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Protein

F-box/LRR-repeat protein 19

Gene

FBXL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri32 – 78CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri85 – 151PHD-typePROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 19
Alternative name(s):
F-box and leucine-rich repeat protein 19
Gene namesi
Name:FBXL19
Synonyms:FBL19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000099364.16
HGNCiHGNC:25300 FBXL19
MIMi609085 gene
neXtProtiNX_Q6PCT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54620
OpenTargetsiENSG00000099364
PharmGKBiPA134911396

Polymorphism and mutation databases

BioMutaiFBXL19
DMDMi322510127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198681 – 694F-box/LRR-repeat protein 19Add BLAST694

Proteomic databases

EPDiQ6PCT2
MaxQBiQ6PCT2
PaxDbiQ6PCT2
PeptideAtlasiQ6PCT2
PRIDEiQ6PCT2
ProteomicsDBi67065
67066 [Q6PCT2-2]
67067 [Q6PCT2-3]

PTM databases

iPTMnetiQ6PCT2
PhosphoSitePlusiQ6PCT2

Expressioni

Gene expression databases

BgeeiENSG00000099364 Expressed in 91 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiQ6PCT2 baseline and differential
GenevisibleiQ6PCT2 HS

Organism-specific databases

HPAiHPA035317

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Il1rl1P147193EBI-6664563,EBI-525078From Mus musculus.

Protein-protein interaction databases

BioGridi120078, 31 interactors
IntActiQ6PCT2, 20 interactors
STRINGi9606.ENSP00000369666

Structurei

Secondary structure

1694
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6PCT2
SMRiQ6PCT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini418 – 464F-boxAdd BLAST47
Repeati492 – 517LRR 1Add BLAST26
Repeati518 – 541LRR 2Add BLAST24
Repeati581 – 606LRR 3Add BLAST26
Repeati607 – 636LRR 4Add BLAST30
Repeati637 – 661LRR 5Add BLAST25
Repeati662 – 694LRR 6Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Ser4
Compositional biasi33 – 47Arg-richAdd BLAST15
Compositional biasi186 – 302Pro-richAdd BLAST117
Compositional biasi324 – 342Ser-richAdd BLAST19
Compositional biasi375 – 425Pro-richAdd BLAST51

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri32 – 78CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri85 – 151PHD-typePROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

Leucine-rich repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1633 Eukaryota
KOG1947 Eukaryota
ENOG410ZJED LUCA
GeneTreeiENSGT00550000074396
HOGENOMiHOG000112677
HOVERGENiHBG061227
InParanoidiQ6PCT2
KOiK10285
OMAiMCQMLER
OrthoDBiEOG091G04FK
PhylomeDBiQ6PCT2
TreeFamiTF338452

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF16866 PHD_4, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 2 hits
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PCT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGMKVPGKGE SGPSALLTPP MSSSSRGPGA GARRRRTRCR RCRACVRTEC
60 70 80 90 100
GDCHFCRDMK KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV
110 120 130 140 150
EGEEEKFGLS LMECTICNEI VHPGCLKMGK AEGVINAEIP NCWECPRCTQ
160 170 180 190 200
EGRTSKDSGE GPGRRRADNG EEGASLGSGW KLTEEPPLPP PPPRRKGPLP
210 220 230 240 250
AGPPPEDVPG PPKRKEREAG NEPPTPRKKV KGGRERHLKK VGGDACLLRG
260 270 280 290 300
SDPGGPGLLP PRVLNPSQAF SSCHPGLPPE NWEKPKPPLA SAEGPAVPSP
310 320 330 340 350
SPQREKLERF KRMCQLLERV PDTSSSSSDS DSDSDSSGTS LSEDEAPGEA
360 370 380 390 400
RNGRRPARGS SGEKENRGGR RAVRPGSGGP LLSWPLGPAP PPRPPQLERH
410 420 430 440 450
VVRPPPRSPE PDTLPLAAGS DHPLPRAAWL RVFQHLGPRE LCICMRVCRT
460 470 480 490 500
WSRWCYDKRL WPRMDLSRRK SLTPPMLSGV VRRQPRALDL SWTGVSKKQL
510 520 530 540 550
MWLLNRLQGL QELVLSGCSW LSVSALGSAP LPALRLLDLR WIEDVKDSQL
560 570 580 590 600
RELLLPPPDT KPGQTESRGR LQGVAELRLA GLELTDASLR LLLRHAPQLS
610 620 630 640 650
ALDLSHCAHV GDPSVHLLTA PTSPLRETLV HLNLAGCHRL TDHCLPLFRR
660 670 680 690
CPRLRRLDLR SCRQLSPEAC ARLAAAGPPG PFRCPEEKLL LKDS
Length:694
Mass (Da):75,707
Last modified:February 8, 2011 - v3
Checksum:i8D8A3BC4C86AD396
GO
Isoform 2 (identifier: Q6PCT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-283: Missing.

