UniProtKB - Q6PCP7 (GP156_MOUSE)
Protein
Probable G-protein coupled receptor 156
Gene
Gpr156
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled GABA receptor activity Source: GO_Central
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- gamma-aminobutyric acid signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 156Alternative name(s): GABAB-related G-protein coupled receptor |
Gene namesi | Name:Gpr156 Synonyms:Gababl |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2653880, Gpr156 |
Subcellular locationi
Plasma Membrane
- G protein-coupled receptor heterodimeric complex Source: GO_Central
- plasma membrane Source: MGI
- postsynaptic membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 49 | ExtracellularSequence analysisAdd BLAST | 49 | |
Transmembranei | 50 – 70 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 71 – 86 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 87 – 107 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 118 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 119 – 139 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 164 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 165 – 185 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 186 – 222 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 223 – 243 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 257 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 258 – 278 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 288 | ExtracellularSequence analysis | 10 | |
Transmembranei | 289 – 309 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 310 – 798 | CytoplasmicSequence analysisAdd BLAST | 489 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206900 | 1 – 798 | Probable G-protein coupled receptor 156Add BLAST | 798 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q6PCP7 |
PRIDEi | Q6PCP7 |
PTM databases
GlyGeni | Q6PCP7, 1 site |
iPTMneti | Q6PCP7 |
PhosphoSitePlusi | Q6PCP7 |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000055958 |
Miscellaneous databases
RNActi | Q6PCP7, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 353 – 390 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 266 – 269 | Poly-Leu | 4 | |
Compositional biasi | 584 – 587 | Poly-Arg | 4 | |
Compositional biasi | 730 – 735 | Poly-Ser | 6 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1055, Eukaryota |
InParanoidi | Q6PCP7 |
OrthoDBi | 336447at2759 |
PhylomeDBi | Q6PCP7 |
TreeFami | TF313965 |
Family and domain databases
CDDi | cd15292, 7tmC_GPR156, 1 hit |
InterProi | View protein in InterPro IPR002455, GPCR3_GABA-B IPR017978, GPCR_3_C IPR041946, GPR156_7TM |
PANTHERi | PTHR10519, PTHR10519, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6PCP7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPEINCSEF CDSFPGQELD RRPLHDLCKT TITESQHSST AASPLSPALL
60 70 80 90 100
GIMWTFLSCG LLLVLFFLAF TIRCRKNRIV KMSSPNLNVV TLLGSCLTYI
110 120 130 140 150
SAYLFGIQDA LEGSSVEALI QTRLSLLCIG TSLVFGPILG KSWRLYKVFT
160 170 180 190 200
QRVPDKRVII KDLQLLGLVA ALVVADVILL VTWVLTDPIQ CLQMLGVSMK
210 220 230 240 250
VTGRDVSCSL TNTHFCASRY SDVWIALVLG CKGLLLLYGA YLAGLTNHVS
260 270 280 290 300
SPPVNQSLTI MVGVNLLLLT AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
310 320 330 340 350
TTVNCCVFIP QLKQWKAFEG ENQTMRHMAK YFSTPSKSFH SQFDEDPSCH
360 370 380 390 400
LRDEKSCMER LLTEKNAVIE SLQEQVSNAK EKLVKLMSAE CTYDSPEWAV
410 420 430 440 450
PDAASARGLA LPGPSECPAV SENESGAAAR DSLHVPAACQ HVQGPGASRR
460 470 480 490 500
DTSPSPAQQD NMPLKQYCDH LDTGCNQKPK AEQSEGPERG DQEPMAPSQR
510 520 530 540 550
LMADGVACEP HKPRQSPEGL PKKLPGVSSV VREKLQEVLQ ELDLGSEAPL
560 570 580 590 600
SPLPCPQQLW KSTTSRSPQK LSPSKLGFSP YVVRRRRAAQ RARSHIPGSV
610 620 630 640 650
GLNVGHQANS TVSSSQSGLI VQNRDSPRLD HHNARSKVPR SSSVKPSPLS
660 670 680 690 700
EPRRKQGTLE GSKQCETEPQ EAGGACNVAF PCQSSASVQA QSPAAPCLPS
710 720 730 740 750
SPALPRQRQP RPRLSPGCPS LSSGCYNLDS ESSSSDEFFC RCHRPYCEIC
760 770 780 790
FQSSLDSNDS DTSDSDLEQA SGLASWEKLW ARSKPVVNFK DDLKPTLV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J0P3 | A0A0R4J0P3_MOUSE | Probable G-protein-coupled receptor... | Gpr156 | 798 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 341 | S → G in AAH59227 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 484 | S → R in AAN03796 (PubMed:12591167).Curated | 1 | |
Sequence conflicti | 569 | Q → R in AAN03796 (PubMed:12591167).Curated | 1 | |
Sequence conflicti | 573 | P → T in AAN03796 (PubMed:12591167).Curated | 1 | |
Sequence conflicti | 621 | V → I in AAN03796 (PubMed:12591167).Curated | 1 | |
Sequence conflicti | 629 | L → Q in AAN03796 (PubMed:12591167).Curated | 1 | |
Sequence conflicti | 632 | H → N in AAH59227 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 777 | E → G in AAH59227 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488740 mRNA Translation: AAN03796.1 BC059227 mRNA Translation: AAH59227.1 |
CCDSi | CCDS28162.1 |
RefSeqi | NP_700443.2, NM_153394.2 |
Genome annotation databases
GeneIDi | 239845 |
KEGGi | mmu:239845 |
UCSCi | uc007zel.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488740 mRNA Translation: AAN03796.1 BC059227 mRNA Translation: AAH59227.1 |
CCDSi | CCDS28162.1 |
RefSeqi | NP_700443.2, NM_153394.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000055958 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q6PCP7, 1 site |
iPTMneti | Q6PCP7 |
PhosphoSitePlusi | Q6PCP7 |
Proteomic databases
PaxDbi | Q6PCP7 |
PRIDEi | Q6PCP7 |
Genome annotation databases
GeneIDi | 239845 |
KEGGi | mmu:239845 |
UCSCi | uc007zel.1, mouse |
Organism-specific databases
CTDi | 165829 |
MGIi | MGI:2653880, Gpr156 |
Phylogenomic databases
eggNOGi | KOG1055, Eukaryota |
InParanoidi | Q6PCP7 |
OrthoDBi | 336447at2759 |
PhylomeDBi | Q6PCP7 |
TreeFami | TF313965 |
Miscellaneous databases
BioGRID-ORCSi | 239845, 1 hit in 17 CRISPR screens |
ChiTaRSi | Gpr156, mouse |
PROi | PR:Q6PCP7 |
RNActi | Q6PCP7, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd15292, 7tmC_GPR156, 1 hit |
InterProi | View protein in InterPro IPR002455, GPCR3_GABA-B IPR017978, GPCR_3_C IPR041946, GPR156_7TM |
PANTHERi | PTHR10519, PTHR10519, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP156_MOUSE | |
Accessioni | Q6PCP7Primary (citable) accession number: Q6PCP7 Secondary accession number(s): Q8K452 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | August 16, 2005 | |
Last modified: | December 2, 2020 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries