Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTPase-activating protein and VPS9 domain-containing protein 1

Gene

Gapvd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activating protein binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB-KW
  • guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor
Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTPase-activating protein and VPS9 domain-containing protein 1
Alternative name(s):
GAPex-5
Rab5-activating protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gapvd1
Synonyms:Gapex5, Kiaa1521
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913941 Gapvd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003247721 – 1458GTPase-activating protein and VPS9 domain-containing protein 1Add BLAST1458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227PhosphoserineBy similarity1
Modified residuei390PhosphothreonineBy similarity1
Modified residuei458PhosphothreonineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei470PhosphothreonineBy similarity1
Modified residuei566PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei746PhosphoserineBy similarity1
Modified residuei757PhosphoserineCombined sources1
Modified residuei762PhosphothreonineBy similarity1
Modified residuei766PhosphoserineBy similarity1
Modified residuei876PhosphoserineBy similarity1
Modified residuei902PhosphoserineCombined sources1
Modified residuei903PhosphoserineBy similarity1
Modified residuei908PhosphoserineCombined sources1
Modified residuei964PhosphoserineBy similarity1
Modified residuei1017PhosphoserineBy similarity1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1076PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6PAR5

PeptideAtlas

More...
PeptideAtlasi
Q6PAR5

PRoteomics IDEntifications database

More...
PRIDEi
Q6PAR5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PAR5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PAR5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in adipocytes and fibroblasts (at protein level). Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026867 Expressed in 247 organ(s), highest expression level in pes

CleanEx database of gene expression profiles

More...
CleanExi
MM_GAPVD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PAR5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PAR5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB5A (By similarity). Interacts with TRIP10/CIP4.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
211649, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6PAR5, 3 interactors

Molecular INTeraction database

More...
MINTi
Q6PAR5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028224

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6PAR5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PAR5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 353Ras-GAPPROSITE-ProRule annotationAdd BLAST223
Domaini1318 – 1458VPS9PROSITE-ProRule annotationAdd BLAST141

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GAPVD1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ83 Eukaryota
ENOG410XRXX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156611

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107936

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6PAR5

Identification of Orthologs from Complete Genome Data

More...
OMAi
CISSIMS

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00G1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6PAR5

TreeFam database of animal gene trees

More...
TreeFami
TF105908

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1050.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR003123 VPS9
IPR037191 VPS9_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00616 RasGAP, 1 hit
PF02204 VPS9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00167 VPS9, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109993 SSF109993, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51205 VPS9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PAR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKLDIHTLA HHLKQERLYV SSEKQLIQRL NADVLKTAEK LYRTAWIAKQ
60 70 80 90 100
QRINLDRLII TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL
110 120 130 140 150
SRLRENPRLI ASSLVAGEKL NQENTQSVIY TVFTSLYGNC IMQEDESYLL
160 170 180 190 200
QVLRYLIEFE LKESDNPRRL LRRGTCAFSI LFKLFSEGLF SAKLFLTATL
210 220 230 240 250
HEPIMQLLVE DEDHLETDPN KLIERFSPAQ QEKLFGEKGS DRFRQKVQEM
260 270 280 290 300
VDSNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ
360 370 380 390 400
LAMTGTEEGD PRTKNSLGKF DKGCVAAFLD VVIGGRAVET PPMSSVNLLE
410 420 430 440 450
GLSRTVVYIS YSQLITLVNF MKSVMSGDQL KEDRMALDNL LANLPQAKPG
460 470 480 490 500
KSSSLDMTPY STPQMSPATT PANKKNRLPI ATRSRSRSNM LMDLHMDHEG
510 520 530 540 550
SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL SDGGQGDVPV
560 570 580 590 600
DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET
660 670 680 690 700
VSETWSTDVL GSDFDPNVDE DRLQEIAGAA AENVLGSLLC LPGSGSVLLD
710 720 730 740 750
PCTGSTISET TSEAWSVEVL PSDSEAPDLK QEERLQELES CSGLGSTSDD
760 770 780 790 800
TDVREVSSRP STPGLSVVSG ISATSEDIPN KIEDLRSECS SDFGGKDSVT
810 820 830 840 850
SPDMDDIAHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV VRPKVHYARP
860 870 880 890 900
SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT AAEMEAFKQR HSYPERLVRS
910 920 930 940 950
RSSDIVSSVR RPMSDPSWNR RPGNEELPPA AATGATSLVA APHSSSSSPS
960 970 980 990 1000
KDSSRGETEE RKDSDDERSD RSRPWWRKRF VSAMPKAPIP FRKKEKQEKD
1010 1020 1030 1040 1050
KDDLGPDRFS TLTDEPSPRL SAQAQVAEDI LDKYRNAIKR TSPSEGAMAN
1060 1070 1080 1090 1100
DESAEVMGDG ESAHDSPREE ALQNISADDL PDSASQAAHP QDSAFSYRDV
1110 1120 1130 1140 1150
KKKLRLALCS ADSVAFPVLT HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI
1160 1170 1180 1190 1200
NLQDKSLMAQ LQETMRCVCR FDNRTCRKLL ASIAEDYRKR APYIAYLTRC
1210 1220 1230 1240 1250
RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES KEKKIREFIQ
1260 1270 1280 1290 1300
DFQKLTAADD KTAQVEDFLQ FLYGVMAQDV IWQNASEEQL QDAQLAIERS
1310 1320 1330 1340 1350
VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR
1360 1370 1380 1390 1400
EAPWPSAQSE IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD
1410 1420 1430 1440 1450
DFVPVLVFVL IKANPPCLLS TVQYISSFYA SCLSGEESYW WMQFTAAVEF

IKTIDDRK
Length:1,458
Mass (Da):162,402
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3D2EAF22051FD7
GO
Isoform 2 (identifier: Q6PAR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-577: Missing.

Show »
Length:1,437
Mass (Da):160,111
Checksum:i99CB3966DC97D605
GO
Isoform 3 (identifier: Q6PAR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-379: GCVAAFL → VGMSVVS
     380-1458: Missing.

Show »
Length:379
Mass (Da):43,381
Checksum:i7123D700EE30972C
GO
Isoform 4 (identifier: Q6PAR5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-480: I → IGQQLAAITAWDSSATNLTAHIPLVTPF
     557-577: Missing.

Show »
Length:1,464
Mass (Da):162,917
Checksum:iC34EEFDA11081BA7
GO
Isoform 5 (identifier: Q6PAR5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-577: Missing.
     1202-1202: Missing.

Show »
Length:1,436
Mass (Da):159,982
Checksum:i4367B45EA4C2D537
GO
Isoform 6 (identifier: Q6PAR5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1055-1055: Missing.

Show »
Length:1,457
Mass (Da):162,273
Checksum:i67DC7B5E4E46334D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7ADS7F7ADS7_MOUSE
GTPase-activating protein and VPS9 ...
Gapvd1
828Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6X819F6X819_MOUSE
GTPase-activating protein and VPS9 ...
Gapvd1
835Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ADT6F7ADT6_MOUSE
GTPase-activating protein and VPS9 ...
Gapvd1
548Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ADQ2F7ADQ2_MOUSE
GTPase-activating protein and VPS9 ...
Gapvd1
896Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q0D1E9Q0D1_MOUSE
GTPase-activating protein and VPS9 ...
Gapvd1
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YRL2F6YRL2_MOUSE
GTPase-activating protein and VPS9 ...
Gapvd1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UFP6F6UFP6_MOUSE
GTPase-activating protein and VPS9 ...
Gapvd1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH31478 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH43715 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH48847 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH57164 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29377 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98191 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE22277 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE29251 differs from that shown. Reason: Frameshift at position 811.Curated
The sequence CAM15445 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM15446 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM15455 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM15456 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM24604 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM24605 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti581N → D in BAE29251 (PubMed:16141072).Curated1
Sequence conflicti661G → E in AAH31478 (PubMed:15489334).Curated1
Sequence conflicti893Y → H in BAE22277 (PubMed:16141072).Curated1
Sequence conflicti1257A → V in BAC98191 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032363373 – 379GCVAAFL → VGMSVVS in isoform 3. 1 Publication7
Alternative sequenceiVSP_032364380 – 1458Missing in isoform 3. 1 PublicationAdd BLAST1079
Alternative sequenceiVSP_032365480I → IGQQLAAITAWDSSATNLTA HIPLVTPF in isoform 4. 1 Publication1
Alternative sequenceiVSP_032366557 – 577Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsAdd BLAST21
Alternative sequenceiVSP_0323671055Missing in isoform 6. 1 Publication1
Alternative sequenceiVSP_0323681202Missing in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF155419 mRNA Translation: ABM68541.1
AK129381 Transcribed RNA Translation: BAC98191.1 Different initiation.
AK014474 mRNA Translation: BAB29377.2 Different initiation.
AK088851 mRNA Translation: BAC40613.1
AK003521 mRNA Translation: BAB22834.1
AK134776 mRNA Translation: BAE22277.1 Different initiation.
AK150026 mRNA Translation: BAE29251.1 Frameshift.
AK165047 mRNA Translation: BAE38017.1
AL845262, AL929106 Genomic DNA Translation: CAM15445.1 Sequence problems.
AL845262, AL929106 Genomic DNA Translation: CAM15446.1 Sequence problems.
AL845262, AL929106 Genomic DNA Translation: CAM15447.1
AL845262 Genomic DNA Translation: CAM15455.1 Sequence problems.
AL845262 Genomic DNA Translation: CAM15456.1 Sequence problems.
AL929106, AL845262 Genomic DNA Translation: CAM24604.1 Sequence problems.
AL929106, AL845262 Genomic DNA Translation: CAM24605.1 Sequence problems.
AL929106, AL845262 Genomic DNA Translation: CAM24606.1
BC031478 mRNA Translation: AAH31478.1 Sequence problems.
BC043715 mRNA Translation: AAH43715.1 Different initiation.
BC048847 mRNA Translation: AAH48847.1 Sequence problems.
BC057164 mRNA Translation: AAH57164.1 Different initiation.
BC060123 mRNA Translation: AAH60123.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15949.1 [Q6PAR5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_079985.2, NM_025709.2 [Q6PAR5-2]
XP_011237449.1, XM_011239147.1 [Q6PAR5-4]
XP_011237450.1, XM_011239148.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.156452
Mm.393397

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028224; ENSMUSP00000028224; ENSMUSG00000026867 [Q6PAR5-2]
ENSMUST00000102800; ENSMUSP00000099864; ENSMUSG00000026867 [Q6PAR5-2]
ENSMUST00000113099; ENSMUSP00000108723; ENSMUSG00000026867 [Q6PAR5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66691

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66691

UCSC genome browser

More...
UCSCi
uc008jiq.2 mouse [Q6PAR5-2]
uc008jir.1 mouse [Q6PAR5-3]
uc012bug.1 mouse [Q6PAR5-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF155419 mRNA Translation: ABM68541.1
AK129381 Transcribed RNA Translation: BAC98191.1 Different initiation.
AK014474 mRNA Translation: BAB29377.2 Different initiation.
AK088851 mRNA Translation: BAC40613.1
AK003521 mRNA Translation: BAB22834.1
AK134776 mRNA Translation: BAE22277.1 Different initiation.
AK150026 mRNA Translation: BAE29251.1 Frameshift.
AK165047 mRNA Translation: BAE38017.1
AL845262, AL929106 Genomic DNA Translation: CAM15445.1 Sequence problems.
AL845262, AL929106 Genomic DNA Translation: CAM15446.1 Sequence problems.
AL845262, AL929106 Genomic DNA Translation: CAM15447.1
AL845262 Genomic DNA Translation: CAM15455.1 Sequence problems.
AL845262 Genomic DNA Translation: CAM15456.1 Sequence problems.
AL929106, AL845262 Genomic DNA Translation: CAM24604.1 Sequence problems.
AL929106, AL845262 Genomic DNA Translation: CAM24605.1 Sequence problems.
AL929106, AL845262 Genomic DNA Translation: CAM24606.1
BC031478 mRNA Translation: AAH31478.1 Sequence problems.
BC043715 mRNA Translation: AAH43715.1 Different initiation.
BC048847 mRNA Translation: AAH48847.1 Sequence problems.
BC057164 mRNA Translation: AAH57164.1 Different initiation.
BC060123 mRNA Translation: AAH60123.1
CCDSiCCDS15949.1 [Q6PAR5-2]
RefSeqiNP_079985.2, NM_025709.2 [Q6PAR5-2]
XP_011237449.1, XM_011239147.1 [Q6PAR5-4]
XP_011237450.1, XM_011239148.2
UniGeneiMm.156452
Mm.393397

3D structure databases

ProteinModelPortaliQ6PAR5
SMRiQ6PAR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211649, 1 interactor
IntActiQ6PAR5, 3 interactors
MINTiQ6PAR5
STRINGi10090.ENSMUSP00000028224

PTM databases

iPTMnetiQ6PAR5
PhosphoSitePlusiQ6PAR5

Proteomic databases

PaxDbiQ6PAR5
PeptideAtlasiQ6PAR5
PRIDEiQ6PAR5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028224; ENSMUSP00000028224; ENSMUSG00000026867 [Q6PAR5-2]
ENSMUST00000102800; ENSMUSP00000099864; ENSMUSG00000026867 [Q6PAR5-2]
ENSMUST00000113099; ENSMUSP00000108723; ENSMUSG00000026867 [Q6PAR5-1]
GeneIDi66691
KEGGimmu:66691
UCSCiuc008jiq.2 mouse [Q6PAR5-2]
uc008jir.1 mouse [Q6PAR5-3]
uc012bug.1 mouse [Q6PAR5-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26130
MGIiMGI:1913941 Gapvd1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IQ83 Eukaryota
ENOG410XRXX LUCA
GeneTreeiENSGT00940000156611
HOVERGENiHBG107936
InParanoidiQ6PAR5
OMAiCISSIMS
OrthoDBiEOG091G00G1
PhylomeDBiQ6PAR5
TreeFamiTF105908

Enzyme and pathway databases

ReactomeiR-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6PAR5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026867 Expressed in 247 organ(s), highest expression level in pes
CleanExiMM_GAPVD1
ExpressionAtlasiQ6PAR5 baseline and differential
GenevisibleiQ6PAR5 MM

Family and domain databases

Gene3Di1.20.1050.80, 1 hit
InterProiView protein in InterPro
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF00616 RasGAP, 1 hit
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51205 VPS9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGAPD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PAR5
Secondary accession number(s): A0PJI8
, A2AR09, A2AR10, A2AR17, A2AR18, Q3TNS1, Q3UDL0, Q3UYD5, Q6ZPP0, Q80V37, Q80ZK4, Q8BTS5, Q9CRS2, Q9CTI1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 5, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again