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UniProtKB - Q6PC90 (Q6PC90_DANRE)

Entry version 123 (25 May 2022)
Sequence version 1 (05 Jul 2004)
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Protein

40S ribosomal protein S12

Gene

rps12

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal proteinUniRule annotationImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DRE-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DRE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-DRE-72649, Translation initiation complex formation
R-DRE-72689, Formation of a pool of free 40S subunits
R-DRE-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DRE-72702, Ribosomal scanning and start codon recognition
R-DRE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DRE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DRE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S12UniRule annotationARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rps12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-8951, rps12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000036875, Expressed in somite and 33 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000053541

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 110Ribosomal_L7AeInterPro annotationAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS12 family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3406, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_110343_1_1_1

Identification of Orthologs from Complete Genome Data

More...OMAi		CDEPMYK

Database of Orthologous Groups

More...OrthoDBi		1474866at2759

TreeFam database of animal gene trees

More...TreeFami		TF300196

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1330.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029064, L30e-like
IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45
IPR000530, Ribosomal_S12e

The PANTHER Classification System

More...PANTHERi		PTHR11843, PTHR11843, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01248, Ribosomal_L7Ae, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00972, RIBSOMALS12E

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55315, SSF55315, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01189, RIBOSOMAL_S12E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6PC90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEGIAAGG VMDVNTALPE VLKTALIHDG LARGIREAAK ALDKRQAHLC 
        60         70         80         90        100
VLAANCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGKP 
       110        120        130 
RKVVGCSCVV IKDYGKESQA KDVIEEYFKS KK
Length:132
Mass (Da):14,466
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF453D1888392ED8E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX322566 Genomic DNA No translation available.
CR759830 Genomic DNA No translation available.
BC059433 mRNA Translation: AAH59433.1
AY561510 mRNA Translation: AAS66963.1

NCBI Reference Sequences

More...RefSeqi		NP_001269106.1, NM_001282177.1
NP_956340.1, NM_200046.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000053542.6; ENSDARP00000053541.5; ENSDARG00000036875.7
ENSDART00000138350.3; ENSDARP00000120403.1; ENSDARG00000036875.7
ENSDART00000187214.1; ENSDARP00000152860.1; ENSDARG00000115157.1

Database of genes from NCBI RefSeq genomes

More...GeneIDi		337007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:337007

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX322566 Genomic DNA No translation available.
CR759830 Genomic DNA No translation available.
BC059433 mRNA Translation: AAH59433.1
AY561510 mRNA Translation: AAS66963.1
RefSeqiNP_001269106.1, NM_001282177.1
NP_956340.1, NM_200046.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053541

Genome annotation databases

EnsembliENSDART00000053542.6; ENSDARP00000053541.5; ENSDARG00000036875.7
ENSDART00000138350.3; ENSDARP00000120403.1; ENSDARG00000036875.7
ENSDART00000187214.1; ENSDARP00000152860.1; ENSDARG00000115157.1
GeneIDi337007
KEGGidre:337007

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6206
ZFINiZDB-GENE-030131-8951, rps12

Phylogenomic databases

eggNOGiKOG3406, Eukaryota
GeneTreeiENSGT00390000018318
HOGENOMiCLU_110343_1_1_1
OMAiCDEPMYK
OrthoDBi1474866at2759
TreeFamiTF300196

Enzyme and pathway databases

ReactomeiR-DRE-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DRE-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DRE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-DRE-72649, Translation initiation complex formation
R-DRE-72689, Formation of a pool of free 40S subunits
R-DRE-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DRE-72702, Ribosomal scanning and start codon recognition
R-DRE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DRE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DRE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Gene expression databases

BgeeiENSDARG00000036875, Expressed in somite and 33 other tissues

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064, L30e-like
IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45
IPR000530, Ribosomal_S12e
PANTHERiPTHR11843, PTHR11843, 1 hit
PfamiView protein in Pfam
PF01248, Ribosomal_L7Ae, 1 hit
PRINTSiPR00972, RIBSOMALS12E
SUPFAMiSSF55315, SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01189, RIBOSOMAL_S12E, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6PC90_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PC90
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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