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Protein

Breakpoint cluster region protein

Gene

Bcr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Breakpoint cluster region protein (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bcr
Synonyms:Kiaa3017
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88141 Bcr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002737311 – 1270Breakpoint cluster region proteinAdd BLAST1270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei178Phosphotyrosine; by HCKBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei247Phosphotyrosine; by FESCombined sources1
Modified residuei358PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei384PhosphoserineCombined sources1
Modified residuei387PhosphothreonineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei473Omega-N-methylarginineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei487PhosphoserineBy similarity1
Modified residuei553PhosphotyrosineBy similarity1
Modified residuei640PhosphothreonineBy similarity1
Modified residuei643PhosphotyrosineBy similarity1
Modified residuei692PhosphothreonineBy similarity1
Modified residuei1263PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-178 by HCK is important for interaction with GRB2 (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6PAJ1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6PAJ1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6PAJ1

PeptideAtlas

More...
PeptideAtlasi
Q6PAJ1

PRoteomics IDEntifications database

More...
PRIDEi
Q6PAJ1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6PAJ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6PAJ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000009681 Expressed in 267 organ(s), highest expression level in olfactory tubercle

CleanEx database of gene expression profiles

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CleanExi
MM_BCR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6PAJ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6PAJ1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Interacts with PDZK1. Interacts with HCK, FES/FPS, ABL1, PIK3R1 and GRB2 (By similarity). May interact with CCPG1. Interacts with SH2D5 (PubMed:25331951).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
225455, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q6PAJ1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000126377

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6PAJ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6PAJ1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini497 – 690DHPROSITE-ProRule annotationAdd BLAST194
Domaini707 – 865PHPROSITE-ProRule annotationAdd BLAST159
Domaini869 – 1001C2PROSITE-ProRule annotationAdd BLAST133
Domaini1053 – 1247Rho-GAPPROSITE-ProRule annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni198 – 387Binding to ABL SH2-domainBy similarityAdd BLAST190

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi135 – 140Poly-Ala6
Compositional biasi317 – 384Ser-richAdd BLAST68

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase (By similarity).By similarity
The DH domain is involved in interaction with CCPG1.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4269 Eukaryota
ENOG410XPGZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006779

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004165

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6PAJ1

KEGG Orthology (KO)

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KOi
K08878

Identification of Orthologs from Complete Genome Data

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OMAi
DRIMGKG

Database of Orthologous Groups

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OrthoDBi
EOG091G03M3

TreeFam database of animal gene trees

More...
TreeFami
TF105082

Family and domain databases

Conserved Domains Database

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CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.20.900.10, 1 hit
2.60.40.150, 1 hit
4.10.280.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037769 Abr/Bcr
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

The PANTHER Classification System

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PANTHERi
PTHR23182 PTHR23182, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF00168 C2, 1 hit
PF00620 RhoGAP, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48350 SSF48350, 1 hit
SSF69036 SSF69036, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6PAJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDSVGFAEA WRAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
60 70 80 90 100
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQPPDGAAEP RASAPRPPPA
110 120 130 140 150
PADGADPAPV EESEARPDGE GSPSKGRSAS ARRPAAAASA DRDDRGPPTS
160 170 180 190 200
VAALRSNFEK IRKGPAQPGS ADAEKPFYVN VEFHHERGLV KVNDKEVSDR
210 220 230 240 250
ISSLGSQAMQ MERKKSQQSA GQGLGEAPRP HYRGRSSESS CGLDGDYEDA
260 270 280 290 300
ELNPRFLKDN LINANGGNRP PWPPLEYQPY QSIYVGGMMV EGEGKSPLLR
310 320 330 340 350
SQSTSEQEKR LTWPRRSYSP RSFEDSGGGY TPDCSSNENL TSSEEDFSSG
360 370 380 390 400
QSSRVSPSPT TYRMFRDKSR SPSQNSQQSF DSSSPPTPQC QKRHRQCQVV
410 420 430 440 450
VSEATIVGVR KTGQIWPSDG DSTFQGEADS SFGTPPGYGC AADQAEEQRR
460 470 480 490 500
HQDGLPYIDD SPSSSPHLSS KGRGSLASGA LDPTKVSELD LEKGLEMRKW
510 520 530 540 550
VLSGILASEE TYLSHLEALL LPMKPLKAAA TTSQPVLTSQ QIETIFFKVP
560 570 580 590 600
ELYEIHKEFY DGLFPRVQQW SHQQRVGDLF QKLASQLGVY RAFVDNYGVA
610 620 630 640 650
METAEKCCQA NAQFAEISEN LRARSNKDVK DSTTKNSLET LLYKPVDRVT
660 670 680 690 700
RSTLVLHDLL KHTPSSHPDH SLLQDALRIS QNFLSSINEE ITPRRQSMTV
710 720 730 740 750
KKGEHRQLLK DSFMVELVEG ARKLRHIFLF TDLLLCTKLK KQSGGKTQQY
760 770 780 790 800
DCKWYIPLTD LSFQMVDELE ALPNIPLVPD EELDALKIKI SQIKSDIQRE
810 820 830 840 850
KRANKGSKVM ERLRKKLSEQ ESLLLLMSPS MAFRVHSRNG KSYTFLISSD
860 870 880 890 900
YERAEWRESI REQQKKCFKS FSLTSVELQM LTNSCVKLQT VHHIPLTINK
910 920 930 940 950
EDDESPGLYG FLHVIVHSAT GFKQSSNLYC TLEVDSFGYF VNKAKTRVYR
960 970 980 990 1000
DTTEPNWNEE FEIELEGSQT LRILCYEKCY NKMKMTKEDG ESADKLMGKG
1010 1020 1030 1040 1050
QVQLDPQTLQ DRDWQRTVID MNGIEVKLSV KFTSREFSLK RMPSRKQTGV
1060 1070 1080 1090 1100
FGVKIAVVTK RERSKVPYIV RQCVEEIERR GMEEVGIYRV SGVATDIQAL
1110 1120 1130 1140 1150
KAAFDVNNKD VSVMMSEMDV NAIAGTLKLY FRELPEPLFT DEFYPNFAEG
1160 1170 1180 1190 1200
IALSDPVAKE SCMLNLLLSL PEANLLTFLF LLDHLKRVAE KETVNKMSLH
1210 1220 1230 1240 1250
NLATVFGPTL LRPSEKESKL PANPSQPITM TDSWSLEVMS QVQVLLYFLQ
1260 1270
LEAIPAPDSK RQSILFSTEV
Length:1,270
Mass (Da):143,072
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F3E6D8485DE6717
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6I7A0A1W2P6I7_MOUSE
Breakpoint cluster region protein
Bcr
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6J3A0A1W2P6J3_MOUSE
Breakpoint cluster region protein
Bcr
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti418S → H in CAA37013 (PubMed:2263470).Curated1
Sequence conflicti1213P → S in AAH60270 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC160402 Genomic DNA No translation available.
BC002193 mRNA Translation: AAH02193.1
BC060270 mRNA Translation: AAH60270.1
X52831 Genomic DNA Translation: CAA37013.1
AK129482 mRNA Translation: BAC98292.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35935.1

Protein sequence database of the Protein Information Resource

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PIRi
S14194 S14193

NCBI Reference Sequences

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RefSeqi
NP_001074881.1, NM_001081412.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.333722

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000164107; ENSMUSP00000126377; ENSMUSG00000009681

Database of genes from NCBI RefSeq genomes

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GeneIDi
110279

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:110279

UCSC genome browser

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UCSCi
uc007fqb.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160402 Genomic DNA No translation available.
BC002193 mRNA Translation: AAH02193.1
BC060270 mRNA Translation: AAH60270.1
X52831 Genomic DNA Translation: CAA37013.1
AK129482 mRNA Translation: BAC98292.1
CCDSiCCDS35935.1
PIRiS14194 S14193
RefSeqiNP_001074881.1, NM_001081412.2
UniGeneiMm.333722

3D structure databases

ProteinModelPortaliQ6PAJ1
SMRiQ6PAJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225455, 12 interactors
IntActiQ6PAJ1, 6 interactors
STRINGi10090.ENSMUSP00000126377

PTM databases

iPTMnetiQ6PAJ1
PhosphoSitePlusiQ6PAJ1

Proteomic databases

EPDiQ6PAJ1
MaxQBiQ6PAJ1
PaxDbiQ6PAJ1
PeptideAtlasiQ6PAJ1
PRIDEiQ6PAJ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164107; ENSMUSP00000126377; ENSMUSG00000009681
GeneIDi110279
KEGGimmu:110279
UCSCiuc007fqb.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
613
MGIiMGI:88141 Bcr

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG4269 Eukaryota
ENOG410XPGZ LUCA
GeneTreeiENSGT00940000153491
HOGENOMiHOG000006779
HOVERGENiHBG004165
InParanoidiQ6PAJ1
KOiK08878
OMAiDRIMGKG
OrthoDBiEOG091G03M3
TreeFamiTF105082

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Bcr mouse

Protein Ontology

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PROi
PR:Q6PAJ1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000009681 Expressed in 267 organ(s), highest expression level in olfactory tubercle
CleanExiMM_BCR
ExpressionAtlasiQ6PAJ1 baseline and differential
GenevisibleiQ6PAJ1 MM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.900.10, 1 hit
2.60.40.150, 1 hit
4.10.280.30, 1 hit
InterProiView protein in InterPro
IPR037769 Abr/Bcr
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PANTHERiPTHR23182 PTHR23182, 1 hit
PfamiView protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF00168 C2, 1 hit
PF00620 RhoGAP, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48350 SSF48350, 1 hit
SSF69036 SSF69036, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCR_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6PAJ1
Secondary accession number(s): E9PZL3
, Q61339, Q6ZPE5, Q99LW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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