UniProtKB - Q6PD62 (CTR9_HUMAN)
RNA polymerase-associated protein CTR9 homolog
CTR9
Functioni
GO - Molecular functioni
- RNA polymerase II complex binding Source: GO_Central
- SH2 domain binding Source: Ensembl
GO - Biological processi
- blastocyst growth Source: Ensembl
- blastocyst hatching Source: Ensembl
- cellular response to lipopolysaccharide Source: UniProtKB
- endodermal cell fate commitment Source: UniProtKB
- histone H2B ubiquitination Source: UniProtKB
- histone H3-K4 trimethylation Source: UniProtKB
- histone monoubiquitination Source: UniProtKB
- inner cell mass cell differentiation Source: Ensembl
- interleukin-6-mediated signaling pathway Source: UniProtKB
- negative regulation of mRNA polyadenylation Source: UniProtKB
- negative regulation of myeloid cell differentiation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of histone H2B ubiquitination Source: UniProtKB
- positive regulation of histone H3-K4 methylation Source: UniProtKB
- positive regulation of histone H3-K79 methylation Source: UniProtKB
- protein ubiquitination Source: Reactome
- receptor signaling pathway via JAK-STAT Source: UniProtKB
- regulation of genetic imprinting Source: Ensembl
- regulation of histone H3-K4 methylation Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
- stem cell population maintenance Source: UniProtKB
- transcription by RNA polymerase II Source: Reactome
- transcription elongation from RNA polymerase II promoter Source: GO_Central
- trophectodermal cell differentiation Source: Ensembl
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q6PD62 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-75955, RNA Polymerase II Transcription Elongation R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins |
Names & Taxonomyi
Protein namesi | Recommended name: RNA polymerase-associated protein CTR9 homologAlternative name(s): SH2 domain-binding protein 1 |
Gene namesi | Name:CTR9 Synonyms:KIAA0155, SH2BP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16850, CTR9 |
MIMi | 609366, gene |
neXtProti | NX_Q6PD62 |
VEuPathDBi | HostDB:ENSG00000198730.7 |
Subcellular locationi
Nucleus
- Nucleus speckle By similarity
Nucleus
- Cdc73/Paf1 complex Source: UniProtKB
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
Other locations
- transcriptionally active chromatin Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9646 |
OpenTargetsi | ENSG00000198730 |
PharmGKBi | PA134896774 |
Miscellaneous databases
Pharosi | Q6PD62, Tbio |
Genetic variation databases
BioMutai | CTR9 |
DMDMi | 74758318 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000231588 | 1 – 1173 | RNA polymerase-associated protein CTR9 homologAdd BLAST | 1173 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 925 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 932 | PhosphoserineCombined sources | 1 | |
Modified residuei | 941 | PhosphoserineCombined sources | 1 | |
Modified residuei | 943 | PhosphoserineCombined sources | 1 | |
Modified residuei | 970 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1020 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1021 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1039 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1041 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1043 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1081 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1085 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1087 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1097 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1102 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6PD62 |
jPOSTi | Q6PD62 |
MassIVEi | Q6PD62 |
MaxQBi | Q6PD62 |
PaxDbi | Q6PD62 |
PeptideAtlasi | Q6PD62 |
PRIDEi | Q6PD62 |
ProteomicsDBi | 67068 |
PTM databases
iPTMneti | Q6PD62 |
MetOSitei | Q6PD62 |
PhosphoSitePlusi | Q6PD62 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198730, Expressed in caput epididymis and 252 other tissues |
ExpressionAtlasi | Q6PD62, baseline and differential |
Genevisiblei | Q6PD62, HS |
Organism-specific databases
HPAi | ENSG00000198730, Low tissue specificity |
Interactioni
Subunit structurei
Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (PubMed:16024656, PubMed:19952111, PubMed:20178742). The PAF1 complex interacts with PHF5A (By similarity).
Interacts with KMT2A/MLL1 (PubMed:20541477).
Interacts with STAT3 (By similarity).
Interacts with SETD5 (By similarity).
Interacts with ERCC6 (PubMed:26030138).
By similarity5 Publications(Microbial infection) The PAF1 complex interacts with Zika virus French Polynesia 10087PF/2013 non-structural protein 5/NS5 (PubMed:30550790). The interaction with viral NS5 proteins may reduce the antiviral immune response by inhibiting the recruitment of the PAF1 complex to interferon-stimulated genes, thus preventing their transcription (PubMed:30550790).
1 Publication(Microbial infection) The PAF1 complex interacts with Dengue virus DENV2 16681 non-structural protein 5/NS5 (PubMed:30550790). The PAF1 complex interacts with Dengue virus DENV4 Dominica/814669/1981 non-structural protein 5/NS5 (PubMed:30550790). The interaction with viral NS5 proteins may reduce the antiviral immune response by inhibiting the recruitment of the PAF1 complex to interferon-stimulated genes, thus preventing their transcription (PubMed:30550790).
1 PublicationBinary interactionsi
Hide detailsQ6PD62
With | #Exp. | IntAct |
---|---|---|
CDC73 [Q6P1J9] | 23 | EBI-1019583,EBI-930143 |
KMT2A [Q03164] | 5 | EBI-1019583,EBI-591370 |
PAF1 [Q8N7H5] | 26 | EBI-1019583,EBI-2607770 |
WDR61 [Q9GZS3] | 12 | EBI-1019583,EBI-358545 |
GO - Molecular functioni
- RNA polymerase II complex binding Source: GO_Central
- SH2 domain binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 115004, 134 interactors |
CORUMi | Q6PD62 |
DIPi | DIP-31693N |
IntActi | Q6PD62, 113 interactors |
MINTi | Q6PD62 |
STRINGi | 9606.ENSP00000355013 |
Miscellaneous databases
RNActi | Q6PD62, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6PD62 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 41 – 75 | TPR 1Add BLAST | 35 | |
Repeati | 129 – 162 | TPR 2Add BLAST | 34 | |
Repeati | 163 – 196 | TPR 3Add BLAST | 34 | |
Repeati | 198 – 231 | TPR 4Add BLAST | 34 | |
Repeati | 235 – 268 | TPR 5Add BLAST | 34 | |
Repeati | 306 – 339 | TPR 6Add BLAST | 34 | |
Repeati | 341 – 374 | TPR 7Add BLAST | 34 | |
Repeati | 412 – 444 | TPR 8Add BLAST | 33 | |
Repeati | 451 – 484 | TPR 9Add BLAST | 34 | |
Repeati | 497 – 530 | TPR 10Add BLAST | 34 | |
Repeati | 531 – 564 | TPR 11Add BLAST | 34 | |
Repeati | 566 – 598 | TPR 12Add BLAST | 33 | |
Repeati | 613 – 646 | TPR 13Add BLAST | 34 | |
Repeati | 647 – 680 | TPR 14Add BLAST | 34 | |
Repeati | 681 – 714 | TPR 15Add BLAST | 34 | |
Repeati | 717 – 750 | TPR 16Add BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 844 – 1011 | Lys-richAdd BLAST | 168 | |
Compositional biasi | 904 – 908 | Poly-Gly | 5 | |
Compositional biasi | 933 – 936 | Poly-Lys | 4 | |
Compositional biasi | 956 – 959 | Poly-Lys | 4 | |
Compositional biasi | 1015 – 1172 | Ser-richAdd BLAST | 158 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG2002, Eukaryota |
GeneTreei | ENSGT00390000005097 |
HOGENOMi | CLU_006386_0_0_1 |
InParanoidi | Q6PD62 |
OMAi | MLAAHYV |
OrthoDBi | 396755at2759 |
PhylomeDBi | Q6PD62 |
TreeFami | TF314342 |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR031101, Ctr9 IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR14027, PTHR14027, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 3 hits |
SMARTi | View protein in SMART SM00028, TPR, 10 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 10 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSRGSIEIPL RDTDEVIELD FDQLPEGDEV ISILKQEHTQ LHIWIALALE
60 70 80 90 100
YYKQGKTEEF VKLLEAARID GNLDYRDHEK DQMTCLDTLA AYYVQQARKE
110 120 130 140 150
KNKDNKKDLI TQATLLYTMA DKIIMYDQNH LLGRACFCLL EGDKMDQADA
160 170 180 190 200
QFHFVLNQSP NNIPALLGKA CISFNKKDYR GALAYYKKAL RTNPGCPAEV
210 220 230 240 250
RLGMGHCFVK LNKLEKARLA FSRALELNSK CVGALVGLAV LELNNKEADS
260 270 280 290 300
IKNGVQLLSR AYTIDPSNPM VLNHLANHFF FKKDYSKVQH LALHAFHNTE
310 320 330 340 350
VEAMQAESCY QLARSFHVQE DYDQAFQYYY QATQFASSSF VLPFFGLGQM
360 370 380 390 400
YIYRGDKENA SQCFEKVLKA YPNNYETMKI LGSLYAASED QEKRDIAKGH
410 420 430 440 450
LKKVTEQYPD DVEAWIELAQ ILEQTDIQGA LSAYGTATRI LQEKVQADVP
460 470 480 490 500
PEILNNVGAL HFRLGNLGEA KKYFLASLDR AKAEAEHDEH YYNAISVTTS
510 520 530 540 550
YNLARLYEAM CEFHEAEKLY KNILREHPNY VDCYLRLGAM ARDKGNFYEA
560 570 580 590 600
SDWFKEALQI NQDHPDAWSL IGNLHLAKQE WGPGQKKFER ILKQPSTQSD
610 620 630 640 650
TYSMLALGNV WLQTLHQPTR DREKEKRHQD RALAIYKQVL RNDAKNLYAA
660 670 680 690 700
NGIGAVLAHK GYFREARDVF AQVREATADI SDVWLNLAHI YVEQKQYISA
710 720 730 740 750
VQMYENCLRK FYKHQNTEVV LYLARALFKC GKLQECKQTL LKARHVAPSD
760 770 780 790 800
TVLMFNVALV LQRLATSVLK DEKSNLKEVL NAVKELELAH RYFSYLSKVG
810 820 830 840 850
DKMRFDLALA ATEARQCSDL LSQAQYHVAR ARKQDEEERE LRAKQEQEKE
860 870 880 890 900
LLRQKLLKEQ EEKRLREKEE QKKLLEQRAQ YVEKTKNILM FTGETEATKE
910 920 930 940 950
KKRGGGGGRR SKKGGEFDEF VNDDTDDDLP ISKKKKRRKG SGSEQEGEDE
960 970 980 990 1000
EGGERKKKKR RRHPKGEEGS DDDETENGPK PKKRRPPKAE KKKAPKPERL
1010 1020 1030 1040 1050
PPSMKGKIKS KAIISSSDDS SDEDKLKIAD EGHPRNSNSN SDSDEDEQRK
1060 1070 1080 1090 1100
KCASSESDSD ENQNKSGSEA GSPRRPRRQR SDQDSDSDQP SRKRRPSGSE
1110 1120 1130 1140 1150
QSDNESVQSG RSHSGVSEND SRPASPSAES DHESERGSDN EGSGQGSGNE
1160 1170
SEPEGSNNEA SDRGSEHGSD DSD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YCE8 | H0YCE8_HUMAN | RNA polymerase-associated protein C... | CTR9 | 300 | Annotation score: | ||
A0A2R8Y3S3 | A0A2R8Y3S3_HUMAN | RNA polymerase-associated protein C... | CTR9 | 52 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63875 mRNA Translation: BAA09925.2 Different initiation. CH471064 Genomic DNA Translation: EAW68557.1 CH471064 Genomic DNA Translation: EAW68558.1 BC058914 mRNA Translation: AAH58914.1 |
CCDSi | CCDS7805.1 |
RefSeqi | NP_055448.1, NM_014633.4 |
Genome annotation databases
Ensembli | ENST00000361367; ENSP00000355013; ENSG00000198730 |
GeneIDi | 9646 |
KEGGi | hsa:9646 |
UCSCi | uc001mja.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63875 mRNA Translation: BAA09925.2 Different initiation. CH471064 Genomic DNA Translation: EAW68557.1 CH471064 Genomic DNA Translation: EAW68558.1 BC058914 mRNA Translation: AAH58914.1 |
CCDSi | CCDS7805.1 |
RefSeqi | NP_055448.1, NM_014633.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5ZYQ | X-ray | 2.53 | A | 1-249 | [»] | |
6GMH | electron microscopy | 3.10 | Q | 301-1173 | [»] | |
6TED | electron microscopy | 3.10 | Q | 1-1173 | [»] | |
SMRi | Q6PD62 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115004, 134 interactors |
CORUMi | Q6PD62 |
DIPi | DIP-31693N |
IntActi | Q6PD62, 113 interactors |
MINTi | Q6PD62 |
STRINGi | 9606.ENSP00000355013 |
PTM databases
iPTMneti | Q6PD62 |
MetOSitei | Q6PD62 |
PhosphoSitePlusi | Q6PD62 |
Genetic variation databases
BioMutai | CTR9 |
DMDMi | 74758318 |
Proteomic databases
EPDi | Q6PD62 |
jPOSTi | Q6PD62 |
MassIVEi | Q6PD62 |
MaxQBi | Q6PD62 |
PaxDbi | Q6PD62 |
PeptideAtlasi | Q6PD62 |
PRIDEi | Q6PD62 |
ProteomicsDBi | 67068 |
Protocols and materials databases
Antibodypediai | 24416, 185 antibodies |
Genome annotation databases
Ensembli | ENST00000361367; ENSP00000355013; ENSG00000198730 |
GeneIDi | 9646 |
KEGGi | hsa:9646 |
UCSCi | uc001mja.4, human |
Organism-specific databases
CTDi | 9646 |
DisGeNETi | 9646 |
GeneCardsi | CTR9 |
HGNCi | HGNC:16850, CTR9 |
HPAi | ENSG00000198730, Low tissue specificity |
MIMi | 609366, gene |
neXtProti | NX_Q6PD62 |
OpenTargetsi | ENSG00000198730 |
PharmGKBi | PA134896774 |
VEuPathDBi | HostDB:ENSG00000198730.7 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2002, Eukaryota |
GeneTreei | ENSGT00390000005097 |
HOGENOMi | CLU_006386_0_0_1 |
InParanoidi | Q6PD62 |
OMAi | MLAAHYV |
OrthoDBi | 396755at2759 |
PhylomeDBi | Q6PD62 |
TreeFami | TF314342 |
Enzyme and pathway databases
PathwayCommonsi | Q6PD62 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-75955, RNA Polymerase II Transcription Elongation R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins |
Miscellaneous databases
BioGRID-ORCSi | 9646, 611 hits in 882 CRISPR screens |
ChiTaRSi | CTR9, human |
GeneWikii | CTR9 |
GenomeRNAii | 9646 |
Pharosi | Q6PD62, Tbio |
PROi | PR:Q6PD62 |
RNActi | Q6PD62, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198730, Expressed in caput epididymis and 252 other tissues |
ExpressionAtlasi | Q6PD62, baseline and differential |
Genevisiblei | Q6PD62, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR031101, Ctr9 IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR14027, PTHR14027, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 3 hits |
SMARTi | View protein in SMART SM00028, TPR, 10 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 10 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTR9_HUMAN | |
Accessioni | Q6PD62Primary (citable) accession number: Q6PD62 Secondary accession number(s): D3DQV8, Q15015 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references