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Protein

Alpha-taxilin

Gene

Txlna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.By similarity

GO - Molecular functioni

GO - Biological processi

  • B cell activation Source: MGI
  • exocytosis Source: UniProtKB-KW

Keywordsi

Biological processExocytosis

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-taxilin
Gene namesi
Name:Txlna
Synonyms:Txln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:105968 Txlna

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894221 – 554Alpha-taxilinAdd BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineBy similarity1
Modified residuei515PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PAM1
PaxDbiQ6PAM1
PeptideAtlasiQ6PAM1
PRIDEiQ6PAM1

PTM databases

iPTMnetiQ6PAM1
PhosphoSitePlusiQ6PAM1

Expressioni

Gene expression databases

BgeeiENSMUSG00000053841 Expressed in 247 organ(s), highest expression level in primitive streak
CleanExiMM_TXLNA
ExpressionAtlasiQ6PAM1 baseline and differential
GenevisibleiQ6PAM1 MM

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi224938, 1 interactor
IntActiQ6PAM1, 1 interactor
STRINGi10090.ENSMUSP00000042153

Structurei

3D structure databases

ProteinModelPortaliQ6PAM1
SMRiQ6PAM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 491Sequence analysisAdd BLAST306

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ6PAM1
OMAiTEAPCCP
OrthoDBiEOG091G0GVB
PhylomeDBiQ6PAM1
TreeFamiTF318595

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6PAM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKNQDKKNGP AKHSNSKGSP GQREAGPEGA HGRPRQTAPG AEAEGSTSQA
60 70 80 90 100
PGKTEGARAK AAQPGALCDV SEELSRQLED ILSTYCVDNN QGGPAEEGAQ
110 120 130 140 150
GEPTEPEDTE KSRTYAARNG EPEPGIPVVN GEKETSKGEP GTEEIRASDE
160 170 180 190 200
VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN TLSTPEEKLA ALCKKYAELL
210 220 230 240 250
EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK LESLCRELQR
260 270 280 290 300
HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ
310 320 330 340 350
ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE
360 370 380 390 400
AEERHQREKE FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT
410 420 430 440 450
LSKSSEVFTT FKQEMEKMTK KIKKLEKETT MYRSRWESSN KALLEMAEEK
460 470 480 490 500
TVRDKELEGL QVKIQRLEKL CRALQTERND LNKRVQDLTA GGITDIGSER
510 520 530 540 550
RPEATTASKE QGVESPGAQP ASSPRATDAP CCSGAPSTGT AGQTGPGEPT

PATA
Length:554
Mass (Da):62,369
Last modified:July 5, 2004 - v1
Checksum:i5CFDD86C4E744D06
GO
Isoform 2 (identifier: Q6PAM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-409: LLKEAVESQR...TLSKSSEVFT → VRLRPQGCGG...CLSRQQSESR
     410-554: Missing.

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):46,271
Checksum:i563972E2D2E28CFB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ADZ2A2ADZ2_MOUSE
Alpha-taxilin
Txlna
296Annotation score:
A2ADZ3A2ADZ3_MOUSE
Alpha-taxilin
Txlna
248Annotation score:
A2ADZ4A2ADZ4_MOUSE
Alpha-taxilin
Txlna
254Annotation score:
A8Y5J8A8Y5J8_MOUSE
Alpha-taxilin
Txlna
90Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011833362 – 409LLKEA…SEVFT → VRLRPQGCGGAGRKWAGFWL SSIYFLWMGEILPAQSSNCL SRQQSESR in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_011834410 – 554Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060227 mRNA Translation: AAH60227.1
BC065115 mRNA Translation: AAH65115.1
CCDSiCCDS38887.1 [Q6PAM1-1]
RefSeqiNP_001005506.2, NM_001005506.3 [Q6PAM1-1]
NP_001186624.1, NM_001199695.1 [Q6PAM1-1]
XP_006502722.1, XM_006502659.3 [Q6PAM1-1]
UniGeneiMm.268863

Genome annotation databases

EnsembliENSMUST00000046425; ENSMUSP00000042153; ENSMUSG00000053841 [Q6PAM1-1]
ENSMUST00000084264; ENSMUSP00000081285; ENSMUSG00000053841 [Q6PAM1-1]
GeneIDi109658
KEGGimmu:109658
UCSCiuc008uxx.2 mouse [Q6PAM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060227 mRNA Translation: AAH60227.1
BC065115 mRNA Translation: AAH65115.1
CCDSiCCDS38887.1 [Q6PAM1-1]
RefSeqiNP_001005506.2, NM_001005506.3 [Q6PAM1-1]
NP_001186624.1, NM_001199695.1 [Q6PAM1-1]
XP_006502722.1, XM_006502659.3 [Q6PAM1-1]
UniGeneiMm.268863

3D structure databases

ProteinModelPortaliQ6PAM1
SMRiQ6PAM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224938, 1 interactor
IntActiQ6PAM1, 1 interactor
STRINGi10090.ENSMUSP00000042153

PTM databases

iPTMnetiQ6PAM1
PhosphoSitePlusiQ6PAM1

Proteomic databases

EPDiQ6PAM1
PaxDbiQ6PAM1
PeptideAtlasiQ6PAM1
PRIDEiQ6PAM1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046425; ENSMUSP00000042153; ENSMUSG00000053841 [Q6PAM1-1]
ENSMUST00000084264; ENSMUSP00000081285; ENSMUSG00000053841 [Q6PAM1-1]
GeneIDi109658
KEGGimmu:109658
UCSCiuc008uxx.2 mouse [Q6PAM1-1]

Organism-specific databases

CTDi200081
MGIiMGI:105968 Txlna

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ6PAM1
OMAiTEAPCCP
OrthoDBiEOG091G0GVB
PhylomeDBiQ6PAM1
TreeFamiTF318595

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Miscellaneous databases

PROiPR:Q6PAM1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053841 Expressed in 247 organ(s), highest expression level in primitive streak
CleanExiMM_TXLNA
ExpressionAtlasiQ6PAM1 baseline and differential
GenevisibleiQ6PAM1 MM

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXLNA_MOUSE
AccessioniPrimary (citable) accession number: Q6PAM1
Secondary accession number(s): Q6P1E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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