Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase

Gene

ppiab

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

  • cyclosporin A binding Source: GO_Central
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central
  • unfolded protein binding Source: GO_Central

GO - Biological processi

  • protein folding Source: InterPro
  • response to hypoxia Source: ZFIN

Keywordsi

Molecular functionIsomerase, RotamaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:ppiabImported
Synonyms:ppialImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-030131-7459 ppiab

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ6PC53

Expressioni

Gene expression databases

BgeeiENSDARG00000103994 Expressed in 29 organ(s), highest expression level in head

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061957

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 163PPIase cyclophilin-typeInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
HOVERGENiHBG001065
KOiK03767
OMAiASQRPKV
OrthoDBiEOG091G0BGL
TreeFamiTF312801

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PC53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANPKVFFDI TIDGKEAGRI VMELRADVVP KTAENFRALC TGEKGFGYKG
60 70 80 90 100
SGFHRVIPQF MCQGGDFTNH NGTGGKSIYG NKFEDENFTL KHGGKGTLSM
110 120 130 140 150
ANAGPNTNGS QFFICTADTN WLDGKHVVFG KVVDGLDVVD AIEKKGSSSG
160
KCSAKVVIAN CGQL
Length:164
Mass (Da):17,489
Last modified:July 5, 2004 - v1
Checksum:iB8755219F1BF91F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP074878 Genomic DNA No translation available.
BC059470 mRNA Translation: AAH59470.1
BC071370 mRNA Translation: AAH71370.1
RefSeqiNP_001315353.1, NM_001328424.1
UniGeneiDr.78109

Genome annotation databases

EnsembliENSDART00000166085; ENSDARP00000134856; ENSDARG00000103994
GeneIDi335519
KEGGidre:335519

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP074878 Genomic DNA No translation available.
BC059470 mRNA Translation: AAH59470.1
BC071370 mRNA Translation: AAH71370.1
RefSeqiNP_001315353.1, NM_001328424.1
UniGeneiDr.78109

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061957

Proteomic databases

PRIDEiQ6PC53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000166085; ENSDARP00000134856; ENSDARG00000103994
GeneIDi335519
KEGGidre:335519

Organism-specific databases

CTDi335519
ZFINiZDB-GENE-030131-7459 ppiab

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
HOVERGENiHBG001065
KOiK03767
OMAiASQRPKV
OrthoDBiEOG091G0BGL
TreeFamiTF312801

Gene expression databases

BgeeiENSDARG00000103994 Expressed in 29 organ(s), highest expression level in head

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PC53_DANRE
AccessioniPrimary (citable) accession number: Q6PC53
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again