UniProtKB - Q6PDC8 (MFD4A_MOUSE)
Protein
Major facilitator superfamily domain-containing protein 4A
Gene
Mfsd4a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- glucose transmembrane transporter activity Source: GO_Central
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Major facilitator superfamily domain-containing protein 4AAlternative name(s): Major facilitator superfamily domain-containing protein 4 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442786, Mfsd4a |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 39 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 303 – 323 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 380 – 400 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 434 – 454 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 462 – 482 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273396 | 1 – 510 | Major facilitator superfamily domain-containing protein 4AAdd BLAST | 510 |
Proteomic databases
PaxDbi | Q6PDC8 |
PRIDEi | Q6PDC8 |
PTM databases
iPTMneti | Q6PDC8 |
PhosphoSitePlusi | Q6PDC8 |
SwissPalmi | Q6PDC8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000059149, Expressed in epithelium of stomach and 239 other tissues |
Genevisiblei | Q6PDC8, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107989 |
Miscellaneous databases
RNActi | Q6PDC8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRVK, Eukaryota |
GeneTreei | ENSGT00530000063320 |
InParanoidi | Q6PDC8 |
OMAi | LSETGCG |
OrthoDBi | 952222at2759 |
PhylomeDBi | Q6PDC8 |
TreeFami | TF314613 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6PDC8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGCDGRVSEL LRRNLQPTLT YWSVFFSFGL CIAFLGPTLL DLRCQTHSSL
60 70 80 90 100
PQISWVFFSQ QLCLLLGSAL GGVFKRTLAQ SLWALFTSTL VISLVFAVIP
110 120 130 140 150
FCHDVKVLAS VIALAGLAMG CIDTVANMQL VRIYQKDSAF FLQVLHFFVG
160 170 180 190 200
LGALLSPLIA DPFLSEANCF PANNTANATS RSHGSRVLSQ HHAAAQPWIN
210 220 230 240 250
QTIPRLPPKE VTENHVSYAF WIMALINLPV PLAVLFLLSK ERLLTCAQRK
260 270 280 290 300
PLLLSADELA LETRPAEKED TSSLAPKFQP HSGQEDLFSC CQRKNFRGAP
310 320 330 340 350
CSFFAIHITA ALVLFMTDGM MGAYSAFVYS YAVEKPLSIG HKSAGYLPSL
360 370 380 390 400
FWGFITLGRF ISIPVSSRMR PATMVFINVV GVVVTFLMLL IFSYNVIFLF
410 420 430 440 450
VGTASLGLFL SSTFPSMLAY TEDILQYKGC ATTVLVTGAG IGEMVLQMLV
460 470 480 490 500
GLIFQAQGSY SFLVCGVIFG CLAFIFYILL LFFHRIHPEL SSVLTQDKAL
510
GVENPECYQR
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE0CX35 | E0CX35_MOUSE | Major facilitator superfamily domai... | Mfsd4a Mfsd4 | 425 | Annotation score: | ||
F8WIG8 | F8WIG8_MOUSE | Major facilitator superfamily domai... | Mfsd4a Mfsd4 | 464 | Annotation score: | ||
F7D4J0 | F7D4J0_MOUSE | Major facilitator superfamily domai... | Mfsd4a Mfsd4 | 406 | Annotation score: | ||
H7BXC0 | H7BXC0_MOUSE | Major facilitator superfamily domai... | Mfsd4a Mfsd4 | 88 | Annotation score: | ||
F6UGV8 | F6UGV8_MOUSE | Major facilitator superfamily domai... | Mfsd4a Mfsd4 | 67 | Annotation score: |
Sequence cautioni
The sequence BAC30158 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022541 | 1 – 222 | Missing in isoform 2. 1 PublicationAdd BLAST | 222 | |
Alternative sequenceiVSP_022542 | 228 – 379 | Missing in isoform 3. 1 PublicationAdd BLAST | 152 | |
