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Protein

SWI/SNF complex subunit SMARCC2

Gene

Smarcc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036).2 Publications2 Publications

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF complex subunit SMARCC2
Alternative name(s):
BRG1-associated factor 170
Short name:
BAF170
SWI/SNF complex 170 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
Gene namesi
Name:Smarcc2
Synonyms:Baf170
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1915344 Smarcc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

SMARCD2 knockout mice show aberrant hematopoiesis, characterized by defective myeloid and erythroid differentiation, a reduction in granulocyte/macrophage progenitors as well as reduced neutrophil granulocytes and monocytes. Knockout embryos die late during fetal development and are characterized by reduced size, pallor, and decreased temporal vascularization.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971181 – 1213SWI/SNF complex subunit SMARCC2Add BLAST1213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei306PhosphoserineBy similarity1
Modified residuei326N6-acetyllysineBy similarity1
Modified residuei347PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Cross-linki564Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki566Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki568Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki592Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki787Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei813PhosphoserineBy similarity1
Cross-linki848Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6PDG5
PeptideAtlasiQ6PDG5
PRIDEiQ6PDG5

PTM databases

iPTMnetiQ6PDG5
PhosphoSitePlusiQ6PDG5
SwissPalmiQ6PDG5

Expressioni

Developmental stagei

Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000025369 Expressed in 252 organ(s), highest expression level in brain
ExpressionAtlasiQ6PDG5 baseline and differential
GenevisibleiQ6PDG5 MM

Interactioni

Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204). May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. Interacts with SMARD1 (By similarity). Interacts with KDM6B (PubMed:21095589). Interaction with RCOR1 (By similarity). Interacts with DPF2 (By similarity).2 PublicationsBy similarity2 Publications

Protein-protein interaction databases

BioGridi212652, 13 interactors
ComplexPortaliCPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1263 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1264 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CORUMiQ6PDG5
DIPiDIP-48884N
IntActiQ6PDG5, 13 interactors
MINTiQ6PDG5
STRINGi10090.ENSMUSP00000100868

Structurei

3D structure databases

ProteinModelPortaliQ6PDG5
SMRiQ6PDG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 521SWIRMPROSITE-ProRule annotationAdd BLAST98
Domaini596 – 647SANTPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili907 – 934Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 189Poly-Glu4
Compositional biasi747 – 855Glu-richAdd BLAST109
Compositional biasi861 – 870Poly-Ala10
Compositional biasi956 – 961Poly-Gln6
Compositional biasi962 – 1212Pro-richAdd BLAST251

Sequence similaritiesi

Belongs to the SMARCC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1279 Eukaryota
COG5259 LUCA
GeneTreeiENSGT00390000018166
HOGENOMiHOG000047736
HOVERGENiHBG054849
InParanoidiQ6PDG5
KOiK11649
OMAiFLGPLGC
OrthoDBiEOG091G06AJ
PhylomeDBiQ6PDG5
TreeFamiTF314710

Family and domain databases

CDDicd00024 CHROMO, 1 hit
cd00167 SANT, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR036420 BRCT_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR038044 SMARCC2
IPR032451 SMARCC_C
IPR032450 SMARCC_N
IPR007526 SWIRM
IPR032448 SWIRM-assoc
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR12802:SF38 PTHR12802:SF38, 1 hit
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF04433 SWIRM, 1 hit
PF16495 SWIRM-assoc_1, 1 hit
PF16496 SWIRM-assoc_2, 1 hit
PF16498 SWIRM-assoc_3, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS51293 SANT, 1 hit
PS50934 SWIRM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PDG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS
60 70 80 90 100
SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGSL CHILAAAYKF
110 120 130 140 150
KSDQGWRRYD FQNPSRMDRN VEMFMTIEKS LVQNNCLSRP NIFLCPEIEP
160 170 180 190 200
KLLGKLKDIV KRHQGTISED KSNASHVVYP VPGNLEEEEW VRPVMKRDKQ
210 220 230 240 250
VLLHWGYYPD SYDTWIPASE IEASVEDAPT PEKPRKVHAK WILDTDTFNE
260 270 280 290 300
WMNEEDYEVS DDKSPVSRRK KISAKTLTDE VNSPDSDRRD KKGGNYKKRK
310 320 330 340 350
RSPSPSPTPE AKKKNAKKGP STPYTKSKRG HREEEQEDLT KDMDEPSPVP
360 370 380 390 400
NVEEVTLPKT VNTKKDSESA PVKGGTMTDL DEQDDESMET TGKDEDENST
410 420 430 440 450
GNKGEQTKNP DLHEDNVTEQ THHIIIPSYA AWFDYNSVHA IERRALPEFF
460 470 480 490 500
NGKNKSKTPE IYLAYRNFMI DTYRLNPQEY LTSTACRRNL AGDVCAIMRV
510 520 530 540 550
HAFLEQWGLI NYQVDAESRP TPMGPPPTSH FHVLADTPSG LVPLQPKPPQ
560 570 580 590 600
QSSASQQMLN FPEKGKEKPA DMQNFGLRTD MYTKKNVPSK SKAAASATRE
610 620 630 640 650
WTEQETLLLL EALEMYKDDW NKVSEHVGSR TQDECILHFL RLPIEDPYLE
660 670 680 690 700
DSEASLGPLA YQPIPFSQSG NPVMSTVAFL ASVVDPRVAS AAAKSALEEF
710 720 730 740 750
SKMKEEVPTA LVEAHVRKVE EAAKVTGKAD PAFGLESSGI AGTASDEPER
760 770 780 790 800
IEESGTEEAR PEGQAADEKK EPKEPREGGG AVEEEAKEEI SEVPKKDEEK
810 820 830 840 850
GKEGDSEKES EKSDGDPIVD PEKDKEPTEG QEEVLKEVAE PEGERKTKVE
860 870 880 890 900
RDIGEGNLST AAAAALAAAA VKAKHLAAVE ERKIKSLVAL LVETQMKKLE
910 920 930 940 950
IKLRHFEELE TIMDREREAL EYQRQQLLAD RQAFHMEQLK YAEMRARQQH
960 970 980 990 1000
FQQMHQQQQQ QPPTLPPGSQ PIPPTGAAGP PTVHGLAVPP AAVASAPPGS
1010 1020 1030 1040 1050
GAPPGSLGPS EQIGQAGTTA GPQQPQQAGA PQPGAVPPGV PPPGPHGPSP
1060 1070 1080 1090 1100
FPNQPTPPSM MPGAVPGSGH PGVAGNAPLG LPFGMPPPPP AAPSVIPFGS
1110 1120 1130 1140 1150
LADSISINLP PPPNLHGHHH HLPFAPGTIP PPNLPVSMAN PLHPNLPATT
1160 1170 1180 1190 1200
TMPSSLPLGP GLGSAAAQSP AIVAAVQGNL LPSASPLPDP GTPLPPDPTA
1210
PSPGTVTPVP PPQ
Length:1,213
Mass (Da):132,604
Last modified:January 4, 2005 - v2
Checksum:i6239489440320676
GO
Isoform 2 (identifier: Q6PDG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1075-1188: Missing.

Show »
Length:1,099
Mass (Da):121,372
Checksum:i3DE4278FA2639DC6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UID0Q3UID0_MOUSE
SWI/SNF complex subunit SMARCC2
Smarcc2
1,130Annotation score:
A0A1W2P6N7A0A1W2P6N7_MOUSE
SWI/SNF complex subunit SMARCC2
Smarcc2
142Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti550Missing in AAH62102 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0124921075 – 1188Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058720 mRNA Translation: AAH58720.1
BC062102 mRNA Translation: AAH62102.1
CCDSiCCDS24278.1 [Q6PDG5-2]
CCDS48727.1 [Q6PDG5-1]
RefSeqiNP_001107568.1, NM_001114096.1
NP_001107569.1, NM_001114097.1 [Q6PDG5-1]
NP_937803.1, NM_198160.2 [Q6PDG5-2]
UniGeneiMm.417338

Genome annotation databases

EnsembliENSMUST00000026433; ENSMUSP00000026433; ENSMUSG00000025369 [Q6PDG5-2]
ENSMUST00000105235; ENSMUSP00000100868; ENSMUSG00000025369 [Q6PDG5-1]
GeneIDi68094
KEGGimmu:68094
UCSCiuc007hmw.2 mouse [Q6PDG5-2]
uc007hmx.2 mouse [Q6PDG5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058720 mRNA Translation: AAH58720.1
BC062102 mRNA Translation: AAH62102.1
CCDSiCCDS24278.1 [Q6PDG5-2]
CCDS48727.1 [Q6PDG5-1]
RefSeqiNP_001107568.1, NM_001114096.1
NP_001107569.1, NM_001114097.1 [Q6PDG5-1]
NP_937803.1, NM_198160.2 [Q6PDG5-2]
UniGeneiMm.417338

3D structure databases

ProteinModelPortaliQ6PDG5
SMRiQ6PDG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212652, 13 interactors
ComplexPortaliCPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1263 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1264 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CORUMiQ6PDG5
DIPiDIP-48884N
IntActiQ6PDG5, 13 interactors
MINTiQ6PDG5
STRINGi10090.ENSMUSP00000100868

PTM databases

iPTMnetiQ6PDG5
PhosphoSitePlusiQ6PDG5
SwissPalmiQ6PDG5

Proteomic databases

PaxDbiQ6PDG5
PeptideAtlasiQ6PDG5
PRIDEiQ6PDG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026433; ENSMUSP00000026433; ENSMUSG00000025369 [Q6PDG5-2]
ENSMUST00000105235; ENSMUSP00000100868; ENSMUSG00000025369 [Q6PDG5-1]
GeneIDi68094
KEGGimmu:68094
UCSCiuc007hmw.2 mouse [Q6PDG5-2]
uc007hmx.2 mouse [Q6PDG5-1]

Organism-specific databases

CTDi6601
MGIiMGI:1915344 Smarcc2

Phylogenomic databases

eggNOGiKOG1279 Eukaryota
COG5259 LUCA
GeneTreeiENSGT00390000018166
HOGENOMiHOG000047736
HOVERGENiHBG054849
InParanoidiQ6PDG5
KOiK11649
OMAiFLGPLGC
OrthoDBiEOG091G06AJ
PhylomeDBiQ6PDG5
TreeFamiTF314710

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRSiSmarcc2 mouse
PROiPR:Q6PDG5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025369 Expressed in 252 organ(s), highest expression level in brain
ExpressionAtlasiQ6PDG5 baseline and differential
GenevisibleiQ6PDG5 MM

Family and domain databases

CDDicd00024 CHROMO, 1 hit
cd00167 SANT, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR036420 BRCT_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR038044 SMARCC2
IPR032451 SMARCC_C
IPR032450 SMARCC_N
IPR007526 SWIRM
IPR032448 SWIRM-assoc
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR12802:SF38 PTHR12802:SF38, 1 hit
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF04433 SWIRM, 1 hit
PF16495 SWIRM-assoc_1, 1 hit
PF16496 SWIRM-assoc_2, 1 hit
PF16498 SWIRM-assoc_3, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS51293 SANT, 1 hit
PS50934 SWIRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMRC2_MOUSE
AccessioniPrimary (citable) accession number: Q6PDG5
Secondary accession number(s): Q6P6P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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