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UniProtKB - Q6PAZ3 (DGAT2_XENLA)
Protein
Diacylglycerol O-acyltransferase 2
Gene
dgat2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity).
By similarityCatalytic activityi
- EC:2.3.1.20By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:2.3.1.76By similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
: triacylglycerol biosynthesis Pathwayi
This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.
GO - Molecular functioni
- diacylglycerol O-acyltransferase activity Source: UniProtKB
- retinol O-fatty-acyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- diacylglycerol biosynthetic process Source: UniProtKB
- glycerol metabolic process Source: UniProtKB-KW
- monoacylglycerol biosynthetic process Source: UniProtKB
- triglyceride biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Glycerol metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00282 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dgat2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-6078761, dgat2.L |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Lipid droplet By similarity
- perinuclear region By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
- perinuclear endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- lipid droplet Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 42 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 43 – 61 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 62 – 65 | LumenalSequence analysis | 4 | |
Transmembranei | 66 – 85 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 86 – 361 | CytoplasmicSequence analysisAdd BLAST | 276 |
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Lipid droplet, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249049 | 1 – 361 | Diacylglycerol O-acyltransferase 2Add BLAST | 361 |
Structurei
3D structure databases
AlphaFoldDBi | Q6PAZ3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the diacylglycerol acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OMAi | NDPKHAG |
OrthoDBi | 1347007at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6PAZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTIIAAYSG VLRGTGSSLL SAVHDLPSIP WLSKSSVVRH LQIISVLQWV
60 70 80 90 100
LSFLILGVAC TAVLVYIFCT DLWLIAALYF TWMVLDWNTP YKGGRRSSWV
110 120 130 140 150
RNWAVWRYFR DYFPVKLVKT HNLLPSRNYI FGYHPHGIMC LGAFCNFGTE
160 170 180 190 200
ATGVSKKFPG IKCHLATLAG NFRMPVLREY LMSGGICPVN RDTINYILSK
210 220 230 240 250
NGTGNAVVIA VGGAAESLNC RPGKNTVTLL HRKGFVKVAL QHGADLVPIY
260 270 280 290 300
SFGENETYKQ VVFEEGSWGR WIQQKFQKYV GFAPCLFHGC SFFSSNSWGL
310 320 330 340 350
VPYANPITTV VGEPITVPKI EQPTQKDVEL YHSMYLSSLH RLFDKYKTKL
360
GLPDSETLEF I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC059991 mRNA Translation: AAH59991.1 |
RefSeqi | NP_001083204.1, NM_001089735.1 |
Genome annotation databases
GeneIDi | 398800 |
KEGGi | xla:398800 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC059991 mRNA Translation: AAH59991.1 |
RefSeqi | NP_001083204.1, NM_001089735.1 |
3D structure databases
AlphaFoldDBi | Q6PAZ3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 398800 |
Genome annotation databases
GeneIDi | 398800 |
KEGGi | xla:398800 |
Organism-specific databases
CTDi | 398800 |
Xenbasei | XB-GENE-6078761, dgat2.L |
Phylogenomic databases
OMAi | NDPKHAG |
OrthoDBi | 1347007at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00282 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DGAT2_XENLA | |
Accessioni | Q6PAZ3Primary (citable) accession number: Q6PAZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families