Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrator complex subunit 6

Gene

Ints6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.By similarity

GO - Biological processi

  • snRNA 3'-end processing Source: GO_Central
  • snRNA processing Source: HGNC

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 6
Short name:
Int6
Alternative name(s):
DBI-1
Protein DDX26
Gene namesi
Name:Ints6
Synonyms:Dbi1, Ddx26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1202397 Ints6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595441 – 883Integrator complex subunit 6Add BLAST883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei800PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PCM2
PeptideAtlasiQ6PCM2
PRIDEiQ6PCM2

PTM databases

iPTMnetiQ6PCM2
PhosphoSitePlusiQ6PCM2

Expressioni

Gene expression databases

BgeeiENSMUSG00000035161 Expressed in 32 organ(s), highest expression level in camera-type eye
CleanExiMM_INTS6

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.By similarity

Protein-protein interaction databases

BioGridi201810, 2 interactors
IntActiQ6PCM2, 1 interactor
MINTiQ6PCM2
STRINGi10090.ENSMUSP00000086788

Structurei

3D structure databases

ProteinModelPortaliQ6PCM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 227VWFAPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the Integrator subunit 6 family.Curated

Phylogenomic databases

eggNOGiKOG3768 Eukaryota
ENOG410XRER LUCA
GeneTreeiENSGT00390000016655
HOGENOMiHOG000015308
HOVERGENiHBG081468
InParanoidiQ6PCM2
KOiK13143
OMAiRQSFENY
OrthoDBiEOG091G03YA
PhylomeDBiQ6PCM2
TreeFamiTF323386

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029307 INT_SG_DDX_CT_C
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF15300 INT_SG_DDX_CT_C, 1 hit
PF13519 VWA_2, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6PCM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPILLFLIDT SASMNQRSHL GTTYLDTAKG AVETFMKLRA RDPASRGDRY
60 70 80 90 100
MLVTFEEPPY AIKAGWKENH ATFMNELKNL QAEGLTTLGQ SLRTAFDLLN
110 120 130 140 150
LNRLVTGIDN YGQGRNPFFL EPAIIITITD GSKLTTTSGV QDELHLPLNS
160 170 180 190 200
PLPGSELTKE PFRWDQRLFA LVLRLPGTMS VESEQLTGVP LDDSAITPMC
210 220 230 240 250
EVTGGRSYSV CSPRMLNQCL ESLVQKVQSG VVINFEKAGP DPPPAEEGQP
260 270 280 290 300
DISRPFGSQP WHSCHKLIYV RPNPKTGVPI GHWPVPESFW PDQNSPTLPP
310 320 330 340 350
RTSHPVVKFS CTDCEPMVID KLPFDKYELE PSPLTQFILE RKSPQTCWQV
360 370 380 390 400
YVSNSAKYNE LGHPFGYLKA STALTCVNLF VMPYNYPVLL PLLDDLFKVH
410 420 430 440 450
KAKPTLKWRQ SFESYLKTMP PYYLGPLKKA VRMMGAPNLI ADSMEYGLSY
460 470 480 490 500
SVISYLKKLS QQAKIESDRV IGSVGKKVVQ ETGIKVRSRS HGLSMAHRKG
510 520 530 540 550
FQVLQGISED VPHRLLDLNM KEYTGFQVAL LNKDLKPQTF RNAYDIPRRN
560 570 580 590 600
LLDHLTRMRS NLLKSTRKFL KGQDEDQVHS VPIAQMGNYQ EYLKQVPSPL
610 620 630 640 650
RELDPDQPRR LHTFGNPFKL DKKGMMIDEA DEFVAGPQNK HKRPGEPSMQ
660 670 680 690 700
GIPKRRRCAS PLLRGRRQSP AVNSHIGGKG PPAPMTQAQP GLIKPLPLHK
710 720 730 740 750
EATNDSIVDD VVENHVADQL SSDMTPNAMD TEFLTSPPNL LEPSTNHTEA
760 770 780 790 800
LGHEHLGNND LTVGGFLENH EEPRNKEQSA EENIPASSLN KGKKLMHCRS
810 820 830 840 850
HEEVNTELKA QIMKEIRKPG RKYERIFTLL KHVQGSLQTR LIFLQNVIKE
860 870 880
ASRFKKRMLI EQLENFLDEI HRRANQINHI NSN
Length:883
Mass (Da):99,661
Last modified:July 5, 2004 - v1
Checksum:iC6364701690B8B84
GO
Isoform 2 (identifier: Q6PCM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-246: E → EA
     691-700: Missing.

Show »
Length:874
Mass (Da):98,635
Checksum:iE416BF36975A235B
GO
Isoform 3 (identifier: Q6PCM2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-219: RSYSVCSPRMLNQC → KVFAKSNSGLKQFI
     220-883: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,194
Checksum:iC7085B5BB1CFE01F
GO

Sequence cautioni

The sequence AAB01338 differs from that shown. Chimera.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → G in BAE42868 (PubMed:16141072).Curated1
Sequence conflicti95A → G in BAE42868 (PubMed:16141072).Curated1
Sequence conflicti160E → G in BAE42868 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021459206 – 219RSYSV…MLNQC → KVFAKSNSGLKQFI in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_021460220 – 883Missing in isoform 3. 1 PublicationAdd BLAST664
Alternative sequenceiVSP_021461246E → EA in isoform 2. 2 Publications1
Alternative sequenceiVSP_021462691 – 700Missing in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046055 mRNA Translation: BAC32584.1
AK172178 mRNA Translation: BAE42868.1
BC058637 mRNA Translation: AAH58637.1
BC059263 mRNA Translation: AAH59263.1
U57368 mRNA Translation: AAB01338.1 Sequence problems.
CCDSiCCDS27191.1 [Q6PCM2-1]
PIRiT30176
RefSeqiNP_032741.2, NM_008715.2 [Q6PCM2-1]
XP_006518745.1, XM_006518682.3 [Q6PCM2-2]
XP_011243288.1, XM_011244986.2 [Q6PCM2-1]
XP_017171398.1, XM_017315909.1 [Q6PCM2-2]
UniGeneiMm.319684
Mm.441110

Genome annotation databases

EnsembliENSMUST00000053959; ENSMUSP00000086788; ENSMUSG00000035161 [Q6PCM2-1]
ENSMUST00000223585; ENSMUSP00000152954; ENSMUSG00000035161 [Q6PCM2-1]
GeneIDi18130
KEGGimmu:18130
UCSCiuc007ugp.2 mouse [Q6PCM2-1]
uc007ugr.1 mouse [Q6PCM2-2]
uc007ugu.1 mouse [Q6PCM2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046055 mRNA Translation: BAC32584.1
AK172178 mRNA Translation: BAE42868.1
BC058637 mRNA Translation: AAH58637.1
BC059263 mRNA Translation: AAH59263.1
U57368 mRNA Translation: AAB01338.1 Sequence problems.
CCDSiCCDS27191.1 [Q6PCM2-1]
PIRiT30176
RefSeqiNP_032741.2, NM_008715.2 [Q6PCM2-1]
XP_006518745.1, XM_006518682.3 [Q6PCM2-2]
XP_011243288.1, XM_011244986.2 [Q6PCM2-1]
XP_017171398.1, XM_017315909.1 [Q6PCM2-2]
UniGeneiMm.319684
Mm.441110

3D structure databases

ProteinModelPortaliQ6PCM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201810, 2 interactors
IntActiQ6PCM2, 1 interactor
MINTiQ6PCM2
STRINGi10090.ENSMUSP00000086788

PTM databases

iPTMnetiQ6PCM2
PhosphoSitePlusiQ6PCM2

Proteomic databases

PaxDbiQ6PCM2
PeptideAtlasiQ6PCM2
PRIDEiQ6PCM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053959; ENSMUSP00000086788; ENSMUSG00000035161 [Q6PCM2-1]
ENSMUST00000223585; ENSMUSP00000152954; ENSMUSG00000035161 [Q6PCM2-1]
GeneIDi18130
KEGGimmu:18130
UCSCiuc007ugp.2 mouse [Q6PCM2-1]
uc007ugr.1 mouse [Q6PCM2-2]
uc007ugu.1 mouse [Q6PCM2-3]

Organism-specific databases

CTDi26512
MGIiMGI:1202397 Ints6

Phylogenomic databases

eggNOGiKOG3768 Eukaryota
ENOG410XRER LUCA
GeneTreeiENSGT00390000016655
HOGENOMiHOG000015308
HOVERGENiHBG081468
InParanoidiQ6PCM2
KOiK13143
OMAiRQSFENY
OrthoDBiEOG091G03YA
PhylomeDBiQ6PCM2
TreeFamiTF323386

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

ChiTaRSiInts6 mouse
PROiPR:Q6PCM2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035161 Expressed in 32 organ(s), highest expression level in camera-type eye
CleanExiMM_INTS6

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029307 INT_SG_DDX_CT_C
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF15300 INT_SG_DDX_CT_C, 1 hit
PF13519 VWA_2, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT6_MOUSE
AccessioniPrimary (citable) accession number: Q6PCM2
Secondary accession number(s): Q3TA02
, Q61204, Q6PDL7, Q8BQZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again