UniProtKB - Q6PCB8 (EMB_HUMAN)
Protein
Embigin
Gene
EMB
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).By similarity
GO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- dendrite self-avoidance Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
- plasma membrane lactate transport Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q6PCB8 |
Reactomei | R-HSA-433692, Proton-coupled monocarboxylate transport |
Protein family/group databases
TCDBi | 8.A.23.1.2, the basigin (basigin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Embigin |
Gene namesi | Name:EMB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30465, EMB |
MIMi | 615669, gene |
neXtProti | NX_Q6PCB8 |
VEuPathDBi | HostDB:ENSG00000170571.11 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- synapse By similarity
Note: Localizes to the neuromuscular junctions.By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 260 | ExtracellularSequence analysisAdd BLAST | 228 | |
Transmembranei | 261 – 281 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 282 – 327 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 133418 |
OpenTargetsi | ENSG00000170571 |
PharmGKBi | PA134917460 |
Miscellaneous databases
Pharosi | Q6PCB8, Tbio |
Genetic variation databases
BioMutai | EMB |
DMDMi | 83286878 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000014749 | 33 – 327 | EmbiginAdd BLAST | 295 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 88 ↔ 142 | PROSITE-ProRule annotation | ||
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 180 ↔ 237 | PROSITE-ProRule annotation | ||
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 213 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 218 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 309 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q6PCB8 |
jPOSTi | Q6PCB8 |
MassIVEi | Q6PCB8 |
MaxQBi | Q6PCB8 |
PaxDbi | Q6PCB8 |
PeptideAtlasi | Q6PCB8 |
PRIDEi | Q6PCB8 |
ProteomicsDBi | 67061 [Q6PCB8-1] 6995 |
PTM databases
GlyGeni | Q6PCB8, 9 sites |
iPTMneti | Q6PCB8 |
PhosphoSitePlusi | Q6PCB8 |
SwissPalmi | Q6PCB8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170571, Expressed in bone marrow and 124 other tissues |
ExpressionAtlasi | Q6PCB8, baseline and differential |
Genevisiblei | Q6PCB8, HS |
Organism-specific databases
HPAi | ENSG00000170571, Tissue enhanced (bone marrow, intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with SLC16A1 and SLC16A7.
By similarityGO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 126358, 19 interactors |
IntActi | Q6PCB8, 12 interactors |
STRINGi | 9606.ENSP00000302289 |
Miscellaneous databases
RNActi | Q6PCB8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 71 – 158 | Ig-like V-type 1Add BLAST | 88 | |
Domaini | 159 – 253 | Ig-like V-type 2Add BLAST | 95 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYF2, Eukaryota |
GeneTreei | ENSGT00940000158944 |
HOGENOMi | CLU_065379_0_0_1 |
InParanoidi | Q6PCB8 |
OMAi | LCEVYTQ |
OrthoDBi | 1101147at2759 |
PhylomeDBi | Q6PCB8 |
TreeFami | TF326759 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR027114, Embigin IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR013151, Immunoglobulin |
PANTHERi | PTHR10075, PTHR10075, 1 hit PTHR10075:SF4, PTHR10075:SF4, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6PCB8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRALPGLLEA RARTPRLLLL QCLLAAARPS SADGSAPDSP FTSPPLREEI
60 70 80 90 100
MANNFSLESH NISLTEHSSM PVEKNITLER PSNVNLTCQF TTSGDLNAVN
110 120 130 140 150
VTWKKDGEQL ENNYLVSATG STLYTQYRFT IINSKQMGSY SCFFREEKEQ
160 170 180 190 200
RGTFNFKVPE LHGKNKPLIS YVGDSTVLTC KCQNCFPLNW TWYSSNGSVK
210 220 230 240 250
VPVGVQMNKY VINGTYANET KLKITQLLEE DGESYWCRAL FQLGESEEHI
260 270 280 290 300
ELVVLSYLVP LKPFLVIVAE VILLVATILL CEKYTQKKKK HSDEGKEFEQ
310 320
IEQLKSDDSN GIENNVPRHR KNESLGQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RDX7 | D6RDX7_HUMAN | Embigin | EMB | 273 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055593 | 1 – 50 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK300860 mRNA Translation: BAH13359.1 AK304226 mRNA Translation: BAH14138.1 AC035145 Genomic DNA No translation available. AC091833 Genomic DNA No translation available. CH471123 Genomic DNA Translation: EAW54853.1 CH471123 Genomic DNA Translation: EAW54854.1 BC059398 mRNA Translation: AAH59398.1 |
CCDSi | CCDS3953.1 [Q6PCB8-1] |
RefSeqi | NP_940851.1, NM_198449.2 [Q6PCB8-1] XP_011541448.1, XM_011543146.2 [Q6PCB8-2] |
Genome annotation databases
Ensembli | ENST00000303221; ENSP00000302289; ENSG00000170571 [Q6PCB8-1] ENST00000514111; ENSP00000426404; ENSG00000170571 [Q6PCB8-2] |
GeneIDi | 133418 |
KEGGi | hsa:133418 |
UCSCi | uc003jom.4, human [Q6PCB8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK300860 mRNA Translation: BAH13359.1 AK304226 mRNA Translation: BAH14138.1 AC035145 Genomic DNA No translation available. AC091833 Genomic DNA No translation available. CH471123 Genomic DNA Translation: EAW54853.1 CH471123 Genomic DNA Translation: EAW54854.1 BC059398 mRNA Translation: AAH59398.1 |
CCDSi | CCDS3953.1 [Q6PCB8-1] |
RefSeqi | NP_940851.1, NM_198449.2 [Q6PCB8-1] XP_011541448.1, XM_011543146.2 [Q6PCB8-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126358, 19 interactors |
IntActi | Q6PCB8, 12 interactors |
STRINGi | 9606.ENSP00000302289 |
Protein family/group databases
TCDBi | 8.A.23.1.2, the basigin (basigin) family |
PTM databases
GlyGeni | Q6PCB8, 9 sites |
iPTMneti | Q6PCB8 |
PhosphoSitePlusi | Q6PCB8 |
SwissPalmi | Q6PCB8 |
Genetic variation databases
BioMutai | EMB |
DMDMi | 83286878 |
Proteomic databases
EPDi | Q6PCB8 |
jPOSTi | Q6PCB8 |
MassIVEi | Q6PCB8 |
MaxQBi | Q6PCB8 |
PaxDbi | Q6PCB8 |
PeptideAtlasi | Q6PCB8 |
PRIDEi | Q6PCB8 |
ProteomicsDBi | 67061 [Q6PCB8-1] 6995 |
Protocols and materials databases
Antibodypediai | 2626, 178 antibodies |
DNASUi | 133418 |
Genome annotation databases
Ensembli | ENST00000303221; ENSP00000302289; ENSG00000170571 [Q6PCB8-1] ENST00000514111; ENSP00000426404; ENSG00000170571 [Q6PCB8-2] |
GeneIDi | 133418 |
KEGGi | hsa:133418 |
UCSCi | uc003jom.4, human [Q6PCB8-1] |
Organism-specific databases
CTDi | 133418 |
DisGeNETi | 133418 |
GeneCardsi | EMB |
HGNCi | HGNC:30465, EMB |
HPAi | ENSG00000170571, Tissue enhanced (bone marrow, intestine, lymphoid tissue) |
MIMi | 615669, gene |
neXtProti | NX_Q6PCB8 |
OpenTargetsi | ENSG00000170571 |
PharmGKBi | PA134917460 |
VEuPathDBi | HostDB:ENSG00000170571.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYF2, Eukaryota |
GeneTreei | ENSGT00940000158944 |
HOGENOMi | CLU_065379_0_0_1 |
InParanoidi | Q6PCB8 |
OMAi | LCEVYTQ |
OrthoDBi | 1101147at2759 |
PhylomeDBi | Q6PCB8 |
TreeFami | TF326759 |
Enzyme and pathway databases
PathwayCommonsi | Q6PCB8 |
Reactomei | R-HSA-433692, Proton-coupled monocarboxylate transport |
Miscellaneous databases
BioGRID-ORCSi | 133418, 5 hits in 846 CRISPR screens |
ChiTaRSi | EMB, human |
GenomeRNAii | 133418 |
Pharosi | Q6PCB8, Tbio |
PROi | PR:Q6PCB8 |
RNActi | Q6PCB8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170571, Expressed in bone marrow and 124 other tissues |
ExpressionAtlasi | Q6PCB8, baseline and differential |
Genevisiblei | Q6PCB8, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR027114, Embigin IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR013151, Immunoglobulin |
PANTHERi | PTHR10075, PTHR10075, 1 hit PTHR10075:SF4, PTHR10075:SF4, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EMB_HUMAN | |
Accessioni | Q6PCB8Primary (citable) accession number: Q6PCB8 Secondary accession number(s): B7Z6S3, B7Z902 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM