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Protein

IQ domain-containing protein E

Gene

Iqce

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:24582806).1 Publication

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-5635838 Activation of SMO

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein E
Gene namesi
Name:Iqce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921489 Iqce

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002841111 – 778IQ domain-containing protein EAdd BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei322PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PCQ0
PRIDEiQ6PCQ0

PTM databases

iPTMnetiQ6PCQ0
PhosphoSitePlusiQ6PCQ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000036555 Expressed in 227 organ(s), highest expression level in testis
CleanExiMM_IQCE
ExpressionAtlasiQ6PCQ0 baseline and differential
GenevisibleiQ6PCQ0 MM

Interactioni

Subunit structurei

Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE (PubMed:24582806). Interacts (via N-terminus) with EFCAB7 (via EF-hands 1 and 2); this interaction anchors the EVC-EVC2 complex in a signaling microdomain at the base of cilia and stimulates the Hedgehog (Hh) pathway. Interacts with EVC2 (via N-terminal end) (PubMed:24582806). Interacts with EVC (PubMed:24582806).1 Publication

Protein-protein interaction databases

BioGridi216599, 1 interactor
STRINGi10090.ENSMUSP00000045913

Structurei

3D structure databases

ProteinModelPortaliQ6PCQ0
SMRiQ6PCQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini553 – 582IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini615 – 644IQ 2PROSITE-ProRule annotationAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili157 – 323Sequence analysisAdd BLAST167
Coiled coili398 – 486Sequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi707 – 710Poly-Ser4

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IFFR Eukaryota
ENOG41104K8 LUCA
GeneTreeiENSGT00390000006040
HOGENOMiHOG000113097
HOVERGENiHBG103684
InParanoidiQ6PCQ0
OMAiKSPYHSK
OrthoDBiEOG091G0LX1
PhylomeDBiQ6PCQ0
TreeFamiTF351136

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PCQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLGTTDIAS ETGDDSLSAI TFESDIESKT KRKSFHKPPS TSPKSPYYSK
60 70 80 90 100
PRKVTSWRSL KTAGSMPLSS RMSLTPQKLW LGSSKQGSVA QPPSPTLTSE
110 120 130 140 150
HAWTHPPSCT PDYLTEAVRA KRADLRRSGS HGHVSGTSVY REKEDMYDEI
160 170 180 190 200
IELKKSLHMQ KSDVDLMRTK LRRLEEENSR KDRQIEQLLD PSRGPDFVRT
210 220 230 240 250
LAEKKPDTGW VITGLKQRIF RLEQQCKEKD NTINKLQTDM KTTNLEEMRI
260 270 280 290 300
AMETYYEEIH RLQTLLASSE ATGKKPMVEK KLGVKRQKKM SSALLNLTRS
310 320 330 340 350
VQELTEENQS LKEDLDRMLS NSPTISKIKG YGDWSKPRLL RRIAELEKKV
360 370 380 390 400
SSSESPKQST SELVNPNPLV RSPSNISVQK QPKGDQSPED LPKVAPCEEQ
410 420 430 440 450
EHLQGTVKSL REELGALQEQ LLEKDLEMKQ LLQSKIDLEK ELETAREGEK
460 470 480 490 500
GRQEQEQALR EEVEALTKKC QELEEAKREE KNSFVAVTHE AHPELHAPSP
510 520 530 540 550
CSRHSEPDSD NSAGEEGSSQ PPAPCSEERR EAAIRTLQAQ WKAHRRKKRE
560 570 580 590 600
AALDEAATVL QAAFRGHLAR SKLVRSKVPD SRSPSLPGLL SPLNQSSPAP
610 620 630 640 650
RVLSPISPAE ENPTQEEAVI VIQSILRGYL AQARFIASCC REIAASSQRE
660 670 680 690 700
TVSLTPSGSA SPPSLRASPG VIRKELCASE ELRETSASEP APSVPYSAQG
710 720 730 740 750
GHGDCPSSSS LEAVPSMKDA MCEERSSSPR SAGPSLAEPS PPELQPLSPP
760 770
PVEDICSDDS DDIIFSPFLP RKKSPSPF
Length:778
Mass (Da):86,356
Last modified:July 5, 2004 - v1
Checksum:i607FE6BDAED56BA6
GO
Isoform 2 (identifier: Q6PCQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-131: Missing.
     669-669: P → PGKNSEASSGEAAKDEDEAEEPPDLQPYS

Show »
Length:761
Mass (Da):84,438
Checksum:i055338FC14E4ADB9
GO
Isoform 3 (identifier: Q6PCQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-131: Missing.
     276-290: PMVEKKLGVKRQKKM → YALMWGLSPVSLWRL
     291-778: Missing.

Show »
Length:245
Mass (Da):28,228
Checksum:iA3607421DB50562E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6R782F6R782_MOUSE
IQ domain-containing protein E
Iqce
396Annotation score:
D3YXD4D3YXD4_MOUSE
IQ domain-containing protein E
Iqce
185Annotation score:
A0A0G2JG25A0A0G2JG25_MOUSE
IQ domain-containing protein E
Iqce
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti587P → Q in BAB24605 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02443687 – 131Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_024437276 – 290PMVEK…RQKKM → YALMWGLSPVSLWRL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_024438291 – 778Missing in isoform 3. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_024439669P → PGKNSEASSGEAAKDEDEAE EPPDLQPYS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006472 mRNA Translation: BAB24605.1
AK029333 mRNA Translation: BAC26400.1
BC059223 mRNA Translation: AAH59223.1
CCDSiCCDS39358.1 [Q6PCQ0-1]
CCDS84987.1 [Q6PCQ0-2]
RefSeqiNP_001334446.1, NM_001347517.1 [Q6PCQ0-2]
NP_083109.2, NM_028833.3 [Q6PCQ0-1]
UniGeneiMm.179704

Genome annotation databases

EnsembliENSMUST00000041783; ENSMUSP00000045913; ENSMUSG00000036555 [Q6PCQ0-1]
ENSMUST00000077890; ENSMUSP00000077050; ENSMUSG00000036555 [Q6PCQ0-2]
GeneIDi74239
KEGGimmu:74239
UCSCiuc009ahx.1 mouse [Q6PCQ0-1]
uc009ahy.1 mouse [Q6PCQ0-2]
uc009ahz.1 mouse [Q6PCQ0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006472 mRNA Translation: BAB24605.1
AK029333 mRNA Translation: BAC26400.1
BC059223 mRNA Translation: AAH59223.1
CCDSiCCDS39358.1 [Q6PCQ0-1]
CCDS84987.1 [Q6PCQ0-2]
RefSeqiNP_001334446.1, NM_001347517.1 [Q6PCQ0-2]
NP_083109.2, NM_028833.3 [Q6PCQ0-1]
UniGeneiMm.179704

3D structure databases

ProteinModelPortaliQ6PCQ0
SMRiQ6PCQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216599, 1 interactor
STRINGi10090.ENSMUSP00000045913

PTM databases

iPTMnetiQ6PCQ0
PhosphoSitePlusiQ6PCQ0

Proteomic databases

PaxDbiQ6PCQ0
PRIDEiQ6PCQ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041783; ENSMUSP00000045913; ENSMUSG00000036555 [Q6PCQ0-1]
ENSMUST00000077890; ENSMUSP00000077050; ENSMUSG00000036555 [Q6PCQ0-2]
GeneIDi74239
KEGGimmu:74239
UCSCiuc009ahx.1 mouse [Q6PCQ0-1]
uc009ahy.1 mouse [Q6PCQ0-2]
uc009ahz.1 mouse [Q6PCQ0-3]

Organism-specific databases

CTDi23288
MGIiMGI:1921489 Iqce

Phylogenomic databases

eggNOGiENOG410IFFR Eukaryota
ENOG41104K8 LUCA
GeneTreeiENSGT00390000006040
HOGENOMiHOG000113097
HOVERGENiHBG103684
InParanoidiQ6PCQ0
OMAiKSPYHSK
OrthoDBiEOG091G0LX1
PhylomeDBiQ6PCQ0
TreeFamiTF351136

Enzyme and pathway databases

ReactomeiR-MMU-5635838 Activation of SMO

Miscellaneous databases

PROiPR:Q6PCQ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036555 Expressed in 227 organ(s), highest expression level in testis
CleanExiMM_IQCE
ExpressionAtlasiQ6PCQ0 baseline and differential
GenevisibleiQ6PCQ0 MM

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIQCE_MOUSE
AccessioniPrimary (citable) accession number: Q6PCQ0
Secondary accession number(s): Q8CDZ1, Q9D9U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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