQLPVV AISLSEYPSS GARSQPASIP GSPKFQSPVP APRNKIGTLQ
410 420 430 440 450
DRPPSPFREP PGTERVLTSS PSRQLVGRTF SDGLAATRTL QPPESPRLGR
460 470 480 490 500
RGLDSMRELP PLSPSLSRRA LSPLPARTAP DPKLSREVAE SPRPRRWAAH
510 520 530 540 550
GTSPEDFSLT LGARGRRTRS PSPTLGESLA PRKGSFSGRL SPAYSLGSLT
560 570 580 590 600
GASPRQSPRA QRKLSSGDLR VPIPRERKNS ITEISDNEDE LLEYHRRQRQ
610 620 630 640 650
ERLREQEMER LERQRLETIL NLCAEYSRAD GGPETGELPS IGEATAALAL
660 670 680 690 700
AGRRPSRGLA GAIVVSGRCG EESGGASQRL WESMERSDEE NLKEECSSTE
710 720 730 740 750
STQQEHEDAP GAKHQGEVLA VEEERAQVLG RVEQLKIRVK ELEQQLQEAA
760 770 780 790 800
REAEMERALL QGEREAERAS LQKEQRAVDQ LQEKLVALET GIQKDRDKEA
810 820 830 840 850
DALETETKLF EDLEFQQLER ESRVEEEREL AGQGLLRSKA ELLRSVSKRK
860 870 880 890 900
ERLAVLDSQA GQIRAQAVQE SERLAREKNA ALQLLQKEKE KLNVLERRYH
910 920 930 940 950
SLTGGRPFPK TTSTLKEMEK LLLPAVDLEQ WYQELMSGLG TGLAAASPRS
960 970 980 990 1000
SPPPLPAKAS RQLQVYRSKM DSDAASPLPR TRSGPLPSSS GSSSSSSQLS
1010 1020 1030 1040 1050
VATLGRSPSP KSALLAQNGT SSLPRNLAAT LQDIETKRQL ALQQKGHQVI
1060 1070 1080 1090 1100
EEQRRRLAEL KQKAAAEAQC QWDALHGAGP FSAGPSGFPA LMHHSILHHL
1110 1120 1130 1140 1150
PAGRERGEEG EHAYDTLSLE SSDSMETSIS TGGNSACSPD NMSSASGLDM
1160 1170 1180 1190 1200
GKIEEMEKML KEAHAEKSRL MESREREMEL RRQALEEERR RREQVERRLQ
1210 1220 1230 1240 1250
SESARRQQLV EKEVKLREKQ FSQARPLTRY LPNRKEDFDL KTHIESSGHG
1260 1270 1280 1290 1300
VDTCLHVVLS SKVCRGYLIK MGGKIKSWKK RWFVFDRLKR TLSYYVDKHE
1310 1320 1330 1340 1350
TKLKGVIYFQ AIEEVYYDHL RSAAKSPNPA LTFCVKTHDR LYYMVAPSAE
1360 1370
AMRIWMDVIV TGAEGYTQFM N
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z0X5 | D3Z0X5_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 1,449 | Annotation score: | ||
E9PWB1 | E9PWB1_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 1,324 | Annotation score: | ||
E9PWW4 | E9PWW4_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 684 | Annotation score: | ||
D3Z4N0 | D3Z4N0_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 1,382 | Annotation score: | ||
E9Q340 | E9Q340_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 495 | Annotation score: | ||
F6RUK9 | F6RUK9_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 1,131 | Annotation score: | ||
F6RYD0 | F6RYD0_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 832 | Annotation score: | ||
E9Q307 | E9Q307_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 641 | Annotation score: | ||
F7AWU3 | F7AWU3_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 262 | Annotation score: | ||
F7B296 | F7B296_MOUSE | Pleckstrin homology-like domain fam... | Phldb1 | 309 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 402 | R → H in BAC65618 (PubMed:12693553).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016741 | 917 | E → EYVTLEQLRVVWGTPPMPPS PSPGLPSWASASQDLAPITC LPPMLPSSFASITRSSK in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_016742 | 1174 | R → RVRLTGARRQQV in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_016743 | 1325 | K → KKRFFHFTMVTE in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC058712 mRNA Translation: AAH58712.1 AK122336 mRNA Translation: BAC65618.1 |
CCDSi | CCDS23118.1 [Q6PDH0-1] |
RefSeqi | NP_705765.3, NM_153537.4 [Q6PDH0-1] |
Genome annotation databases
Ensembli | ENSMUST00000034611; ENSMUSP00000034611; ENSMUSG00000048537 [Q6PDH0-1] |
GeneIDi | 102693 |
KEGGi | mmu:102693 |
UCSCi | uc009peh.2, mouse [Q6PDH0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC058712 mRNA Translation: AAH58712.1 AK122336 mRNA Translation: BAC65618.1 |
CCDSi | CCDS23118.1 [Q6PDH0-1] |
RefSeqi | NP_705765.3, NM_153537.4 [Q6PDH0-1] |
3D structure databases
SMRi | Q6PDH0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 221937, 4 interactors |
STRINGi | 10090.ENSMUSP00000034611 |
PTM databases
iPTMneti | Q6PDH0 |
PhosphoSitePlusi | Q6PDH0 |
Proteomic databases
jPOSTi | Q6PDH0 |
PaxDbi | Q6PDH0 |
PeptideAtlasi | Q6PDH0 |
PRIDEi | Q6PDH0 |
Protocols and materials databases
Antibodypediai | 45815, 67 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034611; ENSMUSP00000034611; ENSMUSG00000048537 [Q6PDH0-1] |
GeneIDi | 102693 |
KEGGi | mmu:102693 |
UCSCi | uc009peh.2, mouse [Q6PDH0-1] |
Organism-specific databases
CTDi | 23187 |
MGIi | MGI:2143230, Phldb1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPZY, Eukaryota |
GeneTreei | ENSGT00940000155231 |
InParanoidi | Q6PDH0 |
OrthoDBi | 70229at2759 |
TreeFami | TF329165 |
Miscellaneous databases
BioGRID-ORCSi | 102693, 4 hits in 17 CRISPR screens |
ChiTaRSi | Phldb1, mouse |
PROi | PR:Q6PDH0 |
RNActi | Q6PDH0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048537, Expressed in ear vesicle and 301 other tissues |
ExpressionAtlasi | Q6PDH0, baseline and differential |
Genevisiblei | Q6PDH0, MM |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd14673, PH_PHLDB1_2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037810, PHLDB1/2/3_PH IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHLB1_MOUSE | |
Accessioni | Q6PDH0Primary (citable) accession number: Q6PDH0 Secondary accession number(s): Q80TV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot