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Protein

Putative chondrosarcoma-associated gene 1 protein

Gene

CSAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Putative chondrosarcoma-associated gene 1 protein
Alternative name(s):
Cancer/testis antigen 24.1
Short name:
CT24.1
Cancer/testis antigen CSAGE
Gene namesi
Name:CSAG1
Synonyms:CSAGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198930.12
HGNCiHGNC:24294 CSAG1
MIMi300944 gene
neXtProtiNX_Q6PB30

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198930
PharmGKBiPA134962241

Polymorphism and mutation databases

BioMutaiCSAG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029184820 – 78Putative chondrosarcoma-associated gene 1 proteinAdd BLAST59

Proteomic databases

PaxDbiQ6PB30
PRIDEiQ6PB30
ProteomicsDBi67052
67053 [Q6PB30-2]

PTM databases

iPTMnetiQ6PB30
PhosphoSitePlusiQ6PB30

Expressioni

Tissue specificityi

Expressed in chondrosarcoma, melanoma, cartilage and testis, but not in other normal tissues.1 Publication

Gene expression databases

BgeeiENSG00000198930
CleanExiHS_CSAG1
ExpressionAtlasiQ6PB30 baseline and differential

Organism-specific databases

HPAiHPA078264

Interactioni

Protein-protein interaction databases

BioGridi127689, 3 interactors
IntActiQ6PB30, 2 interactors
STRINGi9606.ENSP00000359310

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KCEY Eukaryota
ENOG4110P1E LUCA
GeneTreeiENSGT00390000012766
HOGENOMiHOG000112006
HOVERGENiHBG099380
InParanoidiQ6PB30
OMAiKRFPRQP
PhylomeDBiQ6PB30
TreeFamiTF340411

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PB30-1) [UniParc]FASTAAdd to basket
Also known as: CSAG1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSATTACWPA FTVLGEARGD QVDWSRLYRD TGLVKMSRKP RASSPFSNNH
60 70
PSTPKRFPRQ PRREKGPVKE VPGTKGSP
Length:78
Mass (Da):8,697
Last modified:March 28, 2018 - v3
Checksum:i643C38BDDB554575
GO
Isoform 2 (identifier: Q6PB30-2) [UniParc]FASTAAdd to basket
Also known as: CSAG1c

The sequence of this isoform differs from the canonical sequence as follows:
     57-78: FPRQPRREKGPVKEVPGTKGSP → RGRGKHPLIPGPEALSK

Show »
Length:73
Mass (Da):8,062
Checksum:iEA0C1F6E61B90ACB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28Y → C in AF195880 (PubMed:12039054).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03286828Y → F. Corresponds to variant dbSNP:rs1894359Ensembl.1
Natural variantiVAR_04733662R → K. Corresponds to variant dbSNP:rs2515848Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02626757 – 78FPRQP…TKGSP → RGRGKHPLIPGPEALSK in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195880 mRNA No translation available.
AF268419 mRNA No translation available.
AC244102 Genomic DNA No translation available.
AF002997 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99433.1
CH471169 Genomic DNA Translation: EAW99435.1
BC059947 mRNA Translation: AAH59947.1
CCDSiCCDS76047.1 [Q6PB30-1]
RefSeqiNP_001096046.2, NM_001102576.2 [Q6PB30-1]
NP_705611.2, NM_153478.2 [Q6PB30-1]
UniGeneiHs.423718

Genome annotation databases

EnsembliENST00000370287; ENSP00000359310; ENSG00000198930 [Q6PB30-1]
ENST00000370291; ENSP00000359314; ENSG00000198930 [Q6PB30-2]
ENST00000452779; ENSP00000396520; ENSG00000198930 [Q6PB30-1]
GeneIDi158511
KEGGihsa:158511
UCSCiuc033fah.1 human
uc065brz.1 human [Q6PB30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCSAG1_HUMAN
AccessioniPrimary (citable) accession number: Q6PB30
Secondary accession number(s): A0A024RC18, A6NE22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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