UniProtKB - Q6PCB7 (S27A1_HUMAN)
Long-chain fatty acid transport protein 1
SLC27A1
Functioni
Catalytic activityi
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the backward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphateBy similarityEC:6.2.1.15By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 246 – 257 | AMPBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- arachidonate-CoA ligase activity Source: UniProtKB-EC
- biotin transmembrane transporter activity Source: ARUK-UCL
- efflux transmembrane transporter activity Source: ARUK-UCL
- fatty acid transmembrane transporter activity Source: GO_Central
- long-chain fatty acid-CoA ligase activity Source: UniProtKB
- long-chain fatty acid transporter activity Source: ARUK-UCL
- nucleotide binding Source: UniProtKB-KW
- very long-chain fatty acid-CoA ligase activity Source: Ensembl
GO - Biological processi
- adiponectin-activated signaling pathway Source: GO_Central
- biotin import across plasma membrane Source: ARUK-UCL
- biotin transport Source: ARUK-UCL
- cardiolipin biosynthetic process Source: UniProtKB
- export across plasma membrane Source: ARUK-UCL
- lipid transport across blood-brain barrier Source: ARUK-UCL
- long-chain fatty acid import across plasma membrane Source: ARUK-UCL
- long-chain fatty acid import into cell Source: UniProtKB
- long-chain fatty acid transport Source: ARUK-UCL
- medium-chain fatty acid transport Source: GO_Central
- negative regulation of phospholipid biosynthetic process Source: UniProtKB
- phosphatidic acid biosynthetic process Source: UniProtKB
- phosphatidylcholine biosynthetic process Source: UniProtKB
- phosphatidylethanolamine biosynthetic process Source: UniProtKB
- phosphatidylglycerol biosynthetic process Source: UniProtKB
- phosphatidylinositol biosynthetic process Source: UniProtKB
- phosphatidylserine biosynthetic process Source: UniProtKB
- positive regulation of heat generation Source: GO_Central
- positive regulation of protein serine/threonine kinase activity Source: GO_Central
- positive regulation of triglyceride biosynthetic process Source: UniProtKB
- regulation of lipid metabolic process Source: Reactome
- response to cold Source: GO_Central
- response to insulin Source: GO_Central
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport |
Ligand | Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6PCB7 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-804914, Transport of fatty acids |
Protein family/group databases
TCDBi | 4.C.1.1.9, the fatty acid transporter (fat) family |
Chemistry databases
SwissLipidsi | SLP:000000427 |
Names & Taxonomyi
Protein namesi | Recommended name: Long-chain fatty acid transport protein 1Curated (EC:6.2.1.15By similarity)Short name: FATP-11 Publication Short name: Fatty acid transport protein 11 Publication Alternative name(s): Solute carrier family 27 member 1Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130304.16 |
HGNCi | HGNC:10995, SLC27A1 |
MIMi | 600691, gene |
neXtProti | NX_Q6PCB7 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass membrane protein By similarity
Other locations
- Endomembrane system By similarity; Single-pass membrane protein By similarity
- Cytoplasm By similarity
Note: Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Mitochondrion
- mitochondrion Source: GO_Central
Plasma Membrane
- basal plasma membrane Source: ARUK-UCL
- integral component of plasma membrane Source: Ensembl
- plasma membrane Source: ARUK-UCL
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 13 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 35 – 646 | CytoplasmicBy similarityAdd BLAST | 612 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 376497 |
OpenTargetsi | ENSG00000130304 |
PharmGKBi | PA35869 |
Miscellaneous databases
Pharosi | Q6PCB7, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2052038 |
GuidetoPHARMACOLOGYi | 1108 |
Polymorphism and mutation databases
BioMutai | SLC27A1 |
DMDMi | 74749156 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193201 | 1 – 646 | Long-chain fatty acid transport protein 1Add BLAST | 646 |
Proteomic databases
EPDi | Q6PCB7 |
jPOSTi | Q6PCB7 |
MassIVEi | Q6PCB7 |
MaxQBi | Q6PCB7 |
PaxDbi | Q6PCB7 |
PeptideAtlasi | Q6PCB7 |
PRIDEi | Q6PCB7 |
ProteomicsDBi | 67060 [Q6PCB7-1] |
PTM databases
iPTMneti | Q6PCB7 |
PhosphoSitePlusi | Q6PCB7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130304, Expressed in heart left ventricle and 192 other tissues |
ExpressionAtlasi | Q6PCB7, baseline and differential |
Genevisiblei | Q6PCB7, HS |
Organism-specific databases
HPAi | ENSG00000130304, Low tissue specificity |
Interactioni
Subunit structurei
Self-associates. May function as a homodimer (By similarity).
Interacts with EPRS1; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids (PubMed:28178239).
Interacts with DGAT2 and this interaction is enhanced in the presence of ZFYVE1 (PubMed:28178239).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 132009, 2 interactors |
IntActi | Q6PCB7, 1 interactor |
MINTi | Q6PCB7 |
STRINGi | 9606.ENSP00000252595 |
Chemistry databases
BindingDBi | Q6PCB7 |
Miscellaneous databases
RNActi | Q6PCB7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 191 – 475 | Sufficient for oligomerizationBy similarityAdd BLAST | 285 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1179, Eukaryota |
GeneTreei | ENSGT00940000159323 |
HOGENOMi | CLU_000022_46_2_1 |
InParanoidi | Q6PCB7 |
OMAi | PNAIYQE |
OrthoDBi | 312083at2759 |
PhylomeDBi | Q6PCB7 |
TreeFami | TF313430 |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR030308, FATP1 |
PANTHERi | PTHR43107:SF7, PTHR43107:SF7, 1 hit |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT
60 70 80 90 100
ARRDLFGLSV LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT
110 120 130 140 150
GECWTFAQLD AYSNAVANLF RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK
160 170 180 190 200
AGMEAALLNV NLRREPLAFC LGTSGAKALI FGGEMVAAVA EVSGHLGKSL
210 220 230 240 250
IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM DDRLFYIYTS
260 270 280 290 300
GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG
310 320 330 340 350
VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR
360 370 380 390 400
EAERRHRVRL AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD
410 420 430 440 450
GKVGSCGFNS RILPHVYPIR LVKVNEDTME LLRDAQGLCI PCQAGEPGLL
460 470 480 490 500
VGQINQQDPL RRFDGYVSES ATSKKIAHSV FSKGDSAYLS GDVLVMDELG
510 520 530 540 550
YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY GVAVPGVEGK
560 570 580 590 600
AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ
610 620 630 640
KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QXY2 | M0QXY2_HUMAN | Long-chain fatty acid transport pro... | SLC27A1 | 96 | Annotation score: | ||
B7Z225 | B7Z225_HUMAN | Long-chain fatty acid transport pro... | SLC27A1 | 224 | Annotation score: | ||
M0QZC9 | M0QZC9_HUMAN | Long-chain fatty acid transport pro... | SLC27A1 | 166 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055806 | 1 – 8 | MRAPGAGA → MTHVLGTT in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_055807 | 9 – 187 | Missing in isoform 2. 1 PublicationAdd BLAST | 179 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299852 mRNA Translation: BAH13148.1 AC010319 Genomic DNA No translation available. AC010618 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84611.1 BC059399 mRNA Translation: AAH59399.1 |
CCDSi | CCDS32953.1 [Q6PCB7-1] |
RefSeqi | NP_940982.1, NM_198580.2 [Q6PCB7-1] XP_011526305.1, XM_011528003.2 [Q6PCB7-1] |
Genome annotation databases
Ensembli | ENST00000252595; ENSP00000252595; ENSG00000130304 [Q6PCB7-1] ENST00000598424; ENSP00000472313; ENSG00000130304 [Q6PCB7-2] |
