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Entry version 133 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Alpha- and gamma-adaptin-binding protein p34

Gene

AAGAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in endocytic recycling of growth factor receptors such as EGFR.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6PD74

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha- and gamma-adaptin-binding protein p34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AAGAB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103591.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25662, AAGAB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614888, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6PD74

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Keratoderma, palmoplantar, punctate 1A (PPKP1A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant dermatological disorder characterized by multiple hyperkeratotic, centrally indented, papules that develop in early adolescence, or later, and are irregularly distributed on the palms and soles (other palmoplantar keratoses have mostly diffuse hyperkeratinization). In mechanically irritated areas, confluent plaques can be found. Interfamilial and intrafamilial severity shows broad variation. In some cases, PPKP1 is associated with the development of early- and late-onset malignancies, including squamous cell carcinoma.
Related information in OMIM

Keywords - Diseasei

Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
79719

MalaCards human disease database

More...
MalaCardsi
AAGAB
MIMi148600, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000103591

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79501, Punctate palmoplantar keratoderma type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165478457

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6PD74, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AAGAB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62286981

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000581341 – 315Alpha- and gamma-adaptin-binding protein p34Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei310PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6PD74

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6PD74

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6PD74

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PD74

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PD74

PeptideAtlas

More...
PeptideAtlasi
Q6PD74

PRoteomics IDEntifications database

More...
PRIDEi
Q6PD74

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4104
67069 [Q6PD74-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PD74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PD74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in skin and keratinocytes, with highest levels in adrenal gland, rectum and thymus.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103591, Expressed in islet of Langerhans and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PD74, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PD74, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000103591, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associated with AP-1 and AP-2 complexes.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122835, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PD74, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261880

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6PD74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PD74

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4273, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007218

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_056826_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PD74

KEGG Orthology (KO)

More...
KOi
K23878

Identification of Orthologs from Complete Genome Data

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OMAi
ETVVWYP

Database of Orthologous Groups

More...
OrthoDBi
1618204at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PD74

TreeFam database of animal gene trees

More...
TreeFami
TF328856

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019341, Alpha/Gamma-adaptin-bd_p34

The PANTHER Classification System

More...
PANTHERi
PTHR14659, PTHR14659, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PD74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGVPCALV TSCSSVFSGD QLVQHILGTE DLIVEVTSND AVRFYPWTID
60 70 80 90 100
NKYYSADINL CVVPNKFLVT AEIAESVQAF VVYFDSTQKS GLDSVSSWLP
110 120 130 140 150
LAKAWLPEVM ILVCDRVSED GINRQKAQEW CIKHGFELVE LSPEELPEED
160 170 180 190 200
DDFPESTGVK RIVQALNANV WSNVVMKNDR NQGFSLLNSL TGTNHSIGSA
210 220 230 240 250
DPCHPEQPHL PAADSTESLS DHRGGASNTT DAQVDSIVDP MLDLDIQELA
260 270 280 290 300
SLTTGGGDVE NFERLFSKLK EMKDKAATLP HEQRKVHAEK VAKAFWMAIG
310
GDRDEIEGLS SDEEH
Length:315
Mass (Da):34,594
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1C765B4F9717E0B
GO
Isoform 2 (identifier: Q6PD74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.

Show »
Length:206
Mass (Da):22,719
Checksum:i28477F7B5DDAB3A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YL49H0YL49_HUMAN
Alpha- and gamma-adaptin-binding pr...
AAGAB
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26I → T in CAB66649 (PubMed:11230166).Curated1
Sequence conflicti26I → T in CAG38571 (Ref. 3) Curated1
Sequence conflicti77V → A in CAG38571 (Ref. 3) Curated1
Sequence conflicti88Q → R in CAB66649 (PubMed:11230166).Curated1
Sequence conflicti88Q → R in CAG38571 (Ref. 3) Curated1
Sequence conflicti131C → S in CAB66649 (PubMed:11230166).Curated1
Sequence conflicti131C → S in CAG38571 (Ref. 3) Curated1
Sequence conflicti265L → P in CAB66649 (PubMed:11230166).Curated1
Sequence conflicti265L → P in CAG38571 (Ref. 3) Curated1
Sequence conflicti313E → G in CAB66649 (PubMed:11230166).Curated1
Sequence conflicti313E → G in CAG38571 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021533132I → L3 PublicationsCorresponds to variant dbSNP:rs7173826Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545971 – 109Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136715 mRNA Translation: CAB66649.1
AK021568 mRNA Translation: BAB13845.1
AK294402 mRNA Translation: BAG57655.1
CR533540 mRNA Translation: CAG38571.1
AC012568 Genomic DNA No translation available.
AC110292 Genomic DNA No translation available.
BC001975 mRNA Translation: AAH01975.1
BC047026 mRNA Translation: AAH47026.1
BC058886 mRNA Translation: AAH58886.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42050.1 [Q6PD74-1]
CCDS61679.1 [Q6PD74-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001258814.1, NM_001271885.1 [Q6PD74-2]
NP_001258815.1, NM_001271886.1 [Q6PD74-2]
NP_078942.3, NM_024666.4 [Q6PD74-1]
XP_011520322.1, XM_011522020.1 [Q6PD74-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261880; ENSP00000261880; ENSG00000103591 [Q6PD74-1]
ENST00000542650; ENSP00000440735; ENSG00000103591 [Q6PD74-2]
ENST00000561452; ENSP00000453263; ENSG00000103591 [Q6PD74-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79719

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79719

UCSC genome browser

More...
UCSCi
uc002aqk.6, human [Q6PD74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136715 mRNA Translation: CAB66649.1
AK021568 mRNA Translation: BAB13845.1
AK294402 mRNA Translation: BAG57655.1
CR533540 mRNA Translation: CAG38571.1
AC012568 Genomic DNA No translation available.
AC110292 Genomic DNA No translation available.
BC001975 mRNA Translation: AAH01975.1
BC047026 mRNA Translation: AAH47026.1
BC058886 mRNA Translation: AAH58886.1
CCDSiCCDS42050.1 [Q6PD74-1]
CCDS61679.1 [Q6PD74-2]
RefSeqiNP_001258814.1, NM_001271885.1 [Q6PD74-2]
NP_001258815.1, NM_001271886.1 [Q6PD74-2]
NP_078942.3, NM_024666.4 [Q6PD74-1]
XP_011520322.1, XM_011522020.1 [Q6PD74-2]

3D structure databases

SMRiQ6PD74
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122835, 23 interactors
IntActiQ6PD74, 21 interactors
STRINGi9606.ENSP00000261880

PTM databases

iPTMnetiQ6PD74
PhosphoSitePlusiQ6PD74

Polymorphism and mutation databases

BioMutaiAAGAB
DMDMi62286981

Proteomic databases

EPDiQ6PD74
jPOSTiQ6PD74
MassIVEiQ6PD74
MaxQBiQ6PD74
PaxDbiQ6PD74
PeptideAtlasiQ6PD74
PRIDEiQ6PD74
ProteomicsDBi4104
67069 [Q6PD74-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26235, 107 antibodies

The DNASU plasmid repository

More...
DNASUi
79719

Genome annotation databases

EnsembliENST00000261880; ENSP00000261880; ENSG00000103591 [Q6PD74-1]
ENST00000542650; ENSP00000440735; ENSG00000103591 [Q6PD74-2]
ENST00000561452; ENSP00000453263; ENSG00000103591 [Q6PD74-2]
GeneIDi79719
KEGGihsa:79719
UCSCiuc002aqk.6, human [Q6PD74-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79719
DisGeNETi79719
EuPathDBiHostDB:ENSG00000103591.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AAGAB
HGNCiHGNC:25662, AAGAB
HPAiENSG00000103591, Low tissue specificity
MalaCardsiAAGAB
MIMi148600, phenotype
614888, gene
neXtProtiNX_Q6PD74
OpenTargetsiENSG00000103591
Orphaneti79501, Punctate palmoplantar keratoderma type 1
PharmGKBiPA165478457

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4273, Eukaryota
GeneTreeiENSGT00390000007218
HOGENOMiCLU_056826_0_0_1
InParanoidiQ6PD74
KOiK23878
OMAiETVVWYP
OrthoDBi1618204at2759
PhylomeDBiQ6PD74
TreeFamiTF328856

Enzyme and pathway databases

PathwayCommonsiQ6PD74

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79719, 22 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AAGAB, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FLJ11506

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79719
PharosiQ6PD74, Tbio

Protein Ontology

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PROi
PR:Q6PD74
RNActiQ6PD74, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103591, Expressed in islet of Langerhans and 229 other tissues
ExpressionAtlasiQ6PD74, baseline and differential
GenevisibleiQ6PD74, HS

Family and domain databases

InterProiView protein in InterPro
IPR019341, Alpha/Gamma-adaptin-bd_p34
PANTHERiPTHR14659, PTHR14659, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAGAB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PD74
Secondary accession number(s): B4DG44
, Q6FI86, Q7Z5X9, Q9H0P1, Q9HAK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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