Alternative sequenceiVSP_022543 | 493 – 510 | VLTQD…ECYQR → GENMILIAASSTERETHHHP in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK038882 mRNA Translation: BAC30158.1 Different initiation. AK048692 mRNA Translation: BAC33423.1 AK085484 mRNA Translation: BAC39455.1 AK162495 mRNA Translation: BAE36946.1 AC107837 Genomic DNA No translation available. BC058790 mRNA Translation: AAH58790.1 |
CCDSi | CCDS15280.2 [Q6PDC8-4] CCDS48357.1 [Q6PDC8-1] |
RefSeqi | NP_001108134.1, NM_001114662.1 [Q6PDC8-1] NP_766098.2, NM_172510.4 [Q6PDC8-4] XP_006529407.1, XM_006529344.3 [Q6PDC8-4] XP_006529408.1, XM_006529345.3 [Q6PDC8-2] XP_017175139.1, XM_017319650.1 [Q6PDC8-2] |
Genome annotation databases
Ensembli | ENSMUST00000046658; ENSMUSP00000039635; ENSMUSG00000059149 [Q6PDC8-3] ENSMUST00000112370; ENSMUSP00000107989; ENSMUSG00000059149 [Q6PDC8-4] ENSMUST00000126927; ENSMUSP00000116706; ENSMUSG00000059149 [Q6PDC8-4] ENSMUST00000144548; ENSMUSP00000116282; ENSMUSG00000059149 [Q6PDC8-4] ENSMUST00000159038; ENSMUSP00000125558; ENSMUSG00000059149 [Q6PDC8-1] |
GeneIDi | 213006 |
KEGGi | mmu:213006 |
UCSCi | uc007coe.2, mouse [Q6PDC8-4] uc007cog.2, mouse [Q6PDC8-3] uc011wrs.1, mouse [Q6PDC8-2] uc011wru.1, mouse [Q6PDC8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK038882 mRNA Translation: BAC30158.1 Different initiation. AK048692 mRNA Translation: BAC33423.1 AK085484 mRNA Translation: BAC39455.1 AK162495 mRNA Translation: BAE36946.1 AC107837 Genomic DNA No translation available. BC058790 mRNA Translation: AAH58790.1 |
CCDSi | CCDS15280.2 [Q6PDC8-4] CCDS48357.1 [Q6PDC8-1] |
RefSeqi | NP_001108134.1, NM_001114662.1 [Q6PDC8-1] NP_766098.2, NM_172510.4 [Q6PDC8-4] XP_006529407.1, XM_006529344.3 [Q6PDC8-4] XP_006529408.1, XM_006529345.3 [Q6PDC8-2] XP_017175139.1, XM_017319650.1 [Q6PDC8-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107989 |
PTM databases
iPTMneti | Q6PDC8 |
PhosphoSitePlusi | Q6PDC8 |
SwissPalmi | Q6PDC8 |
Proteomic databases
PaxDbi | Q6PDC8 |
PRIDEi | Q6PDC8 |
Protocols and materials databases
Antibodypediai | 34569, 79 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000046658; ENSMUSP00000039635; ENSMUSG00000059149 [Q6PDC8-3] ENSMUST00000112370; ENSMUSP00000107989; ENSMUSG00000059149 [Q6PDC8-4] ENSMUST00000126927; ENSMUSP00000116706; ENSMUSG00000059149 [Q6PDC8-4] ENSMUST00000144548; ENSMUSP00000116282; ENSMUSG00000059149 [Q6PDC8-4] ENSMUST00000159038; ENSMUSP00000125558; ENSMUSG00000059149 [Q6PDC8-1] |
GeneIDi | 213006 |
KEGGi | mmu:213006 |
UCSCi | uc007coe.2, mouse [Q6PDC8-4] uc007cog.2, mouse [Q6PDC8-3] uc011wrs.1, mouse [Q6PDC8-2] uc011wru.1, mouse [Q6PDC8-1] |
Organism-specific databases
CTDi | 148808 |
MGIi | MGI:2442786, Mfsd4a |
Phylogenomic databases
eggNOGi | ENOG502QRVK, Eukaryota |
GeneTreei | ENSGT00530000063320 |
InParanoidi | Q6PDC8 |
OMAi | LSETGCG |
OrthoDBi | 952222at2759 |
PhylomeDBi | Q6PDC8 |
TreeFami | TF314613 |
Miscellaneous databases
BioGRID-ORCSi | 213006, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mfsd4a, mouse |
PROi | PR:Q6PDC8 |
RNActi | Q6PDC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000059149, Expressed in epithelium of stomach and 239 other tissues |
Genevisiblei | Q6PDC8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFD4A_MOUSE | |
Accessioni | Q6PDC8Primary (citable) accession number: Q6PDC8 Secondary accession number(s): Q8C3M3, Q8C816, Q8CAF5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families