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Entry version 96 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Rho GTPase-activating protein 29

Gene

arhgap29

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42 (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri676 – 723Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 29
Alternative name(s):
Rho-type GTPase-activating protein 29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arhgap29
ORF Names:zgc:63950
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-031010-44, arhgap29b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003175851 – 1337Rho GTPase-activating protein 29Add BLAST1337

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PCS4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000115452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PCS4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini225 – 488F-BARPROSITE-ProRule annotationAdd BLAST264
Domaini737 – 950Rho-GAPPROSITE-ProRule annotationAdd BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni369 – 397DisorderedSequence analysisAdd BLAST29
Regioni513 – 551DisorderedSequence analysisAdd BLAST39
Regioni564 – 654DisorderedSequence analysisAdd BLAST91
Regioni960 – 983DisorderedSequence analysisAdd BLAST24
Regioni1016 – 1066DisorderedSequence analysisAdd BLAST51
Regioni1083 – 1114DisorderedSequence analysisAdd BLAST32
Regioni1149 – 1210DisorderedSequence analysisAdd BLAST62
Regioni1273 – 1337DisorderedSequence analysisAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili326 – 443Sequence analysisAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi513 – 549Polar residuesSequence analysisAdd BLAST37
Compositional biasi567 – 615Polar residuesSequence analysisAdd BLAST49
Compositional biasi960 – 975Polar residuesSequence analysisAdd BLAST16
Compositional biasi1025 – 1051Polar residuesSequence analysisAdd BLAST27
Compositional biasi1083 – 1105Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1153 – 1181Polar residuesSequence analysisAdd BLAST29
Compositional biasi1291 – 1313Polar residuesSequence analysisAdd BLAST23
Compositional biasi1318 – 1337Basic and acidic residuesSequence analysisAdd BLAST20

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri676 – 723Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1453, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PCS4

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PCS4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR002219, PE/DAG-bd
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51741, F_BAR, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6PCS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRQGSNSGN KRMTSGARLS QPIIPLSLPT ASSKTLEMGR SSKTNPLNAM
60 70 80 90 100
GLDHNIATSG GDPEYIMQLV NDVRKFSDVL LSLKEAFHSK ESQECSQHVV
110 120 130 140 150
NERLGELVHV LKAVIGKHQA LNSSEILGAA GTVIAKVKGV NFKEVNNENK
160 170 180 190 200
STIFGEIHTS IDTLAFTFGN VVSDFLMGDV DGGSRLGYPQ ARRSRSFENL
210 220 230 240 250
SEDSRGCSQN DLADHSLSPE LSTVEQVDLL LLKNDSGVES ALLYAKAWSK
260 270 280 290 300
YTKDVLAWVE KRLSLDMECA KSFAKMAESA KAVASQQDFM PFRDIYVSAF
310 320 330 340 350
KNEIEYNHVL LQTAAALQTN KFTQPLLARK NDLDKQRKEI KEQWQRELKK
360 370 380 390 400
MNESESALKK ARLLKMQKRE EYEKARSSTS RTEEEQPAAG GRTLEKKRRV
410 420 430 440 450
EEEALQKAEE AQEQYKACVA DLEAKKVSLS NAKSEILAQI RKLVFQCDLT
460 470 480 490 500
LKAVTVNWFQ MQQAQTMPLS VNYQALSEQA KKYEPGQRYS EFVRSLPKER
510 520 530 540 550
VWLESLSQDI TASSKTGMSL HKRSQNSTRS SHGNLSQGSA TSMDNHSADE
560 570 580 590 600
VEGNMQPCKA KIAERRSNSS IDMQVPRTQG SQRAWSSGSA GGGGMCSDSE
610 620 630 640 650
SAGGSSESRS MDSPTASPGD FKRRLPRTPS TGTMSSADDL DEREPPSPSD
660 670 680 690 700
TGLSEMVMET ASSPGPFRNA QMSKAAHTHK LRKLRAPSKC RECDSLVVFH
710 720 730 740 750
GAECEECSLA CHKKCLETLA IQCGHKKLQG RLHLFGIDFA QVVKNSPDGI
760 770 780 790 800
PFIIKKCTSE IESRALTIKG IYRVNGAKSR VEKLCQAFEN GKDLVELSDL
810 820 830 840 850
HPHDISNVLK LYLRQLPEPL ILYRYYNDVI GLAKETQNMD KTDSAKEKSA
860 870 880 890 900
GEQLGLSTEL KRVLFKVRDL LRQLPAPHYK TLQFLITHLH RVSEQAEENK
910 920 930 940 950
MTASNLGIIF GPTLIKPRHL EAEVSLSSLV DYPHQARMVE LLIKHHQMIF
960 970 980 990 1000
DVPLSPMSPT SPTVSQASFG SSIQDKESKL SRHSRSLMDI KESAKLYKRH
1010 1020 1030 1040 1050
SSVIIPAQLM EEGKEMKTGD HRVQTSGEGS DVNGVGLTSV DSTSVFNRPG
1060 1070 1080 1090 1100
ASSRMVQLRP QRAKPVSRPI SMPIDRLLNE RNSRNTVEHD HSPAAIEETT
1110 1120 1130 1140 1150
EPEKPTTPRH TNFYRNPFID TQTLRRTWDR QYRHYDVTPR TAMIVANLPP
1160 1170 1180 1190 1200
SGVQKQPEIS MASQSSTSRK DGTSQSGVAP ISFRAARTLK PSSPGTFYRP
1210 1220 1230 1240 1250
PSGGQLKPSD LLAKSVSRAP TTTTGAIYTT AITVLTTAST SSVMTISTAV
1260 1270 1280 1290 1300
TTPPTTPTTS VTVALTSKPT FTTVSRSVSG GAGEGLSESD LLSPVTLSPP
1310 1320 1330
QSPGSSTEEL SPTDAKPLYQ RRSRRMQELE HREAHFV
Length:1,337
Mass (Da):147,666
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2061AE2507489079
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0UYG6B0UYG6_DANRE
Rho GTPase-activating protein 29b
arhgap29b
1,289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6NQ92F6NQ92_DANRE
Rho GTPase-activating protein 29b
arhgap29b
1,337Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC059184 mRNA Translation: AAH59184.1

NCBI Reference Sequences

More...
RefSeqi
NP_956405.1, NM_200111.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
378998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:378998

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059184 mRNA Translation: AAH59184.1
RefSeqiNP_956405.1, NM_200111.1

3D structure databases

SMRiQ6PCS4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000115452

Proteomic databases

PaxDbiQ6PCS4

Genome annotation databases

GeneIDi378998
KEGGidre:378998

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
378998
ZFINiZDB-GENE-031010-44, arhgap29b

Phylogenomic databases

eggNOGiKOG1453, Eukaryota
InParanoidiQ6PCS4
OrthoDBi1300981at2759
PhylomeDBiQ6PCS4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6PCS4

Family and domain databases

CDDicd00029, C1, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR002219, PE/DAG-bd
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS51741, F_BAR, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG29_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PCS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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