UniProtKB - Q6PCZ4 (MAGE1_MOUSE)
Protein
Melanoma-associated antigen E1
Gene
Magee1
Organism
Mus musculus (Mouse)
Status
Functioni
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity).By similarity
Keywordsi
Molecular function | Tumor antigen |
Biological process | Ubl conjugation pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma-associated antigen E1Alternative name(s): Alpha-dystrobrevin-associated MAGE Protein Short name: DAMAGE MAGE-E1 antigen |
Gene namesi | Name:Magee1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2148149, Magee1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- perinuclear region 1 Publication
Note: In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane.
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
- postsynaptic membrane Source: UniProtKB
Other locations
- dendrite Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000404299 | 1 – 918 | Melanoma-associated antigen E1Add BLAST | 918 |
Proteomic databases
EPDi | Q6PCZ4 |
MaxQBi | Q6PCZ4 |
PaxDbi | Q6PCZ4 |
PRIDEi | Q6PCZ4 |
PTM databases
iPTMneti | Q6PCZ4 |
PhosphoSitePlusi | Q6PCZ4 |
Expressioni
Tissue specificityi
Expressed in cell bodies and dendrites of hippocampal and Purkinje neurons. Also expressed in peripheral nerve, where it localizes to the perineurium and myelin (at protein level). Predominantly expressed in brain and at low levels in the heart, liver, kidney, spleen, testis, lung, thymus, placenta and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031227, Expressed in primary visual cortex and 217 other tissues |
Genevisiblei | Q6PCZ4, MM |
Interactioni
Subunit structurei
Interacts with DTNA.
Interacts with TRIM28 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 223366, 1 interactor |
IntActi | Q6PCZ4, 1 interactor |
STRINGi | 10090.ENSMUSP00000094078 |
Miscellaneous databases
RNActi | Q6PCZ4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 459 – 658 | MAGE 1PROSITE-ProRule annotationAdd BLAST | 200 | |
Domaini | 706 – 897 | MAGE 2PROSITE-ProRule annotationAdd BLAST | 192 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 704 – 918 | Interaction with DTNA1 PublicationAdd BLAST | 215 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 12 | Poly-Arg | 4 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000163182 |
HOGENOMi | CLU_012911_0_0_1 |
InParanoidi | Q6PCZ4 |
OMAi | YRPITDC |
OrthoDBi | 1195799at2759 |
PhylomeDBi | Q6PCZ4 |
TreeFami | TF328505 |
Family and domain databases
Gene3Di | 1.10.10.1200, 2 hits 1.10.10.1210, 2 hits |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 5 hits |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 2 hits |
PROSITEi | View protein in PROSITE PS50838, MAGE, 2 hits |
i Sequence
Sequence statusi: Complete.
Q6PCZ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLVSQNSRR RRGGRANARR NNGKGHPAAV PGPDVPRDRN DPKILQGLRA
60 70 80 90 100
SEGPGTSMLP TPREGPSASV PPTASEGSSA PRQFIISQGP NTSEMPTSRK
110 120 130 140 150
GRGASRPPAV SAGLNTAMSI TASEGPNSPV PPTAPKGSKA YEHLPVSEGL
160 170 180 190 200
AISEQRHSDG GPNMEPTLGE GPGISVPPTF SEESGISDEG LSIFMSPNIS
210 220 230 240 250
EGPGINEPYS VSEDPSTSVP PTDSNGLGIN LPPTFGEGLS ISMLFSALEE
260 270 280 290 300
PDIFAPPPSA EGLFASMSPP SGEIQSSWVS PIIMEGCNVN VPPTSKKGLR
310 320 330 340 350
TSVPSAACES PSTSAEGLSS SLSSISAEGF CSSLAPCAAE GSCELLPCGE
360 370 380 390 400
GRSTSELHCL GEGSSTSQMS LAAEGPSASG MPTEANNPEE ALSCCASERR
410 420 430 440 450
NKSTSRALQK AKDPSVRPKR EDRFLDFQVL RDSKNSNSIT IMGLGTSRVA
460 470 480 490 500
LTLKPQDPME QNVAELLQFL LLKDQTKYPI KESDMREFID KDYRHQFPEI
510 520 530 540 550
LRRAAVHLEC IFRFELKELD TEEHIYILLN KLGPVPFEGL EDVPNGPKMG
560 570 580 590 600
LLMMILGHIL LNGNQAREAD IWEMLWRFGV QRERRLSVFG NVKRLLSVEF
610 620 630 640 650
VWQRYLDYRP LTDCVPVEYE FYWGPRSRAE TTKMKILKFM AKIYNKDPMD
660 670 680 690 700
WPALYNEALE EDADRVVVNN FRVARPFRRP LFAEVAPELD ASGSKYSPHS
710 720 730 740 750
WPESRLESKA RKLVQLFLLM DSTKLPIPKK GILYYIGREC TKVFPDLLNR
760 770 780 790 800
AARTLNHVYG TELVVLDPRN HSYTLYNRRE MEDTEEIMDS PNRPGNNFLM
810 820 830 840 850
QVLSFIFIMG NHARESAVWA FLRGLGVQNG RKHVITCRYL SQRYLDSLRV
860 870 880 890 900
PDSDPVQYDF VWGPRARLET SKMKALRYVA RIHRKEPEDW PEQYREAMED
910
EANRAEAGRR PLIVRNLR
Sequence cautioni
The sequence BAC26750 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC34694 differs from that shown. Reason: Frameshift.Curated
The sequence BAC38206 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EDL14072 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | G → V in BAC34694 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 164 | M → V in BAC26750 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 164 | M → V in BAC38206 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 164 | M → V in EDL14072 (Ref. 4) Curated | 1 | |
Sequence conflicti | 497 | F → Y in AAK01206 (Ref. 6) Curated | 1 | |
Sequence conflicti | 505 | A → P in AAK01206 (Ref. 6) Curated | 1 | |
Sequence conflicti | 584 | R → K in AAK01206 (Ref. 6) Curated | 1 | |
Sequence conflicti | 799 | L → F in BAC34694 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030032 mRNA Translation: BAC26750.1 Different initiation. AK051625 mRNA Translation: BAC34694.1 Frameshift. AK081378 mRNA Translation: BAC38206.1 Different initiation. AL672248 Genomic DNA No translation available. CH466564 Genomic DNA Translation: EDL14072.1 Sequence problems. BC059039 mRNA Translation: AAH59039.1 AF319978 mRNA Translation: AAK01206.1 |
CCDSi | CCDS41094.1 |
RefSeqi | NP_444431.3, NM_053201.4 |
Genome annotation databases
Ensembli | ENSMUST00000033578; ENSMUSP00000094078; ENSMUSG00000031227 |
GeneIDi | 107528 |
KEGGi | mmu:107528 |
UCSCi | uc009uav.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030032 mRNA Translation: BAC26750.1 Different initiation. AK051625 mRNA Translation: BAC34694.1 Frameshift. AK081378 mRNA Translation: BAC38206.1 Different initiation. AL672248 Genomic DNA No translation available. CH466564 Genomic DNA Translation: EDL14072.1 Sequence problems. BC059039 mRNA Translation: AAH59039.1 AF319978 mRNA Translation: AAK01206.1 |
CCDSi | CCDS41094.1 |
RefSeqi | NP_444431.3, NM_053201.4 |
3D structure databases
SMRi | Q6PCZ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 223366, 1 interactor |
IntActi | Q6PCZ4, 1 interactor |
STRINGi | 10090.ENSMUSP00000094078 |
PTM databases
iPTMneti | Q6PCZ4 |
PhosphoSitePlusi | Q6PCZ4 |
Proteomic databases
EPDi | Q6PCZ4 |
MaxQBi | Q6PCZ4 |
PaxDbi | Q6PCZ4 |
PRIDEi | Q6PCZ4 |
Protocols and materials databases
Antibodypediai | 560, 61 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033578; ENSMUSP00000094078; ENSMUSG00000031227 |
GeneIDi | 107528 |
KEGGi | mmu:107528 |
UCSCi | uc009uav.1, mouse |
Organism-specific databases
CTDi | 57692 |
MGIi | MGI:2148149, Magee1 |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000163182 |
HOGENOMi | CLU_012911_0_0_1 |
InParanoidi | Q6PCZ4 |
OMAi | YRPITDC |
OrthoDBi | 1195799at2759 |
PhylomeDBi | Q6PCZ4 |
TreeFami | TF328505 |
Miscellaneous databases
BioGRID-ORCSi | 107528, 1 hit in 17 CRISPR screens |
ChiTaRSi | Magee1, mouse |
PROi | PR:Q6PCZ4 |
RNActi | Q6PCZ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031227, Expressed in primary visual cortex and 217 other tissues |
Genevisiblei | Q6PCZ4, MM |
Family and domain databases
Gene3Di | 1.10.10.1200, 2 hits 1.10.10.1210, 2 hits |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 5 hits |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 2 hits |
PROSITEi | View protein in PROSITE PS50838, MAGE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGE1_MOUSE | |
Accessioni | Q6PCZ4Primary (citable) accession number: Q6PCZ4 Secondary accession number(s): Q8BG82, Q8BQ37, Q99PB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 8, 2011 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot