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Protein

Glucose 1,6-bisphosphate synthase

Gene

PGM2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5-bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities.2 Publications

Catalytic activityi

3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69SubstrateBy similarity1
Binding sitei73SubstrateBy similarity1
Active sitei175Phosphoserine intermediateBy similarity1
Metal bindingi175Magnesium; via phosphate groupBy similarity1
Metal bindingi332MagnesiumBy similarity1
Metal bindingi334MagnesiumBy similarity1
Metal bindingi336MagnesiumBy similarity1
Binding sitei448SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Transferase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-3322077 Glycogen synthesis
R-HSA-70171 Glycolysis
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-70370 Galactose catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose 1,6-bisphosphate synthase (EC:2.7.1.106)
Alternative name(s):
PMMLP
Phosphoglucomutase-2-like 1
Gene namesi
Name:PGM2L1
Synonyms:BM32A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000165434.7
HGNCiHGNC:20898 PGM2L1
MIMi611610 gene
neXtProtiNX_Q6PCE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165434
PharmGKBiPA134938366

Polymorphism and mutation databases

BioMutaiPGM2L1
DMDMi317373530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477841 – 622Glucose 1,6-bisphosphate synthaseAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PCE3
MaxQBiQ6PCE3
PaxDbiQ6PCE3
PeptideAtlasiQ6PCE3
PRIDEiQ6PCE3
ProteomicsDBi67064

PTM databases

iPTMnetiQ6PCE3
PhosphoSitePlusiQ6PCE3

Expressioni

Gene expression databases

BgeeiENSG00000165434 Expressed in 196 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_PGM2L1
GenevisibleiQ6PCE3 HS

Organism-specific databases

HPAiHPA056995
HPA060948

Interactioni

Protein-protein interaction databases

BioGridi129496, 9 interactors
IntActiQ6PCE3, 4 interactors
STRINGi9606.ENSP00000298198

Structurei

3D structure databases

ProteinModelPortaliQ6PCE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 176Substrate bindingBy similarity2
Regioni336 – 337Substrate bindingBy similarity2
Regioni434 – 436Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG1220 Eukaryota
COG1109 LUCA
GeneTreeiENSGT00390000017247
HOGENOMiHOG000268676
HOVERGENiHBG056917
InParanoidiQ6PCE3
KOiK11809
OMAiHWKVFTG
OrthoDBiEOG091G040C
PhylomeDBiQ6PCE3
TreeFamiTF300692

Family and domain databases

InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PCE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENTEGDLN SNLLHAPYHT GDPQLDTAIG QWLRWDKNPK TKEQIENLLR
60 70 80 90 100
NGMNKELRDR LCCRMTFGTA GLRSAMGAGF CYINDLTVIQ STQGMYKYLE
110 120 130 140 150
RCFSDFKQRG FVVGYDTRGQ VTSSCSSQRL AKLTAAVLLA KDVPVYLFSR
160 170 180 190 200
YVPTPFVPYA VQKLKAVAGV MITASHNRKE DNGYKVYWET GAQITSPHDK
210 220 230 240 250
EILKCIEECV EPWNGSWNDN LVDTSPLKRD PLQDICRRYM EDLKKICFYR
260 270 280 290 300
ELNSKTTLKF VHTSFHGVGH DYVQLAFKVF GFKPPIPVPE QKDPDPDFST
310 320 330 340 350
VKCPNPEEGE SVLELSLRLA EKENARVVLA TDPDADRLAA AELQENGCWK
360 370 380 390 400
VFTGNELAAL FGWWMFDCWK KNKSRNADVK NVYMLATTVS SKILKAIALK
410 420 430 440 450
EGFHFEETLP GFKWIGSRII DLLENGKEVL FAFEESIGFL CGTSVLDKDG
460 470 480 490 500
VSAAVVVAEM ASYLETMNIT LKQQLVKVYE KYGYHISKTS YFLCYEPPTI
510 520 530 540 550
KSIFERLRNF DSPKEYPKFC GTFAILHVRD VTTGYDSSQP NKKSVLPVSK
560 570 580 590 600
NSQMITFTFQ NGCVATLRTS GTEPKIKYYA EMCASPDQSD TALLEEELKK
610 620
LIDALIENFL QPSKNGLIWR SV
Length:622
Mass (Da):70,442
Last modified:January 11, 2011 - v3
Checksum:i8AE00403B5D973CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69T → A in BAB71227 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02809414L → P1 PublicationCorresponds to variant dbSNP:rs12049823Ensembl.1
Natural variantiVAR_028095531V → I2 PublicationsCorresponds to variant dbSNP:rs592644Ensembl.1
Natural variantiVAR_056665608N → I. Corresponds to variant dbSNP:rs36014178Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019210 mRNA Translation: BAA82756.1
AK056591 mRNA Translation: BAB71227.1
AP001085 Genomic DNA No translation available.
BC059360 mRNA Translation: AAH59360.1
CCDSiCCDS8231.1
RefSeqiNP_775853.2, NM_173582.4
UniGeneiHs.26612

Genome annotation databases

EnsembliENST00000298198; ENSP00000298198; ENSG00000165434
GeneIDi283209
KEGGihsa:283209
UCSCiuc001ovb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019210 mRNA Translation: BAA82756.1
AK056591 mRNA Translation: BAB71227.1
AP001085 Genomic DNA No translation available.
BC059360 mRNA Translation: AAH59360.1
CCDSiCCDS8231.1
RefSeqiNP_775853.2, NM_173582.4
UniGeneiHs.26612

3D structure databases

ProteinModelPortaliQ6PCE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129496, 9 interactors
IntActiQ6PCE3, 4 interactors
STRINGi9606.ENSP00000298198

PTM databases

iPTMnetiQ6PCE3
PhosphoSitePlusiQ6PCE3

Polymorphism and mutation databases

BioMutaiPGM2L1
DMDMi317373530

Proteomic databases

EPDiQ6PCE3
MaxQBiQ6PCE3
PaxDbiQ6PCE3
PeptideAtlasiQ6PCE3
PRIDEiQ6PCE3
ProteomicsDBi67064

Protocols and materials databases

DNASUi283209
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298198; ENSP00000298198; ENSG00000165434
GeneIDi283209
KEGGihsa:283209
UCSCiuc001ovb.2 human

Organism-specific databases

CTDi283209
EuPathDBiHostDB:ENSG00000165434.7
GeneCardsiPGM2L1
HGNCiHGNC:20898 PGM2L1
HPAiHPA056995
HPA060948
MIMi611610 gene
neXtProtiNX_Q6PCE3
OpenTargetsiENSG00000165434
PharmGKBiPA134938366
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1220 Eukaryota
COG1109 LUCA
GeneTreeiENSGT00390000017247
HOGENOMiHOG000268676
HOVERGENiHBG056917
InParanoidiQ6PCE3
KOiK11809
OMAiHWKVFTG
OrthoDBiEOG091G040C
PhylomeDBiQ6PCE3
TreeFamiTF300692

Enzyme and pathway databases

ReactomeiR-HSA-3322077 Glycogen synthesis
R-HSA-70171 Glycolysis
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-70370 Galactose catabolism

Miscellaneous databases

ChiTaRSiPGM2L1 human
GenomeRNAii283209
PROiPR:Q6PCE3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165434 Expressed in 196 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_PGM2L1
GenevisibleiQ6PCE3 HS

Family and domain databases

InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGM2L_HUMAN
AccessioniPrimary (citable) accession number: Q6PCE3
Secondary accession number(s): Q96MQ7, Q9UIK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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