GeneIDi | 376497 |
KEGGi | hsa:376497 |
UCSCi | uc002ngu.2, human [Q6PCB7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299852 mRNA Translation: BAH13148.1 AC010319 Genomic DNA No translation available. AC010618 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84611.1 BC059399 mRNA Translation: AAH59399.1 |
CCDSi | CCDS32953.1 [Q6PCB7-1] |
RefSeqi | NP_940982.1, NM_198580.2 [Q6PCB7-1] XP_011526305.1, XM_011528003.2 [Q6PCB7-1] |
3D structure databases
SMRi | Q6PCB7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132009, 2 interactors |
IntActi | Q6PCB7, 1 interactor |
MINTi | Q6PCB7 |
STRINGi | 9606.ENSP00000252595 |
Chemistry databases
BindingDBi | Q6PCB7 |
ChEMBLi | CHEMBL2052038 |
GuidetoPHARMACOLOGYi | 1108 |
SwissLipidsi | SLP:000000427 |
Protein family/group databases
TCDBi | 4.C.1.1.9, the fatty acid transporter (fat) family |
PTM databases
iPTMneti | Q6PCB7 |
PhosphoSitePlusi | Q6PCB7 |
Polymorphism and mutation databases
BioMutai | SLC27A1 |
DMDMi | 74749156 |
Proteomic databases
EPDi | Q6PCB7 |
jPOSTi | Q6PCB7 |
MassIVEi | Q6PCB7 |
MaxQBi | Q6PCB7 |
PaxDbi | Q6PCB7 |
PeptideAtlasi | Q6PCB7 |
PRIDEi | Q6PCB7 |
ProteomicsDBi | 67060 [Q6PCB7-1] |
Protocols and materials databases
Antibodypediai | 1644, 155 antibodies |
Genome annotation databases
Ensembli | ENST00000252595; ENSP00000252595; ENSG00000130304 [Q6PCB7-1] ENST00000598424; ENSP00000472313; ENSG00000130304 [Q6PCB7-2] |
GeneIDi | 376497 |
KEGGi | hsa:376497 |
UCSCi | uc002ngu.2, human [Q6PCB7-1] |
Organism-specific databases
CTDi | 376497 |
DisGeNETi | 376497 |
EuPathDBi | HostDB:ENSG00000130304.16 |
GeneCardsi | SLC27A1 |
HGNCi | HGNC:10995, SLC27A1 |
HPAi | ENSG00000130304, Low tissue specificity |
MIMi | 600691, gene |
neXtProti | NX_Q6PCB7 |
OpenTargetsi | ENSG00000130304 |
PharmGKBi | PA35869 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1179, Eukaryota |
GeneTreei | ENSGT00940000159323 |
HOGENOMi | CLU_000022_46_2_1 |
InParanoidi | Q6PCB7 |
OMAi | PNAIYQE |
OrthoDBi | 312083at2759 |
PhylomeDBi | Q6PCB7 |
TreeFami | TF313430 |
Enzyme and pathway databases
PathwayCommonsi | Q6PCB7 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-804914, Transport of fatty acids |
Miscellaneous databases
BioGRID-ORCSi | 376497, 9 hits in 845 CRISPR screens |
ChiTaRSi | SLC27A1, human |
GeneWikii | SLC27A1 |
GenomeRNAii | 376497 |
Pharosi | Q6PCB7, Tchem |
PROi | PR:Q6PCB7 |
RNActi | Q6PCB7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130304, Expressed in heart left ventricle and 192 other tissues |
ExpressionAtlasi | Q6PCB7, baseline and differential |
Genevisiblei | Q6PCB7, HS |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR030308, FATP1 |
PANTHERi | PTHR43107:SF7, PTHR43107:SF7, 1 hit |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S27A1_HUMAN | |
Accessioni | Q6PCB7Primary (citable) accession number: Q6PCB7 Secondary accession number(s): A6NIH2, B7Z662 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM