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Protein

H/ACA ribonucleoprotein complex subunit 2-like protein

Gene

nhp2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 2-like protein
Alternative name(s):
Nucleolar protein family A member 2-like protein
snoRNP protein NHP2
Gene namesi
Name:nhp2
Synonyms:nola2
ORF Names:zgc:73227
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030131-533 nhp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367661 – 150H/ACA ribonucleoprotein complex subunit 2-like proteinAdd BLAST150

Proteomic databases

PaxDbiQ6PBV6

Expressioni

Gene expression databases

BgeeiENSDARG00000069422

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the telomerase holoenzyme complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000091811

Structurei

3D structure databases

ProteinModelPortaliQ6PBV6
SMRiQ6PBV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3167 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00550000074939
HOGENOMiHOG000055227
HOVERGENiHBG000328
InParanoidiQ6PBV6
KOiK11129
OMAiNIPYCYT
OrthoDBiEOG091G0VZK
PhylomeDBiQ6PBV6
TreeFamiTF105839

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR002415 H/ACA_rnp_Nhp2_euk
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00883 NUCLEARHMG
SUPFAMiSSF55315 SSF55315, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PBV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVKKEKAG EEETGGTEKS YQELIANINP IANPLASRKL SKKLYKCVKK
60 70 80 90 100
AAKVKQIRRG VKEVQKFINK GETGIVVFAG DTLPIDVYCH LPIMCEDRSL
110 120 130 140 150
PYAYVPSKVD LGSSAGSKRP TCVIMIKPHD EYKEAYDECV EEVTSLPKPI
Length:150
Mass (Da):16,688
Last modified:July 5, 2004 - v1
Checksum:i0E4227FE6FE32AB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059569 mRNA Translation: AAH59569.1
RefSeqiNP_997762.1, NM_212597.2
UniGeneiDr.76828

Genome annotation databases

EnsembliENSDART00000101037; ENSDARP00000091811; ENSDARG00000069422
GeneIDi100003787
KEGGidre:100003787

Similar proteinsi

Entry informationi

Entry nameiNHP2_DANRE
AccessioniPrimary (citable) accession number: Q6PBV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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