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Protein

E3 ubiquitin-protein ligase TRIM37

Gene

Trim37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).By similarity1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 55RING-type; degeneratePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri90 – 132B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM37Curated (EC:2.3.2.27By similarity)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM37Curated
Tripartite motif-containing protein 37Curated
Gene namesi
Name:Trim37Imported
Synonyms:Kiaa08981 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2153072 Trim37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562551 – 961E3 ubiquitin-protein ligase TRIM37Add BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei454PhosphoserineBy similarity1

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6PCX9
PaxDbiQ6PCX9
PRIDEiQ6PCX9

PTM databases

iPTMnetiQ6PCX9
PhosphoSitePlusiQ6PCX9

Expressioni

Tissue specificityi

Highly expressed in testis and brain. In embryonic tissues, expressed in epithelia, including ducts of the developing pancreas, epithelium of the midgut and nasal epithelium. In adult, detected in the central and peripheral nervous systems, including enteric ganglia, retina and the adrenal medulla (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000018548 Expressed in 303 organ(s), highest expression level in testis
CleanExiMM_TRIM37
ExpressionAtlasiQ6PCX9 baseline and differential
GenevisibleiQ6PCX9 MM

Interactioni

Subunit structurei

Associates with the PRC2/EED-EZH2 complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049057

Structurei

3D structure databases

ProteinModelPortaliQ6PCX9
SMRiQ6PCX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 403MATHPROSITE-ProRule annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili132 – 234Sequence analysisAdd BLAST103
Coiled coili419 – 450Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi535 – 541Poly-Ser7
Compositional biasi579 – 582Poly-Ala4

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 55RING-type; degeneratePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri90 – 132B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG1 Eukaryota
ENOG410YSD5 LUCA
GeneTreeiENSGT00410000025800
HOGENOMiHOG000013010
HOVERGENiHBG057591
InParanoidiQ6PCX9
KOiK10608
OMAiMWRVPPD
OrthoDBiEOG091G01C1
PhylomeDBiQ6PCX9
TreeFamiTF351092

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd03773 MATH_TRIM37, 1 hit
Gene3Di2.60.210.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR002083 MATH/TRAF_dom
IPR008974 TRAF-like
IPR037299 TRIM37_MATH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00917 MATH, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS50119 ZF_BBOX, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6PCX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ
60 70 80 90 100
CPHCRAPLQL RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE
110 120 130 140 150
KLSVFCWTCK KCICHQCALW GGMHGGHTFK PLAEIYEQHV TKVNEEVAKL
160 170 180 190 200
RRRLMELISL VQEVERNVEA VRNAKDERVR EIRNAVEMMI ARLDTQLKNK
210 220 230 240 250
LITLMGQKTS LTQETELLES LLQEVEHQLR SCSKSELISK SSEILMMFQQ
260 270 280 290 300
VHRKPMASFV TTPVPPDFTS ELVPSYDSAT FVLENFSTLR QRADPVYSPP
310 320 330 340 350
LQVSGLCWRL KVYPDGNGVV RGYYLSVFLE LSAGLPETSK YEYRVEMVHQ
360 370 380 390 400
SCNDPTKNII REFASDFEVG ECWGYNRFFR LDLLANEGYL NRQNDTVILR
410 420 430 440 450
FQVRSPTFFQ KCRDQHWYIT QLEAAQTGYI QQINNLKERL TIELSRTQKS
460 470 480 490 500
RDLSPPDNHL SPQNDDSPET RTKKAGSCSD MLLEGGPTCA SVRETKEDED
510 520 530 540 550
EEEKIQNEDY HHELSDGDLD LDLVGEDEVN HLDGSSSSAS STATSNTEEN
560 570 580 590 600
DIDEETMSGE NDVEYNSMEL EEGELMEDAA AAGPPGSSHS YVGASSRMSR
610 620 630 640 650
RTHLCSAATS SLLDIDPLIL IHLLDLKDRS SMENLWGLQP RPSASLLQPT
660 670 680 690 700
ASYSRKDKDQ RKQQAMWRVP SDLKMLKRLK TQMAEVRCMK TDVKTTLSDI
710 720 730 740 750
KGSSVASTDM QTNLFCADQA ALTTCGPENS GRLQDLGMEL LAKSSVAGCY
760 770 780 790 800
IRNPTNKKNS PKSARAIAGS LSLRRAVDSG ENSRSKGDCQ VLAEGSSGSS
810 820 830 840 850
QSGSRHSSPR ALTHGIIGDL LPKSEDRQCK ALDSDAVVVA VFNGLPTVEK
860 870 880 890 900
RRKMVTLGTN AKGGRLEGMQ MADLESHSEA GEVQPTLPEG ASAAPEEGMS
910 920 930 940 950
SDSDIECDTE NEEQEEHTSM GAFNDPFLAQ PPDEDSHSSF PDGEQIDPEN
960
LHFNPDEGGG R
Length:961
Mass (Da):107,660
Last modified:July 5, 2004 - v1
Checksum:i85629CEFE0A1D6EA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQY9Q5SQY9_MOUSE
E3 ubiquitin-protein ligase TRIM37
Trim37
197Annotation score:
F6XMH5F6XMH5_MOUSE
E3 ubiquitin-protein ligase TRIM37
Trim37
339Annotation score:

Sequence cautioni

The sequence BAC41455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227 – 232Missing in BAC41455 (PubMed:12465718).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093271 Transcribed RNA Translation: BAC41455.1 Different initiation.
AK140822 mRNA Translation: BAE24489.1
BC058678 mRNA Translation: AAH58678.1
BC059070 mRNA Translation: AAH59070.1
CCDSiCCDS25210.1
RefSeqiNP_932104.1, NM_197987.2
UniGeneiMm.17436

Genome annotation databases

EnsembliENSMUST00000041282; ENSMUSP00000049057; ENSMUSG00000018548
GeneIDi68729
KEGGimmu:68729
UCSCiuc007ktm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093271 Transcribed RNA Translation: BAC41455.1 Different initiation.
AK140822 mRNA Translation: BAE24489.1
BC058678 mRNA Translation: AAH58678.1
BC059070 mRNA Translation: AAH59070.1
CCDSiCCDS25210.1
RefSeqiNP_932104.1, NM_197987.2
UniGeneiMm.17436

3D structure databases

ProteinModelPortaliQ6PCX9
SMRiQ6PCX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049057

PTM databases

iPTMnetiQ6PCX9
PhosphoSitePlusiQ6PCX9

Proteomic databases

MaxQBiQ6PCX9
PaxDbiQ6PCX9
PRIDEiQ6PCX9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041282; ENSMUSP00000049057; ENSMUSG00000018548
GeneIDi68729
KEGGimmu:68729
UCSCiuc007ktm.2 mouse

Organism-specific databases

CTDi4591
MGIiMGI:2153072 Trim37
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410ITG1 Eukaryota
ENOG410YSD5 LUCA
GeneTreeiENSGT00410000025800
HOGENOMiHOG000013010
HOVERGENiHBG057591
InParanoidiQ6PCX9
KOiK10608
OMAiMWRVPPD
OrthoDBiEOG091G01C1
PhylomeDBiQ6PCX9
TreeFamiTF351092

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiTrim37 mouse
PROiPR:Q6PCX9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018548 Expressed in 303 organ(s), highest expression level in testis
CleanExiMM_TRIM37
ExpressionAtlasiQ6PCX9 baseline and differential
GenevisibleiQ6PCX9 MM

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd03773 MATH_TRIM37, 1 hit
Gene3Di2.60.210.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR002083 MATH/TRAF_dom
IPR008974 TRAF-like
IPR037299 TRIM37_MATH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00917 MATH, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS50119 ZF_BBOX, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI37_MOUSE
AccessioniPrimary (citable) accession number: Q6PCX9
Secondary accession number(s): Q5SX31, Q8CHC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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