Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q6PCJ1 (DCTN1_XENLA)

Entry version 89 (25 May 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Add a publicationFeedback
Protein

Dynactin subunit 1

Gene

dctn1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynactin subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dctn1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1L

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-5933563, dctn1.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000835221 – 1232Dynactin subunit 1Add BLAST1232

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q6PCJ1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to microtubules and to cytoplasmic dynein. Binds preferentially to tyrosinated microtubules than to detyrosinated microtubules.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q6PCJ1, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6PCJ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6PCJ1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 73CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni82 – 183DisorderedSequence analysisAdd BLAST102
Regioni339 – 358DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili170 – 505Sequence analysisAdd BLAST336
Coiled coili908 – 1005Sequence analysisAdd BLAST98
Coiled coili1046 – 1071Sequence analysisAdd BLAST26
Coiled coili1136 – 1166Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 144Polar residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynactin 150 kDa subunit family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		ADKNMRY

Database of Orthologous Groups

More...OrthoDBi		1550378at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036859, CAP-Gly_dom_sf
IPR000938, CAP-Gly_domain
IPR022157, Dynactin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01302, CAP_GLY, 1 hit
PF12455, Dynactin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01052, CAP_GLY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74924, SSF74924, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00845, CAP_GLY_1, 1 hit
PS50245, CAP_GLY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PCJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVEATGKPL KVGSRVEVIG KGYRGTVAYV GATLFATGKW VGVILDDSKG 
        60         70         80         90        100
KNDGTVQGRR YFTCEENHGI FVRQSQIQVI EDGADTTSPE TPEPTASKGL 
       110        120        130        140        150
KKDVMETPKS SKLPTRPSSS AASSGTASAS CGEISSSEPS TPAQTPLAAP 
       160        170        180        190        200
IIPSPSSAIT SPVAPLPGPG PSKEEENLRA QVKDLEEKLE TLKMKRAEDK 
       210        220        230        240        250
AKLKEMEKSK LQLEQVQEWK SKMQEQQADI QRQLKEAKKE AKEALEAKER 
       260        270        280        290        300
YMEEMADTAD AIEMATLDKE MAEERAESLQ QEVDTLKDKV EEHKIDLEIL 
       310        320        330        340        350
KHEIEEKGSD GAASSYQVKQ LEEQNARLKE ALVRMRDLSA SEKQEHIKVQ 
       360        370        380        390        400
KQMEKKNTEL DTLRQQKEKL QEEASHMEKT IDELKEQVDA ALGAEEMVET 
       410        420        430        440        450
LAERNLDLEE KVRELRETVS DLEAINEMND ELQENARETE LELREQLDMA 
       460        470        480        490        500
GARVREAEKR VEAAQETVAD YQQTIKKYRD LTAHLQEVNS ELRNQQEASV 
       510        520        530        540        550
EKEQQPSPEM FDFKIKFAET KAHAKAIEME LRKMEVTQAN RHVSLLTSFM 
       560        570        580        590        600
PDSFLRHGGD HDCILVLLLI PRLICKAELI SKQAQEKFEL SEVGEQKSGM 
       610        620        630        640        650
RGAVGEQMSF AAGLVYSLTL LQATLHKYEQ ALDKCSVEVY KKVGMLYPEM 
       660        670        680        690        700
SVHERSLDFL IELLHKDQLD ETVNVEPLTK AIKYYQHLYS IHLADQAEEC 
       710        720        730        740        750
TMQLSDHIKF TQSALDCMGV EVSRLRAFLH AGQESSDFAI LLKDLETSCS 
       760        770        780        790        800
DIRQFCKKIR RRMPGTEAAG IPAALGFGQQ VCETLLDCRK YLKCVVAVFQ 
       810        820        830        840        850
EVAAAGAQMI APMGENEGLQ ALKLEDVAFK ATEQIYGTKG SNPYECLRQS 
       860        870        880        890        900
CSVVIATMNK MATAMQEGEY DAEKPQSKSP PPVEQRAAAL RAEITDAEGL 
       910        920        930        940        950
GLKLEDRETV IKELKKSLKI KGEELSEANV RLSLLEKKLD SASKEADDRV 
       960        970        980        990       1000
EKIQTKLEET QTVLKKKEKE FEETMDALQA DIDQLESEKA ELRQRLNNQS 
      1010       1020       1030       1040       1050
KRTIEGLRGV PASGVASIVS GLAGGVSSGQ SLINGSGPVQ VKDSPLLLQQ 
      1060       1070       1080       1090       1100
IDALRLSMKH LKHENNKLKA HQIKTDLSSL PALHVPKLTL PKDRQKEEAM 
      1110       1120       1130       1140       1150
SGTLYRKTSQ LLDALQQMSA NAKVVDITHK KAGNPAAQLL EQTARLKSLS 
      1160       1170       1180       1190       1200
DTIDKLKNEV MKETVSQCPG ANVPTDFATF PSTDFIKAKE EKKEDTVYIG 
      1210       1220       1230 
KVTLSCQPGQ GQIHKLVLTP EQLHELHERL IC
Length:1,232
Mass (Da):137,285
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED5FC8DA07C93018
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC059305 mRNA Translation: AAH59305.1

NCBI Reference Sequences

More...RefSeqi		NP_001080006.1, NM_001086537.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		379696

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:379696

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059305 mRNA Translation: AAH59305.1
RefSeqiNP_001080006.1, NM_001086537.1

3D structure databases

AlphaFoldDBiQ6PCJ1
SMRiQ6PCJ1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6PCJ1, 3 interactors

Proteomic databases

PRIDEiQ6PCJ1

Genome annotation databases

GeneIDi379696
KEGGixla:379696

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		379696
XenbaseiXB-GENE-5933563, dctn1.L

Phylogenomic databases

OMAiADKNMRY
OrthoDBi1550378at2759

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859, CAP-Gly_dom_sf
IPR000938, CAP-Gly_domain
IPR022157, Dynactin
PfamiView protein in Pfam
PF01302, CAP_GLY, 1 hit
PF12455, Dynactin, 1 hit
SMARTiView protein in SMART
SM01052, CAP_GLY, 1 hit
SUPFAMiSSF74924, SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845, CAP_GLY_1, 1 hit
PS50245, CAP_GLY_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCTN1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PCJ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again