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Protein

Protein BHLHb9

Gene

Bhlhb9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the control of cellular aging and survival.By similarity

Caution

Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein BHLHb9
Short name:
bHLHb9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bhlhb9
Synonyms:Kiaa1701
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917487 Bhlhb9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003346641 – 539Protein BHLHb9Add BLAST539

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6PB60

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6PB60

PRoteomics IDEntifications database

More...
PRIDEi
Q6PB60

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PB60

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PB60

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000072964 Expressed in 263 organ(s), highest expression level in pes

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PB60 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PB60 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6PB60

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPU4 Eukaryota
ENOG41115S9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000095228

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG098352

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PB60

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIWPKAP

Database of Orthologous Groups

More...
OrthoDBi
860703at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PB60

TreeFam database of animal gene trees

More...
TreeFami
TF335652

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04826 Arm_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6PB60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGSKNKARA QAKLEKRASA QARAVAEREA ANANRGAGKS RDKGKGKAGS
60 70 80 90 100
KSDAVAEVKA GSKGKVVAET KEGARPESKA LVKGTSDFNH RTENKFARST
110 120 130 140 150
RKDKPSSDNW FWAGEDSGIN SWFWKGEELS NNSVAKCENK PSTSIQARAE
160 170 180 190 200
EPAPRTSHKS RSGAEEEEEE NVIGNWFWEG DDTGFDTDPK PVFKIVKPQP
210 220 230 240 250
VDEINEKDRP KDWSEVTIWP KAPAVTPAVL GYRSQDSSEA RSSSYIVLAS
260 270 280 290 300
NEEETSTACT KNTRSSLQSI PEYPFGSDPC IQTLDEIRQQ IKIREENGIK
310 320 330 340 350
PFACPCKLEC YLDSPEFEKL VNILKSTTDP LIHKIAQIAM GIHKVHPFAQ
360 370 380 390 400
EFINEVGVVT LIESLLSFSS PEVSIKKAVI TLNSSGDDRY NKVEFHVKHM
410 420 430 440 450
CKETVSFPLN SPGQQSGLKI IGQLTTESVH HYIVVSYFSE LFHLLSQGNR
460 470 480 490 500
KTRNLVLKVF LNMSENPKAA RDMINMKALA ALKLIFNQKE AKANLVSAVA
510 520 530
IFINIKEHIR KGSIVVVDHL SYNTLTAIFR EVKGIIERM
Length:539
Mass (Da):59,823
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9484323DCF690453
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AGB8A2AGB8_MOUSE
Protein BHLHb9
Bhlhb9
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32514 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD32514 differs from that shown. Reason: Erroneous termination at position 350. Translated as Gln.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK173236 mRNA Translation: BAD32514.1 Sequence problems.
AL683822 Genomic DNA No translation available.
BC059871 mRNA Translation: AAH59871.1
AK143861 mRNA Translation: BAE25572.1
AK157023 mRNA Translation: BAE33934.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30410.1

NCBI Reference Sequences

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RefSeqi
NP_001091692.1, NM_001098222.1
NP_937804.1, NM_198161.2
XP_006528670.1, XM_006528607.2
XP_006528671.1, XM_006528608.2
XP_011246062.1, XM_011247760.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.440847

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000068755; ENSMUSP00000068067; ENSMUSG00000072964
ENSMUST00000180025; ENSMUSP00000137213; ENSMUSG00000072964

Database of genes from NCBI RefSeq genomes

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GeneIDi
70237

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:70237

UCSC genome browser

More...
UCSCi
uc009uhv.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173236 mRNA Translation: BAD32514.1 Sequence problems.
AL683822 Genomic DNA No translation available.
BC059871 mRNA Translation: AAH59871.1
AK143861 mRNA Translation: BAE25572.1
AK157023 mRNA Translation: BAE33934.1
CCDSiCCDS30410.1
RefSeqiNP_001091692.1, NM_001098222.1
NP_937804.1, NM_198161.2
XP_006528670.1, XM_006528607.2
XP_006528671.1, XM_006528608.2
XP_011246062.1, XM_011247760.1
UniGeneiMm.440847

3D structure databases

ProteinModelPortaliQ6PB60
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6PB60
PhosphoSitePlusiQ6PB60

Proteomic databases

MaxQBiQ6PB60
PaxDbiQ6PB60
PRIDEiQ6PB60

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068755; ENSMUSP00000068067; ENSMUSG00000072964
ENSMUST00000180025; ENSMUSP00000137213; ENSMUSG00000072964
GeneIDi70237
KEGGimmu:70237
UCSCiuc009uhv.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80823
MGIiMGI:1917487 Bhlhb9

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IPU4 Eukaryota
ENOG41115S9 LUCA
GeneTreeiENSGT00940000161990
HOGENOMiHOG000095228
HOVERGENiHBG098352
InParanoidiQ6PB60
OMAiTIWPKAP
OrthoDBi860703at2759
PhylomeDBiQ6PB60
TreeFamiTF335652

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Bhlhb9 mouse

Protein Ontology

More...
PROi
PR:Q6PB60

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000072964 Expressed in 263 organ(s), highest expression level in pes
ExpressionAtlasiQ6PB60 baseline and differential
GenevisibleiQ6PB60 MM

Family and domain databases

InterProiView protein in InterPro
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
PfamiView protein in Pfam
PF04826 Arm_2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBHLH9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PB60
Secondary accession number(s): Q3U0C1, Q69ZD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: January 16, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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