Show »
Length:651
Mass (Da):71,329
Checksum:i282689D6317F33E1
GO
Isoform 3 (identifier: Q6PCT2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-694: HCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS → PAGLGPWAPGLYNTVCYKTQNLP

Show »
Length:665
Mass (Da):72,253
Checksum:iB85235994C4852C5
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BME1H3BME1_HUMAN
F-box/LRR-repeat protein 19
FBXL19
558Annotation score:
H3BPZ0H3BPZ0_HUMAN
F-box/LRR-repeat protein 19
FBXL19
674Annotation score:
H3BQP6H3BQP6_HUMAN
F-box/LRR-repeat protein 19
FBXL19
59Annotation score:
H7C112H7C112_HUMAN
F-box/LRR-repeat protein 19
FBXL19
586Annotation score:
H3BVB1H3BVB1_HUMAN
F-box/LRR-repeat protein 19
FBXL19
382Annotation score:
H3BPI8H3BPI8_HUMAN
F-box/LRR-repeat protein 19
FBXL19
138Annotation score:
H3BTJ3H3BTJ3_HUMAN
F-box/LRR-repeat protein 19
FBXL19
122Annotation score:

Sequence cautioni

The sequence AAH59173 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC05410 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013015241 – 283Missing in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_040503643 – 694HCLPL…LLKDS → PAGLGPWAPGLYNTVCYKTQ NLP in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135048 Genomic DNA No translation available.
BC059173 mRNA Translation: AAH59173.1 Different initiation.
AK098777 mRNA Translation: BAC05410.1 Different initiation.
AL137589 mRNA Translation: CAB70830.1
CCDSiCCDS45465.1 [Q6PCT2-1]
PIRiT46301
RefSeqiNP_001093254.2, NM_001099784.2 [Q6PCT2-1]
NP_001269280.1, NM_001282351.1
UniGeneiHs.152149

Genome annotation databases

EnsembliENST00000380310; ENSP00000369666; ENSG00000099364 [Q6PCT2-1]
GeneIDi54620
KEGGihsa:54620
UCSCiuc002eab.2 human [Q6PCT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135048 Genomic DNA No translation available.
BC059173 mRNA Translation: AAH59173.1 Different initiation.
AK098777 mRNA Translation: BAC05410.1 Different initiation.
AL137589 mRNA Translation: CAB70830.1
CCDSiCCDS45465.1 [Q6PCT2-1]
PIRiT46301
RefSeqiNP_001093254.2, NM_001099784.2 [Q6PCT2-1]
NP_001269280.1, NM_001282351.1
UniGeneiHs.152149

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ASBX-ray2.85C/F/I/L31-153[»]
ProteinModelPortaliQ6PCT2
SMRiQ6PCT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120078, 31 interactors
IntActiQ6PCT2, 20 interactors
STRINGi9606.ENSP00000369666

PTM databases

iPTMnetiQ6PCT2
PhosphoSitePlusiQ6PCT2

Polymorphism and mutation databases

BioMutaiFBXL19
DMDMi322510127

Proteomic databases

EPDiQ6PCT2
MaxQBiQ6PCT2
PaxDbiQ6PCT2
PeptideAtlasiQ6PCT2
PRIDEiQ6PCT2
ProteomicsDBi67065
67066 [Q6PCT2-2]
67067 [Q6PCT2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380310; ENSP00000369666; ENSG00000099364 [Q6PCT2-1]
GeneIDi54620
KEGGihsa:54620
UCSCiuc002eab.2 human [Q6PCT2-1]

Organism-specific databases

CTDi54620
DisGeNETi54620
EuPathDBiHostDB:ENSG00000099364.16
GeneCardsiFBXL19
H-InvDBiHIX0020867
HGNCiHGNC:25300 FBXL19
HPAiHPA035317
MIMi609085 gene
neXtProtiNX_Q6PCT2
OpenTargetsiENSG00000099364
PharmGKBiPA134911396
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1633 Eukaryota
KOG1947 Eukaryota
ENOG410ZJED LUCA
GeneTreeiENSGT00550000074396
HOGENOMiHOG000112677
HOVERGENiHBG061227
InParanoidiQ6PCT2
KOiK10285
OMAiMCQMLER
OrthoDBiEOG091G04FK
PhylomeDBiQ6PCT2
TreeFamiTF338452

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXL19 human
GenomeRNAii54620
PROiPR:Q6PCT2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099364 Expressed in 91 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiQ6PCT2 baseline and differential
GenevisibleiQ6PCT2 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF16866 PHD_4, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 2 hits
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFXL19_HUMAN
AccessioniPrimary (citable) accession number: Q6PCT2
Secondary accession number(s): A8MT10, Q8N789, Q9NT14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 8, 2011
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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