UniProtKB - Q6PCB6 (AB17C_HUMAN)
Protein
Alpha/beta hydrolase domain-containing protein 17C
Gene
ABHD17C
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95.1 Publication
Catalytic activityi
- H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein]1 PublicationEC:3.1.2.221 Publication
Activity regulationi
Inhibited by palmostatin-B.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 211 | Charge relay systemBy similarity | 1 | |
Active sitei | 276 | Charge relay systemBy similarity | 1 | |
Active sitei | 305 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- palmitoyl-(protein) hydrolase activity Source: UniProtKB
GO - Biological processi
- negative regulation of protein localization to microtubule Source: Ensembl
- positive regulation of protein localization to endosome Source: Ensembl
- protein depalmitoylation Source: GO_Central
- protein palmitoylation Source: UniProtKB
- regulation of postsynapse organization Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q6PCB6 |
Reactomei | R-HSA-9648002, RAS processing |
Protein family/group databases
ESTHERi | human-ABHD17C, ABHD17-depalmitoylase |
MEROPSi | S09.053 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha/beta hydrolase domain-containing protein 17CCurated (EC:3.1.2.221 Publication)Short name: Abhydrolase domain-containing protein 17CImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000136379.11 |
HGNCi | HGNC:26925, ABHD17C |
MIMi | 617944, gene |
neXtProti | NX_Q6PCB6 |
Subcellular locationi
Endosome
- Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Plasma membrane
- postsynaptic density membrane By similarity
Other locations
- dendritic spine By similarity
Endosome
- endosome membrane Source: GO_Central
- recycling endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic density membrane Source: UniProtKB-SubCell
Other locations
- dendritic spine Source: UniProtKB-SubCell
- glutamatergic synapse Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Endosome, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 58489 |
OpenTargetsi | ENSG00000136379 |
PharmGKBi | PA162385639 |
Miscellaneous databases
Pharosi | Q6PCB6, Tbio |
Polymorphism and mutation databases
BioMutai | ABHD17C |
DMDMi | 156630444 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297513 | 1 – 329 | Alpha/beta hydrolase domain-containing protein 17CAdd BLAST | 329 |
Post-translational modificationi
Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.By similarity
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
EPDi | Q6PCB6 |
jPOSTi | Q6PCB6 |
MassIVEi | Q6PCB6 |
MaxQBi | Q6PCB6 |
PaxDbi | Q6PCB6 |
PeptideAtlasi | Q6PCB6 |
PRIDEi | Q6PCB6 |
ProteomicsDBi | 67058 [Q6PCB6-1] 67059 [Q6PCB6-2] |
PTM databases
iPTMneti | Q6PCB6 |
PhosphoSitePlusi | Q6PCB6 |
SwissPalmi | Q6PCB6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136379, Expressed in colon and 174 other tissues |
ExpressionAtlasi | Q6PCB6, baseline and differential |
Genevisiblei | Q6PCB6, HS |
Organism-specific databases
HPAi | ENSG00000136379, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121819, 2 interactors |
IntActi | Q6PCB6, 1 interactor |
STRINGi | 9606.ENSP00000258884 |
Miscellaneous databases
RNActi | Q6PCB6, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 52 – 86 | Ala-richAdd BLAST | 35 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1552, Eukaryota |
GeneTreei | ENSGT00940000159424 |
HOGENOMi | CLU_029375_5_4_1 |
InParanoidi | Q6PCB6 |
OMAi | FISFELP |
OrthoDBi | 629316at2759 |
PhylomeDBi | Q6PCB6 |
TreeFami | TF314365 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR022742, Hydrolase_4 |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6PCB6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR
60 70 80 90 100
GAGASAPAPA QATAAAAAAQ PAPQQPEEGA GAGPGACSLH LSERADWQYS
110 120 130 140 150
QRELDAVEVF FSRTARDNRL GCMFVRCAPS SRYTLLFSHG NAVDLGQMCS
160 170 180 190 200
FYIGLGSRIN CNIFSYDYSG YGVSSGKPSE KNLYADIDAA WQALRTRYGV
210 220 230 240 250
SPENIILYGQ SIGTVPTVDL ASRYECAAVI LHSPLMSGLR VAFPDTRKTY
260 270 280 290 300
CFDAFPSIDK ISKVTSPVLV IHGTEDEVID FSHGLAMYER CPRAVEPLWV
310 320
EGAGHNDIEL YAQYLERLKQ FISHELPNS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YN98 | H0YN98_HUMAN | Alpha/beta hydrolase domain-contain... | ABHD17C | 94 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027273 | 223 – 256 | Missing in isoform 2. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC059401 mRNA Translation: AAH59401.2 BC115003 mRNA Translation: AAI15004.1 AL390079 mRNA Translation: CAB98203.1 |
CCDSi | CCDS45323.1 [Q6PCB6-1] |
RefSeqi | NP_067037.1, NM_021214.1 [Q6PCB6-1] |
Genome annotation databases
Ensembli | ENST00000258884; ENSP00000258884; ENSG00000136379 [Q6PCB6-1] ENST00000558464; ENSP00000452778; ENSG00000136379 [Q6PCB6-2] |
GeneIDi | 58489 |
KEGGi | hsa:58489 |
UCSCi | uc002bfu.4, human [Q6PCB6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC059401 mRNA Translation: AAH59401.2 BC115003 mRNA Translation: AAI15004.1 AL390079 mRNA Translation: CAB98203.1 |
CCDSi | CCDS45323.1 [Q6PCB6-1] |
RefSeqi | NP_067037.1, NM_021214.1 [Q6PCB6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121819, 2 interactors |
IntActi | Q6PCB6, 1 interactor |
STRINGi | 9606.ENSP00000258884 |
Protein family/group databases
ESTHERi | human-ABHD17C, ABHD17-depalmitoylase |
MEROPSi | S09.053 |
PTM databases
iPTMneti | Q6PCB6 |
PhosphoSitePlusi | Q6PCB6 |
SwissPalmi | Q6PCB6 |
Polymorphism and mutation databases
BioMutai | ABHD17C |
DMDMi | 156630444 |
Proteomic databases
EPDi | Q6PCB6 |
jPOSTi | Q6PCB6 |
MassIVEi | Q6PCB6 |
MaxQBi | Q6PCB6 |
PaxDbi | Q6PCB6 |
PeptideAtlasi | Q6PCB6 |
PRIDEi | Q6PCB6 |
ProteomicsDBi | 67058 [Q6PCB6-1] 67059 [Q6PCB6-2] |
Protocols and materials databases
Antibodypediai | 63038, 59 antibodies |
Genome annotation databases
Ensembli | ENST00000258884; ENSP00000258884; ENSG00000136379 [Q6PCB6-1] ENST00000558464; ENSP00000452778; ENSG00000136379 [Q6PCB6-2] |
GeneIDi | 58489 |
KEGGi | hsa:58489 |
UCSCi | uc002bfu.4, human [Q6PCB6-1] |
Organism-specific databases
CTDi | 58489 |
DisGeNETi | 58489 |
EuPathDBi | HostDB:ENSG00000136379.11 |
GeneCardsi | ABHD17C |
HGNCi | HGNC:26925, ABHD17C |
HPAi | ENSG00000136379, Low tissue specificity |
MIMi | 617944, gene |
neXtProti | NX_Q6PCB6 |
OpenTargetsi | ENSG00000136379 |
PharmGKBi | PA162385639 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1552, Eukaryota |
GeneTreei | ENSGT00940000159424 |
HOGENOMi | CLU_029375_5_4_1 |
InParanoidi | Q6PCB6 |
OMAi | FISFELP |
OrthoDBi | 629316at2759 |
PhylomeDBi | Q6PCB6 |
TreeFami | TF314365 |
Enzyme and pathway databases
PathwayCommonsi | Q6PCB6 |
Reactomei | R-HSA-9648002, RAS processing |
Miscellaneous databases
BioGRID-ORCSi | 58489, 4 hits in 839 CRISPR screens |
ChiTaRSi | ABHD17C, human |
GenomeRNAii | 58489 |
Pharosi | Q6PCB6, Tbio |
PROi | PR:Q6PCB6 |
RNActi | Q6PCB6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136379, Expressed in colon and 174 other tissues |
ExpressionAtlasi | Q6PCB6, baseline and differential |
Genevisiblei | Q6PCB6, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR022742, Hydrolase_4 |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AB17C_HUMAN | |
Accessioni | Q6PCB6Primary (citable) accession number: Q6PCB6 Secondary accession number(s): Q1RMD6, Q9NPM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM