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UniProtKB - Q6PCS4 (RHG29_DANRE)
Protein
Rho GTPase-activating protein 29
Gene
arhgap29
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42 (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 676 – 723 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 29Alternative name(s): Rho-type GTPase-activating protein 29 |
Gene namesi | Name:arhgap29 ORF Names:zgc:63950 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-031010-44, arhgap29b |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317585 | 1 – 1337 | Rho GTPase-activating protein 29Add BLAST | 1337 |
Proteomic databases
PaxDbi | Q6PCS4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 225 – 488 | F-BARPROSITE-ProRule annotationAdd BLAST | 264 | |
Domaini | 737 – 950 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 214 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 369 – 397 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 513 – 551 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 564 – 654 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 960 – 983 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1016 – 1066 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 1083 – 1114 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1149 – 1210 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 1273 – 1337 | DisorderedSequence analysisAdd BLAST | 65 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 326 – 443 | Sequence analysisAdd BLAST | 118 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 513 – 549 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 567 – 615 | Polar residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 960 – 975 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1025 – 1051 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1083 – 1105 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1153 – 1181 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1291 – 1313 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1318 – 1337 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 676 – 723 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1453, Eukaryota |
InParanoidi | Q6PCS4 |
OrthoDBi | 1300981at2759 |
PhylomeDBi | Q6PCS4 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR002219, PE/DAG-bd IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50238, RHOGAP, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q6PCS4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRQGSNSGN KRMTSGARLS QPIIPLSLPT ASSKTLEMGR SSKTNPLNAM
60 70 80 90 100
GLDHNIATSG GDPEYIMQLV NDVRKFSDVL LSLKEAFHSK ESQECSQHVV
110 120 130 140 150
NERLGELVHV LKAVIGKHQA LNSSEILGAA GTVIAKVKGV NFKEVNNENK
160 170 180 190 200
STIFGEIHTS IDTLAFTFGN VVSDFLMGDV DGGSRLGYPQ ARRSRSFENL
210 220 230 240 250
SEDSRGCSQN DLADHSLSPE LSTVEQVDLL LLKNDSGVES ALLYAKAWSK
260 270 280 290 300
YTKDVLAWVE KRLSLDMECA KSFAKMAESA KAVASQQDFM PFRDIYVSAF
310 320 330 340 350
KNEIEYNHVL LQTAAALQTN KFTQPLLARK NDLDKQRKEI KEQWQRELKK
360 370 380 390 400
MNESESALKK ARLLKMQKRE EYEKARSSTS RTEEEQPAAG GRTLEKKRRV
410 420 430 440 450
EEEALQKAEE AQEQYKACVA DLEAKKVSLS NAKSEILAQI RKLVFQCDLT
460 470 480 490 500
LKAVTVNWFQ MQQAQTMPLS VNYQALSEQA KKYEPGQRYS EFVRSLPKER
510 520 530 540 550
VWLESLSQDI TASSKTGMSL HKRSQNSTRS SHGNLSQGSA TSMDNHSADE
560 570 580 590 600
VEGNMQPCKA KIAERRSNSS IDMQVPRTQG SQRAWSSGSA GGGGMCSDSE
610 620 630 640 650
SAGGSSESRS MDSPTASPGD FKRRLPRTPS TGTMSSADDL DEREPPSPSD
660 670 680 690 700
TGLSEMVMET ASSPGPFRNA QMSKAAHTHK LRKLRAPSKC RECDSLVVFH
710 720 730 740 750
GAECEECSLA CHKKCLETLA IQCGHKKLQG RLHLFGIDFA QVVKNSPDGI
760 770 780 790 800
PFIIKKCTSE IESRALTIKG IYRVNGAKSR VEKLCQAFEN GKDLVELSDL
810 820 830 840 850
HPHDISNVLK LYLRQLPEPL ILYRYYNDVI GLAKETQNMD KTDSAKEKSA
860 870 880 890 900
GEQLGLSTEL KRVLFKVRDL LRQLPAPHYK TLQFLITHLH RVSEQAEENK
910 920 930 940 950
MTASNLGIIF GPTLIKPRHL EAEVSLSSLV DYPHQARMVE LLIKHHQMIF
960 970 980 990 1000
DVPLSPMSPT SPTVSQASFG SSIQDKESKL SRHSRSLMDI KESAKLYKRH
1010 1020 1030 1040 1050
SSVIIPAQLM EEGKEMKTGD HRVQTSGEGS DVNGVGLTSV DSTSVFNRPG
1060 1070 1080 1090 1100
ASSRMVQLRP QRAKPVSRPI SMPIDRLLNE RNSRNTVEHD HSPAAIEETT
1110 1120 1130 1140 1150
EPEKPTTPRH TNFYRNPFID TQTLRRTWDR QYRHYDVTPR TAMIVANLPP
1160 1170 1180 1190 1200
SGVQKQPEIS MASQSSTSRK DGTSQSGVAP ISFRAARTLK PSSPGTFYRP
1210 1220 1230 1240 1250
PSGGQLKPSD LLAKSVSRAP TTTTGAIYTT AITVLTTAST SSVMTISTAV
1260 1270 1280 1290 1300
TTPPTTPTTS VTVALTSKPT FTTVSRSVSG GAGEGLSESD LLSPVTLSPP
1310 1320 1330
QSPGSSTEEL SPTDAKPLYQ RRSRRMQELE HREAHFV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0UYG6 | B0UYG6_DANRE | Rho GTPase-activating protein 29b | arhgap29b | 1,289 | Annotation score: | ||
F6NQ92 | F6NQ92_DANRE | Rho GTPase-activating protein 29b | arhgap29b | 1,337 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC059184 mRNA Translation: AAH59184.1 |
RefSeqi | NP_956405.1, NM_200111.1 |
Genome annotation databases
GeneIDi | 378998 |
KEGGi | dre:378998 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC059184 mRNA Translation: AAH59184.1 |
RefSeqi | NP_956405.1, NM_200111.1 |
3D structure databases
SMRi | Q6PCS4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000115452 |
Proteomic databases
PaxDbi | Q6PCS4 |
Genome annotation databases
GeneIDi | 378998 |
KEGGi | dre:378998 |
Organism-specific databases
CTDi | 378998 |
ZFINi | ZDB-GENE-031010-44, arhgap29b |
Phylogenomic databases
eggNOGi | KOG1453, Eukaryota |
InParanoidi | Q6PCS4 |
OrthoDBi | 1300981at2759 |
PhylomeDBi | Q6PCS4 |
Miscellaneous databases
PROi | PR:Q6PCS4 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR002219, PE/DAG-bd IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50238, RHOGAP, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG29_DANRE | |
Accessioni | Q6PCS4Primary (citable) accession number: Q6PCS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | June 2, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |